Patents Assigned to Meso Scale Technologies
  • METHODS FOR CONDUCTING MULTIPLEXED ASSAYS
    Publication number: 20190291103
    Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
    Type: Application
    Filed: December 20, 2018
    Publication date: September 26, 2019
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Sudeep Kumar, Pankaj Oberoi, George Sigal, Michael Tsionsky
  • Packaging for multiplexed assays
    Patent number: 10413904
    Abstract: The invention relates to kits and components thereof used in the conduct of solid-phase binding assays.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: September 17, 2019
    Assignee: Meso Scale Technologies
    Inventors: Yihong Claire Lu, Pankaj Oberoi
  • Assay methods
    Patent number: 10408823
    Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: September 10, 2019
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, George Sigal, Martin Stengelin, David Routenberg
  • BIOMARKERS OF THERAPEUTIC RESPONSIVENESS
    Publication number: 20190265243
    Abstract: The present invention relates to methods of diagnosing breast cancer in a patient, as well as methods of monitoring the progression of breast cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: October 11, 2018
    Publication date: August 29, 2019
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Simone Barbero, Eli N. Glezer, Anu Mathew
  • METHODS AND APPARATUS FOR CONDUCTING MULTIPLE MEASUREMENTS ON A SAMPLE
    Publication number: 20190257823
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: May 2, 2019
    Publication date: August 22, 2019
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Assay apparatuses, methods and reagents
    Patent number: 10302649
    Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: May 28, 2019
    Assignee: Meso Scale Technologies, LLC
    Inventors: Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Sandor L. Kovacs, Sudeep M. Kumar, George Sigal, Carl Stevens, Michael Vock
  • Assay apparatuses, methods and reagants
    Patent number: 10281678
    Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
    Type: Grant
    Filed: January 3, 2014
    Date of Patent: May 7, 2019
    Assignee: Meso Scale Technologies, LLC
    Inventors: Ian Chamberlin, Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Manish Kochar, Sandor Kovacs, D. T. Le, Aaron Leimkuehler, George Sigal, Leo Tabakin, Jon Willoughby
  • Assay cartridge valve system
    Patent number: 10272436
    Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: April 30, 2019
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Kenneth Page, Sandor Kovacs, Sudeep Kumar, Kristian Roth
  • METHODS FOR CONDUCTING MULTIPLEXED ASSAYS
    Publication number: 20190083976
    Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
    Type: Application
    Filed: December 5, 2018
    Publication date: March 21, 2019
    Applicant: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, Sudeep Kumar, Pankaj Oberoi, George Sigal, Michael Tsionsky
  • Methods for conducting multiplexed assays
    Patent number: 10201812
    Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: February 12, 2019
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Sudeep Kumar, Pankaj Oberoi, George Sigal, Michael Tsionsky
  • Assay cartridges and method of using the same
    Patent number: 10184884
    Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: January 22, 2019
    Assignee: Meso Scale Technologies, LLC
    Inventors: Nicholas Anderson, Jeffery Debad, Eli N. Glezar, Sudeep Kumar, Noel Lawrence, Kenneth Page, George Sigal, Sharon West
  • System and method for flexibly representing and processing assay plates
    Patent number: 10184947
    Abstract: A flexible instrument control and data storage/management system and method for representing and processing assay plates having one or more predefined plate locations is disclosed. The system utilizes a graph data structure, layer objects and data objects. The layer objects map the graph data structure to the data objects. The graph data structure can comprise one node for each of the one or more predefined plate locations, wherein the nodes can be hierarchically defined according to a predefined plate location hierarchy. Each node can be given a unique node identifier, a node type and a node association that implements the predefined plate location hierarchy. The layer objects can include an index that maps the node identifiers to the data objects.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: January 22, 2019
    Assignee: Meso Scale Technologies, L.L.C.
    Inventors: Craig P. Lovell, Thomas Lucas Hampton, III
  • ASSAY METHODS
    Publication number: 20190011441
    Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.
    Type: Application
    Filed: September 20, 2018
    Publication date: January 10, 2019
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, John Kenten
  • MULTIPLEXED ASSAY KITS FOR EVALUATION OF SYSTEMIC LUPUS ERYTHEMATOSUS
    Publication number: 20180348217
    Abstract: The present invention relates to methods of diagnosing lupus in a patient, as well as methods of monitoring the progression of lupus and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: August 3, 2018
    Publication date: December 6, 2018
    Applicant: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, Mikayla Higgins, John Kenten, George Sigal
  • CONSUMABLE DATA MANAGEMENT
    Publication number: 20180341708
    Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Xinri Cong, Jerome Jackson, Carl Stevens, Michael Vock, Jacob N. Wohlstadter
  • ANTIBODY ARRAY FOR MEASURING A PANEL OF AMYLOIDS
    Publication number: 20180292419
    Abstract: Described are assay methods, modules and kits useful in the detection, treatment and/or prevention of dementia and related conditions, including but not limited to Alzheimer's disease and mild cognitive disorders.
    Type: Application
    Filed: June 20, 2018
    Publication date: October 11, 2018
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Robert M. Umek, Pankaj Oberoi
  • Consumable data management
    Patent number: 10068020
    Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: September 4, 2018
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Xinri Cong, Jerome Jackson, Carl Stevens, Michael Vock, Jacob N. Wohlstadter
  • BIODOSIMETRY PANELS AND METHODS
    Publication number: 20180246100
    Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
    Type: Application
    Filed: February 22, 2018
    Publication date: August 30, 2018
    Applicants: Meso Scale Technologies, LLC., THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventors: William F. Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
  • KITS SUITABLE FOR USE IN ELECTROCHEMILUMINESCENCE METHODS AND METHODS OF EFFECTING A SPECIFIC-BINDING NON-WASH ASSAY
    Publication number: 20180238882
    Abstract: The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.
    Type: Application
    Filed: February 1, 2018
    Publication date: August 23, 2018
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Michael Tsionsky, Eli N. Glezer, Selen Stromgren, George Sigal, Jonathan K. Leland, Mark A. Billadeau, Svetlana Leytner, Mark Martin, Larry Helms
  • Automated assay system
    Patent number: D829336
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: September 25, 2018
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Jacob N. Wohlstadter, Rodger Darin Osborne, Bandele Jeffrey-Coker, Aaron Leimkuehler, Manish Kochar, Kenneth Page