Patents Assigned to Nipro Corporation
  • Patent number: 6416717
    Abstract: Providing an evacuated blood collection tube for blood collection rapidly, whereby serum of high purity can be isolated in a rapid and simple manner with no occurrence of fibrin deposition. Beads each coated with a blood coagulation-promoting enzyme comprising thrombin and batroxobin are contained in the evacuated blood collection tube. Preferably, thrombin is used in an amount of 0.1 to 3 IU and batroxobin is used in an amount of 0.25 to 2 BU, per 1 ml of collected blood.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: July 9, 2002
    Assignee: Nipro Corporation
    Inventors: Ken Suzuki, Hironori Kondo, Manabu Iwatake
  • Patent number: 6407070
    Abstract: A one-pack solid pharmaceutical composition for dialysate containing sodium bicarbonate which can prevent the reactions between sodium bicarbonate and acetic acid and between sodium bicarbonate and electrolytes, and is excellent in long term storage stability is provided. The solid pharmaceutical composition for dialysate containing sodium bicarbonate is a mixture of an agent A containing sodium chloride, calcium chloride, magnesium chloride, potassium chloride, sodium acetate and acetic acid and an agent B containing sodium bicarbonate coated with sodium acetate.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: June 18, 2002
    Assignee: Nipro Corporation
    Inventors: Toshiya Kai, Kazuyuki Yamamoto, Kazutaka Fujiki, Hiroaki Kato, Makoto Sato
  • Patent number: 6398719
    Abstract: A tube for sperm washing and concentration. The tube is a glass tube 1 having an open end 11 and a bottom portion with a small diameter 12, and an elastic bladder 2 removably provided at the open end 11 of the tube 1. A vulnerable section 13 may be further provided to enable the bottom with small diameter 12 to be easily bent and cut. Contamination of the sperm by bacteria and remaining density gradient carrier are not caused.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: June 4, 2002
    Assignee: Nipro Corporation
    Inventors: Satoru Kaneko, Tadatoshi Uchida
  • Patent number: 6375671
    Abstract: A closure device for transcatheter operations includes a longitudinally elasticated fixing member (1) having a shape-restoring force and being provided with a relatively large-sized, first and second circular portion (11,12) at both ends thereof, and a closure membrane (2) attached to the first circular portion (11) and closing up a ring thereof. The first circular portion (11) is fixed by a connecting portion extending from the fixed circular portion and progressively decreasing in size toward the second circular portion. The second circular portion may be provided with a holding portion (13) as occasion demands.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: April 23, 2002
    Assignee: Nipro Corporation
    Inventors: Toshiki Kobayashi, Yoshikazu Kishigami, Katsuya Miyagawa
  • Patent number: 6342064
    Abstract: An easily foldable closure device for transcatheter operations, comprises: a flat closure member including a closure membrane and a frame for fimbriating a periphery of the membrane; a fixing member for fixing the closure member to a tissue surrounding a defect aperture; and a connecting member fixed at one end to the fixing member and at the other end to the closure member for holding them in close proximity to one another. The frame, fixing member and connecting member are respectively made of the same or different shape-memory alloys with a shape recovery temperature of 30 to 37° C.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: January 29, 2002
    Assignee: Nipro Corporation
    Inventors: Kazuyuki Koike, Toshiki Kobayashi, Yoshikazu Kishigami, Katsuya Miyagawa
  • Patent number: 6333193
    Abstract: Provided are a cell growth accelerator containing a polyphosphoric acid and a cell growth method in which cells are grown by adding the cell growth accelerator to a medium for cells of animals and plants or by using a glass or plastic cell cultivator containing or coated with the cell growth accelerator. When substances are produced in vitro using culture cells, the cell culture and the cell growth acceleration are conducted at low cost safely and efficiently by adding the cell growth accelerator containing the polyphosphoric acid to the medium for cells of animals and plants or by using the cell cultivator containing or coated with the cell growth accelerator.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: December 25, 2001
    Assignee: Nipro Corporation
    Inventor: Toshikazu Shiba
  • Patent number: 6326010
    Abstract: To provide a plastic vessel containing an albumin preparation which completely restrains formation of thermally denatured albumin, a plastic molded member in a cylindrical shape is extruded in a molten state into opened dies, one end of which is closed in the dies, and a vessel is molded by blowing a compressed gas into the molded member in the dies or by bringing inner portions of the dies into a vacuum state. While the vessel is still disposed in the dies, an albumin preparation is introduced from an opening portion into an inner portion of the vessel and, therefore, the albumin preparation can be filled into the vessel in a sterilized state without being brought into contact with the atmosphere. Then, an opening portion of the vessel filled with the albumin preparation is hermetically sealed at an internal temperature of the opening portion of about 40 to 70° C. Thus formation of thermally denatured albumin can be completely restrained.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: December 4, 2001
    Assignee: Nipro Corporation
    Inventors: Minoru Sano, Yoshihisa Hama, Toshiya Kai, Masakazu Mameta
  • Patent number: 6277272
    Abstract: A dialysis system which does not need to use a physiological saline in replenishing a solution or cleaning and priming the dialysis system, does not need a troublesome setting operation and can easily and accurately set a flow rate of a replenisher solution. The dialysis system includes a closed type water-removal control apparatus 1, a dialyzer 2, a fresh dialysate line 3 as well as a used dialysate line 4, a dialysate pressurizing line 5, a dialysate pressurizing pump 51 provided in the dialysate pressurizing line 5, an artery side blood line 6, a blood pump 61 provided in the artery side blood line 6 and a vein side blood line 7. According to the dialysis system, by pressurizing a dialysate into a communication line of the dialysate, the dialysate is made to flow from a dialysate flow path 21 into a blood flow path 22 through a dialysis membrane 23 of the dialyzer 2 and the inside of a blood circulation path can be cleaned and primed.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: August 21, 2001
    Assignee: Nipro Corporation
    Inventors: Taku Nikaido, Mitsutaka Ueda
  • Patent number: 6274034
    Abstract: A dialysis system which does not need to use a physiological saline in replenishing a solution or cleaning and priming the dialysis system, does not need a troublesome setting operation and can easily and accurately set a flow rate of a replenisher solution. The dialysis system includes a closed-type water-removal control apparatus 1, a dialyzer 2, a fresh dialysate line 3 as well as a used dialysate line 4, an RO water pressurizing line 5, an RO water pressurizing pump 51 provided in the RO water pressurizing line 5, an artery side blood line 6, a blood pump 61 provided at the artery side blood line 6 and a vein side blood line 7. According to the dialysis system, by pressurizing RO water into a communication line of the used dialysate, dialysate is made to flow from a dialysate flow path 21 into a blood flow path 22 through a dialysis membrane 23 of the dialyzer 2 and the inside of a blood circulation path can be cleaned and primed.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: August 14, 2001
    Assignee: Nipro Corporation
    Inventors: Taku Nikaido, Mistutaka Ueda
  • Patent number: 6249697
    Abstract: An electrogastrograph measures an electric signal derived from the stomach's action. The signal is decomposed into its frequency components by means of a plurality of band pass filters, and stored in a storage medium. A method for analyzing data obtained by the electrogastrograph comprises the steps of: decomposing the signal into its frequency components by means of the band pass filters; and, evaluating the stomach in its action on the basis of variations in amplitude of said frequency components.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: June 19, 2001
    Assignees: Nipro Corporation, Gram Corporation
    Inventor: Fumitaka Asano