Patents Assigned to Oxford University
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Publication number: 20220260594Abstract: The present invention relates to a method for determining conversion of a subject from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS), the method comprising: a. providing a sample obtained from the subject, wherein the subject has, or is suspected of having, CIS (preferably has CIS); b. measuring a concentration of: i. one or more polypeptides in the sample; and/or ii. one or more metabolites in the sample; c. comparing the measured concentration with the concentration of the same one or more polypeptides and/or metabolites, respectively, in a reference standard; and d. determining that the subject will convert from CIS to CDMS based on the comparison, or determining that the subject will not convert from CIS to CDMS based on the comparison. The invention also relates to methods for diagnosing multiple sclerosis (MS), to methods for determining prognosis of MS and to therapeutics and their uses in a method of treating MS in a subject.Type: ApplicationFiled: July 6, 2020Publication date: August 18, 2022Applicant: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Fay Probert, Daniel Anthony
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Patent number: 11414783Abstract: A method of fabricating one or more colour centres in a crystal is described. The method comprises focusing a laser into a crystal to induce the creation, modification, or diffusion of defects within a focal region of the laser. Fluorescence detection is used to determine when one or more colour centres are formed within the focal region and the laser is terminated when a desired number of colour centres have been formed. The method enables colour centres to be formed in a crystal with a high degree of control in terms of both the number and location of colour centres within the crystal, and a degree of control over other parameters such as colour centre orientation and local environment. In particular, it is possible to form a well-defined pattern of colour centres within a crystal.Type: GrantFiled: May 17, 2019Date of Patent: August 16, 2022Assignee: Oxford University Innovation LimitedInventors: Jason Smith, Martin Booth, Patrick Salter, Yu Chen Chen
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Patent number: 11406603Abstract: The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins.Type: GrantFiled: December 19, 2019Date of Patent: August 9, 2022Assignee: Oxford University Innovation LimitedInventors: John Hagan Pryce Bayley, Andrew Heron, Gabriel Villar
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Patent number: 11409698Abstract: A computer-implemented method of providing a materialisation of a set of logical rules on a logical database comprising a set of logical facts. Each of a plurality of parallel processing threads performs the following steps. A logical fact that has not previously been received by any thread is received by the thread. By applying any of the logical rules to the received logical fact and/or any of the logical facts received by any thread prior to the received logical fact, the thread determines whether a new logical fact is implied, and if so the new logical fact is added to the set of logical facts. The thread then repeats the above steps on any further logical facts in the set of logical facts that have not previously been received by any thread. When all threads are waiting for a new logical fact, the method has completed.Type: GrantFiled: September 18, 2020Date of Patent: August 9, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Boris Motik, Yavor Nenov, Ian Horrocks
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Publication number: 20220225890Abstract: The invention relates to sensing compositional information about material by measuring thermal properties of the material. In one arrangement there is provided a needle probe for sensing compositional information. The probe comprises a needle having a tip region. A resistive element is attached to the needle at the tip region. A measurement system is configured to: 1) drive an electrical current through the resistive element to apply heating to the resistive element, and 2) measure an electrical response of the resistive element to the heating. A processing unit analyses the measured electrical response of the resistive element to the heating to determine compositional information about material in contact with the tip region.Type: ApplicationFiled: April 8, 2022Publication date: July 21, 2022Applicant: Oxford University Innovation LimitedInventors: Kamaljit Singh CHANA, Parvinderpal Singh SAINS
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Patent number: 11393137Abstract: The present invention describes a new functional biomarker of vascular inflammation and its use in predicting all-cause or cardiac mortality. The invention also provides a method for stratifying patients according to their risk of all-cause or cardiac mortality using data gathered from a computer tomography scans of a blood vessel to determine a specific combination of structural and functional biomarkers of vascular inflammation and disease.Type: GrantFiled: October 31, 2017Date of Patent: July 19, 2022Assignee: Oxford University Innovation LimitedInventors: Charalambos Antoniades, Keith Channon, Evangelos Oikonomou, Stefan Neubauer
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Publication number: 20220220507Abstract: The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their uses in medicine. In particular, the present invention provides an adenoviral vector comprising the genome of an adenovirus other than AdHu5 and AdY25, wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the adenovirus and comprises heterologous E4Orfl, E4Orf2 and E4Orf3 coding regions from AdY25.Type: ApplicationFiled: January 28, 2022Publication date: July 14, 2022Applicant: Oxford University Innovation LimitedInventors: Sarah C. Gilbert, Adrian VS Hill, Matthew G. Cottingham, Matthew Dicks, Susan J. Morris, Alexander Douglas
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Patent number: 11387050Abstract: The present invention relates to an optoelectronic device comprising: (a) a substrate comprising at least one first electrode, which at least one first electrode comprises a first electrode material, and at least one second electrode, which at least one second electrode comprises a second electrode material; and (b) a photoactive material disposed on the substrate, which photoactive material is in contact with the at least one first electrode and the at least one second electrode, wherein the substrate comprises: a layer of the first electrode material; and, disposed on the layer of the first electrode material, a layer of an insulating material, which layer of an insulating material partially covers the layer of the first electrode material; and, disposed on the layer of the insulating material, the second electrode material, and wherein the photoactive material comprises a crystalline compound, which crystalline compound comprises: one or more first cations selected from metal or metalloid cations; one or mType: GrantFiled: October 5, 2016Date of Patent: July 12, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Henry James Snaith, Tomas Leijtens, Jack Alexander-Webber, Maximillian Tobias Hoerantner
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Patent number: 11384396Abstract: Method of detection or diagnosis of abnormal gene expression in an individual comprising determining in a sample from the individual the presence or absence of a chromosome structure in which two separate regions of the gene have been brought into close proximity, to thereby detect or diagnose whether the individual has abnormal gene expression.Type: GrantFiled: August 22, 2017Date of Patent: July 12, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Alexandre Akoulitchev, Aroul Selvam Ramadass, Leonid Leonidovich Nikitenko
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Patent number: 11369279Abstract: Systems and methods are provided to incorporate an off-resonance correction into the pulse labeling train of PCASL/VEPCASL. In one or more aspects, the systems and methods are based on a method for generating an encoding scheme for any number and arrangement of blood vessels. The off-resonance correction can be incorporated into the generation of optimized encodings to acquire arterial spin labeling (ASL) data, such as PCASL and VEPCASL data.Type: GrantFiled: April 8, 2016Date of Patent: June 28, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Eleanor Berry, Thomas Okell, Peter Jezzard
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Patent number: 11354527Abstract: A method and system for writing a label (defined within a predetermined region of the sample 110), the label displaying a visible layout of light-modified regions in a predetermined spatial arrangement. The method comprises: modifying regions of a material within the label using light, wherein the modifying comprises using light of a first polarisation state to provide photo-induced optically active regions of a first type having a first optical activity state which is characteristic of having been formed by light of the first polarisation state, in order to encode covert information in the label using the locations of the first type of light-modified regions within the spatial arrangement of the label.Type: GrantFiled: February 19, 2019Date of Patent: June 7, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Angus Ian Kirkland, Paul Ewart, Konstantin Borisenko, Ben Williams, Andrew Luers, Giuliano Siligardi, Rohanah Hussain
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Patent number: 11348274Abstract: A computer-implemented method of determining the location of a mobile device comprising a camera and at least one inertial sensor. A sequence of images are captured over a period of time, and a first neural network determines features indicative of the motion of the device from pairs of consecutive images. Data indicative of the motion of the device is captured, and a second neural network determines features indicative of the motion of the device from the data. A third neural network then determines features indicative of the location of the device from the features determined by the first neural network and the second neural network. The location of the device is the determined from the features determined by the third neural network.Type: GrantFiled: January 17, 2018Date of Patent: May 31, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Ronald Clark, Sen Wang, Agathoniki Trigoni
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Patent number: 11344576Abstract: The invention relates to induced pluripotent stem cells (iPSCs) produced from source dendritic cells (DCs). The invention also relates to synthetic DCs re-differentiated the iPSCs and which display a definitive adult phenotype rather than a primitive fetal/neonatal phenotype. The invention also relates to methods for making and methods of using the iPSCs and DCs of the invention.Type: GrantFiled: January 26, 2017Date of Patent: May 31, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventor: Paul J. Fairchild
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Publication number: 20220160905Abstract: The invention relates to a process for producing a compound comprising the anion [CF218FSO2]?, which process comprises treating a difluorocarbene source with (i) a source of 18F? and (ii) a source of SO2. The invention relates to a compound which comprises that anion. The invention also relates to the use of the compound comprising the anion [CF218FSO2]? to produce a compound comprising an 18F-trifluormethyl functionalised aromatic group. Compounds comprising an 18F-trifluoromethyl functionalised aromatic group are also the subject of the present invention.Type: ApplicationFiled: September 13, 2019Publication date: May 26, 2022Applicant: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Veronique Gouverneur, Choon Wee Kee, Osman Tack, Thomas Charles Wilson
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Patent number: 11324416Abstract: The invention relates to sensing compositional information about material by measuring thermal properties of the material. In one arrangement there is provided a needle probe for sensing compositional information. The probe comprises a needle having a tip region. A resistive element is attached to the needle at the tip region. A measurement system is configured to: 1) drive an electrical current through the resistive element to apply heating to the resistive element, and 2) measure an electrical response of the resistive element to the heating. A processing unit analyses the measured electrical response of the resistive element to the heating to determine compositional information about material in contact with the tip region.Type: GrantFiled: October 10, 2018Date of Patent: May 10, 2022Assignee: Oxford University Innovation LimitedInventors: Kamaljit Singh Chana, Parvinderpal Singh Sains
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Patent number: 11313842Abstract: A method for separating ionic species from an analyte solution to form a fractionated sample, the method comprising contacting the analyte solution with an ion-exchanger that is selectively permeable to ionic species of either a positive or negative charge, contacting an opposing side of the ion-exchanger with a draw solution, wherein the draw solution comprises adsorber particles dispersed in a liquid carrier, establishing a concentration gradient across the ion-exchanger to allow at least some ionic species from the analyte solution to permeate through the ion-exchanger to the draw solution, adsorbing ionic species that permeate from the analyte solution onto the adsorber particles, separating adsorber particles having the ionic species adsorbed thereto from at least part of the draw solution, and eluting the ionic species from the separated adsorber particles to form a fractionated analyte sample comprising eluted ionic species.Type: GrantFiled: June 12, 2018Date of Patent: April 26, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventor: Imad Ahmed
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Patent number: 11311509Abstract: The subject disclosure provides compositions for reducing serum cholesterol and/or triglyceride levels in subjects. These compositions can comprise racemic ?-hydroxybutyrate or D-?-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic ?-hydroxybutyrate or D-?-hydroxybutyrate, esters of D-?-hydroxybutyrate, oligomers of D-?-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject.Type: GrantFiled: November 29, 2018Date of Patent: April 26, 2022Assignees: OXFORD UNIVERSITY INNOVATION LIMITED, Government of the USA, as represented by the Secretary, Department of Health and Human ServicesInventors: Kieran Clarke, Richard Lewis Veech
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Patent number: 11306325Abstract: The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their uses in medicine. In particular, the present invention provides an adenoviral vector comprising the genome of an adenovirus other than AdHu5 and AdY25, wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the adenovirus and comprises heterologous E4Orf1, E4Orf2 and E4Orf3 coding regions from AdY25.Type: GrantFiled: June 23, 2017Date of Patent: April 19, 2022Assignee: Oxford University Innovation LimitedInventors: Sarah C. Gilbert, Adrian V S Hill, Matthew G. Cottingham, Matthew Dicks, Susan J. Morris, Alexander Douglas
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Patent number: 11304903Abstract: The invention provides a compartmentalised gel matrix comprising one or more compartments, wherein each compartment comprises a volume of hydrophobic medium and one or more aqueous droplets therein. The invention further provides a pharmaceutical formulation comprising a compartmentalised gel matrix according to the invention, a synthetic cell comprising a compartmentalised gel matrix according to the invention and a synthetic tissue comprising a compartmentalised gel matrix according to the invention.Type: GrantFiled: March 27, 2018Date of Patent: April 19, 2022Assignees: Oxford University Innovation Limited, Katholieke Universiteit LeuvenInventors: John Hagan Pryce Bayley, Kunwar Tanuj Sapra, Giovanni Maglia, Mariam Mohamed Abdelsattar Bayoumi
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Patent number: 11302833Abstract: The invention provides an optoelectronic device comprising a porous material, which porous material comprises a semiconductor comprising a perovskite. The porous material may comprise a porous perovskite. Thus, the porous material may be a perovskite material which is itself porous. Additionally or alternatively, the porous material may comprise a porous dielectric scaffold material, such as alumina, and a coating disposed on a surface thereof, which coating comprises the semiconductor comprising the perovskite. Thus, in some embodiments the porosity arises from the dielectric scaffold rather than from the perovskite itself. The porous material is usually infiltrated by a charge transporting material such as a hole conductor, a liquid electrolyte, or an electron conductor. The invention further provides the use of the porous material as a semiconductor in an optoelectronic device. Further provided is the use of the porous material as a photosensitizing, semiconducting material in an optoelectronic device.Type: GrantFiled: August 8, 2018Date of Patent: April 12, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Henry Snaith, Michael Lee