Patents Assigned to Oxford University
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Patent number: 11959181Abstract: An electrolyser (F) for generating hydrogen from water, the electrolyser comprising an electrode (102), the electrode (120) comprising nanoparticles selected from Group 1 nanoparticles or alloys or composites or mixtures thereof.Type: GrantFiled: June 27, 2019Date of Patent: April 16, 2024Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Shik Chi Edman Tsang, Jiaying Mo
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Patent number: 11961187Abstract: The present invention relates to a method of producing a 3D centerline of an organ vessel from a plurality of 2D x-ray images. The method comprises the steps of producing a point-cloud of 3D points which represent intersecting and non-intersecting points between projection lines from the 2D images to their respective x-ray sources; fitting a compound curve to the points in the point-cloud of 3D points; removing outliers from the point-cloud; fitting a new compound curve to the remaining points in the point-cloud of 3D points; and repeating certain steps, wherein the resultant compound curve represents the 3D centerline of the organ vessel. The method minimizes reconstruction errors and produces an optimally-reconstructed 3D vessel skeleton.Type: GrantFiled: November 29, 2019Date of Patent: April 16, 2024Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Abhirup Banerjee, Robin P. Choudhury, Vicente Grau
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Patent number: 11948230Abstract: The present invention describes a new functional biomarker of vascular inflammation and its use in predicting all-cause or cardiac mortality. The invention also provides a method for stratifying patients according to their risk of all-cause or cardiac mortality using data gathered from a computer tomography scans of a blood vessel to determine a specific combination of structural and functional biomarkers of vascular inflammation and disease.Type: GrantFiled: December 7, 2022Date of Patent: April 2, 2024Assignee: Oxford University Innovation LimitedInventors: Charalambos Antoniades, Keith Channon, Evangelos Oikonomou, Stefan Neubauer
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Patent number: 11944674Abstract: The present invention relates to particles, particularly virus-like particles (VLPs), comprising fusion polypeptides comprising selected repeat units derived from the repeating regions of Type I and Type II circumsporozoite proteins (CSP) of Plasmodium vivax (Pv), together with an amino acid sequence derived from the C-terminal PvCSP sequence. In some embodiments, the fusion polypeptide additionally comprises an amino acid sequence derived from the N-terminal PvCSP sequence and/or a surface antigen polypeptide derived from Hepatitis B virus (HBV-S). The invention also relates to nucleotide sequences coding for such fusion polypeptides, vectors and plasmids comprising such nucleotide sequences, and host cells comprising such vectors and plasmids. The invention additionally relates to compositions, particularly vaccine compositions, comprising the fusion polypeptides or VLPs for use as vaccines for the prevention of malaria.Type: GrantFiled: December 13, 2021Date of Patent: April 2, 2024Assignee: Oxford University Innovation LimitedInventor: Arturo Reyes-Sandoval
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Patent number: 11943993Abstract: The present invention relates to a process for producing a layer of a crystalline A/M/X material, which crystalline A/M/X material comprises a compound of formula [A]a[M]b[X]c, wherein: [M] comprises one or more first cations, which one or more first cations are metal or metalloid cations; [A] comprises one or more second cations; [X] comprises one or more halide anions; a is an integer from 1 to 6; b is an integer from 1 to 6; and c is an integer from 1 to 18, wherein the process comprises disposing on a substrate a precursor composition comprising: (a) a first precursor compound comprising a first cation (M), which first cation is a metal or metalloid cation; and (b) a solvent, and wherein the solvent comprises: (i) a non-polar organic solvent which is a hydrocarbon solvent, a chlorohydrocarbon solvent or an ether solvent; and (ii) a first organic amine comprising at least three carbon atoms. Also described are compositions useful in the process of the invention.Type: GrantFiled: October 18, 2019Date of Patent: March 26, 2024Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Henry James Snaith, Bernard Wenger, Pabitra Kumar Nayak, Nakita Kimberly Noel
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Patent number: 11931735Abstract: Methods and apparatus for manufacturing a microfluidic arrangement are disclosed. In one arrangement, a continuous body of a first liquid is provided in direct contact with a first substrate. A second liquid covers the first liquid. A separation fluid, immiscible with the first liquid, is propelled through at least the first liquid and into contact with the first substrate along all of a selected path on the surface of the first substrate. First liquid that was initially in contact with all of the selected path is displaced away from the selected path. The first liquid is divided to form sub-bodies of first liquid that are separated from each other. For each of one or more of the sub-bodies, a sub-body footprint represents an area of contact between the sub-body and the first substrate, and all of a boundary of the sub-body footprint is in contact with a closed loop of the selected path surrounding the sub-body footprint.Type: GrantFiled: February 5, 2019Date of Patent: March 19, 2024Assignee: Oxford University Innovation LimitedInventors: Edmond Walsh, Alexander Feuerborn, Peter Richard Cook, Cristian Soitu
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Patent number: 11931374Abstract: The present invention relates to the use of adenosine receptor modulators to affect the circadian rhythm, in particular, to the use of such modulators for the treatment of circadian rhythm disorders. In particular, the invention relates to a composition comprising at least one selective adenosine receptor modulator, wherein said composition modulates two or three, but not all of adenosine receptor subtypes A1, A2A, A2B and/or A3 for use in the treatment of circadian rhythm disorders or for modulating a biological clock.Type: GrantFiled: June 25, 2020Date of Patent: March 19, 2024Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Sridhar Vasudevan, Aarti Jagannath, Russell Foster
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Patent number: 11937517Abstract: A superconducting quantum computing circuit package (1). The package contains a substrate (2) on which a circuit is formed, the circuit including a plurality of circuit elements. The substrate (2) includes holes (8) arranged between the circuit elements which extend through a thickness of the substrate (2). The package also contains a holder (3) with a surface (9) on which the substrate (2) is received, and a cover (4) arranged on an opposite side of the substrate (2). The holder (3) and the cover (4) are formed from a metal and/or a superconductor. The holder (3) also contains projections (12) arranged on and projecting from the surface (9). The projections (12) protrude through the holes (8) in the substrate (2) and contact the cover (4) so to suppress electromagnetic modes in the frequency range of operation of the quantum computing circuit.Type: GrantFiled: August 13, 2019Date of Patent: March 19, 2024Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Peter Spring, Peter Leek
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Publication number: 20240076734Abstract: The invention relates to a method for detection of analyte interaction with a channel molecule held in a membrane, comprising the optical detection of a modification in the flux of a signal molecule as it passes through the channel molecule by the action of a membrane potential, wherein the modification in the flux is caused by at least partial blockage of the channel molecule by the analyte. The invention further relates to bilayer arrays, components, methods of manufacture and use.Type: ApplicationFiled: June 16, 2023Publication date: March 7, 2024Applicant: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Mark WALLACE, Hagan Bayley, Shuo Huang, Oliver Castell, Mercedes Romero-Ruiz
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Patent number: 11921033Abstract: A single-shot Mueller matrix polarimeter (1700), MMP, comprising: a polarization state generator (1706), PSG, arranged to receive a source optical field (1704) and provide a probe field (1708) having a plurality of spatial portions, each portion having a different polarization state; a polarization state analyser (1718), PSA, arranged to receive a modified probe field (1716) resulting from interaction of the probe field generated by the PSG with a sample under investigation, and further arranged to apply, to each of a corresponding plurality of spatial portions of the modified probe field, a plurality of retardances and a plurality of fast axis orientations; and a detector (1720) arranged to detect an output (1722) of the PSA.Type: GrantFiled: December 9, 2019Date of Patent: March 5, 2024Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Martin Booth, Chao He
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Publication number: 20240069040Abstract: The present invention is directed to methods for confirming that a multiple sclerosis (MS) patient is suffering from a relapse. In particular, methods comprising: comparing a concentration of one or more metabolite(s) present in a sample obtained from the patient with the concentration of the same one or more metabolite(s) in a reference standard, wherein the one or more metabolite(s) are selected from: leucine, lysine, asparagine, phenylalanine, glucose, ?-hydroxybutyrate, myo-inositol, a lipoprotein having a —CH3 group of an HDL and/or LDL, a lipoprotein having a —CH3 group of a VLDL, a lipoprotein having a —(CH2)n group of an HDL and/or LDL, a lipoprotein having a ?CH2 group, and an N-acetylated glycoprotein; and confirming or not that the patient is suffering from a relapse.Type: ApplicationFiled: August 27, 2021Publication date: February 29, 2024Applicant: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Tianrong Yeo, Fay Probert, Daniel Anthony
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Patent number: 11908962Abstract: The invention provides an optoelectronic device comprising a porous material, which porous material comprises a semiconductor comprising a perovskite. The porous material may comprise a porous perovskite. Thus, the porous material may be a perovskite material which is itself porous. Additionally or alternatively, the porous material may comprise a porous dielectric scaffold material, such as alumina, and a coating disposed on a surface thereof, which coating comprises the semiconductor comprising the perovskite. Thus, in some embodiments the porosity arises from the dielectric scaffold rather than from the perovskite itself. The porous material is usually infiltrated by a charge transporting material such as a hole conductor, a liquid electrolyte, or an electron conductor. The invention further provides the use of the porous material as a semiconductor in an optoelectronic device. Further provided is the use of the porous material as a photosensitizing, semiconducting material in an optoelectronic device.Type: GrantFiled: March 7, 2022Date of Patent: February 20, 2024Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Henry Snaith, Michael Lee
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Publication number: 20240034757Abstract: The described invention relates to tick chemokine binding polypeptides (tick CKBPs, typically tick Evasins) including hybrid CKBPs based on sequences from two or more tick CKBPs, and the uses of such polypeptides in inhibition of chemokines or detection of chemokine expression and inflammation.Type: ApplicationFiled: January 12, 2023Publication date: February 1, 2024Applicant: Oxford University Innovation LimitedInventor: Shoumo Bhattacharya
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Patent number: 11885810Abstract: A method of detecting a membrane protein by mass spectrometry comprises: (a) providing a solution comprising a native membrane vesicle having a lipid bilayer to which said membrane protein is attached; (b) sonicating the vesicle in the presence of a mass spectrometry-compatible buffer; (c) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (d) vaporising the sonicated solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the vesicle; (e) ionising the membrane protein; (f) resolving the ionised membrane protein using the mass analyser; and (g) detecting the resolved membrane protein using the detector. Also provided are solutions comprising sonicated vesicles for use in mass spectrometry methods.Type: GrantFiled: August 30, 2019Date of Patent: January 30, 2024Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Dror S. Chorev, Carol V. Robinson
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Patent number: 11880916Abstract: The present invention describes a new functional biomarker of vascular inflammation and its use in predicting all-cause or cardiac mortality. The invention also provides a method for stratifying patients according to their risk of all-cause or cardiac mortality using data gathered from a computer tomography scans of a blood vessel to determine a specific combination of structural and functional biomarkers of vascular inflammation and disease.Type: GrantFiled: November 11, 2021Date of Patent: January 23, 2024Assignee: Oxford University Innovation LimitedInventors: Charalambos Antoniades, Keith Channon, Evangelos Oikonomou, Stefan Neubauer
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Patent number: 11873323Abstract: The present invention relates to a two-part linker comprising a peptide tag (peptide) and a polypeptide (protein) that is capable of spontaneously forming an isopeptide bond, particularly wherein: a) said peptide comprises an amino acid sequence as set forth in SEQ ID NO: 1, wherein: (i) X at position 1 is arginine or no amino acid; (ii) X at position 2 is glycine or no amino acid; (iii) X at position 5 is histidine or threonine; (iv) X at position 11 is alanine, glycine or valine; and (v) X at position 14 is arginine or lysine, wherein when X at position 1 is no amino acid, X at position 2 is no amino acid; and b) said polypeptide comprises: i) an amino acid sequence as set forth in SEQ ID NO: 2; ii) a portion of (i) comprising an amino acid sequence as set forth in SEQ ID NO: 101; iii) an amino acid sequence with at least 80% sequence identity to a sequence as set forth in SEQ ID NO: 2, wherein said amino acid sequence comprises a lysine at position 34, a glutamic acid at position 80 and one or more of theType: GrantFiled: July 12, 2021Date of Patent: January 16, 2024Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Mark Howarth, Anthony Keeble
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Patent number: 11864945Abstract: A system for diagnosing a heart condition comprises an imaging system (102) arranged to acquire two images of the heart at respective points in the cardiac cycle, and locating means, which may be manually operated or automatic, for locating a series of pairs of points on the images. Each pair of points indicates the respective positions of a single part of the heart in the two images. The system further comprises a processor (108) arranged to calculate from the positions of said pairs of points a value of at least one parameter of the deformation of the heart. It may further be arranged to compare the value of the at least one parameter with reference data to generate a diagnostic output.Type: GrantFiled: February 18, 2021Date of Patent: January 9, 2024Assignee: OXFORD UNIVERSITY INNOVATION LTD.Inventors: Ross Upton, Paul Leeson
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Patent number: 11860378Abstract: A device (100) for speckle reduction, comprising an optical cell (110) and a controller (130). The optical cell (110) comprises a first and second cell wall (121, 122) spaced apart by a gap, and a liquid crystal composition (114) in the gap. The controller (130) is configured to cause fluid turbulence in the liquid crystal composition. The fluid turbulence in the liquid crystal composition (114) results in time varying spatially random scattering of light (102) transmitted through the liquid crystal composition (114). The liquid crystal composition (114) has a chiral nematic phase.Type: GrantFiled: August 16, 2017Date of Patent: January 2, 2024Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: David J. Hansford, Julian A. J. Fells, Steve Elston, Stephen M. Morris
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Patent number: 11860119Abstract: A sensing method is described. The sensing method comprises providing a time-dependent electrical signal across a conductive connection between first and second terminals of a sensor, the conductive connection capacitively coupled to an environment via a mesoscopic probe element having an electroactive surface for exposure to the environment, the conductive connection having an associated relaxation time. The method further comprises receiving a time-dependent response signal from the sensor. The method further comprises analysing the time-dependent response signal with respect to the time-dependent electrical signal. The method further comprises determining, based on the analysis, a change in the relaxation time, the change in the relaxation time being correlated with an interaction between the electroactive surface and a measurand of the environment. A computer-readable medium, a sensing system and a sensor are also described.Type: GrantFiled: July 16, 2018Date of Patent: January 2, 2024Assignees: OXFORD UNIVERSITY INNOVATION LIMITED, UNIVERSIDADE ESTADUAL PAULISTA “JULIO DE MESQUITA FILHO”—UNESPInventors: Jason J. Davis, Paulo R. Bueno
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Patent number: 11857640Abstract: Recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors are provided. In particular, the an adenovirus vector having a capsid derived from chimpanzee adenovirus AdY25, wherein the capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest are provided.Type: GrantFiled: April 15, 2020Date of Patent: January 2, 2024Assignee: Oxford University Innovation LimitedInventors: Matthew Douglas James Dicks, Matthew Guy Cottingham, Adrian Vivian Sinton Hill, Sarah Gilbert