Patents Assigned to McGill University
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Patent number: 9464048Abstract: The present invention relates to novel pharmaceutically-useful compounds which are antagonists of the 5-oxo-ETE receptors, such as the OXE receptor. These compounds have use as therapeutic and/or prophylactic agents for diseases characterized by tissue eosinophilia, such as inflammatory conditions including respiratory diseases. The invention also relates to pharmaceutical compositions, to the use of such compounds and compositions as medicaments, and to therapeutic methods.Type: GrantFiled: July 7, 2014Date of Patent: October 11, 2016Assignees: Florida Institute of Technology, The Royal Institution for the Advancement of Learning/McGill UniversityInventors: William S. Powell, Joshua Rokach
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Patent number: 9448069Abstract: Micromachined gyroscopes, such as those based upon microelectromechanical systems (MEMS) have the potential to dominate the rate-sensor market mainly due to their small size, low power and low cost. As MEMS gyroscopes are resonant devices requiring active excitation it would be beneficial to improve the resonator Q-factor reducing the electrical drive power requirements for the excitation circuitry. Further, many prior art MEMS gyroscope designs have multiple resonances arising from design and manufacturing considerations which require additional frequency tuning and control circuitry together with the excitation/sense circuitry. It would therefore be beneficial to enhance the bandwidth of the resonators to remove the requirement for such circuitry. Further, to address the relatively large dimensions of MEMS gyroscopes it would be beneficial for the MEMS gyroscopes to be fabricated directly above the CMOS electronics thereby reducing the die dimensions and lowering per die cost.Type: GrantFiled: October 1, 2013Date of Patent: September 20, 2016Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Mourad El-Gamal, Mohannad Elsayed, Paul-Vahe Cicek, Frederic Nabki
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Patent number: 9428447Abstract: The present disclosure relates to novel compounds having vitamin D receptor agonist and histone deacetylase inhibitory efficacy as well as methods for reducing or inhibiting the proliferation of cancer cells or for treating cancer.Type: GrantFiled: December 20, 2012Date of Patent: August 30, 2016Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: James L. Gleason, John H. White, Dainis Kaldre, Joshua Fischer
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Publication number: 20160215347Abstract: A novel gene (EPM2A) that is deleted or mutated in people with Lafora's disease is described. The EPM2A gene encodes a protein having an active catalytic site of a protein tyrosine phosphatase. Many different sequence mutations as well as several microdeletions in EPM2A have been found that co-segregate with Lafora's disease.Type: ApplicationFiled: April 7, 2016Publication date: July 28, 2016Applicants: The Hospital for Sick Children, McGill University, U.S. Government Department of Veterans Affairs, The Regents of the University of CaliforniaInventors: Stephen W. Scherer, Berge A. Minassian, Antonio Delgado-Escueta, Guy Rouleau
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Patent number: 9400127Abstract: Cryogenic electronics based upon semiconductive devices, superconductive devices, or a combination of the two present opportunities for a wide variety of novel, fast, and low power devices. However, such cryogenic electronics require cooling which is typically achieved through fluid refrigerants such as liquid nitrogen or liquid helium. Solid state refrigeration based upon adiabatic demagnetization in paramagnetic salts offers one alternative but requires that the solid state cooler and cryogenic electronic circuits be different physical elements. The inventors present solid state cooling for semiconductor materials including but not limited to silicon. Beneficially active electronic devices can be integrated monolithically with solid state semiconductor coolers exhibiting magnetic cooling within the whole substrate or predetermined regions of the substrate. Alternatively, active devices may be formed with semiconductor layers integral to them that exhibit magnetic cooling.Type: GrantFiled: May 30, 2013Date of Patent: July 26, 2016Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Guillaume Gervais, Thomas Szkopek, Jonathan Guillemette
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Patent number: 9400269Abstract: Systems and methods for detecting target chemicals are disclosed. A system includes a chemical sensor configured to filter light. The chemical sensor includes a referencing arm configured to output light at a first intensity level and a sensing arm sensitive to a target chemical. The sensing arm is configured to output light at a second intensity level. A difference between the first intensity level and the second intensity level indicates a presence of the target chemical.Type: GrantFiled: September 22, 2014Date of Patent: July 26, 2016Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Patanjali Kambhampati, Jonathan Ikola Saari, Nate Quitoriano, James Forbes, Gordon Roberts
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Patent number: 9389214Abstract: A soil analysis apparatus includes at least one sensor element for measuring a property of the soil; a blade assembly having at least one blade and being displaceable between a raised position and an excavation position, the at least one blade being operable to excavate the soil at a test location when the blade assembly is in the excavation position, the blade assembly being further operable to enter a sensor permitting configuration; and a first actuator operable to displace the at least one sensor element between an initial position and a sensing position along a sensor displacement path, the sensor element being proximate the soil at the test location when in the sensing position.Type: GrantFiled: September 24, 2014Date of Patent: July 12, 2016Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Viacheslav Adamchuk, Nandkishor Dhawale, Frédéric René-Laforest, Shiv Prasher, Antoine Pouliot
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Publication number: 20160150742Abstract: A flue gas treatment apparatus has a flue gas inlet, a treated gas outlet downstream of the flue gas inlet, and a gas flow path therebetween. The flue gas treatment apparatus comprises a particulate removal device. A first heater is downstream of the particulate removal device. The first heater heats the flue gas to a first treatment temperature. A first catalytic converter is downstream of the first heater for eliminating at least some CO and SO2 from the flue gas. A second heater is downstream of the first catalytic converter for heating the flue gas to a second treatment temperature. A second catalytic converter is downstream of the second heater for eliminating at least some NOx from the flue gas. At least a first fan forces the flue gas from the flue gas inlet to the treated gas outlet.Type: ApplicationFiled: July 11, 2014Publication date: June 2, 2016Applicant: Royal Institution for the Advancement of Learning/ McGill UniversityInventors: Mark Lefsrud, Yves Roy, Francis Filion, Julien Bouchard, Quoc Nguyen, Louis-Martin Dion, Antony Glover
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Patent number: 9356091Abstract: Semiconductor micro- and nanotubes allow the incorporation of ordered structures such as quantum wells and quantum dots into them providing the potential for ultralow threshold micro- and nanoscale lasers for use in applications such as future ultrahigh-speed photonic systems as well as quantum information processing. According to the invention a means of manufacturing these with high reproducibility, low processing complexity, and at high densities is provided. Also provided is a means of releasing these micro- and nanotubes with low stress and a method of “pick-and-place” allowing micro- and nanotubes to be exploited in devices integrated on substrates that are either incompatible with the manufacturing technique or where the area of substrate required to manufacture them is detrimental to the cost or performance of the circuit.Type: GrantFiled: September 26, 2012Date of Patent: May 31, 2016Assignee: The Royal Institute for the Advancement of Learning/McGill UniversityInventor: Zetian Mi
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Patent number: 9334539Abstract: A novel gene (EPM2A) that is deleted or mutated in people with Lafora's disease is described. The EPM2A gene encodes a protein having an active catalytic site of a protein tyrosine phosphatase. Many different sequence mutations as well as several microdeletions in EPM2A have been found that co-segregate with Lafora's disease.Type: GrantFiled: June 24, 2013Date of Patent: May 10, 2016Assignees: The Hospital for Sick Children, McGill University, The Regents of the University of California, U.S. Department of Veterans AffairsInventors: Stephen W. Scherer, Berge A. Minassian, Antonio Delgado-Escueta, Guy Rouleau
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Patent number: 9315546Abstract: The present invention provides novel peptides that can modulate the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and sub-types, isoforms and variants thereof). These peptides are useful as antagonists of the ghrelin receptor as well as inverse agonist, partial agonist or a combination of these activities as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, diabetes, central nervous system disorders, genetic disorders, and hyperpro-liferative disorders.Type: GrantFiled: June 16, 2011Date of Patent: April 19, 2016Assignees: The Administrators of the Tulane Educational Fund, McGill UniversityInventors: Cyril Y. Bowers, David H. Coy, Simon J. Hocart, Gloria S. Tannenbaum
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Patent number: 9281902Abstract: Broadband access networks are driving the upgrade of DWDM networks from 10 Gb/s per channel to more spectrally-efficient 40 Gb/s or 100 Gb/s. Signal quality degradation due to linear and non-linear impairments are significant and error control coding and signal processing solutions play increasingly key roles in meeting increasing demand, providing improved quality of service, and reduced cost. It would be beneficial to reduce the power consumption of optical receivers for optical links exploiting for example LPDC encoding. Accordingly, the inventors have established a low complexity soft-decision front-end compatible with deployable LDPC codes in next-generation optical transmission systems. Beneficially the optical receiver design can be retro-fitted into deployed hard-decision based optical systems and replaces the 3-to-2 encoder of the prior art in the electrical portion of the receiver with a single gate design. Further, the design may act as a 2-bit Flash ADC in multimode fiber based optical receivers.Type: GrantFiled: April 24, 2013Date of Patent: March 8, 2016Assignee: The Royal Institution for the Advancement of Learning/ McGill UniversityInventors: Odile Liboiron-Ladouceur, Meer Nazmus Sakib
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Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease
Patent number: 9278086Abstract: The invention relates to compounds, methods, uses, compositions, combinations, kits and packages for the prevention and/or treatment of parasite infection (e.g., Plasmodium parasites) and/or disease (e.g., malaria) based on uses of (a) cystamine, cysteamine, and analogs, derivatives, prodrugs, precursors thereof; an agent capable of inducing their production; and/or salts thereof, and (b) artemisinin and functional derivative, analog, conjugate, metabolite, prodrug or precursor thereof, and/or salts thereof.Type: GrantFiled: July 16, 2014Date of Patent: March 8, 2016Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Philippe Gros, Gundula Min-Oo, Anny Fortin -
Publication number: 20160051935Abstract: A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.Type: ApplicationFiled: March 27, 2014Publication date: February 25, 2016Applicants: National Research Council of Canada, The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Kebin LI, Teodor VERES, Tohid Fatanat DIDAR, Maryam TABRIZIAN
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Patent number: 9249175Abstract: The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2? and/or the 5?-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.Type: GrantFiled: September 4, 2009Date of Patent: February 2, 2016Assignees: The Royal Institute for the Advancement of Learning/McGill University, Wisconsin Alumni Research FoundationInventors: Masad Damha, Jeremy Lackey, Debbie Mitra, Marvin Wickens, Franco Cerrina, Saima A. Akhtar, Mark Somoza
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Patent number: 9240516Abstract: Amongst the candidates for very high efficiency electronics, solid state light sources, photovoltaics, and photoelectrochemical devices, and photobiological devices are those based upon metal-nitride nanowires. Enhanced nanowire performance typically require heterostructures, quantum dots, etc which requirement that these structures are grown with relatively few defects and in a controllable reproducible manner. Additionally flexibility according to the device design requires that the nanowire at the substrate may be either InN or GaN. Methods of growing relatively defect free nanowires and associated structures for group IIIA-nitrides are presented without the requirement for foreign metal catalysts, overcoming the non-uniform growth of prior art techniques and allowing self-organizing quantum dot, quantum well and quantum dot-in-a-dot structures to be formed.Type: GrantFiled: July 14, 2015Date of Patent: January 19, 2016Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Zetian Mi, Md Golam Kibria
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Patent number: 9216045Abstract: A bone screw and method of producing the same is described. The method of producing a bone screw includes forming a one-piece headless screw body out of a rigid metallic foam that is entirely porous throughout and defines a plurality of inter-connected pores having a size of about 30 to about 500 microns in diameter. The method includes providing at least one thread on an external surface of the screw body, and forming a bore extending through an entire axial length of the screw body, the bore forming a cannula that defines an annular radial wall thickness of the screw body. The method further includes disposing the inter-connected pores throughout the radial wall thickness of the screw body such as to allow for bone in-growth through the full radial wall thickness and into the cannula.Type: GrantFiled: February 16, 2015Date of Patent: December 22, 2015Assignees: The Royal Institution for the Advancement of Learning/McGill University, National Research Council of CanadaInventors: Paul A. Martineau, Louis-Philippe Lefebvre, Edward J. Harvey
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Patent number: 9193583Abstract: It would be beneficial to integrate MEMS devices with silicon CMOS electronics, package them in controlled environments, e.g. vacuum for MEMS resonators, and provide industry standard electrical interconnections such as solder bumps. However, to do so requires through-wafer via-based electrical interconnections. However, the fragile nature of the MEMS devices, the requirement for vacuum, hermetic sealing, and the stresses placed on metallization membranes are not present in conventional CMOS packaging. Accordingly there is provided a means of reinforcing through-wafer vias for integrated MEMS-CMOS circuits by in-filling the through-wafer electrical vias with low temperature deposited ceramic materials deposited with processes compatible with post-processing of CMOS electronics. Beneficially ceramics such as silicon carbide provide enhanced mechanical strength, enhanced expansion matching, and increased thermal conductivity in comparison to silicon and solder materials.Type: GrantFiled: October 26, 2012Date of Patent: November 24, 2015Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Mourad El-Gamal, Dominique Lemoine, Paul-Vahe Cicek, Frederic Nabki
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Patent number: 9176927Abstract: A polar code decoder includes: processing elements each receiving a pair of input values and applying a first or a second predetermined mathematical function depending on a provided function control signal; a first memory that stores at least one of the outputs from processing elements and a plurality of channel values relating to a received polar code to be decoded; a second memory that stores indices of a plurality of frozen bits each representing a bit within an information-bit vector of the polar code being decoded; and a computation block that receives a plurality of inputs from a portion of the processing elements and generates an output that is can be set to a predetermined frozen value or to a calculated value, depending on whether a current index of the bit being decoded is indicated as frozen or not frozen.Type: GrantFiled: November 8, 2012Date of Patent: November 3, 2015Assignees: The Royal Institution for the Advancement of Learning/McGill University, The Regents of the University of CaliforniaInventors: Warren Gross, Gabi Sarkis, Alexandre Raymond, Camille Leroux, Ido Tal, Alexander Vardy
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Publication number: 20150236353Abstract: A pure and crystalline single-crystal nitrogen-functionalized graphene nano-flake powder comprising from 2 atomic % to at least 35 atomic % of total functionalized nitrogen within the graphene nano-flakes is disclosed. As well, the method of producing the nano-flakes that comprises injecting a carbon source into a thermal plasma system, dissociating the carbon source into carbon atomic species, transporting the carbon atomic species through a controlled nucleation zone to produce a crystalline graphene nano-flake structure, injecting the nitrogen source into the thermal plasma system dissociating the nitrogen source into nitrogen active species, and transporting the nitrogen atomic species to contact the crystalline graphene nano-flakes to produce the crystalline nitrogen-functionalized graphene nano-flakes is also disclosed. Finally, a multilayer composite comprising a carbon substrate and a layer of crystalline nitrogen-functionalized graphene nano-flakes is also described.Type: ApplicationFiled: June 27, 2013Publication date: August 20, 2015Applicant: The Royal Institution For The Advancement Of Learning / McGill UniversityInventors: Jean-Luc Meunier, Dimitrios Berk, Ramona Vasilica Pristavita, Dustin Binny, Norma-Yadira Mendoza Gonzalez, Pierre-Alexandre Pascone