Patents Assigned to Nipro Corporation
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Patent number: 11974967Abstract: In a vacuum heat insulating double walled container 1, adsorbent blocks 30 are formed in block, and each of the adsorbent blocks 30 disposed on the peripheral surface of a sample storage container 25 is placed on a partition plate 27. Moreover, an inner container 10 is hang in an outer container 3 using a connecting tube 20 formed of a thin material having an uneven outer peripheral surface, and a heat insulating tube 40 is disposed on the inner surface of the connecting tube 20. Further, as to a workpiece carrier 50 as a fixing device, a carrier guide 52 is in close contact with the heat insulating tube 40, and a plate-like portion 54 and a workpiece storage portion 51 are disposed in a non-contact state with respect to the sample storage container 25.Type: GrantFiled: December 27, 2019Date of Patent: May 7, 2024Assignees: MDAP Co., Ltd., NIPRO CorporationInventors: Kazuhiko Niikura, Shinji Hayakawa, Masahito Naito, Saori Horiuchi, Takanori Sambuichi, Ryuuya Yamada
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Publication number: 20240122988Abstract: The present invention relates to a synapse formation promoter and a brain plasticity promoter comprising CD24-negative mesenchymal stem cells prepared from a patient's own bone marrow aspirate and treatment of dementia, chronic-phase cerebral infarction, chronic-phase spinal cord injury, mental diseases, and the like using the synapse formation promoter and brain plasticity promoter.Type: ApplicationFiled: April 26, 2023Publication date: April 18, 2024Applicants: Sapporo Medical University, Nipro CorporationInventors: Osamu Honmou, Masanori Sasaki, Rie Maezawa, Shinichi Oka, Yuko Sasaki, Masahito Nakazaki, Toshihiko Yamashita
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Patent number: 11938230Abstract: A hemostatic material is described, which eliminates the risks of conventional chitosan-derived products, such as the onset of shellfish allergy and endotoxin contamination, can be used safely for more people, and has an antibacterial property and a hemostatic function that widely-used hydrogels lack, and a wound dressing containing the same. A hemostatic material containing cationized cellulose and a wound dressing containing the hemostatic are described. At least one of hydroxyl groups of the cationized cellulose is modified with —R2—N+(R3)(R4)(R5).X?, other hydroxyl groups of the cationized cellulose have —H, or —(CH2CH2O)m—H, R2 represents C1-6 alkylene, C2-6 hydroxyalkylene, —(CH2CH2O)1—, or a combination thereof, 1 represents 1 or 2, m represents 1 or 2, and X? may represent an anionic group.Type: GrantFiled: August 9, 2022Date of Patent: March 26, 2024Assignees: Artisan Lab Co., Ltd., NIPRO CorporationInventor: Kazuhiko Shibata
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Patent number: 11690572Abstract: A flush device including: a first housing provided with a first flow path; a second housing provided with a second flow path, the second housing being coupled to the first housing; a flow control device including a protrusion and a through hole connecting the first flow path to the second flow path in fluid communication; and an elastic member provided around the base of the flow control device to seal off a space between the first and the second flow paths. The elastic member is deformed to further connect the first and second flow paths in fluid communication. The first housing has an inner periphery provided with fitting receiving portions each being fitted to each of the fitting projections of the protrusion. According to this structure, the flush device can discharge a chemical liquid at a flow rate close to a defined amount.Type: GrantFiled: September 11, 2018Date of Patent: July 4, 2023Assignee: NIPRO CorporationInventors: Yasushi Matsumoto, Kuniaki Matsumoto
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Patent number: 11666601Abstract: The present invention relates to a synapse formation promoter and a brain plasticity promoter comprising CD24-negative mesenchymal stem cells prepared from a patient's own bone marrow aspirate and treatment of dementia, chronic-phase cerebral infarction, chronic-phase spinal cord injury, mental diseases, and the like using the synapse formation promoter and brain plasticity promoter.Type: GrantFiled: April 26, 2017Date of Patent: June 6, 2023Assignees: Sapporo Medical University, Nipro CorporationInventors: Osamu Honmou, Masanori Sasaki, Rie Maezawa, Shinichi Oka, Yuko Sasaki, Masahito Nakazaki, Toshihiko Yamashita
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Patent number: 11529165Abstract: To provide a catheter having a simple structure capable of excising an atheroma in a blood vessel and capable of obtaining ultrasonic images of a blood vessel. [Solution] A catheter 10 has a shaft 11 having an opening 20 in a part of the side wall on the distal end side, a cutter 12 which is located in the vicinity of the opening 20 in the internal space of the shaft 11 and which can move in the axial direction 101 of the shaft 11, a balloon 23 which is disposed on the side opposite to the opening 20 with respect to the axis of the shaft 11 and which outwardly expands from the side wall of the shaft 11, and a phased array ultrasound probe 17 disposed along the circumferential direction 102 of the outer peripheral surface of the side wall in the vicinity of the opening 20 at least on the same side as the side where the opening 20 is provided with respect to the axis of the shaft 11.Type: GrantFiled: August 2, 2019Date of Patent: December 20, 2022Assignee: Nipro CorporationInventors: Katsuya Miyagawa, Misa Matsumoto, Tomonori Nakamura
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Publication number: 20220133805Abstract: The present invention relates to a pharmaceutical composition for treating amyotrophic lateral sclerosis. More specifically, the present invention relates to a pharmaceutical composition for treating amyotrophic lateral sclerosis, wherein the pharmaceutical composition comprises mesenchymal stem cells and is intravenously administered.Type: ApplicationFiled: March 13, 2020Publication date: May 5, 2022Applicants: Sapporo Medical University, Nipro CorporationInventors: Osamu HONMOU, Masanori SASAKI, Yuko SASAKI, Shinichi OKA, Masahito NAKAZAKI, Rie MAEZAWA
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Publication number: 20220125850Abstract: The present invention relates to a pharmaceutical composition containing mesenchymal stem cells administered to a patient subjected to stenting. The present invention relates specifically to: a pharmaceutical composition for repairing and regenerating tissue, comprising mesenchymal stem cells, wherein the pharmaceutical composition is administered to a patient subjected to stenting; and the prevention of in-stent neointimal hyperplasia or in-stent restenosis with the pharmaceutical composition.Type: ApplicationFiled: February 7, 2020Publication date: April 28, 2022Applicants: Sapporo Medical University, Nipro CorporationInventors: Osamu HONMOU, Masanori SASAKI, Yuko SASAKI, Shinichi OKA, Masahito NAKAZAKI, Rie MAEZAWA
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Patent number: 10925672Abstract: [Object] To provide an ablation system capable of suppressing heat damages to the lumen intima. [Solution] An ablation system 10 has an ablation device 11 in which a balloon 21 is provided on the distal end side of a shaft 22 and an in-side tube 27 causing a fluid to flow into the balloon 21, the internal space of the shaft 22 causing a fluid to flow out of the balloon 21, and an optical fiber 29 guiding laser light into the balloon 21 are individually provided along the shaft 22, a laser light generating unit 12 emitting laser light to the optical fiber 29, and a fluid returning unit 13 returning a fluid into the internal space of the balloon 21. The ablation device 11 has a reflector 33 reflecting laser light emitted from the optical fiber 29 in the balloon 21, in which the reflector 33 is movable along the axial direction 191 in the balloon 21 and is rotatable in the axial direction 101 as the axis line.Type: GrantFiled: March 13, 2020Date of Patent: February 23, 2021Assignee: Nipro CorporationInventors: Katsuya Miyagawa, Yuuki Nishimura, Natsumi Shimazaki
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Publication number: 20200345781Abstract: The present invention relates to a cell-based medicine comprising mesenchymal stem cells, and a method for producing the same. More specifically, the present invention relates to: a cell-based medicine containing mesenchymal stem cells, wherein a) the mesenchymal stem cells express CX3CL1 under stimulation with an inflammatory cytokine, and/or b) 90% or more of the mesenchymal stem cells express EGFR and/or ITGA4; and a method for producing a cell-based medicine containing mesenchymal stem cells, the method comprising the steps of: a) adding an inflammatory cytokine to a culture containing mesenchymal stem cells, and confirming that the mesenchymal stem cells express CX3CL1; and/or b) confirming that 90% or more of the mesenchymal stem cells express EGFR and/or ITGA4.Type: ApplicationFiled: November 9, 2018Publication date: November 5, 2020Applicants: Sapporo Medical University, Nipro CorporationInventors: Osamu HONMOU, Yoshihiro YOSHIKAWA, Ryo TOMII, Masafumi YAO, Yukari NISHII, Yusuke WAGATSUMA
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Patent number: 10631930Abstract: [Object] To provide an ablation system capable of suppressing heat damages to the lumen intima. [Solution] An ablation system 10 has an ablation device 11 in which a balloon 21 is provided on the distal end side of a shaft 22 and an in-side tube 27 causing a fluid to flow into the balloon 21, the internal space of the shaft 22 causing a fluid to flow out of the balloon 21, and an optical fiber 29 guiding laser light into the balloon 21 are individually provided along the shaft 22, a laser light generating unit 12 emitting laser light to the optical fiber 29, and a fluid returning unit 13 returning a fluid into the internal space of the balloon 21. The ablation device 11 has a reflector 33 reflecting laser light emitted from the optical fiber 29 in the balloon 21, in which the reflector 33 is movable along the axial direction 191 in the balloon 21 and is rotatable in the axial direction 101 as the axis line.Type: GrantFiled: October 14, 2014Date of Patent: April 28, 2020Assignee: Nipro CorporationInventors: Katsuya Miyagawa, Yuuki Nishimura, Natsumi Shimazaki
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Patent number: 10563173Abstract: To provide an autoserum-containing bone marrow cell culture system, whereby bone marrow cells, which are collected from a subject without using an anticoagulant, are subjected to an anticoagulation treatment using a medium in a liquid-tight state, cultured and then further cultured using the serum of said subject which is prepared in a liquid-tight state; an autoserum-containing bone marrow cell culture method; and a method for producing a medicinal composition which comprises, as the active ingredient, autoserum-containing cultured bone marrow cells. [Solution] An autoserum-containing bone marrow cell culture system for culturing bone marrow cells, which are collected from a subject without using an anticoagulant, using the serum of said subject, said system comprising a bone marrow cell suspension-storing device, a collected blood-storing device, an autoserum-acquiring device, and a bone marrow cell-culturing device.Type: GrantFiled: May 15, 2017Date of Patent: February 18, 2020Assignee: Nipro CorporationInventors: Osamu Honmou, Yoshihiro Yoshikawa, Naomi Morikawa
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Publication number: 20200016370Abstract: Provided is a catheter with a novel structure which is able to allow its distal end portion to deform to curve more effectively in response to an operation from an outside. In a catheter 10, a control lumen 24 extending in a lengthwise direction is provided to an elongated shaft member 33, a control wire 54 is inserted through the control lumen 24, a fixing part 57 to which a distal end of the control wire 54 is fixed is provided to the shaft member 33, and an exposed part 60 is provided to a distal end portion of the control wire 54 over a predetermined length so as to be exposed through a window part 58 provided to a peripheral wall 28 of the control lumen 24 to a separate internal space 12 in the shaft member 33.Type: ApplicationFiled: August 31, 2017Publication date: January 16, 2020Applicants: Takemore Co., Ltd., Nipro CorporationInventors: Miyoko SASAKI, Kiyofumi YOSHIZAWA
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Publication number: 20190365413Abstract: To provide a catheter having a simple structure capable of excising an atheroma in a blood vessel and capable of obtaining ultrasonic images of a blood vessel. [Solution] A catheter 10 has a shaft 11 having an opening 20 in a part of the side wall on the distal end side, a cutter 12 which is located in the vicinity of the opening 20 in the internal space of the shaft 11 and which can move in the axial direction 101 of the shaft 11, a balloon 23 which is disposed on the side opposite to the opening 20 with respect to the axis of the shaft 11 and which outwardly expands from the side wall of the shaft 11, and a phased array ultrasound probe 17 disposed along the circumferential direction 102 of the outer peripheral surface of the side wall in the vicinity of the opening 20 at least on the same side as the side where the opening 20 is provided with respect to the axis of the shaft 11.Type: ApplicationFiled: August 2, 2019Publication date: December 5, 2019Applicant: Nipro CorporationInventors: Katsuya MIYAGAWA, Misa MATSUMOTO, Tomonori NAKAMURA
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Patent number: 10420704Abstract: A PTP sheet for pharmaceutical packaging has a first sheet in which pockets each capable of housing a solid pharmaceutical are projected to the side of a first surface which is one of a back surface and a front surface and a second sheet which is pasted to a second surface opposite to the first surface in the first sheet and covers an opening of the pocket. The second sheet has a first region having mesh-shaped grooves having a first depth in a third surface opposite to the surface to be pasted to the second surface and a second region having mesh-shaped grooves having a second depth smaller than the first depth or not having a groove.Type: GrantFiled: June 12, 2014Date of Patent: September 24, 2019Assignee: Nipro CorporationInventors: Kazuaki Uetake, Takeshi Kodai
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Patent number: 10405881Abstract: [Object] To provide a catheter having a simple structure capable of excising an atheroma in a blood vessel and capable of obtaining ultrasonic images of a blood vessel. [Solution] A catheter 10 has a shaft 11 having an opening 20 in a part of the side wall on the distal end side, a cutter 12 which is located in the vicinity of the opening 20 in the internal space of the shaft 11 and which can move in the axial direction 101 of the shaft 11, a balloon 23 which is disposed on the side opposite to the opening 20 with respect to the axis of the shaft 11 and which outwardly expands from the side wall of the shaft 11, and a phased array ultrasound probe 17 disposed along the circumferential direction 102 of the outer peripheral surface of the side wall in the vicinity of the opening 20 at least on the same side as the side where the opening 20 is provided with respect to the axis of the shaft 11.Type: GrantFiled: February 4, 2015Date of Patent: September 10, 2019Assignee: Nipro CorporationInventors: Katsuya Miyagawa, Misa Matsumoto, Tomonori Nakamura
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Patent number: D987820Type: GrantFiled: July 19, 2021Date of Patent: May 30, 2023Assignee: Nipro CorporationInventor: Yukihiro Yabe
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Patent number: D987824Type: GrantFiled: June 8, 2021Date of Patent: May 30, 2023Assignee: Nipro CorporationInventors: Misa Matsumoto, Katsuya Miyagawa, Tomoe Morita
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Patent number: D1013163Type: GrantFiled: June 8, 2021Date of Patent: January 30, 2024Assignee: Nipro CorporationInventors: Misa Matsumoto, Katsuya Miyagawa, Tomoe Morita
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Patent number: D1013872Type: GrantFiled: June 8, 2021Date of Patent: February 6, 2024Assignee: Nipro CorporationInventors: Misa Matsumoto, Katsuya Miyagawa, Tomoe Morita