Abstract: The invention relates in one aspect to bispecific antibodies comprising a first antigen-binding site that binds EGFR and a second antigen-binding site that binds Erb B-3, wherein the antibody has a half maximal growth inhibitory concentration (IC50) of less than 200 pM for inhibiting EGFR and/or Erb B-3 ligand induced growth of Bx PC3 cells or Bx PC3-luc2 cells. Further described are method for producing the bispecific antibodies and means and methods for the treatment of subjects with the antibodies.

Abstract: A method performed by a processor of a financial institution computing system includes allowing an account holder at the financial institution to initiate a transaction with the financial institution remotely (e.g., via smartphone app, online banking portal, etc.), by submitting a request for a branch of the financial institution to provide the specified transaction to the account holder's vehicle upon arrival of the account holder. The pickup and completion of the account holder requested transaction occurs in a designated spot near the financial institution's branch location and from the convenience of the account holder's vehicle. The curbside service alleviates the uncertainty and fluctuating time cost to engage in transactions at a branch of a financial institution by providing an account holder with a user interface to make a transaction request that will be ready to complete when the account holder arrives at the chosen time.

Abstract: The invention relates to a position determining apparatus (6) for determining the position of an interventional instrument (1) within a subject (4). A spatial relation between positions of a second part (3) of the interventional instrument outside the subject and a first part (2) of the interventional instrument within the subject is determined based on an actual image of the interventional instrument within the subject being preferentially an x-ray image and a provided position of the second part. Once the spatial relation has been determined, the position of the interventional instrument within the subject can be determined, while the interventional instrument is moved within the subject, based on the determined spatial relation and a determined actual position of the second part outside the subject, without necessarily acquiring a further actual image. This can allow for a reduction of a radiation dose, if rays are used for acquiring the actual image.

Abstract: A rotary control valve and a sieve bed module assembly for use in pressure swing adsorption processes to make enriched oxygen product gas is disclosed. The valve includes a stepping motor with a single shaft extending between ends. At ends of the valve, an air side valve function and oxygen side valve function are provided. Each end includes a stationary plate (stator) with ports, and a disc (rotor) that rotates with the shaft, opening and closing ports to achieve the desired valve function. The valve is integrated into the assembly between two sieve beds and a product storage tank is directly coupled to the oxygen side. Placement of the motor, shaft, and movable parts in the valve and mounting of the beds, valve, and tank in the assembly, result in more compact designs. The motor can be programmed to obtain multiple, different PSA processes and flexibility.

Abstract: The present application relates to a system (10, 60) for treating a part of a body of a person to be treated. The system includes a treating device (20, 70) having a treating unit (22, 72) and a reference member (40, 80) adapted to be mountable to a person in fixed relationship to a part of the body. The treating device (20, 70) has a first motion identifier (28) configured to generate information indicative of the acceleration and/or angular orientation of the treating device (20, 70). The reference member (40, 80) has a second motion identifier (48) configured to generate information indicative of the acceleration and/or angular orientation of the reference member (40, 80). A controller (27, 47) is adapted to produce information indicative of the trajectory and/or orientation of the treating unit (22, 72) relative to the part of the body to be treated based on the information provided by the first and second motion identifiers (28, 48).

Abstract: A computer-implemented system and method includes determining the locations of a user of a mobile device and a merchant, comparing the locations to ensure a match, receiving from the user's mobile device an identification number associated with the user's stored value card, receiving an identifier generated by a financial institution, the identifier being embedded in a code displayable on the mobile device, and transmitting an indication that the transaction has been completed, the transaction being completed based on the identifier and based on the match. The method may further include determining and informing the user that a stored value card may be used at the merchant located within a first predetermined distance. A non-optical code, such as a radio frequency (RF) input, may be generated and provided to the merchant via the mobile device to identify the stored value card.

Abstract: The present invention includes systems and methods directed towards a wearable device (100, 200) that can measure health parameters in two levels. The wearable device can measure a health parameter of a user using an attached sensor (112). This sensor measurement is checked against a threshold database (126, 146, 156) that details an action to be taken if the sensor measurement satisfies a health threshold. The health can be predetermined by the user or by a professional. This action can be a request to the user of the wearable device to move the wearable device to another part of his/her body so that the wearable device can gather a second sensor measurement that can provide more detail or context for the first sensor measurement. The wearable device can thus provide two levels of sensor data measurement, which it can store and synchronize to storage on a network/cloud service (104) or to another electronic device (102).

Abstract: Some embodiments are directed to a computation device configured to verify that an edit script is for transforming a first string to a second string. The edit script has match operations and difference operations as allowed edit operations. The computation device obtains a representation of the edit script and subsequently performs a validation computation. For each match operation, the computation device determines a character at a current position in the first string and a character at a current position in the second string, verifies that they match, increments the current position in the first string by one and increments the current position in the second string by one. For each difference operation, the computation device increments the current position in the first string and/or the current position in the second string by one.

Abstract: The invention provides methods of video processing in an efficient and/or low latency fashion and suitable for use in a streaming environment. Therefore the present invention relates to a system for video processing, a video image processor or a method of generating an output image by performing processing on an input image, wherein the processing is characterized in that it achieves the effect of a plurality of first unit image process steps, the method comprising the steps of performing sequentially one or a plurality of second image process filtering steps on said input image to generate said output image, wherein at least one of said second image process filtering steps achieves the effect of at least two, three, four, or five of said first image process steps.

Abstract: The present application relates to a cold plasma device (13) for treating a surface (6) with cold plasma. The device (13) has a cold plasma generator (14) adapted to generate cold plasma that produces reactive species for treating the surface (6). The device (13) also includes a treatment head (5) that is positionable relative to the surface (6) such that the reactive species are imparted toward the surface (6) during treatment. The device (13) is also provided with an air flow generator (8) to generate an air flow over the surface (6) and a controller (9) configured to control operation of the air flow generator (8) to generate an air flow over the surface (6) after the treatment has been completed such that remaining by-products of the cold plasma are dissipated.

Abstract: A computer-implemented method includes receiving, from a mobile device, a deposit request including a first check image for funds to be deposited into a user account, determining a risk level associated with the deposit request, requesting a second check image having a restricted endorsement based on the risk level, receiving the second check image having the restricted endorsement, determining a confidence level based on the restricted endorsement, and transferring the funds to the user account based on the confidence level.

Abstract: A system, method and computer readable storage medium for selecting a medical provider from a plurality of available medical providers. The selection being made by receiving medical data and one of geographical and financial data corresponding to a patient, comparing the medical data and the one of the geographical and financial data corresponding to the patient to corresponding data of a plurality of medical provider databases to determine a relationship therebetween and generating, via a recommendation generator, a recommendation of a first medical provider for the patient based on the medical data and the one of geographical and financial data and the comparison to the corresponding data of the medical provider databases.

Abstract: A method for responding to a content retrieval request at a server may include receiving the content retrieval request from a computing device; detecting, at a device aware controller, at least one device capability of the computing device; setting, at the device aware controller, a rule boundary for the content retrieval request based on the at least one device capability; forwarding the content retrieval request with the rule boundary to a device agnostic controller, wherein the content retrieval request does not include capability information associated with the computing device; receiving from the device agnostic controller at the device aware controller, data corresponding to the content retrieval request with the rule boundary applied; and providing the data with the rule boundary applied to the computing device for presentation on the computing device.

Abstract: A method, system, and apparatus for managing digital certificates, managing a certificate authority (CA), and cross-referencing CA heirarchies. The method includes receiving, by a processor of a CA computing system, at least one of a digital certificate generation request and a digital certificate revocation from a user via a user computing device, the digital certificate generation request including a user public key and a user identity. The method further includes generating a digital certificate for the user and signing the digital certificate with a CA private key, wherein the CA private key is associated with a known CA public key. The method further includes publishing the digital certificate signed with the CA private key to a digital certificate blockchain, determining a certificate status of the digital certificate, and publishing an update to the digital certificate blockchain to reflect the certificate status of the digital certificate.

Abstract: A determination apparatus determines the pose and shape of an introduction element like a catheter within a living being, wherein the introduction element is adapted to be used by a brachytherapy apparatus for introducing a radiation source close to a target object to be treated. A position determination element like a guidewire with an electromagnetic tracking element is introduced into the introduction element such that it is arranged at different locations within the introduction element, wherein the positions of the position determination element within the introduction element are determined. The determined positions are then acquired depending on the determined positions for determining the pose and shape of the introduction element within the living being. This can lead to a determination procedure with reduced user interaction, thereby simplifying the determination procedure for the user.

Abstract: A roasting device and method of roasting partially roasted coffee beans includes acts of obtaining a roast level of the partially roasted coffee beans; determining a roasting profile for roasting based on at least the roast level of the partially roasted coffee beans prior to roasting; and roasting the partially roasted coffee beans according to the determined roasting profile.

Abstract: One or more embodiments are directed to inter-integrated circuit (I2C) transmitters, receivers, and devices that utilize a stable reference voltage for driving a pre-driver of the transmitter and for driving a first input stage of the receiver. One embodiment is directed to a device A device that includes an inter-integrated circuit (I2C) transmitter and an I2C receiver. The I2C transmitter includes a driver coupled to an I2C data line, and a pre-driver coupled to a variable first supply voltage, a second supply voltage, and a reference voltage. The pre-driver is configured to output a control signal to a control terminal of the driver. The I2C receiver includes a first stage coupled to the I2C data line, the variable first supply voltage, the second supply voltage, and the reference voltage.

Abstract: Apparatus and method comprising an ultrasound transmitter, for placement at a first location on the body of a subject, to emit an ultrasound pulse; an ultrasound receiver, for placement at a second location on the body, to detect an emitted ultrasound pulse; and a controller in communication with the transmitter and receiver. The controller causes an ultrasound pulse to be emitted by the transmitter; receives a measurement signal from the receiver; determines, based on the received measurement signal, a time of arrival at the receiver, T1 s of a first part of the emitted ultrasound pulse; determines, based on the received measurement signal, a time of arrival at the receiver, T2, of a second part of the ultrasound pulse; and calculates, using T1 and T2, a flow velocity of blood in a blood vessel between the first location and the second location.

Abstract: The present application relates to steam iron (10) comprising a soleplate (12), a discharge element (14), a retaining member (16) and a collection compartment (17). The soleplate (12) comprises a steam chamber (13) for generating steam. The steam chamber (13) comprising an opening (13A) arranged at a rear end (R) of the soleplate (12). The discharge element (14) extends from the opening (13A). The collection compartment (17) is formed in the discharge element (14) for collecting calcified deposits (S) formed in the steam chamber (13). The retaining member (16) is arranged in the discharge element (14). T retaining member (16) extends over a front end portion (P1) of the collection compartment (17) to retain the calcified deposits (S) in the collection comportment (17). This invention prevents the calcified deposits from escaping from the collection compartment when the steam iron is tilted.