Abstract: The objective of the present invention is to provide a method for producing a polycarbonate safely and efficiently. A method for producing a polycarbonate is characterized in comprising the step of irradiating a light to a composition comprising a C1-4 halogenated hydrocarbon, the specific diol compound and the specific base in the presence of oxygen.

Abstract: [Problem to be Solved] Provided is a polyvinylidene fluoride resin-made porous membrane having excellent hydrophilicity, permeability, and fouling resistance and having suppressed elution of vinyl ether copolymer by using a small amount of vinyl ether copolymer. [Means to Solve the Problem] The porous membrane according to the invention comprises a polyvinylidene fluoride resin as a matrix material and a vinyl ether copolymer, wherein the vinyl ether copolymer is a copolymer of an oxyethylene group-containing vinyl ether monomer and a hydrocarbon group-containing vinyl ether monomer.

Abstract: The objective of the present invention is to provide a method for producing a fluorinated carbonate derivative in a safe and efficient manner. The method for producing a fluorinated carbonate derivative according to the present invention is characterized in comprising irradiating light on a composition containing a C1-4 halogenated hydrocarbon having one or more kinds of halogen atoms selected from the group consisting of a chlorine atom, a bromine atom and an iodine atom, a fluorine-containing compound having a nucleophilic functional group and a base in the presence of oxygen.

Abstract: The objective of the present invention is to provide a method for producing a carbonate derivative in a safe and efficient manner. The method for producing a carbonate derivative according to the present invention is characterized in comprising irradiating light on a composition containing a C1-4 halogenated hydrocarbon having one or more kinds of halogen atoms selected from the group consisting of a chlorine atom, a bromine atom and an iodine atom, a nucleophilic functional group-containing compound and the specific base in the presence of oxygen.

Abstract: A cap attaching/detaching device 20 is a device for attaching or detaching a cap 141 in which a screw portion is formed to or from a test tube 14 by rotating the cap 141. A cap grip portion 21 grips the cap 141. A rotation mechanism 22 attaches or detaches the cap 141 to or from the test tube 14 by rotating the cap 141 by rotating the cap grip portion 21. The rotation mechanism 22 has an axial portion 221, and a nut portion 222. The axial portion 221 has an outer peripheral surface on which a screw thread 223 is formed. The nut portion 222 has an inner peripheral surface on which a screw groove 224 to be screwed into the screw thread 223 of the axial portion 221 is formed, and rotatably holds the axial portion 221 in a fixed state. A pitch of the screw thread 223 is the same as a pitch of the screw portion formed in the cap 141.

Abstract: A solid-liquid boundary detection device 20 is a device for detecting a boundary 141 between a solid and a liquid in a test tube 14, and includes a surface illumination 21, an imaging unit 22, and a boundary detection processor 31. The surface illumination 21 illuminates the test tube 14 from outside. The imaging unit 22 is arranged on an opposite side of the test tube 14 from the surface illumination 21, and captures an image including the boundary 141. The boundary detection processor 31 detects the boundary 141 from the image captured by the imaging unit 22.

Abstract: A stirring device 11 includes a stirring mechanism 7 and a control unit 15. The stirring mechanism 7 includes a motor 74 and a pedestal portion 77. In the stirring device 11, the motor 74 repeats forward rotation and reverse rotation alternately under the control of the control unit 15. Then, the pedestal portion 77 repeats turning in one direction and turning in the other direction alternately. As a result, the test tube S repeats the movement in one direction and the movement in the other direction alternately, and the vortex rotating in one direction and the vortex rotating in the other direction are alternately generated in the mixed solution in the test tube S. Then, the mixed solution in the test tube S is stirred to be rotated, and is stirred to be moved in the vertical direction. Therefore, the mixed solution in the test tube S can be efficiently stirred. As a result, the time required for stirring the mixed solution in the test tube S can be shortened.

Abstract: When a stirring device 11 performs processing of stirring a mixed solution in a test tube S, a holding mechanism 13 and a movement mechanism 14 are operated so that the test tube S is moved to a position of B2. Then, in the test tube S, the cells attached to the inner surface of the test tube S and the liquid are separated. Further, the cells attached to the inner surface of the test tube S are detected by a color sensor 152. Therefore, it is possible to reduce the work for determining the end of the stirring processing by the user. As a result, the workability of the user when using the stirring device 11 can be improved.

Abstract: A method is for treating a surface of a resin material layer. The method includes a first step of introducing as a substituent at least one selected from the group consisting of an acid halide and an alkyl halide into an aromatic polyether-based resin included in the resin material layer by Friedel-Crafts reaction.

Abstract: A draw solute for forward osmosis membrane process, comprising an addition polymer obtained by addition polymerization of an alkylene oxide having 2 to 10 carbon atoms to an amine compound.

Abstract: The present invention is to provide a photocatalyst electrode less likely to suffer from peeling of hematite-based crystal particles from a substrate and having higher catalytic activity than ever before. A method for producing a photocatalyst electrode includes: an in-process particle of heating a raw material solution to form in-process particles, the raw material solution including a raw material solvent and a hematite raw material dispersed therein, the in-process particle forming step including heating the raw material solution in a closed vessel for more than 12 hours; and a burning step of burning the in-process particles. In this way, a photocatalyst electrode with high catalytic activity can be produced.

Abstract: The objective of the present invention is to provide a composite separation membrane which is excellent in not only a liquid permeable performance and a separation performance relatively but also a durability and which is particularly useful as a membrane for liquid treatment, and a method for treating a liquid by using the composite separation membrane. The composite separation membrane according to the present invention is characterized in comprising a supporting base material and a complex layer, wherein the complex layer is placed on the supporting base material, the complex layer comprises oxidized metal nanosheets, graphene oxide and an alkanolamine, and at least one of the alkanolamine is present between the oxidized metal nanosheets.

Abstract: Provided is a therapeutic agent that effectively acts on a disease associated with abnormal glycosylation of dystroglycan. Also provided is a testing method for diseases associated with abnormal glycosylation of dystroglycan. Specifically, provided is a therapeutic agent for diseases associated with abnormal glycosylation of dystroglycan, containing CDP-ribitol as an active ingredient. Ribitol-phosphate is important in the glycan structure of dystroglycan. In order for ribitol-phosphate to be incorporated into a dystroglycan glycan, a material therefor (sugar donor) is required. In the present invention, it has been found for the first time that CDP-ribitol serves as the sugar donor. It has been confirmed that the glycan of ISPD-deficient cells can be restored by administering CDP-ribitol. Thus, the present invention, which allows CDP-ribitol to be utilized for supplementation therapy, has been completed.

Abstract: The present invention provides a method for modifying a targeted site of a double-stranded DNA in a cell, the method including a step of bringing a complex in which a nucleic acid sequence-recognizing module that specifically binds to a selected target nucleotide sequence in a double-stranded DNA and a nucleic acid base converting enzyme or DNA glycosylase are linked, and a donor DNA containing an insertion sequence into contact with said double-stranded DNA, to substitute the targeted site with the insertion sequence, or insert the insertion sequence into said targeted site, without cleaving at least one strand of said double-stranded DNA in the targeted site.

Abstract: Provided is a measurement device including an application unit, a detection unit, and a calculation unit. The application unit applies a first magnetic field, which is generated by applying a pulse current to a coil or applying currents with a plurality of frequencies to the coil in order, to an object. The detection unit detects a second magnetic field which is generated by applying the first magnetic field to the object. The calculation unit calculates a distribution of a magnetic field source m in the second magnetic field. The calculation unit may further generate an imaging signal for displaying the calculated distribution of the magnetic field source m, as an image. The display unit displays the image indicating the distribution of the magnetic field source m by using the imaging signal.

Abstract: One objective of the present invention is to provide a novel simple and efficient transformation method for gram-positive bacteria, the transformation method being capable of introducing a large-sized DNA into a host DNA of the gram-positive bacteria without damage. In addition, another objective of the present invention is to provide a method in which desired DNA segments are accumulated in a chromosome of a recipient (recipient bacteria) to enable an artificially designed huge DNA to be constructed, and in which a transformed cell does not cause any problems in terms of controlling the natural environment. The present invention relates to a transformation method for gram-positive bacteria by conjugative transfer, characterized to use a helper plasmid having an origin of DNA transfer (oriT) region is inactivated. Preferably, the helper plasmid is a plasmid in which an oriT region is inactivated from pLS20cat.

Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and DNA glycosylase with sufficiently low reactivity with a DNA having an unrelaxed double helix structure (unrelaxed DNA) are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.

Abstract: An anti-SIRP? antibody that can be used as a tumor agent and an anti-tumor agent comprising the antibody as an active ingredient. An antibody that binds specifically to human SIRP? to inhibit binding of human SIRP? to CD47.

Abstract: The present invention provides a method for modifying a targeted site of a double-stranded DNA in a cell, the method including a step of bringing a complex in which a nucleic acid sequence-recognizing module that specifically binds to a selected target nucleotide sequence in a double-stranded DNA and a nucleic acid base converting enzyme or DNA glycosylase are linked, and a donor DNA containing an insertion sequence into contact with said double-stranded DNA, to substitute the targeted site with the insertion sequence, or insert the insertion sequence into said targeted site, without cleaving at least one strand of said double-stranded DNA in the targeted site.

Abstract: A device for fixing biological soft tissue is endowed with strength and deformation performance for being used as a device for coupling biological soft tissue that has been cut or separated due to an incision or the like during a surgical procedure, and is completely degraded in vivo and discharged after adhesion of the soft tissue or after healing of the incision tissue. The device is composed of a ternary Mg alloy material of Mg—Ca—Zn. In the Mg alloy material, the Ca and Zn are contained within the solid-solubility limit with respect to the Mg. The remainder is composed of Mg and unavoidable impurities. The Zn content is 0.5 at % or less. The Ca and Zn content has a relationship of Ca:Zn=1:x (where x is 1 to 3) by atom ratio. The crystal grain structure is equiaxed, the crystal grain size according to linear intercept being 30 to 250 ?m.