Abstract: A co-processor for performing a matrix multiplication of an input matrix with a data matrix in one step may be provided. The co-processor receives input signals for the input matrix as optical signals. A plurality of photonic memory elements is arranged at crossing points of an optical waveguide crossbar array. The plurality of memory elements is configured to store values of the data matrix. Input signals are connected to input lines of the optical waveguide crossbar array. Output lines of the optical waveguide crossbar array represent a dot-product between a respective column of the optical waveguide crossbar array and the received input signals, and values of elements of the input matrix to be multiplied with the data matrix correspond to light intensities received at input lines of the respective photonic memory elements. Additionally, different wavelengths are used for each column of the input matrix optical signals.

Abstract: The present invention relates to a process for producing a composition comprising an aqueous medium and, disposed in the aqueous medium, a first volume of a first hydrogel, which process comprises: (i) providing a composition comprising a first hydrophobic medium and, disposed in the first hydrophobic medium, a first volume of a first hydrogel; (ii) disposing a volume of an aqueous composition comprising a hydrogel compound around the first volume of the first hydrogel; (iii) allowing the aqueous composition comprising the hydrogel compound to form a gel and thereby forming a hydrogel object, which hydrogel object comprises the first volume of the first hydrogel and a second volume of a second hydrogel, which second volume of the second hydrogel is disposed around the first volume of the first hydrogel; and (iv) transferring the hydrogel object from the first hydrophobic medium to an aqueous medium and thereby producing the composition comprising the aqueous medium and, disposed in the aqueous medium, the fir

Abstract: A probe comprises a resistive element configured to be brought into thermal contact with an entity to be sensed. A measurement system applies a plurality of heating pulses to the resistive element by driving an electrical current through the resistive in element and measures an electrical response of the resistive element to the heating pulses in order to determine information about either or both of the composition and state of the entity. The measurement system generates an output signal using the measured electrical response, wherein the output signal is generated by progressively offsetting the measured electrical response such that, in the event of an average temperature of the resistive element changing between different heating pulses due to a drift in the average temperature of a portion of the entity being sensed, a variance over the plurality of heating pulses of a value of the output signal at a predetermined common reference point within each heating pulse is reduced.

Abstract: The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide constructs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments related to the inventive EVs.

Abstract: The present disclosure is directed to systems and methods of multiphase pseudo-continuous arterial spin labeling.

Abstract: The invention provides an optoelectronic device comprising a photoactive region, which photoactive region comprises: an n-type region comprising at least one n-type layer; a p-type region comprising at least one p-type layer; and, disposed between the n-type region and the p-type region: a layer of a perovskite semiconductor without open porosity. The perovskite semiconductor is generally light-absorbing. In some embodiments, disposed between the n-type region and the p-type region is: (i) a first layer which comprises a scaffold material, which is typically porous, and a perovskite semiconductor, which is typically disposed in pores of the scaffold material; and (ii) a capping layer disposed on said first layer, which capping layer is said layer of a perovskite semiconductor without open porosity, wherein the perovskite semiconductor in the capping layer is in contact with the perovskite semiconductor in the first layer.

Abstract: A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

Abstract: A method of manufacturing a polymer dispersed liquid crystal, PDLC, film, the method comprising: forming a region of liquid polymer (206) on a substrate (212); depositing one or more liquid crystal, LC, formulations (214) into the liquid polymer; and thereafter curing (234) the liquid polymer (206) to thereby induce phase separation between the polymer (206) and the liquid crystal formulations (214), resulting in PDLC pixels (236) which are phase separated from the surrounding, cured polymer—thereby producing a PDLC film.

Abstract: A surgical tool for separating two components, for example removing a femoral head from a femoral stem, having a four bar chain whose four bars are a first handle (L1), an crossover component (L2), a second handle (L3) and a crossbar (L4) pivotally connected respectively by: a first joint (J1) between the first handle and the crossover component; a second, crossover joint (J2) between the crossover component and the second handle; a third joint (J3) between the second handle and the crossbar, and a fourth joint (J4) between the crossbar and the first handle, and wherein, upon application of a gripping force to the first and second handles, the first and second jaws separate from one another so as to separate the two components engaged therewith.

Abstract: Described herein are methods and systems for extracting or determining subject motion from multi-channel electrical coupling in imaging of the subject, in particular in magnetic resonance (MR) imaging of the subject. The motion can be of a region of interest of the subject (such as an organ or specific tissue). Changes in the position of the subject and the subjects organs can be monitored by measuring how external coils, such as RF coils, couple to the subject and to one another and change the scattering of the RF coils, for example scattering of RF pulses transmitted by the coils. Changes in position influence this coupling and the scattering and can be detrimental to the quality of the imaging The present methods and systems address and overcome this problem.

Abstract: A composition, which may be in the form of a film, comprises a network of carbon nanotubes. One or more non-conjugated polymer molecules are associated with individual carbon nanotubes or small bundles of carbon nanotubes in the form of polymer-nanotube complexes.

Abstract: The invention provides an optoelectronic device comprising a photoactive region, which photoactive region comprises: an n-type region comprising at least one n-type layer; a p-type region comprising at least one p-type layer; and, disposed between the n-type region and the p-type region: a layer of a perovskite semiconductor without open porosity. The perovskite semiconductor is generally light-absorbing. In some embodiments, disposed between the n-type region and the p-type region is: (i) a first layer which comprises a scaffold material, which is typically porous, and a perovskite semiconductor, which is typically disposed in pores of the scaffold material; and (ii) a capping layer disposed on said first layer, which capping layer is said layer of a perovskite semiconductor without open porosity, wherein the perovskite semiconductor in the capping layer is in contact with the perovskite semiconductor in the first layer.

Abstract: Method of laser modifying an optical fibre to form a modified region at a target location within the fibre, comprising positioning at least a portion of an optical fibre in a laser system for modification by a laser, applying a correction to an active optical element of the laser system to modify wavefront properties of the laser to counteract an effect of aberration on laser focus, and laser modifying the optical fibre at the target location using the laser with the corrected wavefront properties to produce the modified region.

Abstract: The present disclosure relates to a system (100) for scoring motion of a heart wall (214, 218). The system (100) includes an imaging system (102) operable to acquire a first image (230) of the heart wall (214, 218) at a first time and a second image (240) of the heart wall (214, 218) at a second time. A processor (108) is provided to identify a first set of contour data in the first image (230); and a second set of contour data in the second image (240). The processor (108) defines at least one element (Ei) representing a cardiac cyclic change in a section of the heart wall (214, 218) in dependence on the first and second sets of contour data. Each element (Ei) is analysed to generate at least one metric which is compared with a reference data model to score the motion of the corresponding section of the heart wall (214, 218). The disclosure also relates to a method of scoring motion of a heart wall (214, 218); and a non-transitory computer-readable medium.

Abstract: A device for modulation of light (16) having a wavelength, comprising: a first substrate (10) with a first face (81) and a second opposite face (82), and comprising a first electrode (11); a second substrate (20) adjacent to the second face (82) and defining a gap between the first and second substrate (10, 20), the second substrate (20) comprising a second electrode (21); a responsive liquid crystal layer (15) disposed in the gap, wherein the responsive liquid crystal layer (15) has a flexoelectro-optic chiral nematic phase, and is birefringent with an optic axis that tilts in response to an applied electric field between the first and second electrode (11, 21); and a mirror adjacent to the second substrate (20), the mirror configured to reflect incident circular polarised light while preserving its handedness.

Abstract: The present invention relates to certain compounds, in particular, indole derivatives that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection.

Abstract: A computer-implemented method of determining the location of a mobile device comprising a camera. The method comprises the steps of capturing, using the camera, a sequence of images over a period of time; for pairs of consecutive images from the sequence of images, determining, using a first neural network, features indicative of the motion of the device between the time the first image of the pair of images was captured and the time the second image of the pair of images was captured; for a sequence of consecutive images, determining, using a second neural network, features indicative of the location of the device from the features determined by the first neural network; and for a sequence of consecutive images, determining the location of the device from the features determined by the second neural network.

Abstract: The invention provides a process for producing a printed article wherein a deposit liquid is provided to a substrate together with a carrier liquid. Also provided is a printed article obtained or obtainable by the process of the invention, such as a printed article. The invention further provides an apparatus suitable for carrying out the process of the invention, comprising devices configured to provide a flow of each of the deposit liquid and carrier liquid to a substrate, a flow channel for carrying each of the said liquids and an aperture through which at least the deposit liquid must pass. In some embodiments, the process of the invention is performed using the apparatus of the invention. The invention therefore also provides the use of the apparatus of the invention to perform the process of the invention.

Abstract: The present invention relates to conjugates formed from a cell-penetrating peptide carrier linked to a therapeutic molecule, wherein the peptide carrier is defined by specific domains and the therapeutic molecule is a nucleic acid formed of trinucleotide repeats. The present invention further relates to the use of such a conjugate in methods of treatment or as a medicament, especially in the treatment of trinucleotide repeat disorders such as myotonic dystrophy (DM1).

Abstract: This invention relates generally to antibodies or antigen binding fragments that bind to human B and T lymphocyte attenuator (BTLA) and uses thereof. More specifically, the invention relates to agonistic antibodies that bind human BTLA and modulate its activity, and their use in treating inflammatory, autoimmune and proliferative diseases and disorders.