Abstract: A hollow fiber porous membrane includes polyethersulfone or polysulfone. The hollow fiber porous membrane has an inner diameter from 300 to 600 ?m, a thickness from 70 to 200 ?m, a molecular weight cut-off of 10000 or lower, and a plurality of pores having a pore diameter from 0.1 to 0.5 ?m throughout an outer surface; and a swelling rate of less than 5% as defined below: Swelling Rate (%): for 20 or more of the hollow fiber porous membranes, after a membrane thickness in a cross section of each one of the hollow fiber porous membranes in the width direction is measured at randomly selected 10 or more locations, an average membrane thickness is calculated based on 200 or more locations in total, and the swelling rate is calculated by a formula below: Swelling Rate (%)=(location numbers where the membrane thickness as measured exceeded 1.3 times the average membrane thickness)/(membrane thickness measurement numbers)×100.

Abstract: A medical valve which is able to more reliably support an outer peripheral part of an elastic valve body with respect to a housing, and prevent a problem of the elastic valve body becoming dislodged inward. A medical valve includes an elastic valve body with annular grooves formed thereon and a tubular support part formed at an outer peripheral side of an annular joining part positioned between the annular grooves. Inside and outside holding parts engage the annular grooves provided to the valve inside and outside surfaces of the annular joining part. The outside holding part and inside holding part are provided to an opening member, and with the tubular support part, a part projecting inward in an axial direction is sandwiched and supported between the inside holding part and outside holding part.

Abstract: An internal spray device for medical powder whereby the medical powder is supplied via a powder channel to an spray channel in which pressurized gas flows, and the medical powder and the pressurized gas are sprayed into a body via the spray channel, the device including a conductive member that is exposed to the powder channel, and a static eliminator that is exposed to an external space that is outside the powder channel, wherein the conductive member and the static eliminator are electrically connected.

Abstract: A syringe-shaped spraying device includes: a barrel; a nozzle; a packing disposed therebetween; and a core disposed inside the nozzle. The nozzle is connected to a connecting portion provided at a front end of the barrel. The nozzle has a first facing surface facing a front end surface of the connecting portion and a second facing surface facing an outer circumferential surface of the connecting portion. The outer circumferential surface is provided with an annular recess portion, and the second facing surface is provided with a first annular protrusion portion and a second annular protrusion portion. By engaging the first annular protrusion portion with the annular recess portion, the packing is compressed in an axial direction by the front end surface and the first facing surface. The second annular protrusion portion is in pressure contact with the outer circumferential surface of the connecting portion entirely in a circumferential direction.

Abstract: A drug delivering apparatus includes a drug container, a pre-filled syringe including a cylindrical container having a nozzle portion and an injection needle attachment portion, and a connecting tool configured to allow communication between the inside of the cylindrical container and the inside of the drug container. The connecting tool further includes a nozzle insertion portion. The pre-filled syringe further includes a cap member configured to be detachably fitted on the injection needle attachment portion, the cap member having an opening into which the nozzle insertion portion can be inserted. The injection needle attachment portion has a guiding groove in the inner periphery thereof. In the state where the cap member is fitted on the injection attachment portion, at least a part of the edge of the opening is located on the inner side relative to the bottom portion of the guiding groove.

Abstract: An extracellular fluid volume calculator may include: an acquirement unit configured to acquire a membrane area of a dialyzer used for hemodialysis; and a processor configured to calculate a post-hemodialysis extracellular fluid volume based on a difference between a pre-hemodialysis amount of uric acid and a post-hemodialysis amount of uric acid. The processor may be configured to: calculate a removal amount of uric acid removed by hemodialysis based on a dialyzer overall mass transfer-area coefficient for uric acid; and calculate the dialyzer overall mass transfer-area coefficient for uric acid based on the membrane area of the dialyzer acquired by the acquirement unit.

Abstract: A valved needle assembly including a needle hub provided to a proximal end side of a hollow needle, and a valve member incorporated therein for blocking communication with the hollow needle. A protrusion protrudes from a distal end side toward a proximal end side inside the needle hub and the valve member blocks the proximal end side of the protrusion inside the needle hub. A central valve part of the valve member having a slit moves toward the protrusion such that the slit is opened and placed in communication by the protrusion. The central valve part includes a distal end tubular part and a proximal end tubular part extending from its outer circumferential portion toward the distal end side and the proximal end side respectively.

Abstract: Provided is a guide wire having a novel structure, with which it is possible to improve production efficiency and to effectively prevent large irregularities from forming on an outer circumferential surface of a core wire. Further provided is a guide wire having a novel structure, with which it is possible to more meticulously set bending rigidity to a distal end portion thereof. In a guide wire having a coil externally mounted about a distal end portion of a core wire, a proximal end portion of the coil is integrally joined to the core wire during formation of the coil. Furthermore, in a guide wire having a coil externally mounted about a distal end portion of a core wire, a cross-sectional shape of a wire that constitutes the coil varies in a lengthwise direction of the coil.

Abstract: A hub assembly with a hub body connected to a tube from an external appliance, a hub outer casing which is coupled to the hub body and forms a liquid passage, a slitted separating wall disposed in the liquid passage in the hub outer casing, a filter disposed on the living body-side of the separating wall to allow the passage of gas and regulate the passage of liquid, and a ventilation passage which communicates between the liquid passage and the outside of the hub outer casing by way of the filter, wherein an end portion of the ventilation passage on the separating wall side of an opening portion facing the liquid passage is in a location at most 10 mm toward the distal end side relative to the distal end of the separating wall.

Abstract: Provided is a locking plate system for treatment of a distal radius fracture including a locking plate (4) that is a flat laminate of intermediate molding materials that includes carbon fibers as a reinforcing material and thermoplastic resin as a matrix; a screw anchor (5) having a shaft portion (10) which has a principal thread (13) achieving a self-tapping action formed thereon and an outer circumference of a head portion of the screw anchor (5) which has an auxiliary thread (13) achieving a self-tapping action tapped thereon; and a through-hole (6) in the radius locking plate (4), which allows the radius main body (3) and the fractured bone piece (2) to be threadably fixed to the radius locking plate (4) and having a diameter that is oversized relative to the principal thread (11), and that is undersized relative to the auxiliary thread (13).

Abstract: [Object] To provide an ablation system capable of suppressing heat damages to the lumen intima. [Solution] An ablation system 10 has an ablation device 11 in which a balloon 21 is provided on the distal end side of a shaft 22 and an in-side tube 27 causing a fluid to flow into the balloon 21, the internal space of the shaft 22 causing a fluid to flow out of the balloon 21, and an optical fiber 29 guiding laser light into the balloon 21 are individually provided along the shaft 22, a laser light generating unit 12 emitting laser light to the optical fiber 29, and a fluid returning unit 13 returning a fluid into the internal space of the balloon 21. The ablation device 11 has a reflector 33 reflecting laser light emitted from the optical fiber 29 in the balloon 21, in which the reflector 33 is movable along the axial direction 191 in the balloon 21 and is rotatable in the axial direction 101 as the axis line.

Abstract: A method for producing a vial with low alkali elution by removing a deteriorated region caused by processing on an internal surface of a vial is disclosed. The method involves forming vials from borosilicate glass tubes including a first step of forming a borosilicate glass tube into a cup-shaped body by formation of a bottom of a vial, and a second step of forming the cup-shaped body into the vial by formation of a mouth of the cup-shaped body.

Abstract: A biomedical electrode including: an attachment sheet being elastically stretchable and contractible with an electrically insulating property on a back surface side, an adhesive surface suitable for attachment to the skin; a plurality of electrodes located apart from one another on the back surface side of the attachment sheet and exposed on the back surface side; a plurality of connecting parts located at a central part on the back surface side of the attachment sheet and covered with electrical insulation while being exposed toward a front surface side through openings of the attachment sheet; and electrode connecting wires located on the back surface side of the attachment sheet and covered with electrical insulation that electrically connect respective ones of the plurality of electrodes with corresponding ones of the plurality of connecting parts, wherein at least one of the electrode connecting wires extends in a stretchable, contractible, and bendable manner.

Abstract: A stent having a line-shaped body that extends helically in a circumferential direction while reciprocating in an axial direction by continuously alternating straight parts and curved parts, wherein the plurality of straight parts in the line-shaped body have a substantially constant thickness throughout the entire stent, and a certain number of the plurality of curved parts in the line-shaped body have different thicknesses.

Abstract: The present invention relates to a cell-based medicine comprising mesenchymal stem cells, and a method for producing the same. More specifically, the present invention relates to: a cell-based medicine containing mesenchymal stem cells, wherein a) the mesenchymal stem cells express CX3CL1 under stimulation with an inflammatory cytokine, and/or b) 90% or more of the mesenchymal stem cells express EGFR and/or ITGA4; and a method for producing a cell-based medicine containing mesenchymal stem cells, the method comprising the steps of: a) adding an inflammatory cytokine to a culture containing mesenchymal stem cells, and confirming that the mesenchymal stem cells express CX3CL1; and/or b) confirming that 90% or more of the mesenchymal stem cells express EGFR and/or ITGA4.

Abstract: A means capable of simply and efficiently concentrating a cell suspension. A concentrator has a culture vessel having a first port and a second port, a server bag having a port, a case having a hollow fiber bundle in the internal space, a filtering device having an inlet port, a first outlet port, and a second outlet port, a collection vessel having a port, a liquid supply circuit connected to the first port, the inlet port, and the server bag's port so that flow passages are switchable, a liquid discharge circuit connected to the second port, the first outlet port, the second outlet port, and the collection vessel's port so that flow passages are switchable, a liquid supply mechanism having a switching mechanism, a supply pump, and a discharge pump, and a rotation mechanism rotating the filtering device.

Abstract: A microcapsule contains a biodegradable polymer and risperidone and has a sustained release property. The biodegradable polymer contained in the microcapsule has a molecular weight corresponding to 85% or more of an initial molecular weight (Mw) of the biodegradable polymer. A method of producing the microcapsule is also disclosed. The method of producing a microcapsule has (A) a step of preparing a first phase by mixing a solution of a biodegradable polymer and a solution of risperidone which are prepared separately, (B) a step of, immediately after the preparation of the first phase, mixing the first phase with a second phase being an aqueous phase to prepare an emulsion, and (C) a step of subjecting the resulting emulsion to in-water drying.

Abstract: Provided is a method for preventing postoperative adhesion of an organ in a wound site using the application of an antiadhesive material thereto. The antiadhesive material contains a poly-?-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and/or a salt thereof, as an effective ingredient. The antiadhesive material may be in a form such as powder, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion.