Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
Type:
Application
Filed:
December 19, 2023
Publication date:
May 16, 2024
Applicant:
Meso Scale Technologies, LLC.
Inventors:
Charles M. CLINTON, Eli N. GLEZER, Bandele JEFFREY-COKER, Sandor L. KOVACS, Sudeep M. KUMAR, George SIGAL, Carl STEVENS, Michael VOCK
Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Type:
Application
Filed:
January 16, 2024
Publication date:
May 9, 2024
Applicant:
Meso Scale Technologies, LLC.
Inventors:
Eli N. Glezer, Anu Mathew, Martin Stengelin, Mingyue Wang
Abstract: We describe a detection module useful with an apparatus and/or system for conducting luminescence assays, and a kit, a system, an apparatus, and a method incorporating the detection module.
Type:
Grant
Filed:
November 16, 2020
Date of Patent:
April 30, 2024
Assignee:
Meso Scale Technologies, LLC.
Inventors:
Charles M. Clinton, Jacob N. Wohlstadter
Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Type:
Grant
Filed:
February 8, 2021
Date of Patent:
April 30, 2024
Assignee:
Meso Scale Technologies, LLC.
Inventors:
Eli N. Glezer, John Kenten, Galina Nikolenko
Abstract: Methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. Also, algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
Type:
Grant
Filed:
February 22, 2018
Date of Patent:
April 23, 2024
Assignees:
Meso Scale Technologies, LLC, THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
Inventors:
William F Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
Abstract: In examples, a method of controlling customer access to an assay system comprises (a) receiving a system identifier; (b) identifying said system identifier; and (c) utilizing information obtained from the system identifier to perform one or more operations selected from: (i) enabling full access to said system and/or a consumable used in said system; (ii) enabling partial access to said system and/or a consumable used in said system; or (iii) denying access to said system and/or a consumable used in said system.
Type:
Grant
Filed:
March 17, 2023
Date of Patent:
April 16, 2024
Assignee:
Meso Scale Technologies, LLC.
Inventors:
Xinri Cong, Jerome Jackson, Carl Stevens, Michael Vock, Jacob N. Wohlstadter
Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
Type:
Grant
Filed:
February 7, 2019
Date of Patent:
March 26, 2024
Assignee:
Meso Scale Technologies, LLC.
Inventors:
Charles M. Clinton, Eli N. Glezer, Sharon West, George Sigal, Carl Stevens, Michael L. Vock
Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Type:
Application
Filed:
March 27, 2023
Publication date:
February 15, 2024
Applicant:
Meso Scale Technologies, LLC.
Inventors:
Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko
Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
Type:
Grant
Filed:
October 1, 2020
Date of Patent:
February 6, 2024
Assignee:
Meso Scale Technologies, LLC.
Inventors:
Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Sandor L. Kovacs, Sudeep M. Kumar, George Sigal, Carl Stevens, Michael Vock
Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Type:
Application
Filed:
October 4, 2023
Publication date:
January 25, 2024
Applicant:
Meso Scale Technologies, LLC.
Inventors:
Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin, Srikant Vaithilingam
Abstract: The application is directed to a device housing. The device housing includes a first light device, the first light device including a first electrical supply configured to provide an electrical signal to a first light emitting diode (LED), the first LED separated from a first surface of a diffuser film by a space, wherein the diffuser film includes a second surface, opposite the first surface, the second surface configured to contact a first light pipe.
Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay kits used in connection with the diagnostic methods described herein.
Abstract: In examples, a method of controlling customer access to an assay system comprises (a) receiving a system identifier; (b) identifying said system identifier; and (c) utilizing information obtained from the system identifier to perform one or more operations selected from: (i) enabling full access to said system and/or a consumable used in said system; (ii) enabling partial access to said system and/or a consumable used in said system; or (iii) denying access to said system and/or a consumable used in said system.
Type:
Application
Filed:
March 17, 2023
Publication date:
July 20, 2023
Applicant:
Meso Scale Technologies, LLC.
Inventors:
Xinri CONG, Jerome JACKSON, Carl STEVENS, Michael VOCK, Jacob N. WOHLSTADTER
Abstract: The present invention is directed to improved methods for conducting immunoassays. The methods are designed to amplify signals in immunoassays and anchor immunoassay complexes employed therein.
Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.
Type:
Grant
Filed:
February 25, 2021
Date of Patent:
April 18, 2023
Assignee:
Meso Scale Technologies, LLC.
Inventors:
Xinri Cong, Jerome Jackson, Carl Stevens, Michael Vock, Jacob N. Wohlstadter
Abstract: The application is directed to a device housing. The device housing includes a first light device, the first light device including a first electrical supply configured to provide an electrical signal to a first light emitting diode (LED), the first LED separated from a first surface of a diffuser film by a space, wherein the diffuser film includes a second surface, opposite the first surface, the second surface configured to contact a first light pipe.
Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient’s treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
Type:
Application
Filed:
April 14, 2022
Publication date:
February 9, 2023
Applicant:
Meso Scale Technologies, LLC.
Inventors:
Jeff D. Debad, Eli N. Glezer, Sudeep M. Kumar