Abstract: The invention relates to a liquid crystalline medium characterized by containing one or more compounds of general formula (I) and one or more compounds of formula (II), wherein R1, R2, R3, R4 and c have the meanings as cited in Claim No. 1.
Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, which medium comprises one or more compounds the general formula Ia and one or more compounds selected from the group consisting of compounds of the formula III and V to VIII: The notations r, R, R0, X0, Z0 and Y1-4 are defined herein.
Abstract: A tetrahydropyran derivative comprising at least three cyclic rings and one aromatic endgroup of the formula A a process for preparing said tetrahydropyran derivatives, and the use of said tetrahydropyran derivatives as a component in a liquid crystal composition.
Type:
Grant
Filed:
May 27, 2004
Date of Patent:
April 4, 2006
Assignee:
Merck Patent GmbH
Inventors:
Mark John Goulding, Warren Duffy, Kevin Adlem, Peer Kirsch, Alexander Hahn, Eike Poetsch, Werner Binder, Volker Meyer, Melanie Klasen-Memmer, Michael Heckmeier, Georg Lüssem
Abstract: A body pigment with a good skin feel for cosmetics is provided which has an appropriate crumbling property and combines slipping property and adhesiveness without compromising oil absorption. The body pigment is comprised of a metal-containing compound and has a structure in which leaf-shaped flakes are combined and/or intersected.
Abstract: The invention relates to fluorinated aromatics of the formula (I) where X is CH2, C?O, CF2, O or S, Y is H or F, with the proviso that Y has to be F when X is CH2, and where the other parameters are as defined in claim 1, and also to their use in liquid-crystal mixtures, and also to liquid-crystal mixtures comprising these compounds and to liquid-crystal displays comprising these mixtures.
Type:
Grant
Filed:
January 10, 2002
Date of Patent:
March 28, 2006
Assignee:
Merck Patent GmbH
Inventors:
Wolfgang Schmidt, Rainer Wingen, Barbara Hornung
Abstract: Novel indole derivatives of the formula (I), in which X, Y, R1, R1?, m and n have the meanings indicated in Patent Claim 1, have a strong affinity to the 5-HT1A and in some cases to the 5-HT1D receptors.
Type:
Application
Filed:
October 30, 2003
Publication date:
March 23, 2006
Applicant:
Merck Patent GmbH
Inventors:
Guenter Hoelzemann, Kai Schiemann, Timo Heinrich, Henning Boettcher, Joachim Leibrock, Christoph Van Amsterdam, Gerd Bartoszyk
Abstract: Compounds of the formula (I) in which the parameters are as defined herein, are suitable for use in liquid-crystal media and liquid-crystal displays which contain these media.
Type:
Grant
Filed:
June 9, 2003
Date of Patent:
March 21, 2006
Assignee:
Merck Patent GmbH
Inventors:
Matthias Bremer, Melanie Klasen-Memmer, Barbara Hornung, Wolfgang Schmidt, Rainer Wingen
Abstract: The invention concerns alkali-stable hydrophilic sorbents for ion-exchange chromatography. The invention is characterized in that it consists in using as base material a crosslinked vinyl polymerconsisting of vinyl monomers containing diol groups and crosslinking monomers whereof the polymerizable groups are bound by carbonamide-containing chains. Monomers containing ionic groups are grafted on said base material using cerium (IV) salts.
Abstract: The present invention relates to novel compositions containing a combination of the plant St. John's Wort (Hypericum perforatum L.), its extracts of active ingredients and derivatives of dihydro- and tetrahydrofolic acid. This natural formulation is useful for the treatment and prevention of depression with a better effect than the ingredient compounds alone.
Type:
Grant
Filed:
October 8, 1999
Date of Patent:
March 21, 2006
Assignee:
Merck Patent GmbH
Inventors:
Herwig Buchholz, Angela Dudda, Jerzy Meduski
Abstract: This invention relates to an anhydrous composition comprising an antioxidant comprising over 40% by weight of hydrolysable tannins having molecular-weight of less than 1,000 and a substantially anhydrous or non-aqueous liquid vehicle functioning to disperse the antioxidant. The composition is suitable as cosmetic composition and/or therapeutic and/or prophylactic composition and/or anhydrous delivery system of cosmetic and/or pharmaceutical ingredients. The invention further relates to processes for producing such compositions.
Abstract: Seripancrin polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Seripancrin polypeptides and polynucleotides in diagnostic assays.
Type:
Grant
Filed:
July 4, 2000
Date of Patent:
March 14, 2006
Assignee:
Merck Patent GmbH
Inventors:
Britta Sundermann, Uwe Hofmann, Siegfried Matzku, Oliver Wilbert
Abstract: The invention relates to compounds of the formula I: and to the pharmaceutically acceptable salts thereof, to processes for the preparation of them and to pharmaceutical compositions comprising them, which are useful especially for the treatment and prevention of dyslipidaemia, atherosclerosis and diabetes.
Type:
Application
Filed:
August 11, 2003
Publication date:
March 9, 2006
Applicant:
Merck Patent GmbH
Inventors:
Michel Brunet, Jean-Jacques Zeiller, Gerard Ferrand, Yves Bonhomme
Abstract: The present invention relates to the use of at least one compound with inhibitory activity on kynurenine 3-hydroxylase, for the preparation of a medica ment for increasing the number of islets of Langerhans cells, which is intended especially for the prevention and/or treatment of diabetes.
Abstract: Novel compounds of the formula (I), in which D, W, X, Y, T, m and R1 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
Type:
Application
Filed:
October 30, 2003
Publication date:
March 9, 2006
Applicant:
Merck Patent GmbH
Inventors:
Dieter Dorsch, Bertram Cezanne, Werner Mederski, Christos Tsaklakidis, Hanns Wurziger, Johannes Gleitz, Christoph Van Amsterdam
Abstract: The present invention relates to substances of the general formula (I) in which X is selected from the group consisting of NH, NR4, O and S, R1 is selected from the group consisting of hydrogen, linear and branched, substituted and unsubstituted C1–C10-alkyl groups, substituted and unsubstituted C5–C10-aryl groups, substituted and unsubstituted C4–C10-heteroaryl groups, acyl groups, thioacyl groups, carbonylcarboxy groups, N-organyl-substituted carbamoyl groups and organosulfonyl groups, R2, R3 are selected, independently of one another, from the group consisting of C1–C10-alkyl groups, C5–C12-aryl groups and C4–C12-heteroaryl groups, these groups being unsubstituted or having one or more substituents which are selected, independently of one another, from the group consisting of halogens, alkoxy groups, aryloxy groups, nitro groups, C1–C5-alkoxycarbonyl groups, optionally fluorine-substituted alkyl or acyl groups and cyano groups, R4 is selected from the group consisting of hydrogen, linear and branched,
Abstract: The invention relates to a method for the 1,3 dipolar cycloaddition of organic compounds, characterized in that the reaction is carried out in a microreactor.
Abstract: The invention relates to a method and an installation for processing thermoplastic synthetic materials. According to the invention, the melt strands or the like are displaced in oscillation or pulsation in order to indent or penetrate the joint lines between at least two injection strands.
Abstract: The invention relates to a process for the preparation of flavone derivatives in which a 2-hydroxyacetophenone compound is metallated using a lithium compound at low temperatures and subsequently reacted with a keto compound, and where the ratio of the molar equivalents of lithium compound to the 2-hydroxyacetophenone compound functional groups to be metallated is from 1 to 1.2. The resultant ?-diketone compound is subsequently cyclized with warming in an acidic medium.
Abstract: The invention relates to the use of 5-HT2 receptor antagonists for the preparation of a medicament for extending both non-REM sleep an REM sleep.
Type:
Application
Filed:
September 3, 2003
Publication date:
February 23, 2006
Applicant:
Merck Patent GmbH
Inventors:
Gerd Bartoszyk, Christoph Van Amsterdam