Abstract: This invention relates to compounds of formula 1, 2 or 3 a pharmaceutically acceptable salt, or solvate thereof, wherein X1, Y, R1, R2, R3, R4, and R5 are as defined herein. The compounds are antimicrobial agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1, 2 or 3.

Abstract: The present disclosure provides an effective stress cell for direct measurement of effective stress in saturated soil. The effective stress cell comprises a sensing diaphragm, a porous diaphragm, a connector and a strain sensor. The porous diaphragm allows pore-water to enter the interior space between the sensing diaphragm and the porous diaphragm to provide complete balance of pore-water pressures in the front and back of the sensing diaphragm. Thus, the effective stress cell can directly and accurately measure the effective stress in saturated soil using only one diaphragm at one location without measuring pore-water pressure.

Abstract: A thin-film composite polyamide reverse osmosis membrane with anti-bacterial and anti-biofouling effects and a preparation method thereof are disclosed. The preparation method includes: dissolving a highly water-stable metal organic framework CuBTTri in an n-hexane solution containing trimesoyl chloride by ultrasonic wave, immersing a polyethersulfone ultrafiltration membrane in an aqueous solution of m-phenylene diamine and taking out, and then immersing the ultrafiltration membrane in the trimesoyl chloride-n-hexane solution containing the aforementioned metal organic framework for reaction and modification, so as to obtain the thin-film composite polyamide reverse osmosis membrane. The resulting composite reverse osmosis membrane integrated with the anti-bacterial metal organic framework CuBTTri has a high reverse osmosis membrane permeability and possesses greatly improved and persistent anti-bacterial and anti-biofouling properties.

Abstract: A machine learning method predicts whether a specified subject is at high risk of developing cognitive impairment based upon a data record for said specified subject, and a method of training a dual neural network for such. These methods may work by automatically classifying said subject into a first class associated with a first predicted risk of cognitive impairment or a second class associated with a second predicted risk of cognitive impairment. Subject records are obtained comprising a first set of measured data and a second set of data including results for two or more health assessment questionnaires; and a label indicating that the subject belongs to the first class or second class. These records are used to train first and second neural networks, and in the latter method these trained networks are able to predict whether a specified subject should belong to said first class or second class.

Abstract: A spectacle lens can inhibit ametropia of the eyes and ensure full visibility. The spectacle lens comprises: first refraction areas and second refraction areas. Each first refraction area has a first refraction force that may be based on a prescription for correcting the ametropia of the eyes. Each second refraction area has a refraction force different from the first refraction force and may function to focus images on the positions except the retina of the eyes, to inhibit the development of the ametropia. Near the central part of the lens, the second refraction areas form a plurality of independent island-shaped areas, and the first refraction areas form the areas beyond the areas of the second refraction areas.

Abstract: This disclosure provides a biodegradable antimicrobial material based on polylactic acid oligomer represented by formula 1 as an active ingredient. The disclosure also provides a process for preparing the polylactic acid oligomer and an antimicrobial product prepared therefrom.

Abstract: The present invention relates to the preparation of a series of chiral DOTA, DO3A, DO2A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA-based compounds, and hence are potentially valuable as a platform for diagnostic applications. The chiral DOTAs reveal a high abundance of twisted square antiprism (TSA) geometry favoring them to be used as potential MRI contrast agents, whereas their rapid labelling properties at mild conditions make them excellent candidates for use as radiometal chelators.

Abstract: Disclosed is an apparatus for the batch polishing of workpieces, the apparatus includes an annular cavity, in which several workpieces are mounted, magnetic abrasives, which are arranged in the annular cavity and used for polishing the workpieces, and multiple magnet sets, which are used for generating a magnetic field for the magnetic abrasives in order to remove a surface material of the workpieces, wherein each of the magnet sets comprises magnets arranged on both inner and outer sides of the annular cavity and configured to rotate about the axis of the annular cavity.

Abstract: Methods and systems for storing digital data into peptide sequences and retrieving digital data from peptide sequences are disclosed. The method for storing digital data into peptide sequences may include: encoding the digital data into a digital code; translating the digital code into the peptide sequences; and synthesizing the translated peptide sequences. The method for retrieving digital data from peptide sequences may include: sequencing and determining an order of the peptide sequences; converting the peptide sequences with the determined order into a digital code; and decoding the digital data from the digital code. Codes with error-correction capability are developed for encoding digital data into peptide sequences, and a computational method implemented in a software is developed for sequencing the digital data bearing peptides.

Abstract: The present technology for the detection and analysis of analytes within a sample is based on molecular biology methods, including western blotting, gel electrophoresis, mass spectrometry, enzyme-linked immunosorbent assays and RT-PCR, which are normally time-consuming and laborious. The present disclosure provides novel OECT based electrochemical biosensors that can enable the convenient and cost-effective determination of analytes within a sample with high sensitivity and selectivity.

Abstract: Provided herein are a lithium electrode and a sulfur electrode for batteries. The lithium electrode comprises lithium metal and a metal-coated fabric. The fibers of the metal-coated fabric are covered by a metal layer, on which the lithium metal is attached. The sulfur electrode comprises a sulfur composite and a nickel-coated fabric. The fibers of the nickel-coated fabric are covered by a nickel layer, on which the sulfur composite is attached. The lithium electrode can inhibit dendrite formation and the sulfur electrode can speed up the redox kinetics of soluble polysulfides.

Abstract: Methods and systems for storing digital data into peptide sequences and retrieving digital data from peptide sequences are disclosed. The method for storing digital data into peptide sequences may include: encoding the digital data into a digital code; translating the digital code into the peptide sequences; and synthesizing the translated peptide sequences. The method for retrieving digital data from peptide sequences may include: sequencing and determining an order of the peptide sequences; converting the peptide sequences with the determined order into a digital code; and decoding the digital data from the digital code. Codes with error-correction capability are developed for encoding digital data into peptide sequences, and a computational method implemented in a software is developed for sequencing the digital data bearing peptides.

Abstract: The invention relates to a targeted seed implanting robot suitable for clinical human lithotomy position. The targeted seed implanting robot includes a rack, and further includes a position and posture adjusting mechanism, a contact force feedback friction wheel type targeted seed implant and a sine elastic amplification moment compensation mechanism; and the specific use steps are as follows: S1, driving; S2, meshing; S3, swing; S4, transverse movement; S5, compensation moment; S6, linear motion; S7, rotary motion; S8, detection; and S9, transmission of information.

Abstract: The present disclosure relates to a surface comprising a photocatalyst affixed thereupon via an adhesive layer and methods for affixing the photocatalyst to the surface via the adhesive layer. The present disclosure also provides a purifier comprising the photocatalyst affixed surface and a purifier system comprising such purifier.

Abstract: Aspects of the present application relate to techniques of diagnosing whether a pathogen (e.g., SARS-CoV-2) is present in a subject using infrared (IR) spectroscopy and machine learning techniques. The techniques use spectral data obtained from performing IR spectroscopy on a biological sample (e.g., saliva or nasal sample, or genetic material extracted therefrom) to generate a set of feature values. The feature values are provided as input to a machine learning model to obtain output indicating whether the pathogen is present in the biological sample. The output of the machine learning model may be used to determine a diagnosis result for a subject.

Abstract: Aspects of the present application relate to techniques of diagnosing whether a pathogen (e.g., SARS-CoV-2) is present in a subject using infrared (IR) spectroscopy and machine learning techniques. The techniques use spectral data obtained from performing IR spectroscopy on a biological sample (e.g., saliva or nasal sample, or genetic material extracted therefrom) to generate a set of feature values. The feature values are provided as input to a machine learning model to obtain output indicating whether the pathogen is present in the biological sample. The output of the machine learning model may be used to determine a diagnosis result for a subject.

Abstract: PbI2 thin film crystallization control is prerequisite of high-quality perovskite layer for the sequentially solution-processed perovskite solar cells. According to the present invention, an efficient-and-simple method has been developed by adding halogen acid additive to improve perovskite thin-film quality and an efficiency of at least 15.2% is obtained. This approach improves coverage, uniformity and stability of pervoskite thin-film. In addition, a nanofiber scaffold is incorporated into the perovskite layer so as to reduce the amount of grain boundaries, thus substantially reducing electron recombination within these boundaries.

Abstract: An electrode for a battery, comprising an active material and a metallic fabric is disclosed. The metallic fabric comprises fibers being at least partially covered by a coating of nickel or copper, which comprises a layer and a plurality of protrusions protruding from the layer. The active material is attached on the protrusions. The metallic fabric provides a high electrical conductivity and a high mechanical stability, and demonstrates outstanding performance for the use as a current collector of battery.

Abstract: Leachate remediation is performed by synergistic chemical oxidation and photocatalytic-oxidation enhancer system (SCOPES) of municipal landfill leachate to a level that is safe for disposal within regulatory guidelines. The physico-chemical (chemical, spectroscopic, elemental, microstructural and thermal) characteristics of the pre- and post-treated landfill leachate have been investigated to examine the utility of advanced oxidation (AO) processes such as SCOPES to decontaminate the municipal landfill leachate and/or toxic organic wastewater. The experimental results demonstrated successful lowering of chemical oxygen demand (COD) and UV-Vis absorbance for constituent contaminants in the leachate and/or wastewater solutions.

Abstract: The present invention discloses an anchoring apparatus and an operation method thereof. The anchoring apparatus includes: a movable framework (1); a folding-type working platform (2) that includes a working platform frame (203), a longitudinal guide (204), a transverse guide (205) and a central turntable (206), the longitudinal guide (204) being movable along the transverse guide (205), and the central turntable (206) driving the longitudinal guide (204) and the transverse guide (205) to rotate relative to the working platform frame (203); a drilling machine (3); a workpiece supply system (4); and a power control system (5) that drives the movable framework (1) to move. With the anchoring apparatus, the mechanical and automatic anchoring with anchor bolts and anchor cables can be implemented in anchoring, the labor intensity in anchoring can be greatly reduced, the efficiency of anchoring can be improved, and the safety in the entire process can be enhanced.