Abstract: A vehicle lamp having a light assembly and reflector assembly is provided. The light assembly has a light emitting diode (LED) mounted on a substrate to emit first and second solid angles. A reflective recycling surface is mounted on the substrate adjacent to the LED. The reflector assembly has a first reflector having a macro-focal reflective surface extending at the first solid angle relative to the LED and defines an output light pattern along an output optical axis. A second reflector has an ellipsoid reflective surface extending at the second solid angle relative to the LED and has a first focal point oriented at the LED and a second focal point oriented at the recycling surface. The second reflector reflects light emitted from the LED in the second solid angle back to the recycling surface. The recycling surface reflects light from the second reflector to be incident the first reflector.

Abstract: A light projection device includes a tubular casing having a light-emitting part at one tube end; a light source configured with a light-emitting diode; and a light amount control mechanism positioned between the light source and the light-emitting part. The light amount control mechanism includes a rotating body, an operating part attached to the rotating body such as to allow for rotary operation of the rotating body from outside the casing, a variable resistor, and a link mechanism operably connecting the rotating body and the variable resistor such that a forward movement of the rotating body causes a movable part of the variable resistor to move in a direction in which the amount of current is increased and such that a backward movement of the rotating body causes the movable part of the variable resistor to move in a direction in which the amount of current is decreased.

Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: A light fixture for mounting in a t-bar ceiling structure, the light fixture includes a housing configured to support a ring-shaped lens to at least partially surround an inner reflective surface, the inner reflective surface being configured to at least partially reflect light incident thereon from the lens, to present a mirage effect in a transition zone near the lens.

Abstract: Disclosed herein are methods for performing assays, including general functional assays, on a biological cell. The methods can include contacting a biological cell with a test agent for a period of time; lysing the biological cell while the biological cell is disposed within a sequestration pen located within an enclosure of a microfluidic device; and allowing RNA molecules released from the lysed biological cell to be captured by capture oligonucleotides linked to a capture object disposed within the sequestration pen of the microfluidic device. Each capture oligonucleotide can include a priming sequence that binds a primer, and a capture sequence. Each cDNA transcribed from a captured RNA can have an oligonucleotide sequence complementary to the captured RNA molecule, with the complementary oligonucleotide sequence being covalently linked to one of the capture oligonucleotides of the capture object.

Abstract: A wireless lighting control system includes a remote server system connected to a wide area network and having software for configuring, monitoring, and controlling lighting fixtures at an installation site. The site includes wireless devices in communication with a gateway via a local wireless network and at least some of the wireless devices are configured for scheduled automation associations, for example, to control one or more lighting fixtures depending on the state of one or more wireless devices having sensors or user interface elements. The associations can activate specific lighting effects, such as power, dimming, and scene control and also are dependent on selected scheduling events such as one or more of a time of day, day of week, and time delay.

Abstract: A vehicle lamp is provided having a heat sink having a first end mounted to a lamp housing and having a free distal end extending into a light chamber adjacent a central optical axis of the lamp. A light emitting diode (LED) is mounted adjacent the distal end of the heat sink to have a central light emitting axis opposite the optical axis of the lamp. A parabolic reflector is positioned rearward of the heat sink, a parabolic reflective surface extending at an upper and lower solid angle relative to the LED, wherein the upper and lower combined solid angle is greater than a half-paraboloid.

Abstract: A lens is provided with a light-incident face and a light-emitting face opposite the light-incident face. The lens body has a central optical axis extending in a forward direction through the light-incident face and the light-emitting face. The light-incident-face has a primary collector surface defined by a collimator profile revolved about a transverse axis perpendicular to the central optical axis. A pair of secondary collecting surfaces extend between the light-incident face and the light-emitting face, the secondary collecting surfaces oriented to reflect light internal to the lens body in the forward direction through total internal reflection.

Abstract: A lighting device assembly includes: a heat sink; a light source attached to one end of the heat sink; and an optic assembly including an optic having a recess to receive at least a portion of the light source, the optic being configured to pivot about the light source while the portion of the light source remains within the recess.

Abstract: Methods are provided for the automated detection of micro-objects in a microfluidic device. In addition, methods are provided for repositioning micro-objects in a microfluidic device. In addition, methods are provided for separating micro-objects in a spatial region of the microfluidic device.

Abstract: Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices. Alternative motive modalities are useful to selectively dislodge and displace micro-objects, including biological cells, from a variety of locations within the enclosure of a microfluidic device.

Abstract: The present disclosure provides lighting systems suitable for generating white light. The lighting systems can have a first lighting channel configured to produce a first white light having a first color point and a first spectral power distribution, a second lighting channel configured to produce a second white light having a second color point and a second spectral power distribution, and a control system configured to independently change the intensity of each of the first lighting channel and the second lighting channel. The first lighting channels can have LEDs having an emission with a first peak wavelength of between about 440 nm and about 510 nm. The second lighting channels can have LEDs having an emission with a second peak wavelength of between about 380 nm and about 420 nm. The disclosure provides methods of generating white light using the lighting systems described.

Abstract: A microfluidic apparatus is provided having one or more sequestration pens configured to isolate one or more target micro-objects by changing the orientation of the microfluidic apparatus with respect to a globally active force, such as gravity. Methods of selectively directing the movements of micro-objects in such a microfluidic apparatus using gravitational forces are also provided. The micro-objects can be biological micro-objects, such as cells, or inanimate micro-objects, such as beads.

Abstract: A canopy for use with a ceiling connector mountable at a designated ceiling location to define a mounting end region thereon, includes a body securable to the mounting end region by a rotationally operable connector, wherein the body is configured to form a mounting interface with the mounting end region to block perceptible relative rotation therebetween about a rotation axis defined by the connector by forces associated therewith, wherein the mounting interface is defined by at least one first engagement surface on the canopy configured to be in contact with at least corresponding second engagement surface on the mounting end region.

Abstract: Illumination control systems and methods, including those for influencing circadian rhythm, are disclosed. Embodiments include a control device capable of obtaining desired color temperature (e.g., local daylight) information, generating a color temperature value, and outputting a signal including the color temperature value. Embodiments further include a server having means for obtaining at least one of geographical location information and time of day information relative to the server, a processor to determine local daylight information, and a wireless transmitter to broadcast the signal within a site system. Embodiments further include one or more lighting control devices to control lighting devices, each lighting control having a wireless receiver to continuously listen for and receive the signal broadcasted by the server, and a lighting driver to change the lighting output of the coupled lighting device according to the detected signal.

Abstract: Example embodiments include modular lighting fixtures and methods for forming the same. Some include light emitters and base members with mounting locations for the light emitters, the light emitters and base members being combinable in varying combinations with each combination producing a different lighting effect. Some embodiments include a light guide, such as a planar light guide, that receives and redirects light from the light emitters. Additional embodiments include a reflector with portions that are positioned near a mounting location where no light emitter is mounted when the reflector is mounted to a base member. Further embodiments include a reflector with portions that are positioned near the mounting locations when mounted to a base member, the portions being easily removed, such as with an unpowered hand tool, to avoid interference with a light emitting member mounted adjacent to where the removable portion would be if not removed from the reflector.

Abstract: Microfluidic devices having an electrowetting configuration and an optimized droplet actuation surface are provided. The devices include a conductive substrate having a dielectric layer, a hydrophobic layer covalently bonded to the dielectric layer, and a first electrode electrically coupled to the dielectric layer and configured to be connected to a voltage source. The microfluidic devices also include a second electrode, optionally included in a cover, configured to be connected to the voltage source. The hydrophobic layer features self-associating molecules covalently bonded to a surface of the dielectric layer in a manner that produces a densely-packed monolayer that resists intercalation and or penetration by polar molecules or species.