Abstract: The invention concerns a fusion polypeptide comprising a plurality of conserved peptide sequences, or variants thereof, wherein at least one of the conserved sequences is conserved across: i) HCV genotypes 1a and 1b; ii) HCV genotypes 1 and 3; or iii) HCV genotypes 1 to 6; and wherein at least one of the conserved peptide sequences comprises at least part of a sequence of a non-structural protein of the HCV genotypes; including associated nucleic acid and vector sequences, and use in methods of treatment or prophylaxis, such as vaccination.

Abstract: Methods and apparatus for driving flow in a microfluidic arrangement are provided. In one disclosed arrangement, the microfluidic arrangement comprises a first liquid held predominantly by surface tension in a shape defining a microfluidic pattern on a surface of a substrate. The microfluidic pattern comprises at least an elongate conduit and a first reservoir. The area of contact between the substrate and a portion of the first liquid that forms the elongate conduit defines a conduit footprint. The area of contact between the substrate and a portion of the first liquid that forms the first reservoir defines a first reservoir footprint. The size and shape of each of the conduit footprint and the first reservoir footprint are such that a maximum Laplace pressure supportable by the first liquid in the elongate conduit without any change in the conduit footprint is higher than a maximum Laplace pressure supportable by the first liquid in the first reservoir without any change in the first reservoir footprint.

Abstract: A method of operating a quantum information processing system. The quantum information processing system includes an array of connected qubits. The method of operating the quantum information processing system uses a linear network coding solution to performing an operation between the quantum states of two or more qubits of the array.

Abstract: The present invention relates to an immunogenic composition comprising two or more polypeptides. The invention also provides nucleic acid molecules and vectors encoding the polypeptides, and methods of using the compositions, nucleic acid molecules and vectors for the prevention or treatment of influenza.

Abstract: An optical device comprising a stack of the following layers: a capping layer; a layer of light absorber material; and a reflective layer, wherein the refractive index of the capping layer is at least 1.6.

Abstract: The present disclosure relates to novel dinucleotides comprising at least two locked nucleosides, one of which is directly attached to the 3? end of the triazole linker moiety and the other of which is directly linked to the 5? end of the triazole linker moiety and that are useful for the preparation of oligonucleotides. The disclosed dinucleotides may be used in gene therapy.

Abstract: Embodiments of the present invention provide a computer-implemented method of determining displacement information, comprising receiving (520) image data (485) comprising first pixel data (610) corresponding to movement of a scanning apparatus (130), with respect to at least one object, in a first direction and a second pixel data (620) corresponding to movement of the scanning apparatus (130) in a second direction, and determining (520) displacement information indicative of a displacement of at least a portion of the second pixel data (620) with respect to the first pixel data (610) by minimising a cost function indicative of a similarity between the first and second pixel data.

Abstract: A method (300) for generating random numbers including: mixing (304) a bright quantum state in a first mode with a vacuum input (15), in a two mode transformation for mixing the first mode and an orthogonal second mode; after mixing, detecting (306) the intensity in the first mode, and the second mode; generating random numbers (312) based on the difference between the detected intensity of the first mode and the second mode; and simultaneously to generating random numbers, certifying the numbers as random, based on the sum of the detected intensity of the first mode and the second mode, wherein certifying confirms that the process by which the random numbers are generated is quantum in origin and so the numbers are random.

Abstract: Methods, devices and systems for determining the frequency of a periodic physiological process of a subject, particularly respiration rate or heart rate, are disclosed. In one arrangement plural time windows of physiological data are obtained. Reference features corresponding to modulation modes are identified. Modulations of the reference features are extracted. Quality parameters are obtained by processing the extracted modulations. The quality parameters represent how strongly the extracted modulation exhibits a waveform of the periodic physiological process. The extracted modulations are processed to calculate the frequency of the periodic physiological process of the subject.

Abstract: The present invention relates to novel oligonucleotides comprising at least one locked nucleoside and at least one triazole inter-nucleoside linkage linkage of Formula A or Formula B and methods of making the same.

Abstract: The present invention relates to exosomes, loaded with biotherapeutic protein and/or peptide and methods of producing them and to the use of such exosomes for delivering protein and/or peptide in vivo, in particular the use of such exosomes in methods of therapy.

Abstract: The subject invention provides a method of preventing a consequence of an anticipated injury in a subject which comprises administering to the subject a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, so as to prevent the consequence of the anticipated injury.

Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

Abstract: There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising fragments of Reticulocyte-binding protein Homologue 5 (PfRH5). In particular, the invention provides fragments of PfRH5 rationally designed on the basis of the PfRH5 crystal structure, wherein said fragments which lack disordered regions, particularly the flexible N-terminal region and/or flexible central linker.

Abstract: A photonic device (100) comprising: an optical waveguide (101), and a modulating element (102) that is evanescently coupled to the waveguide (101); wherein the modulating element (102) modifies a transmission, reflection or absorption characteristic of the waveguide (101) dependant on its state, and the state of the modulating element (102) is switchable by an optical switching signal (125) carried by the waveguide (101), or by an electrical signal that heats the modulating element (102).

Abstract: A method for producing a continuous filament from electrospun fibers includes providing a conducting collection surface that is an elongate three-dimensional surface. An attractive electric field gradient is formed between the collection surface and a source of electrically charged fibers. The collection surface is moved in a longitudinal direction relative to the source of electrically charged fibers. The fibers are collected on the collection surface so as to form a continuous filament.

Abstract: The invention provides carriers and kits for use in the identification of ligands. Carriers of the invention are provided to which is attached a DNA encoding a peptide and a ?2 microglobulin. Carriers of the invention are capable of identifying an epitope recognized by a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell receptor. The invention also provides kits for screening for a T-cell epitope and/or an NK-cell epitope and/or an NKT-cell epitope, wherein the kits comprise a carrier of the invention.

Abstract: The present disclosure is directed to combined angiography and perfusion using radial imaging and arterial spin labeling.

Abstract: The invention provides a cerebral nitric oxide donor for use in a method for assessing the extent of brain dysfunction following brain injury, said method comprising contacting at least a portion of the brain of a subject with a brain injury with said cerebral nitric oxide donor and determining whether or not there is a subsequent change in one or more aspects of brain physiology, wherein the extent by which said one or more aspects of brain physiology improves is indicative of the extent of brain dysfunction.

Abstract: An imaging spectrometer (100) is provided, comprising: an entrance opening (101) configured to admit light to the spectrometer (100), a coded aperture (120), at least one dispersive element (111, 112), a two-dimensional array detector (130), and a plurality of converging optical elements (121, 122, 123, 124). The plurality of converging optical elements (121, 122, 123, 124) are configured to focus light from the entrance opening (101) at the coded aperture (120), and to focus light from the coded aperture (120) at the detector (130). The coded aperture (120) is arranged to modulate light from the entrance opening (101) in at least one of the spatial and spectral domain. The at least one dispersive element (111, 112) comprises a dispersive element (111, 112) between the coded aperture (120) and the detector (130). The at least one converging optical element (121, 122, 123, 124) comprises at least one concave reflector.