Patents Assigned to McGill University
  • Patent number: 10420757
    Abstract: The current disclosure relates to methods for treating pancreatic cancer or chronic pancreatitis in a subject comprising administering an antagonist of a dopamine receptor to the subject wherein the dopamine receptor is, in some specific cases dopamine receptor D2 (DRD2). The antagonist in some specific cases is an RNAi construct, an antibody, or a small molecule and in more specific cases pimozide or L-741,626. The disclosure also relates to diagnostic methods comprising the detection of the expression of DRD2 in pancreatic tissue and kits for doing the same.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: September 24, 2019
    Assignees: Deutsches Krebsforschungszentrum Stiftung des Öffentlichenrechts, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Pouria Jandaghi, Jörg Hoheisel, Yasser Riazalhosseini
  • Patent number: 10407556
    Abstract: Many different substrates are used in tissue engineering as platforms to enhance cell attachment, proliferation and activity, either in-vitro, to multiply specific cell lines, or in-vivo, to induce shorter healing time of injured or missing tissue. However, their hydrophobicity and lack of specific functionalities make them non-ideal for cell adhesion and growth. Treating the surfaces by exposing them to a series of steps including, but not limited to, a diazonium based wet chemistry allows one or more functional groups to be applied to the surface improving cell adhesion and growth. Embodiments of the invention exploiting PDLLA, PMMA and roughed PEEK are demonstrated including both a one-stage and a two-stage process, and at times a vacuum treatment, allowing modification of inner and outer surfaces.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: September 10, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Marta Cerruti, Hesameddin Mahjoubi
  • Patent number: 10394978
    Abstract: Herein provided are methods and systems for generating finite element modelling results. Finite element method (FEM) data relating to establish a FEM problem to be solved for a portion of a physical system being analyzed is received. A FEM mesh comprising at least FEM mesh node locations relating to the portion of the physical system is generated. FEM mesh values for each FEM mesh node location are automatically generated with a microprocessor. A factor graph model comprising a plurality of random variable nodes and a plurality of factor nodes is automatically generated with a microprocessor based upon the FEM mesh node locations. A set of belief propagation update rules are automatically executed upon the factor graph model using Gaussian function parametrization and the FEM mesh values. The belief propagation update rules are iteratively executed until a predetermined condition has been met.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: August 27, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Dennis Giannacopoulos, Yousef El Kurdi, Warren Gross
  • Patent number: 10390162
    Abstract: The method can include depositing a graphene oxide containing material from solution to form a laminar nano-structure of graphene oxide paper, and assembling at least a portion of the graphene oxide paper as a diaphragm of the acoustic transducer. The acoustic transducer can be a magnetic induction based microphone, a diaphragm loudspeaker, or a magnetic induction based loudspeaker, for instance.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: August 20, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Peter Gaskell, Robert-Eric Gaskell, Thomas Szkopek, Jung Wook Hong
  • Patent number: 10376611
    Abstract: A synthetic bone graft is described which is adapted to be received within a bone defect and which is structurally load-bearing. The bone graft comprises an entirely synthetic graft body corresponding in shape and size to the bone defect. The graft body is composed of a plurality of superimposed multilayered structures, each of the multilayered structures having a biopolymer layer joined to a biomineral layer to define an interface therebetween. The biomineral layer has a stiffness that is greater than that of the biopolymer layer, and the biopolymer layer has a toughness that is less than that of the biomineral layer.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: August 13, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Francois Barthelat, Michael Tanzer, Sacha Cavelier
  • Patent number: 10377715
    Abstract: The invention relates to 18-20 member bi-polycyclic compounds, methods of making these compounds, and methods of using them in treating hyperproliferative disorders (e.g., cancer) and non-malignant tumors; promoting muscle formation; inhibiting muscle degeneration or the loss of muscle mass or muscle function; and myofibers ex vivo.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: August 13, 2019
    Assignees: Haro Pharmaceuticals Inc., The Royal Institution for the Advancement of Learning/ McGill University, Universite De Montreal
    Inventors: David Bettoun, Eduardo Martinez, James Gleason, Sylvie Mader, Shuo Xing
  • Patent number: 10351963
    Abstract: Important components of direct solar based nanowire enabled chemical processing and electrochemical systems are a high efficiency and highly stable photocathode and 2-photon dual electrodes. The former enables photo-excited electrons that lead to hydrogen generation whereas the later with complementary energy bandgap photoanode and photocathode enables high efficiency, unassisted solar-driven water splitting. Accordingly, it would be beneficial to leverage the high surface areas and self-contained conversion of direct solar illuminated hydrogen generation from such nanowires with multiple junctions for broad solar spectrum absorption by providing monolithically integrated multi-junction photocathodes. It would be further beneficial to provide nanowire based dual-photoelectrode systems that together with a parallel illumination scheme, can fundamentally address these critical challenges.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: July 16, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/ MCGILL UNIVERSITY
    Inventors: Zetian Mi, Shizhao Fan, Bandar Alotaibi
  • Patent number: 10352935
    Abstract: The present invention relates to a method for diagnosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a sample of a subject by detecting oncogenic and cancer related proteins in microvesicles, and to the use of an agent blocking exchange of microvesicles for treating cancer.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: July 16, 2019
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, THE HOSPITAL FOR SICK CHILDREN
    Inventors: Janusz Rak, Khalid Al-Nedawi, Brian Meehan, Abhijit Guha
  • Patent number: 10329194
    Abstract: Highly mineralized natural materials often boast unusual combinations of stiffness, strength and toughness currently unmatched by today's engineering materials. Beneficially, according to the embodiments of the invention, these unusual combinations can be introduced into ceramics, glasses, and crystal materials, for example by the introduction of patterns of weaker interfaces with simple or intricate architectures, which channel propagating cracks into toughening configurations. Further, such deliberately-introduced weaker interfaces, such as exploiting three-dimensional arrays of laser-generated microcracks, can deflect and guide larger incoming cracks. Addition of interlocking interfaces and flexible materials provide further energy dissipation and toughening mechanism, by channeling cracks into interlocking configurations and ligament-like pullout mechanisms. Such biomimetic materials, based on carefully architectured interfaces, provide a new pathway to toughening hard and brittle materials.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: June 25, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Francois Barthelat, Seyed Mohammad Mirkhalaf Valashani, Ahmad Khayer Dastjerdi
  • Patent number: 10329156
    Abstract: The present describes an oxygen functionalized nanoflake (O-GNF), a stable nanofluid in which the graphene nanoflakes remain dispersed or in suspension free of surfactants, and the method of making the oxygen-functionalized nanoflake. The oxygen-functionalized graphene nanoflake (O-GNF and/or O—N-GNF) comprises a single-crystal graphene nanoflake of 5-20 atomic planes comprising a surface oxygen-functionalization, wherein the O-GNF comprise a degree of oxygen functionalization from about 6 to about 25 at. % oxygen by weight of the GNF with a preferred oxygen functionalization of about 14 at. % oxygen.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: June 25, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Jean-Luc Meunier, Dimitrios Berk, Ulrich Legrand, Norma-Yadira Mendoza Gonzalez, Pierre-Alexandre Pascone
  • Patent number: 10328092
    Abstract: Methods of reducing AMPA/NMDA ratio in D1-type medium spiny neurons (MSN) and/or reducing development of behavioral sensitization or suppressing drug induced behavioral sensitization in a subject, optionally a subject that is afflicted with an addiction, the method comprising administering to the subject in need thereof an effective amount of a Toll-like receptor 4 (TLR4) agonist or a composition comprising said TLR4 agonist, preferably wherein the TLR4 agonist is a monophosphoryl lipid A (MPLA).
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: June 25, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: David Stellwagen, Gil Moshe Lewitus
  • Patent number: 10317407
    Abstract: The present invention relates to a method for diagnosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a sample of a subject by detecting oncogenic proteins in microvesicles, and to the use of an agent blocking exchange of microvesicles for treating cancer.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: June 11, 2019
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, THE HOSPITAL FOR SICK CHILDREN
    Inventors: Janusz Rak, Khalid Al-Nedawi, Brian Meehan, Abhijit Guha
  • Patent number: 10312869
    Abstract: There is described herein methods and devices for high DC gain closed loop operation amplifiers exploiting cascaded low gain stages and a controller-based compensation circuit for stability.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: June 4, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Gordon Roberts, Ming Yang
  • Patent number: 10307769
    Abstract: There is described herein methods and devices for confining and/or manipulating molecules. At least one molecule is introduced into a fluidic chamber. The fluidic chamber is formed inside a device comprising at least one first electrode having a first surface spaced from at least one second electrode having a second surface facing the first surface. The at least one second electrode has a plurality of dielectric structures arranged to form openings along the second surface. At least one electrical signal is applied across the at least one first electrode and the at least one second electrode to generate a non-uniform electric field having electric field lines extending from the first surface of the at least one first electrode to the second surface of the at least one second electrode in the openings formed between the dielectric structures. The at least one electrical signal has a frequency level causing the at least one molecule to move inside the fluidic chamber in accordance with a predetermined movement.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: June 4, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Sara Mahshid, Mohammed Jalal Ahamed, Walter Reisner, Robert Sladek
  • Patent number: 10301357
    Abstract: The present disclosure provides agents capable of promoting endogenous steroid production (such as endogenous testosterone production) without altering the endogenous luteinizing hormone. The present disclosure also provides associated therapeutic methods as well as screening assays for identifying further therapeutic agents for the prevention, treatment and/or alleviations of symptoms associated with hypogonadism.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: May 28, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Vassilios Papadopoulos, Yasaman Aghazadeh, Jinjiang Fan
  • Patent number: 10300485
    Abstract: Methods and apparatuses for performing a nanoarray-in-microarray assay is provided, which can be used to estimate a protein concentration in a sample solution. A plurality of nanodots are fabricated on a surface having at least one affinity binder. One or more microspots are superimposed over the nanodots on predetermined regions of the surface, each of the microspots comprising at least one antibody. An assay process is performed on the surface, and the surface is imaged to acquire optical images of the nanodots within each microspot. Image analysis algorithms are the performed on the optical images to identify bindings on individual ones of the plurality of nanodots.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: May 28, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: David Juncker, Gina Zhou, Sebastien Bergeron
  • Patent number: 10305514
    Abstract: There is described a multi-mode unrolled decoder. The decoder comprises a master code input configured to receive a polar encoded master code of length N carrying k information bits and N?k frozen bits, decoding resources comprising processing elements and memory elements connected in an unrolled architecture and defining an operation path between the master code input and an output, for decoding a polar encoded code word, at least one constituent code input configured to receive a polar encoded constituent code of length N/p carrying j information bits and N/p?j frozen bits, where p is a power of 2, and at least one input multiplexer provided in the operation path to selectively transmit N/p bits of one of the master code and the constituent code to a subset of the decoding resources.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: May 28, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Pascal Giard, Gabi Sarkis, Warren Gross, Claude Thibeault
  • Patent number: 10290767
    Abstract: GaN-based nanowire heterostructures have been intensively studied for applications in light emitting diodes (LEDs), lasers, solar cells and solar fuel devices. Surface charge properties play a dominant role on the device performance and have been addressed within the prior art by use of a relatively thick large bandgap AlGaN shell covering the surfaces of axial InGaN nanowire LED heterostructures has been explored and shown substantial promise in reducing surface recombination leading to improved carrier injection efficiency and output power. However, these lead to increased complexity in device design, growth and fabrication processes thereby reducing yield/performance and increasing costs for devices. Accordingly, there are taught self-organizing InGaN/AlGaN core-shell quaternary nanowire heterostructures wherein the In-rich core and Al-rich shell spontaneously form during the growth process.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: May 14, 2019
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Zetian Mi, Songrui Zhao, Renjie Wang
  • Patent number: 10291200
    Abstract: MEMS based sensors, particularly capacitive sensors, potentially can address critical considerations for users including accuracy, repeatability, long-term stability, ease of calibration, resistance to chemical and physical contaminants, size, packaging, and cost effectiveness. Accordingly, it would be beneficial to exploit MEMS processes that allow for manufacturability and integration of resonator elements into cavities within the MEMS sensor that are at low pressure allowing high quality factor resonators and absolute pressure sensors to be implemented. Embodiments of the invention provide capacitive sensors and MEMS elements that can be implemented directly above silicon CMOS electronics.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: May 14, 2019
    Assignee: The Royal Institution for the Advancement of Learning / McGill University
    Inventors: Vamsy Chodavarapu, George Xereas
  • Patent number: D863367
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: October 15, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Viacheslav Adamchuk, Antoine Pouliot, Trevor Stanhope