Abstract: A guide pin piercing jig includes a cylinder unit and a frame having a positioning projection at a tip thereof, in which the cylinder unit has plural parallel guide pin insertion cylinders and tentative fixing unit and is attached to the frame slidably so as to be directed to the tip of the frame. It becomes possible to pierce living body bone with plural guide pins for hollow drills to a proper portion of a living body bone in a proper direction with parallel arrangement to form a bone tunnel that has a rectangular or elliptical opening and is suitable for tendon transplantation.

Abstract: A drill guide has a main body in which a drill insertion hole is formed and plural projection portions to be inserted into plural bone tunnels. The plural projection portions project forward from the main body parallel with the center line of the drill insertion hole, a virtual drill insertion hole which extends from the drill insertion hole of the main body is formed between the plural projection portions parallel with their center lines by cutting out confronting portions of the plural projection portions, and the length of at least one of the drill insertion hole and the virtual drill insertion hole is 5 mm or more. The drill guide can guide a drill so as to be correctly between plural bone tunnels bored through a living body bone without causing axis deviation so that a link bone tunnel for connecting the plural bone tunnels can be formed between them in the same direction as their direction.

Abstract: Provided is a gene for expressing an immunogenic polypeptide on the cell surface of a bifidobacterium, and the gene includes a gene encoding the immunogenic polypeptide, the immunogenic polypeptide includes a predetermined base domain and at least one antigenic peptide, and the at least one antigenic peptide is linked on any of the N-terminal side and the C-terminal side of the base domain. The gene for expressing an immunogenic polypeptide on a cell surface of a bifidobacterium of the present invention can further include a gene encoding a bifidobacterium-derived GNB/LNB substrate-binding membrane protein.

Abstract: The present invention aims to provide a yeast that is genetically modified so as to more highly produce glutathione, and a method of producing glutathione utilizing the yeast. The present invention provides a method of producing glutathione, including culturing a yeast whose thiol oxidase activity is increased as compared to the parent strain in a culture medium to produce glutathione, and recovering glutathione from the cultured broth obtained.

Abstract: A shape evaluation method according to the present invention comprises: a shape error calculation step that calculates a shape error, which is an error between a designed shape and a shape to be evaluated; and a visible error detection step that detects visible shape errors on the basis of the shape error and predetermined visual characteristic data.

Abstract: A method for producing a particulate polymer includes polymerizing a monomer having a vinyl group in an aqueous solvent in the presence of a surfactin salt and a polymerization initiator, wherein a concentration of the surfactin salt in a polymerization reaction liquid is adjusted depending on a target particle diameter of the particulate polymer.

Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and DNA glycosylase with sufficiently low reactivity with a DNA having an unrelaxed double helix structure (unrelaxed DNA) are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.

Abstract: Disclosed is a polynucleotide for cell surface expression. The polynucleotide of the invention comprises a promoter, a secretion signal sequence, a sequence encoding an intended protein, and a sequence encoding a cell surface-localized protein or a cell membrane-binding domain thereof, wherein the promoter is a promoter of a gene encoding the cell surface-localized protein. Provided is a polynucleotide for cell surface expression allowing the production of yeast displaying an enzyme on the cell surface with a high activity.

Abstract: According to one embodiment, a medical image processing apparatus includes an image storage memory, a calculation circuitry, a level decision circuitry, and an output interface circuitry. The image storage memory stores data of a plurality of images in different respiratory phases. The calculation circuitry calculates a motion amount of a region between the plurality of images for each pixel or area. The level decision circuitry decides a level concerning a severity of chronic obstructive pulmonary disease for each pixel or area. The output interface circuitry outputs information concerning the decided level.

Abstract: An expression vector is disclosed which contains a promoter DNA; a DNA encoding a peptide having a defined amino acid sequence and having secretion signal activity; and a DNA encoding an intended protein or a cloning site for insertion of the DNA encoding an intended protein. An expression vector is also disclosed which contains a promoter DNA; a DNA encoding any peptide having a defined amino acid sequence and having secretion signal activity; a DNA encoding an intended protein or a cloning site for insertion of the DNA encoding an intended protein; and a DNA encoding an anchor domain. The peptide having secretion signal activity allows for secretory production and cell surface display of a protein with high activity, in yeast.

Abstract: According to one embodiment, a medical imaging analyzer includes an imaging unit, a calculator, and an analyzer. The imaging unit divides an area including an object of a subject to be captured into a plurality of partial areas such that the partial areas overlap each other to form an overlapping area, and administers a contrast agent to each of the partial areas to capture a plurality of time-series images. The calculator calculates, based on the transition of the pixel value in one of the time-series images having the overlapping area, the transition of the pixel value in the other time-series image having the overlapping area. The analyzer analyzes the time-series images based on the transition of the pixel value in the one and the other of the time-series images to obtain the hemodynamics of the subject.

Abstract: An axial flow blood pump comprises: an impeller (2) that rotates around an axis and is provided with axial flow blades on the peripheral surface thereof, a permanent magnet inside the impeller (2), and a dynamic bearing or a pivot bearing; a first casing (5) that surrounds the peripheral surface of the impeller (2) and is provided with an intake port (11); an annular fixed element (6) that generates a rotating magnetic field in the impeller (2) and can be fitted onto the outer surface of the first casing (5); an outlet port (12); a second casing (3) that is provided with guide vanes (diffusers) (31) in the inner surface thereof; and a socket member (4) that is fittably and securely mounted onto the outer peripheral surface of the second casing (3) and is provided with a joining portion that can join with the fixed element (6).

Abstract: Disclosed is a CO2 permselective membrane 1 having an amino acid ionic liquid and a porous membrane impregnated with the amino acid ionic liquid, wherein the amino acid ionic liquid contains a certain range of water.

Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and a nucleic acid base converting enzyme are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one chain of the double stranded DNA in the targeted site.

Abstract: A distribution analysis device analyzes a distribution of a field having a property satisfying the Laplace equation, and includes: an obtainment unit that obtains measurement data indicating the distribution of the field measured through a sensor sensing area, the sensor sensing area being an area that moves in a measurement area where the distribution of the field is measured and being an area in which the field is sensed as an aggregate; and a calculation unit that calculates analysis data indicating the distribution of the field with a higher resolution than the measurement data, using an arithmetic expression that is obtained by deriving a solution of the Laplace equation using a boundary condition that an integral of the solution of the Laplace equation in a finite interval corresponding to a size of the sensor sensing area matches the measurement data.

Abstract: Provided is an Mg alloy and a method for producing same able to demonstrate high strength without requiring an expensive rare earth element (RE). The high-strength Mg alloy containing Ca and Zn within a solid solubility limit and the remainder having a chemical composition comprising Mg and unavoidable impurities is characterized in comprising equiaxial crystal particles, there being a segregated area of Ca and Zn along the (c) axis of a Mg hexagonal lattice within the crystal particle, and having a structure in which the segregated area is lined up by Mg3 atomic spacing in the (a) axis of the Mg hexagonal lattice. The method for producing the high-strength Mg alloy is characterized in that Ca and Zn are added to Mg in a compounding amount corresponding to the above composition and, after homogenization heat treating an ingot formed by dissolution and casting, the above structure is formed by subjecting the ingot to hot processing.

Abstract: An object recognition system is applicable to practical use, and utilizes image information besides speech information to improve recognition accuracy. The object recognition system comprises a speech recognition unit to determine candidates for a result of speech recognition on input speech and their likelihoods, and an image model generation unit to generate image models of a predetermined number of the candidates having the highest likelihoods. The system further comprises an image likelihood calculation unit to calculate image likelihoods of input images based on the image models, and an object recognition unit to perform object recognition using the image likelihoods. At the time of generating the image model of the candidate, the image model generation unit first searches an image model database, and, when the image model of the candidate is not found in the database, the image model generation unit generates said image model from image information on the web.

Abstract: Disclosed is a polynucleotide for cell surface expression. The polynucleotide of the invention comprises a promoter, a secretion signal sequence, a sequence encoding an intended protein, and a sequence encoding a cell surface-localized protein or a cell membrane-binding domain thereof, wherein the promoter is a promoter of a gene encoding the cell surface-localized protein. Provided is a polynucleotide for cell surface expression allowing the production of yeast displaying an enzyme on the cell surface with a high activity.

Abstract: Provided is a method for efficiently producing ethanol by ethanol fermentation from xylose using a saccharified biomass, which contains various fermentation inhibitors. A method for producing ethanol from biomass of the present invention includes the step of culturing a xylose-utilizing yeast transformed so as to overexpress a gene for an acetic acid-responsive transcription factor in combination with a saccharified biomass.

Abstract: Provided are a glass body for pressure forming enabling press forming in a low-temperature range without the need of a special mold material, and a method for manufacturing the same. A glass body for pressure forming 1 having a porosified layer 1b formed by porosifying a surface thereof and having a Vickers hardness of 85 N/mm2 or less on the porosified surface. The porosified layer 1b can be manufactured by phase-separating the glass body by spinodal decomposition, acid-treating the phase-separated glass body and then treating the acid-treated glass body with alkali or hot water to porosify the surface of the glass body.