Abstract: Provided herein are Mcl-1 antagonist compositions and methods of treating g the compositions described herein.

Abstract: Disclosed are nucleic acid molecules from the genome of Dirofilaria spp. nematodes that contain single nucleotide polymorphisms related to reduced responsiveness of the nematodes to macrocyclic lactones. In one example, the species of Dirofilaria is Dirofilaria immitis (the agent of heartworm in animals). Also disclosed are methods for determining the responsiveness of Dirofilaria spp. nematodes to macrocyclic lactones, methods for selecting a treatment to treat an animal infected with a Dirofilaria spp. nematode, and kits for determining the responsiveness of Dirofilaria spp. nematodes to macrocyclic lactones.

Abstract: Antisense nucleic acid molecules, such as ribozymes, shRNA and siRNA, targeting the Gag region of HIV-1 open reading frame, and uses thereof for inhibiting HIV-1 replication and infection, are disclosed. The antisense nucleic acid molecules more specifically target a sequence corresponding to about nucleotide 1495 to about nucleotide 1526, or nucleotide 1497 to about nucleotide 1521, of HIV-1 clone pNL4-3.

Abstract: The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

Abstract: A method for producing an arene with an aromatic C—N bond ortho to an aromatic C—O bond from a hydroxy arene comprising said aromatic C—O bond is provided.

Abstract: Nutraceutical or pharmaceutical compositions, functional foods, extracts, dietary supplements and food/feed additives enriched in phytochemicals having antioxidant and/or anti-inflammatory activity may be derived from the skin, pith, or cortex from stem tubers of select potato cultivars, such as Onaway, Russet Burbank, Purple Valley or Bora Valley cultivars. These cultivars and combinations thereof provide a useful antioxidant source enriched in ferulic acid, caffeic acid, chlorogenic acids, ascorbic acid, anthocyanins, and rutin, isomers or derivatives thereof having antioxidant and/or anti-inflammatory activity.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

Abstract: A flue gas treatment apparatus has a flue gas inlet, a treated gas outlet downstream of the flue gas inlet, and a gas flow path therebetween. The flue gas treatment apparatus comprises a particulate removal device. A first heater is downstream of the particulate removal device. The first heater heats the flue gas to a first treatment temperature. A first catalytic converter is downstream of the first heater for eliminating at least some CO and SO2 from the flue gas. A second heater is downstream of the first catalytic converter for heating the flue gas to a second treatment temperature. A second catalytic converter is downstream of the second heater for eliminating at least some NOx from the flue gas. At least a first fan forces the flue gas from the flue gas inlet to the treated gas outlet.

Abstract: Systems for analyte detection are disclosed. The system includes absorption channels positioned along a surface of an object. The absorption channels are configured to trap an analyte. The system further includes a sensor embedded in the object and configured to detect the presence of the analyte. The sensor includes a light source configured to transmit light and a detector configured to detect a change in an intensity of light transmitted by the light source. The sensor further includes a cable configured to connect the light source to the detector, wherein the cable comprises detection regions, and wherein the detection regions include a portion of the cable exposed to the analyte in the absorption channel.

Abstract: Energy dissipation measurements in Frequency Modulation-Atomic Force Microscopy (FM-AFM) should provide additional information for dynamic force measurements as well as energy dissipation maps for robust material properties imaging as they should not be dependent directly upon the cantilever surface interaction regime. However, unexplained variabilities in experimental data have prevented progress in utilizing such energy dissipation studies. The inventors have demonstrated that the frequency response of the piezoacoustic cantilever excitation system, traditionally assumed flat, can actually lead to surprisingly large apparent damping by the coupling of the frequency shift to the drive-amplitude signal. Accordingly, means for correcting this source of apparent damping are presented allowing dissipation measurements to be reliably obtained and quantitatively compared to theoretical models.

Abstract: This invention relates to systems and methods for measuring quantitatively multiple species or heavy metals, including mercury, and other toxic pollutants. More specifically, the systems and methods of the invention allows for determination of the analytes even at very low concentration, through concentration on a collection interface, desorption and analysis by mass spectrometry. The invention also provides for a portable device or kit for modifying an existing mass spectrometer.

Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.

Abstract: Radiotherapy is one of the most effective treatments for cancer and its success depends critically on accurate targeting and delivery of the correct radiation dose. Accurate dosimetry is therefore essential to maintain and improve patient survival rates. However, size and long wait times currently limit water and graphite based calorimeters to standards laboratories leaving field-based dosimetry to ionization chamber measurements which depend upon a reference field-specified calibration factor. It would therefore be beneficial to provide radiotherapy equipment operators a direct approach of clinical reference dosimetry wherein the dosimeter provides increased independence on dose, dose rate, radiation energy, and energy type, etc. It would be further beneficial for such novel clinical dosimeters to be compact, function as secondary standards used routinely for measurements and allow radiotherapy doses to be measured directly and in an absolute manner.

Abstract: The identification and determination of aspects of the construction of a patient's heart is important for cardiologists and cardiac surgeons in the diagnosis, analysis, treatment, and management of cardiac patients. For example minimally invasive heart surgery demands knowledge of heart geometry, heart fiber orientation, etc. While medical imaging has advanced significantly the accurate three dimensional (3D) rendering from a series of imaging slices remains a critical step in the planning and execution of patient treatment. Embodiments of the invention construct using diffuse MRI data 3D renderings from iterating connections forms derived from arbitrary smooth frame fields to not only corroborate biological measurements of heart fiber orientation but also provide novel biological views in respect of heart fiber orientation etc.

Abstract: A method for diagnosing the presence of hereditary spastic paraplegia (HSP) or predicting the risk of developing HSP in a human subject, comprising detecting the presence or absence of a defect in a gene encoding a polypeptide comprising the sequence of FIG. 9 (SEQ ID NO: 19), in a nucleic acid sample of the subject, whereby the detection of the defect is indicative that the subject has or is at risk of developing HSP.

Abstract: A method for processing non-lignocellulosic waste comprises pre-treating the non-lignocellulosic waste by enzymatic hydrolysis to yield a pre-treated non-lignocellulosic waste subjecting the pre-treated non-lignocellulosic waste to microwave hydrothermal carbonization to yield at least one of a hydrochar and a biocrude liquor. A system for processing non-lignocellulosic waste includes an enzymatic hydrolysis station for receiving non-lignocellulosic waste and generating a treated non-lignocellulosic waste, and a microwave hydrothermal carbonization station downstream of the enzymatic hydrolysis station for receiving the treated non-lignocellulosic waste from the enzymatic hydrolysis station and generating at least one of a hydrochar and a biocrude liquor.

Abstract: Scalability and energy efficiency are key issues in data centers imposing tight constraints on the networking infrastructure connecting the servers. Optical interconnection mitigates electronic limitations but the additional flexibility offered by WDM and datarate across a data center interconnection network requires architectural design, photonic technologies, and operating strategies be selected and optimized to meet power consumption requirements. Multi-plane architectures based upon space-wavelength domain architectures have been proposed to overcome scalability limitations. It would be beneficial to extend space and time switching domains with the wavelength domain for additional capacity to increase throughput as well as providing same electro-optic interface.

Abstract: A method of growing high quality crystalline films on lattice-mismatched or amorphous layers is presented allowing semiconductor materials that would normally be subject to high stress and cracking to be employed allowing cost reductions and/or performance improvements in devices to be obtained. Catalysis of the growth of these films is based upon utilizing particular combinations of metals, materials, and structures to establish growth of the crystalline film from a predetermined location. The subsequent film growth occurring in one or two dimensions to cover a predetermined area of the amorphous or lattice-mismatched substrate. Accordingly the technique can be used to either cover a large area or provide tiles of crystalline material with or without crystalline film interconnections.

Abstract: Cost, electronic circuitry limitations, and communication channel behavior yield communication systems with strict bandwidth constraints. Hence, maximally utilizing available bandwidth is crucial, for example in wireless networks, to supporting ever increasing numbers of users and their demands for increased data volumes, low latency, and high download speeds. Accordingly, it would be beneficial for such networks to support variable bandwidth allocations such that smaller frequency sub-bands are allocated to users, as their number increases, but the individual users/nodes insert more data-carrying signals in order to compensate for the loss of operating bandwidth arising from the accommodation of more users. It would further be beneficial for transmitters and receivers according to embodiments of such a network architecture to be based upon low cost design methodologies allowing their deployment within a wide range of applications including high volume, low cost consumer electronics for example.

Abstract: CMOS compatible SOI photonic integrated circuits (PICs) offer a low cost and promising solution to future short reach optical links operating beyond 100 Gb/s. A key building block in these optical links is the external optical modulator. Amongst, the PIC geometries for external modulators are those based upon ring resonators and Mach-Zehnder interferometers (MZI) where while the latter have been reported with increased thermal stability and fabrication tolerances, the former have demonstrated lower loss and lower driving voltages leading to a more energy efficient approach. Multi-segmented electrode structure based PAM optical modulator can potentially replace the analog digital-to-analog circuits (DACs) which are commonly used to achieve the multilevel electrical driving signal. Accordingly, it would be beneficial to combine the benefits of ring resonators to provide PAM-N modulators.