Abstract: Provided are a line-of-sight measurement device and method, which perform automatic calibration of line-of-sight measurement for distance-gazing users. The device is provided with: an optical axis-calculating means for calculating the optical axes of both the left and right eyeballs when viewing two distant points; a discrepancy calculating means for calculating, with the visual axes of the left and right eyeballs during distance-gazing being parallel as a constraint, the discrepancies between the optical axes and the visual axes for both the left and right eyeballs; and a fixation point-calculating means for calculating the user's fixation point on the basis of the discrepancy between the optical axes and the visual axes. For the constraint, the outer product value of the respective vectors of the left and right eye visual axes is 0 or the inner product of the respective unit vectors of the left and right eye visual axes is 1.

Abstract: There is provided a method for generating an oil/fat component, in which salt-tolerant algae are cultured in a culture medium of which the salt concentration has been increased in a stepwise manner.

Abstract: The invention provides a method of modifying a targeted site of gram-positive bacterium of a double stranded DNA. The method includes contacting the double-stranded DNA with a complex of a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a given double stranded DNA and a nucleic acid base converting enzyme to convert, delete, or insert one or more nucleotides in the targeted site without cleaving at least one strand of the double stranded DNA in the targeted site, by introducing the nucleic acid encoding the complex into the gram-positive bacterium. The invention also provide a nucleic acid-modifying enzyme complex of a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a double stranded DNA of a gram-positive bacterium and a nucleic acid base converting enzyme bonded to each other, which complex is used for the method.

Abstract: A nobel therapeutic agent for diabetes which can suppress occurrence of side effects such as persistent hypoglycemia is provided. The active ingredient is a derivative of 1,1-diphenylsemicarbazide or 1,1-diphenylthiosemicarbazide. In particular, the active ingredient is a derivative of 1,1-diphenyl-4-cyclohexyl-semicarbazide or 1,1-diphenyl-4-cyclohexyl-thiosemicarbazide exhibiting hypoglycemic action when orally administered.

Abstract: An automatic analyzing apparatus 10 includes a chip rack 11 that stores a pipette chip, a pipette 12 into which a specimen is injected, a conveyance unit that conveys the pipette 12 by parallel translation, a reagent rack 14, a reaction unit 15, a detection unit 16, and a detection block unit 17. The pipette chip stored by the chip rack 11 has a planar structure to directly and optically detect the specimen. The chip rack 11 includes, in a hole that receives the pipette chip, a guide corresponding to the structure of the pipette chip. The pipette 12 sucks or discharges the specimen via the pipette chip mounted onto the tip thereof by a drive of a pump. In the detection unit 16, a measurement is carried out with the pipette chip arranged so that the plane that receives light is vertical to an optical axis.

Abstract: A conductivity distribution derivation method for deriving a conductivity distribution within a battery having an electrode plate that is flat includes: obtaining magnetic field information indicating a magnetic field; and deriving, based on a plurality of relational expressions which (i) an x component of a magnetic field vector in an x direction parallel to the electrode plate, (ii) a y component of the magnetic field vector in a y direction parallel to the electrode plate and perpendicular to the x direction, (iii) the conductivity distribution on a two-dimensional plane parallel to the electrode plate, and (iv) an electric potential distribution on a two-dimensional plane parallel to the electrode plate satisfy, the conductivity distribution that satisfies the plurality of relational expressions with respect to the magnetic field information.

Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA of a monocot cell, comprising a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in the given double stranded DNA and a nucleic acid base converting enzyme are bonded, with said double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into said targeted site, without cleaving at least one strand of said double stranded DNA in the targeted site, wherein the double stranded DNA is contacted with the complex by introducing a nucleic acid encoding the complex into the monocot cell.

Abstract: A guide pin piercing jig includes a curved frame, a front cylinder unit provided at a front end of the frame, and a rear cylinder unit provided at a rear end of the frame, in which the front cylinder unit has a positioning projection and a boring aiming portion at a tip thereof, the rear cylinder unit has a plurality of parallel guide pin insertion cylinders into which to insert the guide pins and a tentative fixing unit provided at a tip of the rear cylinder unit, and the rear cylinder unit is provided at a rear end of the frame slidably so as be directed to a tip of the front cylinder unit. It becomes possible to aim at a proper portion of a living body bone through which to bore a bone tunnel and to pierce the living body bone with guide pins for hollow drills from behind the living body bone to the proper aiming portion in a proper direction.

Abstract: In the present invention: a plurality of meshes are defined on an object surface; the luminance of the object surface when the object surface is viewed from a viewpoint position is calculated for each of the plurality of meshes on the basis of data concerning a processed shape, a surface roughness curve, the viewpoint position, the direction, angle distribution, and intensity of incident light onto the object surface, and a reflectance and scattering characteristics for each wavelength on the object surface; the shape of the object surface is displayed on the basis of the luminances; and data concerning at least the object shape or the surface roughness curve is corrected so as to obtain a desired appearance of the object surface.

Abstract: There is provided a method for generating an oil/fat component by means of culturing algae, in which marine algae belonging to chlamydomonas are cultured in a culture medium containing sea salt.

Abstract: The present invention provides a RO membrane or a FO membrane comprising a coating layer made of a phospholipid bilayer membrane and formed on a surface of a porous membrane body, having a high water permeate flow rate and salt rejection performance, the membrane being a permselective membrane comprising a porous membrane having a pore size of 5 nm to 50 nm and a coating layer made of a phospholipid bilayer and formed on a surface of the porous membrane, wherein (i) the phospholipid bilayer comprises phospholipid, amphotericin B, and ergosterol; (ii) a content of the amphotericin B is 3 to 20 mol % based on the phospholipid bilayer; (iii) a total content of the ergosterol and the amphotericin B in the phospholipid bilayer is 10 to 30 mol %.

Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA in a host cell, the method including introducing (a) a DNA encoding a crRNA containing a sequence complementary to a target strand of a target nucleotide sequence in the given double stranded DNA, and (b) a DNA encoding a protein group constituting Cascade and a nucleic acid base converting enzyme, in which the nucleic acid base converting enzyme is constituted in a form capable of forming a complex with any protein in the protein group, into the host cell to convert one or more nucleotides in the targeted site to other one or more nucleotides, or delete one or more nucleotides, or insert one or more nucleotides into said targeted site, without cleaving the double stranded DNA in the targeted site.

Abstract: The production method of the present invention includes: a first fermentation step of adding at least one microorganism selected from yeast, Escherichia coli, and bacteria of the genus Corynebacterium to a first concentrated sugar solution to ferment the first concentrated sugar solution and subjecting the resulting first fermented solution to solid-liquid separation, the first concentrated sugar solution being obtained by using a nanofiltration membrane and/or a reverse osmosis membrane to concentrate a sugar solution obtained using a herbaceous plant of the family Gramineae or Cucurbitaceae as a raw material; and a second fermentation step of adding a second concentrated sugar solution to a solid component obtained in the first fermentation step to ferment the second concentrated sugar solution with the microorganism used in the first fermentation step, and subjecting the resulting second fermented solution to solid-liquid separation.

Abstract: A method for producing a particulate polymer includes polymerizing a monomer having a vinyl group in an aqueous solvent in the presence of a surfactin salt and a polymerization initiator, wherein a concentration of the surfactin salt in a polymerization reaction liquid is adjusted depending on a target particle diameter of the particulate polymer.

Abstract: Provided are a laser tip, a laser treatment tool, a laser treatment device and a laser treatment system safely performing a surgery for a laser treatment and, if bleeding occurs, stopping the bleeding. A laser tip 70 is attachable to a laser radiation opening 63a provided at a tip end of a laser transmission tube 63. From the laser radiation opening 63a, laser light 57a is directed.

Abstract: Provided is a colorectal cancer inspection method by which the presence of early colorectal cancer at any one of stages from 0 to 2 can be accurately determined. The colorectal cancer inspection method includes: measuring the amounts of at least lactic acid, pyruvic acid, and glycolic acid among a plurality of kinds of in vivo metabolites contained in a biological sample collected from a test subject, based on data obtained by performing a chromatograph-MS/MS analysis on the biological sample; and determining the presence of colorectal cancer at any one of stages from 0 to 2, based on a measurement value of at least one of the lactic acid, the pyruvic acid, and the glycolic acid.

Abstract: A scattering tomography method includes: radiating waves to an object from a plurality of transmitting antenna elements aligned on a side surface of a case; receiving scattered waves by a plurality of receiving antenna elements aligned on the side surface of the case; and reconstructing an image relating to information on an interior of the object using scattered wave data representing the scattered waves. In the reconstructing, a reconstruction function for reconstructing the image relating to the information on the interior of the object is set in advance for a three-dimensional space having the same shape as the case, a scattering field equation which the reconstruction function satisfies is constructed, a visualization function that is obtained by solving the scattering field equation is derived from the scattered wave data, and the image relating to the information on the interior of the object is reconstructed using the visualization function.

Abstract: At least one stable isotope reagent is added to each biological sample and standard sample to prepare biological samples for analysis and standard sample for analysis. The quality of the biological samples is evaluated using data of one set of biological samples for analysis composed of a plurality of biological samples for analysis. Besides, the quality of a pretreatment and/or analysis of each set of samples for analysis is evaluated using data obtained by analyzing the standard sample for analysis before and after an analysis of one set of samples for analysis. An abnormality in a chromatograph or mass analyzer used for the analysis of one set of samples is evaluated by the data obtained by analyzing a sample for device evaluation before and after the analysis of one set of samples for analysis. Thus, the quality of data obtained by chromatographic mass spectrometry on biological samples is comprehensively evaluated.

Abstract: Provided is a tolerance improving agent that can increase or improve environmental stress tolerances (high-temperature tolerance, drought tolerance and the like) of plants. The tolerance improving agent is constituted of at least one kind of unsaturated carbonyl compound selected from unsaturated aldehyde and unsaturated ketone. Such unsaturated carbonyl compound is, for example, a compound having 4-9 carbon atoms, which does not have an unsaturated bond at the terminal, and may be at least one kind selected from ?,?-alkenal, ?,?-alkanone, ?,?-alkenal, ?,?-alkanone, ?,?-alkenal, ?,?-alkanone, ?,?-alkenal, and ?,?-alkanone.

Abstract: The present invention provides: a furoxan compound having a fluorine atom as a substituent group on the ring structure thereof; and a novel nitric oxide donor including the compound. The present invention relates to a fluorofuroxan compound represented by general formula (1) or (2). The compound of formula (1) can be manufactured by reacting a fluoride salt with a nitrofuroxan compound to substitute the nitro group with a fluoro group. The compound of formula (2) can be manufactured by subjecting the compounds of formula (1) to isomerization by irradiation with light.