Patents Assigned to Korea Basic Science Institute
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Publication number: 20120258471Abstract: The present invention relates to a peptide marker for cancer diagnosis and a cancer diagnosis method using the same, more precisely to a peptide marker for cancer diagnosis screened by the following steps: separating and concentrating glycoproteins including a certain glycan chain related to the occurrence of cancer; hydrolyzing the glycoproteins to obtain polypeptides; and quantitatively analyzing the polypeptides to identify certain polypeptides that can track quantitative changes in glycoproteins glycosylated in a specific manner by the occurrence of cancer, and to a cancer diagnosis method using the said peptide marker.Type: ApplicationFiled: December 6, 2010Publication date: October 11, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Yeong Hee Ahn, Jong Shin Yoo
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Publication number: 20120258484Abstract: The present invention relates to a method for diagnosing cancer using information on the aberrant glycosylation of a glycoprotein. More precisely, the present invention relates to a cancer diagnosis peptide marker, which is screened by: a step of separating, using a lectin, a glycoprotein which is aberrantly glycosylated in accordance with the occurrence of cancer; and a step of selecting a hydrolyzed peptide marker derived from the aberrantly glycosylated glycoprotein by observing the quantitative changes in the separated glycoprotein. The present invention also relates to a method for diagnosing cancer using the peptide marker as an agent.Type: ApplicationFiled: December 29, 2009Publication date: October 11, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Yeong Hee Ahn, Jong Shin Yoo
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Publication number: 20120160692Abstract: A liquid medium plasma discharge generating apparatus includes a main body; a power electrode, provided at one side within the main body, for receiving electric power; a diaphragm member provided within the main body, and consisting of a dielectric defining one or more holes or slits; and a liquid medium charged inside the main body, wherein a ground electrode may be further provided in the main body, opposite the power electrode with the diaphragm member therebetween, whereupon the diaphragm member is arranged contacting the ground electrode.Type: ApplicationFiled: July 21, 2010Publication date: June 28, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Dong Chan Seok, Tai Hyeop Loh, Seung Ryul Yoo, Yong Cheol Hong, Bong Ju Lee
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Patent number: 8206566Abstract: Disclosed herein is an electrochemical measurement system for analyzing heavy metals in organic compound-containing samples, comprising: a lower plate; a flow channel plate; an upper plate; an organic compound-decomposing electrode and a heavy metal analysis electrode; and a flow changeover portion. The disclosed system can continuously perform a pretreatment process for organic compound decomposition and a process for heavy metal analysis, thus making it possible to achieve the selective analysis and separation of heavy metals in wastewater. Also, it can substitute for expensive spectrophotometric analysis equipment and makes it possible to monitor trace heavy metals on-line in situ. In addition, it may include a small-sized battery as a power source, such that it is easy to carry and use.Type: GrantFiled: July 20, 2010Date of Patent: June 26, 2012Assignee: Korea Basic Science InstituteInventors: Jang-Hee Yoon, Mi-Sook Won
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Publication number: 20120159153Abstract: An identity-based ring signature authentication method provides an efficient identity-based ring signature method, which has a constant number of bilinear pairing computations independent the number of ring members in a verification process. The method does not use a special type of function, e.g., MapToPoint.Type: ApplicationFiled: December 8, 2011Publication date: June 21, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Kyung Ah Shim, Young Ran Lee
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Publication number: 20120153825Abstract: The present invention relates to the new structure antenna to create the uniform large area plasma using microwave. The microwave antenna to create the plasma of present invention comprises the waveguide, main body of antenna and the coaxial structure connecting part which connects said waveguide and said main body of antenna electrically, the main body of antenna comprises the conductive block in donut shape forming multiple slots, and notches are formed between the multiple slots of the conductive block and multiple permanent magnets are inserted into the notches. The multiple slots can be formed by passing through the inside and outside of the conductive block and the multiple slots can be formed with repetitive square wave pattern.Type: ApplicationFiled: July 6, 2010Publication date: June 21, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Hyun Jong You, Soo Ouk Jang, Yong Ho Jung, Bong Ju Lee
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Publication number: 20120137707Abstract: An apparatus for transferring cryogenic refrigeration includes a cryocooler interface, a housing, a working fluid, a heat exchanger, a flexible thermal link, and a remote cartridge cold head. The cryocooler interface is thermally connected to a cryocooler providing a source of refrigeration. The refrigeration is passed from the crycooler into the heat exchanger via the cryocooler interface. The remote cartridge cold head is attached to a remote location. Heat is drawn from the remote location through the remote cartridge cold head and into the heat exchanger via the working fluid within the flexible thermal link and housing. Within the heat exchanger, heat is transferred from the working fluid to the refrigeration source, such as a cryocooler; accordingly, the remote location is cooled.Type: ApplicationFiled: December 12, 2011Publication date: June 7, 2012Applicants: Korea Basic Science Institute, The Florida State University Research Foundation, Inc.Inventors: Thomas Andrew Painter, Yeon Suk Choi, Dong Lak Kim, Hongyu Bai
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Publication number: 20120119109Abstract: Provided is a holder capable of a precise observation from 3 or more directions to analyze complicated internal structures of a specimen thereof, and more particularly, a specimen holder capable of a 3-axis movement for transmission electron microscope (TEM) 3D analysis that rotates cradles for supporting the specimen and moves the cradles back and forth and left and right, and freely changes directions of the specimen, thereby making it possible to more accurately analyze the specimen in three dimensions.Type: ApplicationFiled: November 30, 2010Publication date: May 17, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Youn-Joong Kim, Jong-Man Jeung
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Publication number: 20120109533Abstract: The present invention relates to a method of analyzing a protein or proteins comprising the steps of: (A) pre-treating a mixture containing at least one protein to obtain peptides; (B) obtaining information about retention times and mass values of the obtained peptides by performing data-independent analysis; (C) searching a first database on the basis of the information obtained in step (B) to quantify and qualify a target protein or proteins; (D) extracting information about the quantified and qualified target protein or proteins; (E) obtaining information about retention times and mass values by performing data-dependent analysis from the extracted information of step (D); (F) searching a second database on the basis of the information obtained in step (E) to further quantify and qualify the target protein or proteins; and (G) comparing the search results of step (C) and (F) to verify the quantification and qualification.Type: ApplicationFiled: December 1, 2011Publication date: May 3, 2012Applicant: Korea Basic Science InstituteInventors: Joseph KWON, Chiyoul PARK, Gookpil ROH, Taehoon LEE, Jongsoon CHOI
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Publication number: 20120107858Abstract: The present invention relates to a cancer diagnosis method using peptides containing information on the glycosylation of a glycoprotein involving cancer development. More particularly, the present invention relates to a cancer diagnosis method which obtains peptides from the glycoprotein involving cancer development through a hydrolysis process using an enzyme, and quantitatively detects, from among the thus-obtained peptides, glycosylation-related specific peptides which are influenced by the glycosylation of proteins and show specific quantitative changes in the hydrolysis process, to thereby select glycosylation-related specific peptides which show specific quantitative changes in accordance with cancer development. The cancer diagnosis method of the present invention uses the thus-selected glycosylation-related specific peptides as a marker.Type: ApplicationFiled: November 19, 2009Publication date: May 3, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Jong Shin Yoo, Yeong Hee Ahn, Ju Yeon Lee, Jin Young Kim
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Patent number: 8167682Abstract: Disclosed is an automatic constant pressure polishing apparatus. The automatic constant pressure polishing apparatus comprises a housing having a hollow section therein, a rubber pad installed in the housing and having superior expansion and contraction characteristics, a pressure fixture having a male screw section, which is formed on an outer peripheral surface thereof in order to press and fix the rubber pad, and a central hole formed at a central portion thereof, a slider screw-coupled into the housing to adjust pressure in the housing according to a rotational degree of the rotating shaft, and a polishing pad installed at a front end portion of the housing.Type: GrantFiled: November 14, 2007Date of Patent: May 1, 2012Assignee: Korea Basic Science InstituteInventors: Geonhee Kim, Sunchoel Yang, Myengsang Kim, Kisoo Chang, Hyosik Kim
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Publication number: 20120073308Abstract: Provided is an apparatus for controlling temperature of a black body. The apparatus includes a black body emitting radiant energy of infrared rays; a first Peltier element adjacent to the black body, the first Peltier element having a 1a surface and a 1b surface that selectively emit or absorb heat; a copper plate adjacent to the 1b surface; a second Peltier element adjacent to the 2b surface, the second Peltier element having a 2a surface and a 2b surface that selectively emit or absorb heat; a heat transfer member comprising a bent surface adjacent to the 2a surface, and an arm extending toward both ends of the black body to be adjacent to the both ends of the black body and a control unit controlling the 2a surface to emit heat when the 1a surface emits heat, and the 2a surface to absorb heat when the 1a surface absorbs heat.Type: ApplicationFiled: November 5, 2010Publication date: March 29, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Geon Hee Kim, Jeong Min Lee, Sun Choel Yang, Ki Soo Chang, Hyo Sik Kim, Moon Seop Yang
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Publication number: 20120049082Abstract: An apparatus for electrospray ionization may include: a platform including an inlet port, a first channel connected to the inlet port, a second channel connected to the first channel, and an outlet port connected to the second channel; a nebulizer provided in the first channel and configured to spray inert gas to a sample sprayed into the first channel through the inlet port; and a focusing lens provided in the second channel and configured to focus ions produced from the sprayed sample toward the outlet port.Type: ApplicationFiled: December 23, 2010Publication date: March 1, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Duk Jin Kang, Myoung Choul Choi, Jong Shin Yoo, Hyun Sik Kim
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Publication number: 20110294020Abstract: This invention relates to a negative active material for a lithium secondary battery, a method of preparing the same and a lithium secondary battery including the same. This negative active material exhibits high capacity and superior cycle-life characteristics and is thus usefully employed in a lithium secondary battery which shows high capacity during high-rate charge•discharge.Type: ApplicationFiled: July 27, 2009Publication date: December 1, 2011Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Yang Soo Kim, Euh Duck Jeong, Hae Jin Kim, Young Min Kim, Jong Seong Bae, Kyong Soo Hong, Hee Jin Kim, Kyeong Seo Bae
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Publication number: 20110256580Abstract: The present invention relates to a method for screening a new drug candidate using a liquid chromatography/microfluidic device/mass spectrometry system, and to a liquid chromatography/microfluidic device/mass spectrometry system. The present invention involves the detection of an interaction between molecules on a real-time basis through adjustment of a microreaction between traces of natural material or synthesized new drug candidates and a target material (protein or cell, etc.), thus developing materials for new drug candidates at a lower cost and with high efficiency, while improving quality of life and reducing medical costs. The present invention can be valuably used in increasing new scientific technology through the convergence of nanotechnology, biotechnology, and analytical chemistry technology.Type: ApplicationFiled: December 16, 2009Publication date: October 20, 2011Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Sanggoo Kim, Jin-Woo Jung, Chan-Soo Park
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Publication number: 20110150753Abstract: The present invention relates to a method for preparing anatase-type titanium dioxide (TiO2) nanoparticles, the method comprising the steps of: uniformly mixing titanium n-butoxide and cetyltrimethyl ammonium salt (CTAS) in water; subjecting the mixture to hydrothermal treatment at a temperature of 60˜120° C.; and collecting anatase-type titanium dioxide nanoparticles produced by the hydrothermal treatment and drying the collected nanoparticles. According to the present invention, anatase-type titanium dioxide nanoparticles having excellent crystallinity can be easily prepared in large amounts by a simple process without needing heat treatment.Type: ApplicationFiled: February 18, 2011Publication date: June 23, 2011Applicant: Korea Basic Science InstituteInventors: Hae jin Kim, Soon Chang Lee, Jin Bae Lee
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Publication number: 20110140641Abstract: An apparatus of an electron cyclotron resonance ion source may include: a magnet unit containing a magnet for generating magnetic fields; an ionizing chamber housing unit for generating ions through electron cyclotron resonance from a plasma; a microwave generating unit for injecting microwaves to the ionizing chamber housing unit to generate ions; and a beam integrating and guiding unit for treating the generated ions. The magnet unit may include: a bobbin for winding the magnet; a variable spacer for dividing the bobbin into a plurality of sections; and the magnet which is wound into the form of a wire or a tape in the plurality of sections formed by the variable spacer.Type: ApplicationFiled: November 16, 2009Publication date: June 16, 2011Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Mi-Sook Won, Byoung-Seob Lee, Jong-Pil Kim, Jang-Hee Yoon, Jong Seong Bae, Jeong Kyu Bang, Hyosang Lee, Jinyong Park
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Publication number: 20110114834Abstract: A high throughput apparatus for multiple sample analysis is disclosed. The high throughput apparatus for multiple sample analysis may include: a laser light source; a lens array configured to focus laser irradiated by the laser light source into a plurality of focused laser beams; and a focusing unit disposed between the lens array and a sample, the focusing unit configured to focus ions produced from the sample by the plurality of focused laser beams into a plurality of ion beams. A high throughput method for multiple sample analysis may include: producing a plurality of focused laser beams by focusing laser; ionizing a sample by irradiating the plurality of focused laser beams to the sample; and producing a plurality of ion beams by focusing ions, wherein the ions are produced from the sample by the plurality of focused laser beams.Type: ApplicationFiled: November 17, 2010Publication date: May 19, 2011Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Myoung Choul Choi, Hyun Sik Kim, Jong Shin Yoo, Geon Hee Kim, Ki Soo Chang
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Patent number: 7939799Abstract: A tandem Fourier transform ion cyclotron resonance mass spectrometer is provided. In the mass spectrometer, the ions selected by a FT-ICR mass analyzer, which can perform an ion selection process and a mass measurement process with a time interval between the processes, are transmitted through an ion guide to a collision cell, which is located a predetermined distance from the FT-ICR mass analyzer, to split into fragment ions. The fragment ions are transmitted to the FT-ICR mass analyzer that measures the mass of the fragment ions. The fragment ions are generated in the collision cell 60 established separately from the FT-ICR mass analyzer 40 according to the mass spectrometer. Accordingly, It can solve various problems (e.g., the radius reduction of cyclotron motion of colliding ions, or the removal of periphery gas after generating the fragment ions) occurred in a tandem mass spectrometer using a conventional tandem-in-time mass analysis method.Type: GrantFiled: September 12, 2006Date of Patent: May 10, 2011Assignee: Korea Basic Science InstituteInventors: Hyun Sik Kim, Myoung Choul Choi, Jong Shin Yoo
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Patent number: 7889034Abstract: Disclosed is a method for designing a superconducting magnet for generating high magnetic fields with high uniformity for controlling a stray field to be within an allowable range and acquiring structural and magnetic stability by optimizing the arrangement of positions and shapes of coils configuring the superconducting magnet. Volumes of a main coil and a shielding coil are set to be variables, and the critical value of a wires related on the current and magnetic field, the heat transfer depth, and the quench strain are defined to be restriction conditions so that linear programming is applied to determine an initial shape of the shielding coil and division of the main coil based on the sum of total volumes, that is, an objective function. The initial shapes of the main coil and the shielding coil determined through the linear programming are revised and the shape of a shimming coil is determined by using non-linear programming based on the objective function.Type: GrantFiled: November 29, 2005Date of Patent: February 15, 2011Assignee: Korea Basic Science InstituteInventors: Byoung-Seob Lee, Dong-Lak Kim, Hyun-Sik Kim, Jong-Shin Yoo