Patents Assigned to Madison
  • Surgical devices and related methods thereof
    Patent number: 9320540
    Abstract: Surgical devices and methods are configured to access areas of the brain while minimizing brain damage. A brain probe device for removing a lesion from a brain includes a cannula fixable to the skull to align the cannula with the lesion, a tubular stem within the cannula configured to be advanced to the lesion, and a rotatable cutting tube within the tubular stem. Expandable wire loops configured to cut tissue are attached to the distal end of the tubular stem. A loop expander and rotation motor mechanism is operably linked to the wire loops and configured to cause rotation and variable outward expansion of the wire loops. Tissue cut by the wire loops is removed through slots and a central lumen of the tubular stem. The cutting tube is rotatable to sever tissue drawn into the slots into smaller fragments that are removed through the central lumen via aspiration.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: April 26, 2016
    Assignee: MADISON SURGICAL DESIGNS, LLC
    Inventor: Behnam Badie
  • Cleaning composition for the food and beverage industry
    Patent number: 9260679
    Abstract: An aqueous cleaning composition and methods for use in the agricultural, food and beverage industry which comprises at least 3% of hydrogen peroxide and a plurality of non-ionic surfactants, wherein said cleaning composition is substantially free of any alkalinity source.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: February 16, 2016
    Assignee: Madison Chemcial Co., Inc.
    Inventor: David M Craft
  • Galactose cluster-pharmacokinetic modulator targeting moiety for siRNA
    Patent number: 9249179
    Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: February 2, 2016
    Assignee: Arrowhead Madison Inc.
    Inventors: Philipp Hadwiger, Torsten Hoffmann, Eric A. Kitas, Peter Mohr, Ingo Roehl, Linda Valis, David B. Rozema, David L. Lewis, Darren H. Wakefield
  • Filter cloth retention
    Patent number: 9248389
    Abstract: Cloth retention apparatus for retaining the edges of a filter cloth comprises an edge strip having a bead, which can engage with a channel in a frame member, and be retained therein by a wedging member. The wedging member may be separate or attached to the bead, or incorporated therein. The wedging member may be a spring member.
    Type: Grant
    Filed: November 25, 2004
    Date of Patent: February 2, 2016
    Assignee: MADISON FILTER 981 LTD.
    Inventors: Anthony Maquet, Richard Patrick Lydon
  • Peptide-based in vivo siRNA delivery system
    Patent number: 9107957
    Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: August 18, 2015
    Assignee: Arrowhead Madison Inc.
    Inventors: David B Rozema, David L Lewis, Darren Wakefield, Eric Kitas, Philipp Hadwiger, Jon Wolff, Ingo Röhl, Peter Mohr, Torsten Hoffmann, Kerstin Jahn-Hofmann, Hans Martin Mueller, Günther Ott, Andrei V Blokhin, Jonathan D Benson, Jeffrey C Carlson
  • Poly(vinyl ester) polymers for nucleic acid delivery
    Patent number: 9089611
    Abstract: The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: July 28, 2015
    Assignee: Arrowhead Madison Inc.
    Inventors: Darren H Wakefield, Nicholas A Rossi, Dan Sheik
  • Ultrasound diagnostic device and method for forming scan line data
    Patent number: 9022938
    Abstract: An ultrasound diagnostic device includes a plurality of channels configured to receive data and a scan line data forming unit including a plurality of sub-scan line data forming groups and a data summing unit. The sub-scan line data forming group forms partial data of scan lines, and the data summing unit forms scan line data of the scan lines by summing the partial data. The sub-scan line data forming group includes a plurality of sub-scan line data forming units for forming the partial data of the scan lines by using the receiving data and providing a transmission path of the receiving data. First data lines transmit the receiving data between at least one of the sub-scan data forming unit and the channels, and second data lines transfer the receiving data between the sub-scan line data forming units.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: May 5, 2015
    Assignee: Madison Co., Ltd.
    Inventors: Moo Ho Bae, Jeong Ho Ham, Ra Young Yoon, Han Woo Lee
  • Compositions for targeted delivery of siRNA
    Patent number: 9011919
    Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: April 21, 2015
    Assignee: Arrowhead Madison Inc.
    Inventors: David B. Rozema, David L. Lewis, Darren H. Wakefield, Torsten Hoffmann, Eric Kitas, Peter Mohr, Philipp Hadwiger, Wilma Thuer, Linda Valis
  • Poly(acrylate) Polymers for In Vivo Nucleic Acid Delivery
    Publication number: 20150104408
    Abstract: The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
    Type: Application
    Filed: November 25, 2014
    Publication date: April 16, 2015
    Applicant: ARROWHEAD MADISON INC.
    Inventors: Darren H. Wakefield, Nicholas A. Rossi, David B. Rozema, Lauren J. Almeida, Anthony L. Perillo-Nicholas
  • Antimicrobial amphiphiles and methods for their use
    Patent number: 8980925
    Abstract: The present invention is directed to compositions useful for antimicrobial applications. These compositions comprise amphiphilic compounds.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: March 17, 2015
    Assignee: James Madison Innovations, Inc.
    Inventors: Kevin P. Minbiole, Kevin L. Caran, Kyle N. Seifert
  • Poly(vinyl ester) polymers for in vivo nucleic acid delivery
    Patent number: 8932572
    Abstract: The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: January 13, 2015
    Assignee: Arrowhead Madison Inc.
    Inventors: Darren H. Wakefield, Nicholas Rossi, Dan Sheik
  • Poly(acrylate) polymers for in vivo nucleic acid delivery
    Patent number: 8933047
    Abstract: The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: January 13, 2015
    Assignee: Arrowhead Madison Inc.
    Inventors: Darren H. Wakefield, David B. Rozema, Nicholas Rossi, Lauren Almeida, Anthony L. Perillo-Nicholas
  • Cleaning Composition for the Food and Beverage Industry
    Publication number: 20140338703
    Abstract: An aqueous cleaning composition and methods for use in the agricultural, food and beverage industry which comprises at least 3% of hydrogen peroxide and a plurality of non-ionic surfactants, wherein said cleaning composition is substantially free of any alkalinity source.
    Type: Application
    Filed: May 17, 2013
    Publication date: November 20, 2014
    Applicant: Madison Chemical Co., Inc.
    Inventor: David M. CRAFT
  • Elastomeric extractor member
    Patent number: 8887426
    Abstract: A biasing member for a bolt assembly of a firearm is described herein. The biasing member comprises a body having a first portion configured to engage and seat within a biasing member receiving indentation of an arm of the extractor, and a second portion configured to engage and seat within a receiving area along a bolt of the firearm. The body provides a biasing force directed against the extractor arm. The body comprises an elastomeric material, and is configured such that the first and second portions provide varying levels of compression sufficient to maintain a substantially constant extractor tension between the extractor arm and a cartridge.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 18, 2014
    Assignee: Madison
    Inventors: Devin Feese, Jeffrey W. Stone
  • Compositions and methods for inhibiting gene expression of hepatitis B virus
    Patent number: 8809293
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a Hepatitis B Virus gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Hepatitis B Virus infection using said pharmaceutical composition; and methods for inhibiting the expression of a Hepatitis B Virus gene in a cell.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: August 19, 2014
    Assignee: Arrowhead Madison Inc.
    Inventors: Daniel Chin, Jochen Deckert, Markus Hossbach, Matthias John
  • In vivo polynucleotide delivery conjugates having enzyme sensitive linkages
    Patent number: 8802773
    Abstract: The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 12, 2014
    Assignee: Arrowhead Madison Inc.
    Inventors: David B Rozema, David L Lewis, Darren H Wakefield, Eric A Kitas, Philipp Hadwiger, Jon A Wolff, Ingo Roehl, Peter Mohr, Torsten Hoffmann, Kerstin Jahn-Hofmann, Hans Martin Mueller, Guenther Ott, Andrei V Blokhin, Jeffrey C Carlson, Jonathan D Benson
  • ANTIMICROBIAL AMPHIPHILES AND METHODS FOR THEIR USE
    Publication number: 20140148487
    Abstract: The present invention is directed to compositions useful for antimicrobial applications. These compositions comprise amphiphilic compounds.
    Type: Application
    Filed: October 20, 2011
    Publication date: May 29, 2014
    Applicant: James Madison Innovations, Inc,
    Inventors: Kevin P. Minbiole, Kevin l Caren, Kyle n Seifert
  • Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure
    Publication number: 20140128584
    Abstract: We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.
    Type: Application
    Filed: May 31, 2012
    Publication date: May 8, 2014
    Applicant: ARROWHEAD MADISON INC.
    Inventors: Andrei V. Blokhin, David B. Rozema, Jonathan D. Benson, Jeffrey C. Carlson
  • Device for varying range of motion for barbell exercise
    Patent number: D708682
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: July 8, 2014
    Assignee: James Madison Innovations, Inc.
    Inventors: Justin Scott Jones, Corey Marc Anderson, Jim Durning
  • Athletic shoe attachment
    Patent number: D718920
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: December 9, 2014
    Assignee: James Madison Innovations
    Inventors: Justin Scott Jones, Corey Marc Anderson