Abstract: An object of the present invention is to provide a means for the measurement of amylase activity that exists in a biological sample such as saliva in a more convenient manner and particularly to provide a means (method and reagent) where a sample containing amylase in high concentration is directly measured without dilution. In the present invention, there has been found a method, which is an enzymatic method using a modified oligosaccharide substrate, comprising adding saccharide such as oligosaccharide that is competitive to the oligosaccharide substrate whereupon amylase activity in an amylase sample having a high activity value can be directly measured without dilution, and a result, the present invention has been achieved.

Abstract: A guide wire, which has excellent follow-up characteristics, sufficients contrasting characteristics and flexibility at a distal end portion thereof and high elasticity at a proximal end portion thereof, includes a core wire, and a coil wire provided on the distal end portion of this core wire coaxially therewith. The coil wire is formed by winding a plurality of wires, which are formed of different constituent materials and placed side by side on a plane, uniformly in an axial direction of the core wire so that the wires are adjacent to each other on the same plane.

Abstract: An object of the present invention is to provide a means for measuring amylase activity existing in biological samples such as saliva in a more convenient manner and is particularly to provide a means (reagent for measurement, method for measurement and apparatus) by which a sample containing high concentrations of amylase is measured. There has been found a means (reagent for measurement, method for measurement and apparatus), whereby amylase activity in an amylase sample having a high activity value can be quite conveniently measured by making an oligosaccharide substrate carry on a support in an enzymatic method for measuring amylase activity using a modified oligosacharide substrate, whereupon the present invention has been achieved.

Abstract: A protector sheath for winged needle capable of accommodating a winged needle having a needle tube with a sharp blade edge, a hub firmly attached to a proximal end portion of the needle tube, and a wing provided on the hub is provided. The protector sheath has a cylindrical main body, at least one slit is provided in a side wall of the main body, a proximal end portion of the slit is provided so as to be parallel to the axis of the main body, and a distal end portion of the slit is provided so as to extend in a direction which is not parallel to the axial direction of the main body.

Abstract: The present invention provides a nitrosylated albumin variant wherein one or more amino acid residues of constituent amino acid sequences are substituted, or a different amino acid residue is inserted into a part of the constituent amino acid sequences. The albumin variant has sufficient antimicrobial property and permits application as various useful pharmaceutical compositions.

Abstract: A graft grasping device includes a graft grasping member including a soft tubular grasping portion having a substantially C-shaped cross section and a suction tube which communicates with a lumen of the grasping portion and is connected to a side wall of the grasping portion. A recessed portion including at least a communication port which communicates with a lumen of the suction tube and the lumen of the grasping portion is formed on an inner wall of the grasping portion. The recessed portion is covered with a porous sheet and a mesh sheet is interposed between the recessed portion and the porous sheet.

Abstract: A blood collecting needle includes a hub having a hole axially formed therein, a needle tube inserted into the hole of the hub and having a sharp edge on each of the distal end and the proximal end of the needle tube, which respectively project from the hub, and a resilient cap mounted airtightly on the proximal end side of the hub and capable of accommodating a portion of the needle tube and the sharp edge on the proximal end of the needle tube, a small diameter portion being formed on the periphery of the hub, and further a thread portion being formed on the periphery of the hub on a proximal end side of the small diameter portion.

Abstract: [Object] To provide a syringe in which a covering member whose engagement has been released automatically moves to a projection movement terminal where it can be prevented from returning, and returning of a projection positioned at the projection movement terminal can be limited.

Abstract: A bioabsorbable release-sustaining pharmaceutical formulation using a biodegradable release-sustaining base material which can prevent an effective component drug from being released too rapidly just after administration of the formulation and then allow continued release of the drug for at least one month at a defined rate, is provided. For the biodegradable release-sustaining base material, a lactic acid-glycolic acid copolymer (PLGA) with an adjusted distribution in molecular weight is used.

Abstract: A female connector including: a cylindrical core member having a luer taper on a distal inner surface thereof and a tube bonding portion formed on a proximal end inner surface and being formed with a flange at a distal extremity thereof; a cylindrical housing having a male screw formed on an outer surface thereof and mounted to an outer periphery of the core member without being fixed, and a stopper fixed at a position apart from the flange of the core member, wherein the distance (L1) between the flange and the stopper is larger than the length (L2) of the housing in the axial direction when a male connector is connected to the female connector.

Abstract: A syringe-type container for liquid medicine which includes a barrel provided with an easily breakable piercing needle at a distal end of a needle-connecting portion thereof; a gasket inserted and held in the barrel; and a guide means fitted on the barrel from the distal side wherein. The syringe-type container is so constructed that turning of the guide means relative to the barrel breaks off the piercing needle from the needle-connecting portion.

Abstract: A dialyzer in which a nearly cylindrical case is provided therein with a hollow fiber bundle made of a plurality of hollow fiber membranes, a blood flow path formed by lumens of the hollow fiber membranes, a dialyzate flow path formed by a space between the inner wall of the case and the hollow fiber membranes and a cylindrical heat-shrinkable tube provided on the outside of the hollow fiber bundle and at least a part of which can be shrunk by heating, and a method for manufacturing the dialyzer.

Abstract: A guide wire having an elongated core wire provided with a tabular distal end portion, and a coiled wire provided on an outer circumference of the core wire, wherein the distal end portion of the core wire is provided with a cutout section or a rased section so that a diametrical cross-sectional area of the distal end portion of the core wire gradually decreases toward a distal end thereof.

Abstract: A needle for medical use, which is free from breakage of a cannula even if subjected to reapeated bending operations or puncture into the root of teeth in use. The needle is charactrized in that a cannula (2) is fixed to a hub (1) by charging a bonding adhesive in an adhesive-filling portion (11) provided in a distal end of the hub (1) so that a root (21) of the cannula (2) is located below the distal end (121) of the hub (1). The distal end of the hub (1) may be formed into a configuration provided with an annular rib (12) extending axially and surrounding the adhesive-filling portion (11).

Abstract: A holder comprises a base 1 having an inclined plane 11 increased in height from a distal end thereof to the proximal end thereof; air releasing means 2 provided on the proximal end of the base 1; and closing means 3 for closing an opening B1 of a flexible container set on the base 1. The closing means 3 comprises a pressure assembly 31 having closing bars 311, 312 extending in the direction perpendicular to the longitudinal axis X of the base 1,and a lever 32. The pressure assembly 31 is adapted to doubly seal the opening B1 of the flexible container B when the lever 32 is turned over toward the distal end of the base 1.

Abstract: A pharmaceutical for the prophylaxis and/or treatment of amyloidosis such as familial amyloid polyneuropathy is provided. A pharmaceutical for the prophylaxis and/or treatment of amyloidosis that contains a compound containing the trivalent chromium ion, such as a fatty acid chromium salt, as an active ingredient, and that is capable of suppressing the decomposition of mutant transthyretin in amyloidosis.

Abstract: An intracardiac suture device comprises a first shaft assembly 1 including a first shaft 11 and a first suture needle-holding device 4 provided at a distal end of the first shaft 11; a second shaft assembly 2 comprising a second shaft 21; a third shaft assembly 3 comprising a third shaft 31 and a handling portion 33; and a puncture assembly 5 provided at a proximal end thereof with a second suture needle-holding device 51. The second shaft 21 is protrusible by sliding-movement from the distal end of the first shaft 11 toward the first suture needle-holding device 4, and a suture needle 6 is transferable between the first suture needle-holding device 4 and the second suture needle-holding device 51 when the third shaft 31 is slid to the distal end of the second shaft 21 after sliding the second shaft 21 to a position where a suture site is held between the second shaft 21 and the first suture needle-holding device 4.

Abstract: A plural-chamber container capable of indicating whether or not a peelable partition wall is peeled and hence a medical professional can quickly become aware of a state of communication among respective chambers when using the plural-chamber container, wherein the plural-chamber container formed of a synthetic resin film and a plurality of chambers compartmentalized by a peelable partition wall formed by thermally welding part of the opposed films, characterized in that a means capable of indicating the peeling of the partition wall is provided on a surface of the plural-channel container.

Abstract: A connecting coupler which reduces the risk that an endotoxin or the like enters a dialysis solution and that the connecting coupler itself is deformed including a body made of an elastic material in which a tip portion of a connection plug of a dialyzer can be removably fitted into a plug-receiving opening portion of a solution transferring passage inside the body; a line connector which is fitted into the body and communicates with the solution transferring passage; a coupling tube which has a fixing portion fixedly fitted on the tip portion of the body and a coupling portion projecting from the fixing portion toward a front in an axial direction and removably fitable onto the connection plug; and a fixing mechanism which releasably fixes the coupling tube to the connection plug.

Abstract: A pin for forming a hole for inserting an indwelling needle 1 which includes a columnar inserting member 11 and an insertion stopping member 12 provided on a proximal end of the inserting member 1, the insertion stopping member 12 being provided with a recess 121 as a holding part.