Abstract: The invention relates to the treatment or control of unipolar depressive disorder by administering a compound of Formula I or a salt thereof to a subject; wherein: E is S or Se; R1 and R2 are optional substituents, and are at each occurrence independently selected from: (1) a halogen, which is preferably selected from F, Cl and Br; (2) C1-C4 alkyl, such as C1-C2 alkyl or C1 alkyl, optionally substituted with one or more halogen atoms, each of which is preferably selected from F, Cl and Br; and (3) C1-C4 alkoxy, such as C1-C2 alkoxy or C1 alkoxy; optionally substituted with one or more halogen atoms, each of which is preferably selected from F, Cl and Br; m is an integer in the range of from 0 to 5; and n is an integer in the range of from 0 to 4.

Abstract: A compact microscope including an enclosure, a support element, a primary optical support element located within the enclosure and supported by the support element, at least one vibration isolating mount between the support element and the primary optical support element, a sample stage supported on the primary optical support element to support a sample, a return optical system to receive returned light from a sample and transmit returned light to a detection apparatus, wherein the return optical system is mounted on the primary optical support element, and wherein the compact microscope include a at least one of the following elements; a) an objective lens system, b) a temperature-control system, and c) the return optical system being operable to separate returned light into at least a first wavelength band and a second wavelength band.

Abstract: An electrode (1), the electrode (1) comprises a substrate (4, 5) on which is located a porous layer of a conducting or semi-conducting oxide (6) and having located thereon Ferredoxin NADP Reductase (FNR) (3). The electrode (1) can be used to drive organic synthesis via nicotinamide cofactor regeneration.

Abstract: The invention relates to perovskite compounds which have surprisingly good emission properties, particularly photoluminescent emission properties, in the blue region of the visible spectrum. These perovskites contain a mixture of cations or a mixture of halides, or both. The invention also relates to a photoactive material containing the perovskite species of the invention; to an optoelectronic device containing the photoactive material of the invention; to a method of producing blue light; and to the use of the photoactive material of the invention to emit blue light or as a phosphor.

Abstract: The invention provides a method for laser modification of a sample to form a modified region at a target location within the sample. The method comprises positioning a sample in a laser system for modification by a laser; measuring tilt of a surface of the sample through which the laser focusses; using at least the measured tilt to determine a correction to be applied to an active optical element of the laser system; applying the correction to the active optical element to modify wavefront properties of the laser to counteract an effect of coma on laser focus; and laser modifying the sample at the target location using the laser with the corrected wavefront properties to produce the modified region.

Abstract: An immunogenic composition comprising: a) one or more Plasmodium-derived ribosomal or ribosomal associated protein or immunogenic fragment thereof which has a sequence which is at least about 80%, 85%, 90%, 95%, 98%, 99% or 100% identical to a ribosomal or ribosomal associated protein or an immunogenic fragment of a ribosomal or ribosomal associated protein recited in FIG. 1; or a ribosomal or ribosomal associated protein or peptide or immunogenic fragment thereof as recited in FIG. 2 or FIG. 3; and/or b) a polynucleotide encoding one or more protein, peptide or immunogenic fragment of a); wherein the immunogenic composition is for use in eliciting an immune response in a subject to treat or prevent malaria. Also provided are Plasmodium-derived ETRAMPs and/or histones, or immunogenic fragments thereof, for use in eliciting an immune response in a subject, preferably to treat or prevent malaria.

Abstract: A molecular electronic device (10) includes a framework of polynucleotides (3), one or more molecular electronic components (4) and one or more electrical contacts (7). The molecular electronic components and the electrical contacts are each connected to the plurality of polynucleotides such that the molecular electronic components and the electrical contacts are located with respect to the framework and with respect to each other. This forms a coupling between the electrical contacts and the molecular electronic components.

Abstract: A method of performing a multiplication operation in the optical domain using a device (100) comprising: an optical waveguide (101), and a modulating element (102) that is optically coupled to the optical waveguide (101), the modulating element (102) modifying a transmission, reflection or absorption characteristic of the waveguide (101) dependant on its state, wherein the state of the modulating element (102) is adjustable by a write signal (103). The method comprises: encoding a first value to the write signal (103), using the write signal (103) to map the first value to a state of the modulating element (102); encoding a second value to a read signal (104); producing an output signal intensity as the transmitted or reflected read signal, wherein the product of the first value and the second value is encoded in the output signal intensity.

Abstract: The invention provides a process for producing a gel network, which gel network comprises a plurality of joined gel objects, which process comprises: forming a plurality of gel objects in one or more microfluidic channels; dispensing the gel objects from the one or more microfluidic channels into a region for producing the network; and contacting each gel object with at least one other gel object in said region to join each gel object to at least one other gel object at a region of contact between the gel objects. The invention also provides a network of joined gel objects, comprising a plurality of gel objects, wherein each gel object is joined to an adjacent gel object at a region of contact between the gel objects. Also provided are various possible uses of the gel network.

Abstract: A computer-implemented method 1000 of constructing a model of the motion of a mobile device, wherein the method comprises using a sensor of the device to obtain 1002 positional data providing an estimated pose of the mobile device, generating an initial graph 1004 based upon the positional data from the sensor, nodes of which graph provide a series of possible poses of the device, and edges of which graph represent odometry and/or loop closure constraints; processing the graph to estimate 1006 confidence scores for each loop closure by performing pairwise consistency tests between each loop closure and a set of other loop closures; and generating an augmented graph from the initial graph by retaining or deleting 1008 each loop closure based upon the confidence scores.

Abstract: A smart cell, comprising: a positive terminal; a negative terminal; a switching circuit which is arranged to select between a first switching state in which an energy storage device is connected between the positive terminal and the negative terminal and a second switching state which bypasses said energy storage device; an inductor provided between the positive terminal and the output of the switching network; and a controller arranged to monitor the voltage across the inductor and arranged to control a duty cycle of the switching circuit based on the magnitudes of voltage changes detected across the inductor. By monitoring and analysing the magnitude of voltage changes across the inductor, the controller determines the states of charge of other series connected smart cells without any communication between cells.

Abstract: The present invention relates to the electrochemical detection of an analyte by capacitance spectroscopy using a redox active polymer-coated electrode such as a polyaniline-coated electrode.

Abstract: A microfluidic arrangement for manipulating fluids is provided. The microfluidic arrangement comprises a substrate, a first fluid and a second fluid, which is immiscible with the first fluid. The first fluid is arranged to be at least partially covered by the second fluid. The first fluid is arranged in a desired shape on an unpatterned surface of the substrate. The first fluid is retained in said shape by a fluid interface between the first and second fluids. A microfluidic arrangement comprising an array of drops is also provided. The microfluidic arrangement comprises a substrate, a first fluid and a second fluid, which is immiscible with the first fluid. The first fluid is arranged to be at least partially covered by the second fluid. The first fluid is arranged to be covered at least partially by the second fluid. The first fluid is arranged in a given array of drops on an unpatterned surface of the substrate. Each drop cross section area having a (height:width) aspect ratio of (1:2) or less.

Abstract: The invention relates to a new method of determining the presence, absence, number or position(s) of one or more post-translational modifications in a peptide, polypeptide or protein. The invention uses transmembrane pores.

Abstract: Apparatus and methods for jet impingement cooling are provided. In one arrangement, a fluid channelling structure engages against a target surface to define a flow volume. Fluid is jetted onto the target surface from inlets and is removed via outlets. Flow directing features form a plurality of channels with no straight paths between inlets and outlets. A time averaged flow direction of fluid in contact with each flow directing feature is more nearly perpendicular to a direction of jetting of the fluid from a nearest inlet than parallel to the direction of jetting One or more pairs of the inlets and outlets are such that a majority of fluid jetted onto the target surface from the inlet of the pair will be removed from the flow volume through the outlet of the same pair.

Abstract: A method of characterising tremor stability in a subject is described for a subject having an involuntary tremor symptomatic of a neurological disorder. The method comprising: identifying a series of tremor cycles from measured tremor data of the subject, said tremor cycles measuring periodic variation in movement of the subject due to the tremor; determining an instantaneous frequency for each tremor cycle and collating the instantaneous frequencies; determining an instantaneous variation between the instantaneous frequencies of each pair of adjacent tremor cycles within the series; comparing the instantaneous variation to the collation of determined instantaneous frequencies to determine a distribution of instantaneous variations; and determining an index value of the distribution of the instantaneous variations, said index value defining the stability of the tremor.

Abstract: System monitors and methods of monitoring a system are disclosed. In one arrangement a system monitor predicts a future state of a system. A data receiving unit receives system data representing a set of one or more measurements performed on the system. A first statistical model is fitted to the system data. The first statistical model is compared to each of a plurality of dictionary entries in a database. Each dictionary entry comprises a second statistical model. The second statistical model is of the same general class as the first statistical model and obtained by fitting the second statistical model to data representing a set of one or more previous measurements performed on a system of the same type as the system being monitored and having a known subsequent state. A prediction of a future state of the system being monitored is output based on the comparison. The first statistical model and the second statistical model are each a stochastic process or approximation to a stochastic process.

Abstract: An optical device comprising a stack of the following layers: a capping layer; a layer of light absorber material; and a reflective layer, wherein the refractive index of the capping layer is at least 1.6.

Abstract: Embodiments of the present invention are directed to processes for the production of (R)-3-hydroxybutyl (R)-3-hydroxybyrate. Poly (R)-3-hydroxybyrate is transesterified with an alcohol, to form a first ester portion and a second ester portion. The first ester portion is reduced to the diol to form a diol portion and the diol portion is reacted with the second ester portion to produce (R)-3-hydroxybutyl (R)-3-hydroxybyrate.

Abstract: Described herein are antibody conjugates and methods of making antibody conjugates.