Patents Assigned to Meso Scale Technologies
  • ASSAY CARTRIDGES AND METHODS OF USING THE SAME
    Publication number: 20180172595
    Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
    Type: Application
    Filed: February 16, 2018
    Publication date: June 21, 2018
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
  • KIDNEY FUNCTION BIOMARKERS
    Publication number: 20180156824
    Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: December 19, 2017
    Publication date: June 7, 2018
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko
  • BIOMARKERS OF THERAPEUTIC RESPONSIVENESS
    Publication number: 20180088108
    Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: November 15, 2017
    Publication date: March 29, 2018
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Anu Mathew
  • Assay cartridges and methods of using the same
    Patent number: 9921166
    Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: March 20, 2018
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
  • ASSAY PANELS
    Publication number: 20180045720
    Abstract: Described herein are kits and components thereof used for a multiplexed analysis of a set of cytokines.
    Type: Application
    Filed: May 22, 2017
    Publication date: February 15, 2018
    Applicant: Meso Scale Technologies, LLC.
    Inventors: John Joern, Joseph Manimala, Keith McClary, Pankaj Oberoi, Gisbert Spieles, David Stewart, James Wilbur
  • Kits suitable for use in electrochemiluminescence methods and methods of effecting a specific-binding non-wash assay
    Patent number: 9891221
    Abstract: The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: February 13, 2018
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Michael Tsionsky, Eli N. Glezer, Selen Stromgren, George Sigal, Jonathan K. Leland, Mark A. Billadeau, Svetlana Leytner, Mark Martin, Larry Helms
  • MULTIPLEXED ASSAY KIT TO EVALUATE THE EFFICACY OF TREATMENT FOR INFLAMMATORY BOWEL DISEASE
    Publication number: 20180017578
    Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 18, 2018
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Jeff D. Debad, Eli N. Glezer, Sudeep M. Kumar
  • ASSAY PLATES, READER SYSTEMS AND METHODS FOR LUMINESCENCE TEST MEASUREMENTS
    Publication number: 20170370827
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: May 5, 2017
    Publication date: December 28, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
  • CO-BINDER ASSISTED ASSAY METHODS
    Publication number: 20170362668
    Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.
    Type: Application
    Filed: September 6, 2017
    Publication date: December 21, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, George Sigal
  • ASSAY CARTRIDGES AND METHODS OF USING THE SAME
    Publication number: 20170312751
    Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
    Type: Application
    Filed: July 11, 2017
    Publication date: November 2, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Stephen Higgins, Sandor Kovacs, Sudeep Kumar, Kenneth Page, Kristian Roth, George Sigal
  • Reagent storage in an assay device
    Patent number: 9797894
    Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: October 24, 2017
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Sudeep Kumar, George Sigal, Michael Tsionsky
  • BIOMARKERS OF THERAPEUTIC RESPONSIVENESS
    Publication number: 20170242012
    Abstract: The present invention relates to methods of diagnosing breast cancer in a patient, as well as methods of monitoring the progression of breast cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: April 17, 2017
    Publication date: August 24, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Simone Barbero, Eli N. Glezer, Anu Mathew
  • CONSUMABLE DATA MANAGEMENT
    Publication number: 20170235832
    Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.
    Type: Application
    Filed: May 1, 2017
    Publication date: August 17, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Xinri Cong, Jerome Jackson, Carl Stevens, Michael Vock, Jacob N. Wohlstadter
  • METHOD OF DIAGNOSING, PREVENTING AND/OR TREATING DEMENTIA & RELATED DISORDERS
    Publication number: 20170234892
    Abstract: Described are assay methods, modules and kits useful in the detection, treatment and/or prevention of dementia and related conditions, including but not limited to Alzheimer's disease and mild cognitive disorders.
    Type: Application
    Filed: April 28, 2017
    Publication date: August 17, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Robert M. Umek, Pankaj Oberoi
  • BIOMARKERS OF THERAPEUTIC RESPONSIVENESS
    Publication number: 20170205418
    Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: December 21, 2016
    Publication date: July 20, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Simone Barbero, Eli N. Glezer, Anu Mathew, Mingyue Wang
  • ASSAY METHODS
    Publication number: 20170168047
    Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 15, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, George Sigal, Martin Stengelin
  • LUNG CANCER BIOMARKERS
    Publication number: 20170160281
    Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 8, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin
  • DIAGNOSTIC METHODS FOR LIVER DISORDERS
    Publication number: 20170038388
    Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: October 19, 2016
    Publication date: February 9, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Anu Mathew, Martin Stengelin, Mingyue Wang
  • Display screen with graphical user interface
    Patent number: D807902
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: January 16, 2018
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Xinri Cong, Thomas L. Hampton, Carl Stevens, Michael Vock, Edmund Wong
  • Cart
    Patent number: D812836
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: March 13, 2018
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Jacob N. Wohlstadter, Rodger Darin Osborne, Jennifer Parker, Aaron Leimkuehler, Manish Kochar, Peter Bosco, Michael Wade