Patents Assigned to Meso Scale Technologies
  • MULTIPLEXED ASSAY KITS FOR EVALUATION OF SYSTEMIC LUPUS ERYTHEMATOSUS
    Publication number: 20200378966
    Abstract: The present invention relates to methods of diagnosing lupus in a patient, as well as methods of monitoring the progression of lupus and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: March 31, 2020
    Publication date: December 3, 2020
    Applicant: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, Mikayla Higgins, John Kenten, George Sigal
  • ASSAY CARTRIDGES AND METHODS OF USING THE SAME
    Publication number: 20200355616
    Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 12, 2020
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
  • METHODS FOR EVALUATION OF THE EFFECTIVENESS OF A DRUG OR DRUG CANDIDATE IN TREATING AN INFLAMMATORY BOWEL DISEASE BY USE OF A MULTIPLEXED ASSAY KIT COMPRISING VARIOUS BIOMARKERS
    Publication number: 20200309790
    Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
    Type: Application
    Filed: June 15, 2020
    Publication date: October 1, 2020
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Jeff D. Debad, Eli N. Glezer, Sudeep M. Kumar
  • ANTIBODY ARRAY FOR MEASURING A PANEL OF AMYLOIDS
    Publication number: 20200309793
    Abstract: Described are assay methods, modules and kits useful in the detection, treatment and/or prevention of dementia and related conditions, including but not limited to Alzheimer's disease and mild cognitive disorders.
    Type: Application
    Filed: April 28, 2020
    Publication date: October 1, 2020
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Robert M. Umek, Pankaj Oberoi
  • Assay plates, reader systems and methods for luminescence test measurements
    Patent number: 10782227
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: September 22, 2020
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
  • Kits suitable for use in electrochemiluminescence methods and methods of effecting a specific-binding non-wash assay
    Patent number: 10753934
    Abstract: The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: August 25, 2020
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Michael Tsionsky, Eli N. Glezer, Selen Stromgren, George Sigal, Jonathan K. Leland, Mark A. Billadeau, Svetlana Leytner, Mark Martin, Larry Helms
  • ASSAY PLATES, READER SYSTEMS AND METHODS FOR LUMINESCENCE TEST MEASUREMENTS
    Publication number: 20200240903
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: April 10, 2020
    Publication date: July 30, 2020
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
  • REAGENT STORAGE IN AN ASSAY DEVICE
    Publication number: 20200209234
    Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.
    Type: Application
    Filed: March 11, 2020
    Publication date: July 2, 2020
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Sudeep Kumar, George Sigal, Michael Tsionsky
  • METHODS FOR CONDUCTING ASSAYS
    Publication number: 20200191779
    Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
    Type: Application
    Filed: February 6, 2020
    Publication date: June 18, 2020
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, George Sigal, Michael Tsionsky
  • LUNG CANCER BIOMARKERS
    Publication number: 20200158731
    Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: January 21, 2020
    Publication date: May 21, 2020
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin
  • DIAGNOSTIC METHODS FOR INFLAMMATORY DISORDERS
    Publication number: 20200141950
    Abstract: The present invention relates to methods of diagnosing an inflammatory disorder in a patient, as well as methods of monitoring the progression of an inflammatory disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: January 7, 2020
    Publication date: May 7, 2020
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Jeffrey Debad, Eli N. Glezer, Sudeep Kumar
  • Reagent storage in an assay device
    Patent number: 10627399
    Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: April 21, 2020
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Sudeep Kumar, George Sigal, Michael Tsionsky
  • DIAGNOSTIC METHODS FOR LIVER DISORDERS
    Publication number: 20200057070
    Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: October 15, 2019
    Publication date: February 20, 2020
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Anu Mathew, Martin Stengelin, Mingyue Wang
  • ASSAY INFORMATION MANAGEMENT METHODS AND DEVICES
    Publication number: 20200035333
    Abstract: The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.
    Type: Application
    Filed: October 7, 2019
    Publication date: January 30, 2020
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Charles M. Clinton, Xinri Cong, Eli N. Glezer, Sudeep Kumar, Carl Stevens, Michael Vock, Jon S. Willoughby
  • Assay plates, reader systems and methods for luminescence test measurements
    Patent number: 10539501
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: January 21, 2020
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
  • Integrated Consumable Data Management System & Platform
    Publication number: 20190391170
    Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.
    Type: Application
    Filed: January 20, 2017
    Publication date: December 26, 2019
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Manish KOCHAR, Peter J. BOSCO, Ian D. CHAMBERLIN, Bandele JEFFREY-COKER, Eric M. JONES, Gary l. KRIVOY, Aaron H. LEIMKUEHLER, Pei-Ming WU, Kim-Xuan NGUYEN, Pankaj OBEROI, Louis W. PANG, Jennifer PARKER, Victor PELLICIER, Nick SAMMONS, George SIGAL, Jacob WOHLSTADTER, Mike VOCK, Stanley T. SMITH, Carl C. STEVENS, Roger D. OSBORNE, Kenneth PAGE, Michael T. WADE, Jon WILLOUGHBY, Lei WANG, Don E. KRUEGER
  • Biodosimetry panels and methods
    Patent number: 10436784
    Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: October 8, 2019
    Assignees: Meso Scale Technologies, LLC, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: William F Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
  • Automated assay system
    Patent number: D879994
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: March 31, 2020
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Aaron Leimkuehler, Rodger Darin Osborne, Jacob N. Wohlstadter, Kenneth Page, Manish Kochar, Gary Krivoy
  • Cart
    Patent number: D880096
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: March 31, 2020
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Jacob N. Wohlstadter, Rodger Darin Osborne, Jennifer Parker, Aaron Leimkuehler, Manish Kochar, Peter Bosco, Michael Wade
  • Reagent rack
    Patent number: D882818
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: April 28, 2020
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Aaron Leimkuehler, Manish Kochar, Jennifer Parker, Nick Sammons, Bandele Jeffrey-Coker