Patents Assigned to Merck Patent GmbH
  • Emulsifying and separating device for liquid phases
    Patent number: 7001576
    Abstract: A device for the emulsification and separation of small amounts of immiscible liquid phases has essentially a cover plate (2), which can be tightly connected to a base plate (1), where microchannels (4,4a,5,6,6a) in the form of grooves are cut out on the inner surface (3,3a) of the base plate (1) and/or cover plate (2). In a mixing zone, two microchannels (4,4a) run in a wave shape crossing one another a number of times. In a subsequent separation zone, they run essentially straight combined in a common microchannel (5). The otherwise tightly sealed-off microchannels (4,4a,5,6,6a) can be filled and emptied again via inlet apertures (8,8a) and outlet apertures (9,9a).
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: February 21, 2006
    Assignee: Merck Patent GmbH
    Inventors: Michael Hohmann, Michael Schmelz, Günter Brenner, Hanns Wurziger, Norbert Schwesinger
  • Detection of peroxidase activity in milk or milk products
    Patent number: 7001741
    Abstract: The invention relates to an agent and a method for the dry chemical detection of lactoperoxidase in milk or dairy products. The method according to the invention is characterized by rapid execution thereof and said method has a high degree of sensitivity. The high detection sensitivity is achieved by adding iodide ions to the usual reagents.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: February 21, 2006
    Assignee: Merck Patent GmbH
    Inventors: Dieter Tanzer, Karl-Dieter Krenn
  • Liquid crystalline medium
    Patent number: 7001646
    Abstract: The invention relates to a liquid crystalline medium based on a mixture of polar compounds with positive dielectric anisotropy, characterized in that said medium contains one or more alkenyl compounds of the formula (I) and one or more compounds of the formula (IA) wherein R, R1, R2, ring A and ring B, L1, L2; L3; L4; X, Z1, Z2, y and z have the meanings cited in Claim 1.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: February 21, 2006
    Assignee: Merck Patent GmbH
    Inventors: Michael Heckmeier, Brigitte Schuler, Achim Goetz, Peer Kirsch, Eike Poetsch, Detlef Pauluth
  • Process for the preparation of directly compressible ?-mannitol
    Patent number: 6998482
    Abstract: The present invention relates to a process for the preparation of directly compressible mannitol having a content of the ? modification of greater than 90%.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: February 14, 2006
    Assignee: Merck Patent GmbH
    Inventors: Martin Erdmann, Walter Hamm
  • Process for the preparation of ?-mannitol for direct compression
    Patent number: 6998481
    Abstract: The present invention relates to a process for the preparation of mannitol for direct compression having a content of the ?-modification of greater than 90%.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: February 14, 2006
    Assignee: Merck Patent GmbH
    Inventors: Martin Erdmann, Walter Hamm
  • Pigment with a metallic luster
    Patent number: 6997982
    Abstract: The invention relates to a pigment with a metallic luster, comprising a plate-like non-metallic substrate having a thickness lower an 200 nm, which is entirely coated with a metallic layer.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: February 14, 2006
    Assignee: Merck Patent GmbH
    Inventors: Gerhard Pfaff, Stephanie Andes, Michael Uhlig
  • Method and agent for determining total water hardness
    Patent number: 6994973
    Abstract: The invention relates to a dry chemical method and a test strip for determining calcium and magnesium in aqueous samples. Said test strip contains o-cresolphthalein complex (o-CPC; CAS Registry No. 2411-89-4) as a colour-causing reagent in a buffer system with a pH value of below 8.5. By using in particular an aqueous ethanolic imidazole buffer with a pH value of 6.75, conditions can be set up in such a way that the o-CPC has an identical molar sensitivity with respect to Ca and Mg. The total water hardness of aqueous samples can thus be easily determined.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: February 7, 2006
    Assignee: Merck Patent GmbH
    Inventors: Karl-Dieter Krenn, Dieter Tanzer
  • Process for preparing films of polymerized liquid crystal material having a first film of a polymerized liquid crystal material with uniform orientation and a second film of a polymerized liquid crystal material with uniform orientation directly on the first film
    Patent number: 6995825
    Abstract: The invention relates to a process of preparing films and multilayers comprising polymerized liquid crystal material with uniform orientation, to films and multilayers obtained by said process and their use for optical and electrooptical applications.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: February 7, 2006
    Assignee: Merck Patent GmbH
    Inventors: Donald Gordon Graham, Owain Llyr Parri
  • Reducing the immunogenicity of fusion proteins
    Publication number: 20060025573
    Abstract: Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby reducing its interaction with a T-cell receptor. Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T cell receptor. Compositions and methods of the invention are useful in therapy.
    Type: Application
    Filed: September 23, 2005
    Publication date: February 2, 2006
    Applicant: MERCK Patent GmbH
    Inventors: Stephen Gillies, Jeffrey Way, Anita Hamilton
  • Immunoconjugates
    Patent number: 6979726
    Abstract: The present invention relates to new fusion proteins which consist of a tumor-associated targeting element preferentially a monoclonal antibody or a fragment thereof recognizing a molecule which is preferentially expressed on human tumor cells such as the human epidermal growth factor receptor (EGFR), and a biologically active ligand such as a growth and/or differentiation factor. The resulting fusion protein may be used to deliver the biologically active ligand to a specific target cell or tissue. The new immunoconjugates can be used in tumor therapy.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: December 27, 2005
    Assignee: Merck Patent GmbH
    Inventors: Ilka von Hoegen, Uwe Hofmann, Carlota-Silvia Jaggle, Wolfgang Strittmatter, Jörg Stadlmüller, Siegfried Matzku
  • Photostable liquid crystalline medium
    Publication number: 20050279968
    Abstract: The invention relates to a photostable liquid-crystalline medium comprising at least one compound of the formula I and at least one compound of the formula II and to the use thereof for electro-optical purposes, and to displays containing this medium.
    Type: Application
    Filed: September 25, 2003
    Publication date: December 22, 2005
    Applicant: Merck Patent GmbH
    Inventors: Atsutaka Manabe, Ulrich Heywang, Detlef Pauluth, Michael Heckmeier, Peer Kirsch, Elvira Montenegro
  • Method for producing indoles
    Patent number: 6977304
    Abstract: The present invention relates to a process for the preparation of indoles.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: December 20, 2005
    Assignee: MERCK Patent GmbH
    Inventors: Hanns Wurziger, Guido Pieper, Norbert Schwesinger
  • Pyrans as liquid crystals
    Patent number: 6974607
    Abstract: Tetrahydropyran derivatives having at least one ester group (—CO—O—) and at least one group —CN, —NCS, —F, —Cl, —OCHF2, —OCF3, —CF3, —OCHFCF3, —OCF2CHFCF3, SF5, or —OCF2CF3; a process for preparing said tetrahydropyran derivatives, and the use of said tetrahydropyran derivatives as a component in a liquid crystal composition.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: December 13, 2005
    Assignee: Merck Patent GmbH
    Inventors: Mark John Goulding, Warren Duffy, Kevin Adlem, Peer Kirsch, Alexander Hahn, Eike Poetsch, Werner Binder, Volker Meyer, Melanie Klasen-Memmer, Michael Heckmeier, Georg Lüssem
  • Pigment preparation
    Patent number: 6972305
    Abstract: The invention relates to a non-dusting homogeneous pigment preparation notable in that it comprises at least 40% by weight of one or more effect pigments, from 0.5 to 50% by weight of water and/or an organic solvent or solvent mixture and from 0.5 to 59.5% by weight of a styrene-modified polyacrylate resin having an acid number >90 mg KOH/g, and to its use to produce dry preparations.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: December 6, 2005
    Assignee: Merck Patent GmbH
    Inventors: Carsten Griessmann, Gerhard Herget, Jochen Meyer, Thomas Rathschlag
  • Liquid-crystal medium, and electro-optical display containing same
    Patent number: 6969542
    Abstract: The present invention relates to nematic liquid-crystal media which comprise a) a dielectrically negative, liquid-crystalline component A comprising one or more compounds of the formula I in which the parameters are as defined in the text, and b) a dielectrically negative, liquid-crystalline component B, and optionally c) a dielectrically neutral, liquid-crystalline component C, and optionally d) a dielectrically positive, liquid-crystalline component D, and to the use of these media in liquid-crystal displays, and to liquid-crystal displays which use these media, in particular VAN and IPS displays.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: November 29, 2005
    Assignee: Merck Patent GmbH
    Inventors: Melanie Klasen-Memmer, Clarissa Weller, Matthias Bremer
  • Negative retardation film
    Publication number: 20050259200
    Abstract: The invention relates to a negative birefringent retardation film comprising polymerised liquid crystal (LC) material with helically twisted structure and planar orientation, its use in compensators and electrooptical displays like liquid crystal displays, and to compensators and liquid crystal displays comprising such a negative retardation film.
    Type: Application
    Filed: July 11, 2003
    Publication date: November 24, 2005
    Applicant: Merck Patent GmbH
    Inventors: Karl Skjonnemand, Owain Parri, Donald Graham, Tara Perrett
  • Liquid-crystalline medium
    Patent number: 6964794
    Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterized in that it comprises one or more compounds of the formula I in which R1, L1 and L2 are as defined in claim 1.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: November 15, 2005
    Assignee: Merck Patent GmbH
    Inventors: Michael Heckmeier, Brigitte Schuler, Izumi Saito, Volker Reiffenrath, Georg Luessem, Christian Hock
  • Etching pastes for silicon surfaces and layers
    Publication number: 20050247674
    Abstract: The invention relates to novel etching media in the form of etching pastes for etching selected areas or the entire area of silicon surfaces and layers, in addition to the use of said media.
    Type: Application
    Filed: August 8, 2003
    Publication date: November 10, 2005
    Applicant: Merck Patent GmbH
    Inventors: Armin Kubelbeck, Sylke Klein, Werner Stockum
  • Protein for blocking platelet adhesion
    Patent number: 6962801
    Abstract: A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to hard disease and diseases of the circulation system. Furthermore the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: November 8, 2005
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Strittmatter, Detlef Güssow, Uwe Hofmann, Jürgen Hemberger, Zisi Fotev, Bernhard Scheuble
  • Liquid-crystalline medium
    Patent number: 6962733
    Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterized in that it comprises one or more compounds of the formula I in which R1, L1 and L2 are as defined in claim 1.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: November 8, 2005
    Assignee: Merck Patent GmbH
    Inventors: Michael Heckmeier, Brigitte Schuler, Izumi Saito, Volker Reiffenrath, Georg Luessem, Christian Hock