Abstract: The present disclosure provides methods of treating a subject having decreased bone mineral density or at risk of developing decreased bone mineral density, and methods of identifying subjects having an increased risk of developing decreased bone mineral density.

Abstract: The disclosure relates to synthetic oligonucleotides that bind at least a portion of a dimerization initiation site (DIS) of a retrovirus genomic ribonucleic acid (RNA) molecule. In some aspects, the synthetic oligonucleotides include a 2?-deoxy-2?-fluoroarabinonucleotide (2?-FANA)-modified nucleotide sequence. In some embodiments, the 2?-FANA-modified nucleotide sequence inhibits dimerization of retroviral genomes (e.g., an HIV genome). Other embodiments include methods of inhibiting expression of a retrovirus using the synthetic oligonucleotide, and methods of treating or preventing a retroviral infection.

Abstract: A heating mechanism for use in DNA applications such as DNA amplification, extraction and sterilization is provided. Nanoparticles having photo-thermal properties are put in contact with a reaction mixture and irradiated with an activation light beam to activate these photo-thermal properties, thereby releasing heat. Nanoparticles of several types may be used. Use of the same nanoparticles or of different one to monitor the reaction using a different light beam is also presented.

Abstract: Methods and compositions are provided for treatment of peroxisomal biogenesis disorders (PBDs). More particularly, recombinant adeno-associated viruses (rAAV) provided in the form of compositions are used to deliver a nucleic acid encoding human PEX1 to host cells. The rAAVs comprise a AAV capsid, and packaged therein a vector genome comprising an AAV 5? inverted terminal repeat (ITR) sequence; a promoter; a coding sequence encoding a human PEX1; and an AAV 3? ITR.

Abstract: There is described a method and system for regulating an extrusion process by obtaining a first thickness at a first position along an extrudate as material is extruded through a die gap of a die; comparing the first thickness with an expected thickness of the extrudate at the first position to obtain a value for an error, the expected thickness modeled in real-time using a size of the die gap as input; and varying the size of the die gap when the error exceeds a threshold to compensate for the error. There is also described a method and system for determining an expected thickness of a material during an extrusion process.

Abstract: Active dichoptic perceptual-learning tasks or dichoptic game play have been shown to significantly improve visual acuity of amblyopic children and adults. However, these dichoptic perceptual learning tasks are intensive and repetitive such that non-compliance is high. In contrast, the invention provides dichoptic perceptual learning in a manner that the user maintains its use and compliance is increased. Further, compliance becomes automatic if the user performs tasks in a normal manner and “forgets” that they are actually under-going treatment as it is integrated with minimal disruption to their life and activities. Accordingly, a methodology exploiting complementary dichoptic stimulation is presented.

Abstract: The present disclosure relates to methods of treating or preventing a biofilm-related infection and methods of preventing and treating biofilm formation on indwelling medical devices, implants, and non-medical surfaces comprising administering at least one soluble microbial protein that is encoded by an exopolysaccharide biosynthetic operon or functional gene cluster, wherein the protein comprises a glycosyl hydrolase domain. The present disclosure further provides particular soluble glycosyl hydrolases and compositions thereof.

Abstract: Herein provided is a radiation dosimeter and associated systems and methods. The radiation dosimeter comprises a light source configured for producing an input optical signal; a resonant cavity coupled to the light source for receiving the input optical signal, the resonant cavity configured for containing a fluid and for producing an output optical signal from the input optical signal indicative of a radiation dose absorbed by the fluid; and a light detector coupled to the optical fiber for obtaining the output optical signal.

Abstract: A method and apparatus of early-stage detection of glaucoma and other optic nerve or retinal diseases employs dynamic images that are processed differently by Y-like cells and X-like cells to provide a sensitive detection of early Y-like cell impairment which provides early indications of glaucoma isolated from non-specific information from X-like cells.

Abstract: There is disclosed a capillary microfluidic circuit including a main channel communicating with a flow inducing element. The main channel has intermediary inlets. Reservoirs for containing one or more liquids prior to being drawn into the main channel. The reservoirs include a first reservoir and at least a second reservoir. Each of the reservoirs has an upstream end connectable to vents for filling the reservoirs with the one or more liquids and a downstream end. The downstream end of each of the reservoirs is connected to the intermediary inlets of the main channel A conduit is disposed between the first reservoir and the a least a second reservoir. The conduit links the downstream end of the first reservoir with the upstream end of the at least a second reservoir.

Abstract: Methods and systems for establishing a kinetic model input function (IF) in positron emission tomography and single-photon emission computed tomography are provided. A position of interaction along a scintillating fiber coil is determined by: detecting a first plurality and second plurality of photons at first and second ends of the scintillating fiber coil; associating the first plurality of photons and the second plurality of photons with the interaction event based on a timing parameter; and determining a position of interaction for the interaction event based on a comparison between a first parameter of the first plurality of photons and a second parameter of the photons in the second plurality of photons.

Abstract: A neurofeedback method, including: recording electrical signals from at least one brain region of a subject, wherein changes in the recorded electrical signals over time indicate changes in an activity level of the at least one brain region; providing an audio signal having a perceived quality based on the recorded electrical signals and according to an activity level of the at least one brain region; delivering the audio signal to the subject during said recording.

Abstract: Nanofluidic flow cells and systems for single-molecule nanoconfinement and imaging of molecules in a fluid are described. The nanofluidic flow cell comprises a bottom substrate bonded to a top substrate, microchannels and a central chamber carved in the bottom or top substrate. The microchannels and the central chamber define an empty space into which a fluid can flow. The microchannels extend on opposite side of the central chamber, each microchannel comprising a central portion crossing the central chamber and a pair of arms extending outside the central chamber, these arms comprising a fluid port positioned at opposite ends of the microchannel and outside the central chamber. The central chamber comprises a nanoconfinement and imaging area including carved nanostructures configured for single-molecule nanoconfinement. Also described are nanofluidic chips, methods of confinement, pneumatic-based nanofluidic systems and manifold assembly for the nanofluidic flow cell.

Abstract: A system for monitoring a bit condition in a drilling operation comprises a processor unit and a non-transitory computer-readable memory communicatively coupled to the processing unit and comprising computer-readable program instructions executable by the processing unit for: obtaining signals representative of at least vibrations of a drilling mast having at least one bit during a drilling operation; interpreting the signals into vibration values; continuously monitoring the vibration values in real time; and assessing and outputting a condition of the bit as a function of the continuous monitoring of the vibration values.

Abstract: The invention encompasses ex vivo method of stimulating isolated memory T-cell, tumor-infiltrating lymphocyte (TIL), T cell receptor (TCR) engineered cell, and/or chimeric antigen receptor (CAR) engineered cell with compounds of Formula I below, which are inhibitors of the TC-PTP enzyme.

Abstract: Method for producing high molecular weight chitosan comprising milling or grinding chitin and a reagent to produce a chitin/reagent mixture; and aging said chitin/reagent mixture to produce a high molecular weight chitosan. Method for producing low molecular weight chitosan comprising amorphizing chitin; milling or grinding said amorphized chitin and a reagent to produce chitin/reagent mixture; and aging said chitin/reagent mixture producing low molecular weight chitosan.

Abstract: The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and traumatic brain injury.

Abstract: Systems and methods of communicating using asymmetric polar codes are provided which overcome the codeword length constraints of systems and methods of communicating that use traditional polar codes. Used herein, asymmetric polar codes refers to a polarizing linear block code of any arbitrary length that is constructed by connecting together constituent polar codes of unequal length. Asymmetric polar codes may be known by other names. In comparison to conventional solutions for variable codeword length, asymmetric polar codes may provide more flexibility, improved performance, and/or reduced complexity of decoding, encoding, or code design. The system and method provide a flexible, universal, and well-defined coding scheme and to provide sound bit-error correction performance and low decoding latency (compared with current length-compatible methods which can be used with current hardware designs).

Abstract: GaN-based nanowire heterostructures have been intensively studied for applications in light emitting diodes (LEDs), lasers, solar cells and solar fuel devices. Surface charge properties play a dominant role on the device performance and have been addressed within the prior art by use of a relatively thick large bandgap AlGaN shell covering the surfaces of axial InGaN nanowire LED heterostructures has been explored and shown substantial promise in reducing surface recombination leading to improved carrier injection efficiency and output power. However, these lead to increased complexity in device design, growth and fabrication processes thereby reducing yield/performance and increasing costs for devices. Accordingly, there are taught self-organising InGaN/AlGaN core-shell quaternary nanowire heterostructures wherein the In-rich core and Al-rich shell spontaneously form during the growth process.

Abstract: A method for assessing a cancer status of biological tissue includes the steps of: obtaining a Raman spectrum indicating a Raman spectroscopy response of the biological tissue, the Raman spectrum captured using a fiber-optic probe of a fiber-optic Raman spectroscopy system; inputting the Raman spectrum into a boosted tree classification algorithm of a computer program, and using the boosted tree classification algorithm for comparing, in real-time, the captured Raman spectrum to reference data and assessing the cancer status of the biological tissue based on said comparison, the reference data being previously determined based on a set of reference Raman spectra indicating Raman spectroscopy responses of reference biological tissues wherein each of the reference biological tissues is associated with a known cancer status; and generating a real-time output indicating the assessed cancer status of the biological tissue,