Patents Assigned to Merck Patent GmbH
  • Matrix liquid crystal display
    Patent number: 6905740
    Abstract: The invention relates to a matrix liquid crystal display containing integrated non-linear elements and a liquid crystal mixture which has a particularly high resistivity.
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: June 14, 2005
    Assignee: Merck Patent GmbH
    Inventors: Georg Weber, Ludwig Pohl, Reinhard Hittich, Herbert Plach, Bernhard Scheuble, Takamasa Oyama, Bernhard Rieger, Hans Adolf Kurmeier, Ekkehard Bartmann
  • Liquid-crystalline medium
    Patent number: 6902777
    Abstract: A liquid-crystalline mediums which contain one or more compounds of the formula A and at least one compound of the formula B wherein compounds of formula A contain at least one ring selected from and in which Ra, Rb, ring A and ring B, Y, Z1, Z2, a, L1, L2, L3, L4, L5, L6, L7, L8 and L9 are as defined herein, are suitable for use in twisted nematic (TN) and supertwisted nematic (STN) liquid-crystal displays. Such displays have very short response times and good steepnesses and angle dependencies.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: June 7, 2005
    Assignee: Merck Patent GmbH
    Inventors: Harald Hirschmann, Eike Poetsch, Peer Kirsch, Sabine Schoen
  • Optical compensator and liquid crystal display II
    Patent number: 6903789
    Abstract: The invention that relates to an optical compensator for liquid crystal displays comprising: at least one O plate retarder; at least one planar A plate reader; at least one negative C plate retarder; and further relates to a liquid crystal display comprising such a compensator.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: June 7, 2005
    Assignee: MERCK Patent GmbH
    Inventors: Tara Cutler, Owain Llyr Parri, Mark Verrall, Peter Le Masurier
  • Energy-saving liquid-crystal mixtures
    Patent number: 6902776
    Abstract: The invention relates to energy-saving liquid-crystalline media, in particular in twisted nematic (TN) and supertwisted nematic (STN) liquid-crystal displays, having very short response times and good steepnesses and angle dependences, and to electro-optical display devices containing these media and to the use of these media in electro-optical display devices, where the media comprise: a component (?) which comprises at least one compound of the formula I and a component (?) which comprises at least one compound of the formula II where the following applies for the dielectric anisotropy ??corr of the liquid-crystalline medium: ? ? ? ? ? corr ? 5 · V 10 + 32 V 10 2 .
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: June 7, 2005
    Assignee: Merck Patent GmbH
    Inventor: Michael Junge
  • Formulation comprising benzofuranone derivatives for protection against oxidative stress
    Patent number: 6903134
    Abstract: The invention relates to a cosmetic or pharmaceutical formulation comprising at least one compound of formula (I). The cosmetics or pharmaceutical products are particularly suitable for the care of the skin in protecting against oxidative stress and ageing phenomena.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: June 7, 2005
    Assignee: Merck Patent GmbH
    Inventors: Frank Pflücker, Herwig Buchholz, Ralf Rosskopf, Joachim Bünger
  • Method for purifying recombinant proteins expressed as insoluble aggregates
    Patent number: 6900034
    Abstract: The invention relates to a method for solubilising and purifying recombinant proteins which are expressed in bacterial host cells and are deposited as insoluble aggregates (inclusion bodies). The purification is based on conversion of the inclusion bodies into soluble forms using organic denaturing reagents and using chromatographic methods. Inorganic, alkaline, salt-containing eluents are selected here which, after purification is complete, enable the recombinant proteins, after neutralisation, to be made available in a form which can be employed directly for medical use and is physiologically acceptable. The method is particularly suitable for purifying allergens and allergen fragments.
    Type: Grant
    Filed: August 18, 2001
    Date of Patent: May 31, 2005
    Assignee: Merck Patent GmbH
    Inventors: Roland Suck, Oliver Cromwell, Helmug Fiebig
  • Anisotropic polymer layer
    Patent number: 6899929
    Abstract: The invention relates to an optical retardation film comprising two layers of an anisotropic polymer adjacent to each other or adjacent to both sides of a substrate, characterized in that each layer exhibits a tilted structure with an optical symmetry axis having a tilt angle ? relative to the plane of the layer, to a means to produce substantially linear polarized light comprising such an optical retardation film and to a liquid crystal display comprising such an optical retardation film.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: May 31, 2005
    Assignee: Merck Patent GmbH
    Inventors: Mark Verrall, Mark Goulding, Quentin Hodges, Ben Godden
  • Use of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and its physiologically acceptable salts
    Patent number: 6900212
    Abstract: 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine or a physiologically acceptable salt thereof, for the treatment of sub-type anxiety disorders chosen from the sub-types: panic disorder with or without agoraphobia, agoraphobia, obsessive-compulsive spectrum disorders, social phobia, posttraumatic stress disorder, acute stress indication or generalized anxiety disorder, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, anorexia, and fibromyalgia. A preferred salts is 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: May 31, 2005
    Assignee: Merck Patent GmbH
    Inventors: Gerd Bartoszyk, Christoph Seyfried, Christoph Von Amsterdam, Henning Boettcher, Ewen Sedman
  • Liquid-crystal medium, and electro-optical display containing same
    Patent number: 6896939
    Abstract: A nematic liquid-crystal media which comprises a) a dielectrically negative liquid-crystalline component A comprising one or more compounds of the formula I ?in which the parameters are as defined in the text, and b) a further dielectrically negative liquid-crystalline component B, and optionally c) a dielectrically neutral liquid-crystalline component C, and optionally d) a dielectrically positive liquid-crystalline component D, wherein said media is used in liquid-crystal displays.
    Type: Grant
    Filed: April 14, 2003
    Date of Patent: May 24, 2005
    Assignee: Merck Patent GmbH
    Inventors: Melanie Klasen-Memmer, Matthias Bremer, Malgorzata Rillich
  • Fluoroalkylphosphate salts, and process for the preparation of these substances
    Patent number: 6893774
    Abstract: Fluoroalkylphosphate salts of Formula I, described herein, are suitable for use, alone or in mixtures with, e.g., other salts, in electrolytes, primary batteries, secondary batteries, capacitors, supercapacitors or galvanic cells.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: May 17, 2005
    Assignee: Merck Patent GmbH
    Inventors: Michael Schmidt, Andreas Kuhner, Nikolai Ignatyev, Peter Sartori
  • Nematic liquid-crystal composition
    Patent number: 6890606
    Abstract: The invention relates to nematic liquid-crystal compositions comprising bisalkenyl compounds of the formula I and to their use in plasma-addressed LCDs.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: May 10, 2005
    Assignee: Merck Patent GmbH
    Inventors: Harald Hirschmann, Sven Schupfer, Marcus Reuter
  • Liquid-crystalline medium
    Patent number: 6890607
    Abstract: A liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, which contains one or more compounds of the formula I in which R1 is a halogenated or unsubstituted alkyl or alkoxy radical having from 1 to 15 carbon atoms, where one or more CH2 groups in these radicals are optionally, independently of one another, replaced by —C?C—, —CH?CH—, —O—, —CO—O— or —O—CO— in such a way that O atoms are not linked directly to one another, X is SF5, and L1 and L2 are each, independently of one another, H or F. The media are useful in electro-optical liquid crystal displays.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: May 10, 2005
    Assignee: Merck Patent GmbH
    Inventors: Michael Heckmeier, Brigitte Schuler, Izumi Saito, Volker Reiffenrath, Georg Luessem, Christian Hock
  • Colored pigments
    Patent number: 6884289
    Abstract: The present invention relates to colored pigments based on multicoated platelet-shaped substrates which are distinguished by the fact that they comprise (A) a coating having a refractive index of n>1.8 and a layer thickness of 20-500 nm, (B) a colorless coating having a refractive index of n?1.8 and a layer thickness of 10-100 nm, (C) a colorless coating having a refractive index of n>1.8 and a layer thickness of 20-500 nm, (D) a covering of absorbent pigment particles having a particle size of 1-500 nm, and optionally (E) an outer protective layer, and to their use in paints, coatings, printing inks, plastics, ceramic materials, glasses, for laser marking, in cosmetic formulations and for the production of pigment preparations and dry preparations.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: April 26, 2005
    Assignee: Merck Patent Gmbh
    Inventors: Sabine Schoen, Christoph Schmidt
  • Method for selectively dissociating cyclic carboxylic acid anhydrides
    Patent number: 6884893
    Abstract: The invention relates to a method for selectively dissociating cyclic carboxylic acid anhydrides. According to the inventive method, a chiral amino alcohol with a tertiary amino group that may have a partially or completely bridged structure is used as the chiral auxiliary reagent.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: April 26, 2005
    Assignee: MERCK Patent GmbH
    Inventors: Michael Schwarz, Jürgen Eckstein
  • Chromatography column
    Patent number: 6877363
    Abstract: The invention relates to a chromatography column for high-pressure liquid chromatography, which can be provided with different connection systems, such as a cartridge retaining device or a reducing screw. The column tube (1, 11) of the inventive chromatography column has an external thread (4,18) at each end and at least one groove (3,14).
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: April 12, 2005
    Assignee: Merck Patent GmbH
    Inventors: Günther Sättler, Hans-Dieter Pohl
  • Liquid crystalline medium
    Patent number: 6878421
    Abstract: The invention relates to a liquid crystalline medium, based on a mixture of polar compounds with a positive dielectric anisotropy. Said medium is characterised in that it contains one or more compounds of formula (I) wherein R, A1, A2, Z1, Z2, X1, X2, n and o are defined as per claim 1.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: April 12, 2005
    Assignee: Merck Patent GmbH
    Inventors: Michael Heckmeier, Martin Engel, Brigitte Schuler, Matthias Bremer, Detlef Pauluth
  • Bis(alkylthio)carbenium salts
    Patent number: 6875894
    Abstract: The invention relates to bis(alkylthio)carbenium salts of the formula I with the stated definitions for R1, R2, R3 and Y?, and to a process for the preparation thereof. The compounds according to the invention are advantageously suitable as electrophilic reagents for the transfer of fluorinated alkyl and acyl radicals onto nucleophilic compounds.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: April 5, 2005
    Assignee: Merck Patent GmbH
    Inventors: Peer Kirsch, Andreas Ruhl, Gerd-Volker Röschenthaler, Dmitrii Sevenard
  • Histidine phosphatase interacting protein with 120kd
    Publication number: 20050070002
    Abstract: PHPIP-120 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed, also disclosed are methods for utilizing PHPIP-120 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: January 25, 2002
    Publication date: March 31, 2005
    Applicant: Merck Patent GmbH
    Inventors: Bjorn Hock, Klaus Ducker, Roland Kellner
  • Heparanase-2 a member of the heparanase protein family
    Patent number: 6872558
    Abstract: Heparanase-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing heparanese-2 polypeptides and polynucleotides and diagnostic assays.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: March 29, 2005
    Assignee: Merck Patent GmbH
    Inventors: Klaus Dücker, Christian Sirrenberg
  • Optical compensator for LCD including stacked films of only one O-plate, one A-plate and two negative C-plate retarders
    Patent number: 6867834
    Abstract: An optical compensator for liquid crystal displays comprising at least one O plate retarder, at least one low tilt A plate retarder, and at least one negative C plate retarder is described. Also described are liquid crystal displays comprising such a compensator.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: March 15, 2005
    Assignee: Merck Patent GmbH
    Inventors: David Coates, Tara Cutler, Owain Llyr Parri, Mark Verrall, Peter Le Masurier, Stephan Derow