Abstract: A method for anticipating sensitivity to a medicine for osteoporosis is provided which is characterized by analyzing respective genetic polymorphisms of a vitamin D receptor gene, an estrogen receptor gene, and an apolipoprotein E gene from a genome DNA contained in a sample obtained from a human, and anticipating, based on the analyzed combination of the genetic polymorphisms, that the sample is derived from an individual who shows a specific priority to sensitivities to a plurality of remedies for osteoporosis. A reagent for simultaneously detecting genetic polymorphisms is also provided which contains amplification primers and/or detection probes specific to respective genes of the vitamin D receptor gene, apolipoprotein E gene, and estrogen receptor gene. Further, a method for simultaneously detecting these genes, and a method for selecting remedies for bone disease based on the genetic polymorphisms are provided.

Abstract: A drug solution delivery device comprises barrel (1) provided with a port at a distal end thereof and opened at a proximal end thereof, gasket (2) fluid-tightly and slidably arranged in the barrel, cylindrical connecting member (3) having proximal end (32) and distal end (31) to which gasket (2) is releasably connected, plunger (4) removably connected to proximal end (32) of connecting member (3), and pressed helical spring (5) arranged between gasket (2) and connecting member (3).

Abstract: A vein filter having improved collectability of chyme blood or thrombi and stability of indwelling. The filter includes at least 3 wires radially spreading backward of a head member and connected such that the intervals between any adjacent two wires are connected with threads of an equal length at a substantially equal distance from the head member. At respective connection parts where the threads are connected to the wires, hook parts to be hooked on the inner wall of a blood vessel are provided. The head member is on the apex of a shaft extending back and the rear end of each wire is connected to a slide member slidable along the shaft. The wires are preferably made of shape memory alloy or stainless spring steel.

Abstract: A dialysis system which does not need to use a physiological saline in replenishing a solution or cleaning and priming the dialysis system, does not need a troublesome setting operation and can easily and accurately set a flow rate of a replenisher solution. The dialysis system includes a closed type water-removal control apparatus 1, a dialyzer 2, a fresh dialysate line 3 as well as a used dialysate line 4, a dialysate pressurizing line 5, a dialysate pressurizing pump 51 provided in the dialysate pressurizing line 5, an artery side blood line 6, a blood pump 61 provided in the artery side blood line 6 and a vein side blood line 7. According to the dialysis system, by pressurizing a dialysate into a communication line of the dialysate, the dialysate is made to flow from a dialysate flow path 21 into a blood flow path 22 through a dialysis membrane 23 of the dialyzer 2 and the inside of a blood circulation path can be cleaned and primed.

Abstract: The wedge base bulb includes a bulb body having a colored glass bulb and a press-sealed portion. Further, a tubular insulation collar is mounted to cover press-sealed portion. Bulb body is formed in a process in that a molding section of a glass tube including a color-developing compound or a color-developing element is heat-melted under a reducing atmosphere in a predetermined temperature region, placed in a mold and expanded in the mold, and also develops color with colloid generated by the heat-melting. As a result, a wedge base bulb developed a color and chromaticity satisfying a predetermined standard can be provided at a lower cost.

Abstract: An infusion bag which does not generate a significant number of fine particles in liquid contained in the bag, and has excellent transparency and flexibility, and also has sufficient heat resistance so that deformation does not occur even during sterilization at 115° C. A heat resistant sheet to form the infusion bag is formed from a polymer composition containing 50-70% by weight of a straight-chain polyethylene having a density of 0.928 g/cm3 or more and produced using a metallocene catalyst, 10-30% by weight of a low density polyethylene produced under high-pressure and 20-40% by weight of a straight-chain polyethylene having a density of 0.91 g/cm3 or less and produced using a metallocene catalyst.

Abstract: A nutrient infusion preparation comprises a fat emulsion essentially consisting of fat particles having a mean particle size of 0.003 to 0.100 &mgr;m and a dispersion medium, and a solution containing electrolytes and amino acids. Also the nutrient infusion preparation comprises a fat emulsion (A) consisting essentially of fat particles having a mean particle size of 0.003 to 0.100 &mgr;m and a dispersion medium, and a solution (B) containing electrolytes and/or amino acids. A container having a plurality of chambers which are isolated from each other by partitions capable of being easily opened, whose respective chambers contain the fat emulsion (A) and said solution (B) and optionally a solution (C) containing saccharides. The infusion preparation of the present invention supplies various nutrient components including fatty acids required biologically to patients and enables amelioration or prevention of essential fatty acid deficiencies during TPN therapy.

Abstract: A magnetically driven, axial flow pump comprises an electromagnetic unit arranged about the periphery of a pipe. A cylindrical rotor is accommodated within the pipe and is equipped with permanent magnets mounted on the periphery. A spiral, hollow vane is formed on an inner surface of the rotor by either casting or by cutting, such as with a NC machine, thus precluding the occurrence of gaps between the rotor and the vane. The lack of gaps within the pump makes the pump suitable for use as a blood pump.

Abstract: A recording medium includes a sensor circuit unit generating a current in accordance with a blood glucose level in blood, and a control unit calculating blood glucose level data from the data obtained by digital conversion of the generated current at signal processing unit, writing the calculated data to an EEPROM as a memory unit, reading the blood glucose level data from EEPROM and transmitting the same to a portable terminal on which recording medium is mounted, through a communication control unit. The recording medium further includes a power supply control unit receiving power from the portable terminal on which the recording medium is mounted, and supplying power to various portions in the recording medium.

Abstract: A protector for housing a drug administration needle comprised of a winged hub and a cannula bent substantially perpendicular to a longitudinal axis of the hub at a longitudinal central portion of the hub. The protector comprises a tubular cannula-protecting portion having a cannula entrance at one end and a bottom at the opposite end; and a hub-mounting portion for attachment of the winged hub, the hub-mounting portion being coaxially formed on the cannula entrance of the cannula-protecting portion.

Abstract: There is provided a solid pharmaceutical preparation for dialysis consisting of one composition, which is excellent in uniformity of the ingredients contained therein, is capable of preventing not only a reaction between sodium bicarbonate and a solid organic acid or between sodium bicarbonate and electrolytes but also a reaction between a solid organic acid and sodium acetate, and does not require further pulverization of the respective ingredients in the dialysis composition. The solid pharmaceutical preparation for dialysis containing an electrolyte for hemodialysis, a solid organic acid and glucose is characterized by a plurality of layers separated from each other on the surface of a nucleating particle of sodium chloride, wherein the plurality of separated layers include a layer (A) comprising sodium acetate but not containing the solid organic acid, a layer (B) comprising the solid organic acid but not containing sodium acetate, and a layer (C) comprising sodium bicarbonate.

Abstract: There is provided a liquid container capable of transferring liquids germ free in a simple manner within a short period of time and with inconsiderable solution remaining after transfer. The liquid container includes a vessel main body 1, a mouth portion 11 of which is closed by an easily breakable closing member 12, and a hollow needle member 2 crowned pivotably on the mouth portion 11 of the container main body 1. The closing member 12 is provided with a flat knob portion 121. A knob-containing portion 22 of the hollow needle member 2 is provided with a protrusion 24 for joining the knob portion 121 when the hollow needle member 2 is pivoted.

Abstract: An indwelling needle assembly includes an outer needle hub having an outer needle fixed to the distal end portion thereof, an inner needle hub having an inner needle at the distal end portion thereof, and a needle guard that can accommodate the inner needle and the inner needle hub therein. The needle guard has a double-tube structure including an inner tube and an outer tube, and a connector for connecting the inner needle hub and the inner tube via the proximal end of said needle guard. The needle guard is also expandable by sliding the outer tube toward the proximal end of the inner tube. When the needle guard is extended, the inner needle hub is slid in the needle guard toward the proximal end of the needle guard by the connector.

Abstract: A balloon catheter comprises a shaft 2, a ball-shaped balloon 1 twisted in the form of a screw and mounted on the head of the shaft 2, and a two-way stop cock 5 connected through connection tube 4 with hub 3 on the proximal end of the shaft 2. Injection opening 6 for physiological saline is arranged on the proximal end of the two-way stopcock 5 in order to inflate the balloon. The balloon catheter in the present invention, of which the balloon is of a small diameter during deflation and for which a thinner sheath introducer can be used, can readily occlude a blood vessel.

Abstract: A guide wire having a flexible distal end portion, uniform outer diameter and no stepped difference in the external surface is provided. The guide wire comprises a core wire 1 having a core body portion 11 having a relatively large cross sectional area of wire and a distal end portion 12 provided at a distal end 111 of the core body portion 11 and having a relatively small cross sectional area of wire, and a resin layer 2 coated on the core wire 1. At least the distal end portion 12 comprises a sparse bundle of a plurality of slender wire filaments 121, and substantially no stepped difference is present between the distal end portion 12 and the core body portion 11. The core body portion 11 is a slender wire filament having a section formed in a circular shape or a bundle of slender wire filaments whose number is more than that of the distal end portion and when used for inserting a catheter for PTCA, the diameter (average) of the core body portion 11 is generally about 0.05 mm to 0.10 mm.

Abstract: A solid preparation for dialysis for preparing a double preparation type sodium bicarbonate solid preparation for dialysis in which there is no fear that a sugar is decomposed or colored, and which can maintain stability and also is excellent in content homogeneity and a process for producing the same. The solid preparation for dialysis is a mixture of a first composition composed of core particles including sodium chloride that are coated with a coating layer containing one or more electrolytes, a second composition composed of core particles including a sugar that are covered with a coating layer containing one or more electrolytes, and an acid.

Abstract: A body fluid leak sensing device adapted for correctly informing only a caretaker of a leak of body fluid. The sensing device is miniaturized so as to properly operate in any worn state. A liquid sensor applicable to the body fluid leak sensing device is disposable and highly sensitive to even a small amount of body fluid. A sensor (1) comprises a water absorber (11) formed of a porous material with a high electrical resistance and an insulating coating film (14) on which the ends (12a, 13a) of the electrodes (12, 13) are secured at its sides and spaced from each other in such a way that one end (11a) of the water absorber (11) is exposed. There are provided means for detecting leak of body fluid by measuring the resistance of the sensor (1) and means for informing according to the detection.

Abstract: A peritoneal dialysis fluid used for a continuous recirculating peritoneal dialysis wherein the peritoneal dialysis fluid is infused into a peritoneal cavity of a patient and then, typically on a continuous process basis a portion of the dialysis fluid is sequentially drained from the cavity, cleansed through an extracorpreal dialyzer, and reinfused into the cavity. The dialysis fluid contains as an osmotic agent a substance which does not substantially permeate through pores of hollow fiber membrane of an extracorporeal dialyzer, preferably an osmotic agent having a molecular weight of about 20,000 to about 100,000. The supplemented amount of the osmotic agent is reduced or not needed during the dialysis.