Patents Assigned to Madison
  • Publication number: 20120230938
    Abstract: The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation.
    Type: Application
    Filed: February 8, 2012
    Publication date: September 13, 2012
    Applicant: ARROWHEAD MADISON INC.
    Inventors: David B. ROZEMA, Darren H. WAKEFIELD, David L. LEWIS, Jason KLEIN, So WONG, Jon A. WOLFF, James E. HAGSTROM
  • Patent number: 8217015
    Abstract: We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.
    Type: Grant
    Filed: April 1, 2004
    Date of Patent: July 10, 2012
    Assignee: Arrowhead Madison Inc.
    Inventors: David B. Rozema, Darren Wakefield
  • Publication number: 20120172412
    Abstract: The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.
    Type: Application
    Filed: December 23, 2011
    Publication date: July 5, 2012
    Applicant: ARROWHEAD MADISON INC.
    Inventors: David B. Rozema, Darren H. Wakefield, David L. Lewis, Jon A. Wolff, Andrei V. Blokhin, Jonathan D. Benson, Jeffrey C. Carlson, Philipp Hadwiger, Eric A. Kitas, Torsten Hoffmann, Kerstin Jahn-Hofmann, Peter Mohr, Hans Martin Mueller, Guenther Ott, Ingo Roehl
  • Patent number: 8211468
    Abstract: We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: July 3, 2012
    Assignee: Arrowhead Madison Inc.
    Inventors: David B. Rozema, Darren H. Wakefield, Jon A. Wolff, James E. Hagstrom, Kirk Ekena
  • Publication number: 20120165393
    Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
    Type: Application
    Filed: December 15, 2011
    Publication date: June 28, 2012
    Applicant: ARROWHEAD MADISON INC.
    Inventors: David B. Rozema, Darren H. Wakefield, David L. Lewis, Jon A. Wolff, Andrei V. Blokhin, Jonathan D. Benson, Jeffrey C. Carlson, Philipp Hadwiger, Eric A. Kitas, Torsten Hoffman, Kerstin Jahn-Hofmann, Peter Mohr, Hans Martin Mueller, Guenther Ott, Ingo Roehl
  • Patent number: 8138383
    Abstract: The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: March 20, 2012
    Assignee: Arrowhead Madison Inc.
    Inventors: Darren H. Wakefield, David B. Rozema, Jon A. Wolff, James E. Hagstrom
  • Patent number: 8137695
    Abstract: The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: March 20, 2012
    Assignee: Arrowhead Madison Inc.
    Inventors: David B. Rozema, James E. Hagstrom, Jason Klein, David L. Lewis, Sean D. Monahan, Darren H. Wakefield, Jon A. Wolff, So Wong
  • Publication number: 20110291432
    Abstract: A disposable dog waste handling device includes a framework; and a flexible bag, attached to the framework, having a portion capable of lying flat under the dog to capture feces eliminated from the dog, the bag adapted to retain the feces when the device is lifted. The device may be operated by a user using one hand so that, when the user lifts an end of the framework, the bag retains the feces and the user does not feel the eliminated feces. The framework includes a strip of flexible material that forms a loop, and the bag may not detach from the material. The entire device is then thrown away.
    Type: Application
    Filed: May 31, 2011
    Publication date: December 1, 2011
    Applicant: MADISON STREET INNOVATIONS LLC
    Inventor: Robert Machado
  • Patent number: 8021875
    Abstract: The present invention relates to compositions and methods for increasing long term expression in vitro and in vivo, comprising sequences and gene expression cassettes that increase expression of genes to which they are operably linked.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: September 20, 2011
    Assignee: Roche Madison Inc.
    Inventors: Christine I. Wooddell, Hans Herweijer
  • Patent number: 8017109
    Abstract: The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: September 13, 2011
    Assignee: Roche Madison Inc.
    Inventors: Darren H. Wakefield, David B. Rozema, Sean D. Monahan, Lori Higgs, Jon A. Wolff, James E. Hagstrom
  • Patent number: 8008355
    Abstract: The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: August 30, 2011
    Assignee: Roche Madison Inc.
    Inventors: David B. Rozema, Darren H. Wakefield, Sean D. Monahan, Lori Higgs, Jon A. Wolff, James E. Hagstrom
  • Publication number: 20110207799
    Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
    Type: Application
    Filed: February 22, 2011
    Publication date: August 25, 2011
    Applicant: ROCHE MADISON INC.
    Inventors: David B. Rozema, David L. Lewis, Darren H. Wakefield, Torsten Hoffmann, Erik Kitas, Peter Mohr, Philipp Hadwiger, Wilma Thuer, Linda Valis
  • Patent number: 7985406
    Abstract: The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: July 26, 2011
    Assignee: Roche Madison Inc.
    Inventors: Sean D. Monahan, Darren H. Wakefield, David B. Rozema, Lori Higgs, Jon A. Wolff, James E. Hagstrom
  • Patent number: 7985270
    Abstract: A fluidised bed filter comprises a drying pan, and a filter assembly having a membrane over the pan, and a plurality of openings in the membrane. A filter bag is secured to each aperture by means of a clamping ring attached to the rim of the respective aperture, and cooperating with a clamping band within the cuff of the bag. The material of the bag is clamped between the ring and the band. The ring is covered in a cloth strip, which is folded over to produce a flap, which is stitched between the layers of a double fabric forming the membrane. The band is retained in a tunnel formed by a fold in a double fabric forming the filter bag by stitching.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: July 26, 2011
    Assignee: Madison Filter 981 Ltd.
    Inventors: Joseph Johnson, David Anthony Akerman
  • Patent number: 7971470
    Abstract: A non-invasive and non-destructive apparatus and testing method for analytes in sealed containers are provided, which are especially useful for identifying bottles of wine that are contaminated with 2,4,6-trichloroanisole (TCA) without destroying the value of uncontaminated wine by opening the bottles or marring the containers or labeling. The apparatus and method are applicable to non-destructively testing any “stream-of-commerce” containers such as shampoo bottles, aerosol containers, toothpaste tubes, and soft drink cans, and other such containers for the presence of contaminants, explosives, poisons, drugs, and other dangerous or illegal materials. The method provided is orders of magnitude more sensitive than other methods, and can detect the presence of diffused substances at the nanogram per liter (parts-per-billion) level.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: July 5, 2011
    Assignee: Madison Avenue Management Company, Inc.
    Inventor: Joseph S. Broz
  • Publication number: 20110061353
    Abstract: A filter element comprises a pleated filter (10), one end of which is received in an end cap (11), which is made up of a unitary moulding comprising an end part (21) of a harder plastics material, and a lower part (22) of a softer plastics material, the plastics being compatible or of the same composition, differing only in hardness. A groove (24) engages with a support plate (14), the groove being formed in the softer material abutting the harder material so that the latter forms one face of the groove. A perforated support sleeve (29) can be inserted by dropping into the filter, and an end cap (12) at the other end of the filter either closes the end or is adapted for connection to a further similar filter.
    Type: Application
    Filed: August 22, 2008
    Publication date: March 17, 2011
    Applicant: MADISON FILTER 981 LIMITED
    Inventor: Niels Fischer
  • Patent number: D639661
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: June 14, 2011
    Assignee: The Madison Company, Ltd
    Inventor: Sergio Llerena
  • Patent number: D639663
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: June 14, 2011
    Assignee: The Madison Company, Ltd
    Inventor: Sergio Llerena
  • Patent number: D640559
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: June 28, 2011
    Assignee: The Madison Company, Ltd.
    Inventor: Sergio Llerena
  • Patent number: D661406
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: June 5, 2012
    Assignee: Madison Electric Products, Inc.
    Inventors: Ronald Bruce Finch, Ronald Brengartner, Jr.