Abstract: The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE.

Abstract: The invention pertains to a apparatus for performing operations, in particular cutting, embossing, creasing, folding and/or sealing, on a moving web provided with a series of identical images, which apparatus comprises a sensor for at least partially detecting the images on the web, and a processing unit which, dependent on a comparison of the data obtained with the sensor and a reference, generates an output signal to be used for one or more of the said operations. The processing unit comprises a memory and is arranged to select at least part of the detected data, store the selected data in the memory, and utilize the selected data as the reference. The invention further pertains to module for performing operations on a moving web and method of generating an output signal.

Abstract: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

Abstract: An apparatus measures properties of an object such as a heart in a patient (2). The apparatus includes an antenna (3, 4) for sending and/or receiving electromagnetic waves to and/or from the object (2) for measuring a property of the object. The antenna (3, 4) includes an electrically conductive element for functioning as an electrode for measuring a further property of the object. The electromagnetic waves are reflected by the object, causing a Doppler shift. The apparatus uses this shift to provide mechanical information about the object and uses the electrode to provide electrical information about the object, such as an electrocardiogram.

Abstract: The present invention relates to the typing of HLA alleles. The sequence of exon 2 and exon 3 of the alleles HLA-B*3913, HLA-B*1406 and HLA-B*51new and of exon 2 of the alleles HLA-DRB1*0820, HLA-DRB1*04new and HLA-DRB4*01new are disclosed. The present invention relates to methods for typing of the alleles HLA-B*3913, HLA-B*1406 and HLA-B*51new. The present invention further provides primers and probes to be used in the methods for typing. A diagnostic kit comprising these primers and probes is also part of the present invention.

Abstract: Methods and systems of the invention provide a variety of techniques for processing microtransactions. In accordance with the invention, the method starts with a customer initiating a purchase through interaction with a merchant. The purchase is associated with purchase information, which includes the particulars of the purchase, such as the purchase price. In the purchase, the customer uses a transaction account, obtained from a payment enabler. The purchase is classified as a microtransaction, if the purchase price is below a predetermined monetary amount. Thereafter, the purchase information is forwarded for processing based on the classifying, i.e., either as a regular transaction or as a microtransaction. Then, upon receipt of the purchase information by an appropriate recipient, such as an interchange entity or an alternate interchange entity, the purchase information is processed to effect the microtransaction, if so classified, between the customer and the merchant.

Abstract: The invention relates to an illumination system (100), a projection device, and a color wheel (20, 22, 24). The illumination system comprises a light source comprising a first light-emitting unit (50) and a second light-emitting unit each emitting light towards a light output window (110). The illumination system comprises the color wheel including a spoke (40) between two adjacent color segments. The system is configured to prevent the spoke when transiting the optical path (80) between the light source and the light output window to simultaneously transit a first optical path between the first light-emitting unit and the light output window and a second optical path between the second light-emitting unit and the light output window. The illumination system further comprises a drive unit (92) which is configured for switching off the first light-emitting unit during a time interval (p1) when the spoke transits the first optical path.

Abstract: A measuring device is provided having a protective cover and a sensor arranged in the protective cover. The protective cover has a carrier tube made of metal and closed on one end. A first coating made of an aluminum non-wettable material is arranged on an outer surface of the carrier tube, and a further coating made of aluminum-wettable material is applied on the first coating.

Abstract: The present invention is directed to a method of efficiently maintaining or increasing brightness and whiteness of refined paper. In one aspect, the invention is directed to a method for substantially maintaining (or even increasing) brightness and/or whiteness of paper with increased pulp refining, the method including refining the pulp down to reduce the freeness at least about 100 CSF and adding a combination of an OBA and a carrier polymer to the paper surface in the size press in amounts sufficient to increase brightness and/or whiteness of the final paper. In another aspect, the invention is directed to a method of making paper from refined pulp that includes refining a cellulosic fiber suspension to reduce the freeness at least about 100 CSF and contacting the cellulosic fibers with at least one optical brightening agent (OBA) during or after the refining step prior to adding any additional wet end chemicals.

Abstract: A system and method for funding a collective account such as a charitable account includes issuing a plurality of financial instruments, linking the financial instruments to the collective account, aggregating individual financial instrument usage, calculating a bonus or other reward based on the aggregate financial instrument usage and funding or distributing the reward to the collective account. According to the invention, members of a civic, charitable, political or other entity may generate collective rewards or other benefits which may be attributed to the designated organization.

Abstract: A lighting device (1) comprises a plurality of LEDs (11-14) producing light (21-24) of mutually different colors. The LEDs are driven in switching cycles (63) with a duty cycle controlled supply current of constant magnitude. In each switching cycle, each LED is first switched ON (61) and then switched OFF (62). In a measuring mode, during one switching cycle (63B), all ON phases of all LEDs are briefly interrupted, except for one LED (11), so that a light sensor (70) measures the light from this one LED. This measurement can be used to adapt the duty cycle of this one LED. In the next switching cycle (63C), the interruption of the ON phases is compensated by extending the ON phases of all LEDs except said one LED, the extension having a duration equal to the duration (?D) of the interruption.

Abstract: A radio communication system comprises a secondary station (110) having a plurality of communication channels (226a,226b,226c) with a plurality of primary stations (100a,100b,100c). Separate closed loop power control is performed for each of the communication channels (226a,226b, 226c). This enables the optimum primary station for transmission of data to the secondary station (110) to be selected. Parameters derived from operation of each power control loop enable optimum setting of channel parameters for each primary station (100a,100b,100c). Such an arrangement is particularly suitable for a high speed downlink data service, where the fast selection of the optimum primary station and/or channel parameters improves link robustness and system throughput.

Abstract: An autostereoscopic display 101, which provides a depth perception by providing a viewer's left and right eyes (104a, 104b) with two slightly different perspectives of an image to be displayed, is provided for ultrasound guided interventions with a surgical instrument (103). The surgeon watches displayed ultrasound data (102), rendered for at least two views. The plane at which those views (L, R) intersect is adjusted to correspond exactly with the tracked three-dimensional position within a displayed scene of the surgical instrument (103), which position can be extracted from the three-dimensional ultrasound data by means of, for example, 3D object recognition. Thus, the point of reconstruction of the image presented to the viewer can be dynamically adjusted to correspond with the position of the surgical instrument on which the surgeon's eyes are presumed to be focused.

Abstract: A micro fluidic device includes a valve/pump-unit with reduced dead volume having a substrate. The lower surface of the substrate includes two micro channels spaced apart by a valve area of the substrate that separates the two micro channels. A flexible membrane is arranged on the lower surface of the substrate facing an actuating element located in a through going cut-out of a cover element. Movement of the actuating element towards and away from the valve area of the substrate causes a pump and/or valve action of the flexible membrane area, respectively, to cause or stop a directed fluid flow between the two micro channels through a channel formed between the valve area of the substrate and the flexible membrane.

Abstract: The present invention concerns apparatus for efficiently dispensing and applying a wristband identification bracelet that is meant for attachment around an extremity of an animal or person. The apparatus is provided with a supply of identity bands that are adapted to become a bracelet by having a first portion of the band affixed to a second portion to form a continuous loop around the extremity. The extremity is positioned within a receptacle in the apparatus, permitting the identification band to be wrapped closely around the extremity by the band fixing mechanism of the apparatus. The identification band is fixed to itself to form a bracelet, so as to prevent its removal from the extremity without damaging the integrity of the bracelet.

Abstract: An efficient approach for cascading out-of-box services is disclosed. The inventive system has a packet router, with out-of-box interfaces, and out-of-box servers, the latter being connected to the interfaces and implementing the out-of-box services. The interfaces and the serves are configured in a virtual local area network (VLAN), as identified by a VLAN identifier (ID), which performs a specific number of the services and in a specific order on a stream of packets. The packet router, in a single action, routes packets with the VLAN ID to a particular VLAN in order to subject those packets to the number and order of services then associated with that VLAN ID.

Abstract: A therapeutic system includes a therapy module to direct a therapeutic action, e.g. focused ultrasound or RF energy to a target. An imaging module, such as a magnetic resonance examination system, generates image information of a therapy region that includes the target. By way of a motion analysis module, a motion vector field is derived from the image information of the therapy region. A control module controls the therapy module based on the motion vector field. For example, based on t the motion vector field, an accurate temperature distribution is derived from magnetic resonance signals and the motion vector field. Also magnetic resonance elastography data may be employed to improve the accuracy of the temperature distribution.

Abstract: A system and method transcodes an input video bit stream having a first encoding profile into an output video bit stream having a second encoding profile. The system includes a first module and a second module. The system further includes a memory module. The first module decodes the input video bit stream for generating pixel data and macroblock specifications. The second module encodes the pixel data and the macroblock specifications for constructing the output video bit stream. The memory module includes a first buffer module and a second buffer module. The first buffer module stores the pixel data and the second buffer module stores the macroblock specifications.

Abstract: A method for dynamically visualizing coronary information and an apparatus adapted to implement such method is described. In a preferred embodiment of the method, first dynamic cardiac data is acquired during a first cardiac stage and second dynamic cardiac data is acquired during a second cardiac stage. Then, the two data sets are visualized continuously the in a superimposed presentation, wherein the first cardiac data and the second cardiac data corresponding to a same phase within the cardiac cycle are visualized simultaneously. In this way for example information about the vessel geometry may be immediately linked with information about the muscle irrigation or perfusion. Furthermore, this useful information may be displayed in a high-contrasted and low-noise presentation.

Abstract: A system and method for pre-operatively obtaining a prediction of a post-operative image of at least part of a body is disclosed. A 3D pre-operative description is determined of at least part of a body, and a pre-operative 2D photograph is acquired of the at least part of the body from any viewing position. The 3D pre-operative description is matched with the pre-operative 2D photograph, and a deformation field is determined for deforming the 3D pre-operative description. A predicted post-operative image of a 3D post-operative description of the at least part of the body is derived by means of the deformation field and the pre-operative 2D photograph.