Patents Assigned to Meso Scale Technologies
  • ASSAY CARTRIDGES AND METHODS OF USING THE SAME
    Publication number: 20160356722
    Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
    Type: Application
    Filed: July 28, 2016
    Publication date: December 8, 2016
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeffery D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
  • REAGENT STORAGE IN AN ASSAY DEVICE
    Publication number: 20160349253
    Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.
    Type: Application
    Filed: July 11, 2016
    Publication date: December 1, 2016
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Sudeep Kumar, George Sigal, Michael Tsionsky
  • CONSUMABLE DATA MANAGEMENT
    Publication number: 20160283594
    Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.
    Type: Application
    Filed: June 10, 2016
    Publication date: September 29, 2016
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Xinri Cong, Jerome Jackson, Carl Stevens, Michael Vock, Jacob N. Wohlstadter
  • METHODS AND APPARATUS FOR CONDUCTING MULTIPLE MEASUREMENTS ON A SAMPLE
    Publication number: 20160245799
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: May 4, 2016
    Publication date: August 25, 2016
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Assay cartridges and methods of using the same
    Patent number: 9404881
    Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: August 2, 2016
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeffery D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
  • BIODOSIMETRY PANELS AND METHODS
    Publication number: 20160003822
    Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
    Type: Application
    Filed: September 15, 2015
    Publication date: January 7, 2016
    Applicants: Meso Scale Technologies, LLC, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: William F. Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
  • Assay plates, reader systems and methods for luminescence test measurements
    Patent number: 9034263
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: May 19, 2015
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
  • LUNG CANCER BIOMARKERS
    Publication number: 20150038365
    Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: July 31, 2014
    Publication date: February 5, 2015
    Applicant: Meso Scale Technologies, LLC
    Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin, Srikant Vaithilingam
  • KIDNEY FUNCTION BIOMARKERS
    Publication number: 20150025004
    Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: February 26, 2014
    Publication date: January 22, 2015
    Applicant: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko
  • DIAGNOSTIC TEST
    Publication number: 20140378347
    Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Applicant: Meso Scale Technologies, LLC
    Inventors: Jeff D. Debad, Eli N. Glezer, Sudeep M. Kumar
  • Assay cartridges and methods of using the same
    Patent number: 8852922
    Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: October 7, 2014
    Assignee: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
  • Modular assay plates, reader systems and methods for test measurements
    Patent number: 8845963
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: September 30, 2014
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Kent Johnson, Bandele Jeffrey-Coker, Alan Kishbaugh, Charles M. Clinton
  • SEROLOGY ASSAYS
    Publication number: 20140255916
    Abstract: The invention provides methods and kits for measuring the ability of a test sample to inhibit the binding of a receptor expressed by a pathogen to a host cell ligand of the pathogen.
    Type: Application
    Filed: May 22, 2014
    Publication date: September 11, 2014
    Applicant: Meso Scale Technologies, LLC.
    Inventor: George Sigal
  • Assay electrode having immobilized lipid/protein layers, methods of making the same and methods of using the same for luminescence test measurements
    Patent number: 8815577
    Abstract: Improved systems, system components, and methods for performing assays involving biological membranes and/or components thereof. Preferred luminescence test measurements are conducted using an assay module with integrated electrodes having biological membranes and/or components thereof immobilized thereon with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: August 26, 2014
    Assignee: Meso Scale Technologies, LLC
    Inventors: Robert M. Umek, Paula Denney Eason, Gargi Maheshwari, Anu Mathew, Douglas Woods
  • Assay plates, reader systems and methods for luminescence test measurements
    Patent number: 8808627
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: August 19, 2014
    Assignee: Meso Scale Technologies, LLC
    Inventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
  • GLOMERULONEPHRITIS BIOMARKERS
    Publication number: 20140221325
    Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: January 30, 2014
    Publication date: August 7, 2014
    Applicant: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, John Kenten, Galina Nikolenko
  • Display panel or screen with a graphical user interface
    Patent number: D713852
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: September 23, 2014
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Michael L. Vock, Kent Johhnson
  • Instrument
    Patent number: D721184
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: January 13, 2015
    Assignee: Meso Scale Technologies, LLC
    Inventors: Ian Chamberlin, Charles M. Clinton, Eli N. Glezer, Manish Kochar, Sandor Kovacs, Aaron Leimkuehler, Rodger Darin Osborne, Jacob N. Wohlstadter
  • Touchscreen instrument
    Patent number: D725285
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: March 24, 2015
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Jacob N. Wohlstadter, Sandor Kovacs, Rodger Darin Osborne
  • Display screen with graphical user interface
    Patent number: D748115
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: January 26, 2016
    Assignee: Meso Scale Technologies, LLC
    Inventors: Xinri Cong, Thomas L. Hampton, Carl Stevens, Michael Vock, Edmund Wong