Abstract: A non-invasive glucose sensor (10) for detecting an amount of glucose in bodily fluid, comprising: an organic electrochemical transistor (OECT) having a gate electrode (20); wherein a surface of the gate electrode (20) is modified with an enzyme and a nanomaterial to increase sensitivity and selectivity of the gate electrode (20).
Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.
Type:
Grant
Filed:
March 1, 2013
Date of Patent:
April 4, 2017
Assignees:
The Hong Kong Polytechnic University, McGill University
Inventors:
Larry Ming Cheung Chow, Tak Hang Chan, Kin Fai Chan, Iris Lai King Wong, Man Chun Law
Abstract: A method for stabilizing conjugates between macromolecule and nanoparticle by forming a thin reinforcement layer over the surface of a nanoparticle after macromolecule chains have attached to the surface of the nanoparticle. The stabilized conjugates can be used in a wide range of applications such as in vitro diagnostics, in vivo imaging and therapeutics, which need to be conducted under various severe or harsh conditions.
Type:
Grant
Filed:
April 3, 2012
Date of Patent:
March 28, 2017
Assignee:
The Hong Kong Polytechnic University
Inventors:
Thomas Ming Hung Lee, Kwun Fung Wong, Shea Ping Yip
Abstract: The present invention relates to a smart textile capable of providing acupuncture therapy to the wearer through strategically positioned electrodes throughout the textile, connected via silver coated fabric. Through the instant invention, heat therapy can be applied to specific points on the body, while being safe due to the absence of wires.
Type:
Grant
Filed:
July 7, 2008
Date of Patent:
March 21, 2017
Assignee:
The Hong Kong Polytechnic University
Inventors:
Li Li, Raymond Wai-man Au, Thomas K. S. Wong, Yi Li, Joanne W. Y. Chung, Sai Ho Wan
Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.
Type:
Grant
Filed:
February 26, 2015
Date of Patent:
February 7, 2017
Assignee:
The Hong Kong Polytechnic University
Inventors:
Larry Ming-Cheung Chow, William Tak Hang Chan, Kin-Fai Chan, Iris Lai King Wong, Wing-Yiu Kan
Abstract: A sensor for measuring flow speed of a fluid, comprising: a light-absorbing optical fiber having a fiber Bragg grating inscribed in the fiber; wherein light is emitted into the light-absorbing optical fiber to heat the optical fiber and the fiber Bragg grating, and when the fluid passes over the sensor, the flow speed of the fluid is determined by the rate of heat loss from the sensor, and the temperature of the sensor is determined from the wavelength shift of the central wavelength of the fiber Bragg grating.
Type:
Grant
Filed:
July 12, 2011
Date of Patent:
January 31, 2017
Assignee:
The Hong Kong Polytechnic University
Inventors:
Hwayaw Tam, Aping Zhang, Shaorui Gao, Lok Hin Cho
Abstract: A system and method relate to receiving, by a processing device, a plurality of sound signals captured at a plurality of microphone sensors, wherein the plurality of sound signals are from a sound source, and wherein a number (M) of the plurality of microphone sensors is greater than three, determining a number (K) of layers for a multistage minimum variance distortionless response (MVDR) beamformer based on the number (M) of the plurality of microphone sensors, wherein the number (K) of layers is greater than one, and wherein each layer of the multistage MVDR beamformer comprises one or more mini-length MVDR beamformers, and executing the multistage MVDR beamformer to the plurality of sound signals to calculate an estimate of the sound source.
Abstract: A semi-crystalline shape memory polymer with transition temperature near body temperature and the production method thereof is disclosed. The shape memory polymer comprises a polymer chain which further comprises a plurality of prepolymers and a plurality of chain extenders bonding the prepolymers together in which each prepolymer further comprises a plurality of synthesized units. The above mentioned synthesized unit is obtained by reacting polymer diol with first diisocyanate. The obtained synthesized units are polymerized together with second diisocyanate and chain extender to form the shape memory polymer.
Type:
Grant
Filed:
June 10, 2013
Date of Patent:
December 27, 2016
Assignee:
The Hong Kong Polytechnic University
Inventors:
Jinlian Hu, Yong Zhu, Jianping Han, Jing Lu
Abstract: An intelligent adjustable mannequin having a body shape parameter input module and a mannequin backbone structure, the mannequin including an adjustment plate on the backbone structure according to body shape parameters, a curse adjustment mechanism positioned between the adjustment plate and the backbone structure, the backbone structure is also provided with a detector which detects the body shape parameters, and a relative movement between the adjustment plate and the backbone structure is controlled by the girth adjustment mechanism to achieve precise adjustment of body shape curse parameters. The backbone structure is further provided with a length adjustment mechanism to control upward and downward movements of respective parts of the backbone structure to achieve precise adjustment of length parameters.
Abstract: The present invention discloses a contactless 3D biometric feature identification system and the method thereof. The system comprises of a fixed-viewpoint image capturing means, a lighting module capable of producing different illuminations on the object of interest and a microprocessor configured to execute a biometric identification algorithm. The algorithm starts with capturing a plurality of images with different illuminations. The captured images are then utilized to reconstruct a three dimensional surface model. Different features, for instance 2D and 3D coordinates and orientations of the biometric feature, surface curvature of the object and the local surface orientation of the object, are extracted from the captured images and the reconstructed 3D surface model. Different matching scores are also developed based on the aforesaid features to establish the identity of the biometric features.
Abstract: A multispectral imaging color measurement system, comprising a dark room, a sample platform and an imaging device for capturing said object being measured; a controllable illumination device, a filter wheel unit, an imaging signal processing unit and an electronic control unit. A method for processing imaging signals of the multispectral imaging color measurement is also proposed. The multispectral imaging color measurement system and the method for processing imaging signals thereof can overcome the inaccuracy of traditional digital imaging systems and the limits of spectrophotometer systems and provide users in the textile industry with highly accurate color measurement and evaluation.
Abstract: A posture correction girdle comprises a body wrapping shell, a plurality of pockets and a plurality of paddings is disclosed. The paddings are configured to be inserted into pockets at predetermined positions. Thereby, when the posture correction girdle is worn by the user, pressure is exerted onto a corresponding predetermined section of the user's spine for posture correction purpose. The posture correction girdle further comprises a pair of elastic shoulder straps, an elastic waist strap and a plurality of elongated bones to provide additional support to the user's spine. A micro-system comprising a processor, an output device and a plurality of sensors can also be embedded into the posture correction girdle to provide information regarding the efficiency of the posture correction girdle and the progression of the treatment. Such information is provided to the users using the output device.
Type:
Grant
Filed:
April 7, 2013
Date of Patent:
July 26, 2016
Assignee:
The Hong Kong Polytechnic University
Inventors:
Yiu Wan Joanne Yip, Kit Lun Yick, Chi Yung Tse, Chun Wah Marcus Yuen, Sun Pui Ng, Pak Yiu Liu, Ka Ming Law
Abstract: The present invention provides a site-specific pegylated arginase conjugate and method for producing thereof. The site-specific pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method for producing the arginase conjugate comprises genetically modifying the gene encoding an arginase so that the PEG moiety can be attached to the enzyme at a predetermined, specific intended sites. This is achieved by removing the PEG-attaching amino acid residue(s) at undesirable site(s) while keeping or adding cysteine(s) at the desirable site(s) of the enzyme. Two exemplary embodiments of the pegylated arginase conjugate are directed to human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys45 of the enzyme and Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys161 of the enzyme.
Abstract: The invention relates to a preparation method of a polymeric phase-change material, comprising: using 1, 2 or 3 of (meth)acrylate poly(ethylene glycol) n-alkyl ether ester as a raw material, wherein the (meth)acrylate poly(ethylene glycol) n-alkyl ether ester has a structural general formula of CH2?C(CH3)—COO(CH2CH2O)mCnH2n+1 or CH2?CH—COO(CH2CH2O)mCnH2n+1, m=1 to 100, and n=10 to 50; washing the raw material with a solution of sodium hydroxide, potassium hydroxide, sodium carbonate or potassium carbonate having a mass percentage of 1% to 10% to remove a polymerization inhibitor, and subjecting reduced-pressure distillation, and then to a polymerization reaction by adopting one of the following process; 1. polymerization reaction initiated by irradiation; 2. polymerization reaction initiated by an initiator; 3.
Type:
Grant
Filed:
March 21, 2013
Date of Patent:
June 7, 2016
Assignee:
Tianjin Polytechnic University
Inventors:
Xing Xiang Zhang, Xiao Fen Tang, Jie Yun Meng, Hai Feng Shi, Zhi Li Zhang
Abstract: A method for retarding or reversing progression of myopia of a viewer includes providing an object in front of the viewer; providing a transparent layer between the viewer and the object; and providing a primary image on the transparent layer, the transparent layer allows the viewer to see the object as a secondary image simultaneously with the primary image, wherein the secondary image is focused in front of the central region of the retina. A method for reducing hyperopia of a viewer includes providing an object in front of the viewer to provide a primary image; providing a transparent layer between the viewer and the object; providing a secondary image on the transparent layer, the transparent layer allows the viewer to see the primary image simultaneously with the secondary image, wherein the secondary image is focused behind the central region of the retina. Other systems are also described herein.
Abstract: A method of fabricating Fiber Bragg gratings in a micro/nanofiber using ultrashort pulse irradiation, the method includes elongating and flame-brushing a single mode optical fiber to create a micro/nanofiber, and generating the ultrashort pulse irradiation to induce a plurality of refractive index changes at predetermined intervals within the micro/nanofiber, wherein the ultrashort pulse propagates through a focusing element and a diffractive element prior to propagating on the micro/nanofiber.
Abstract: The present invention relates methods of preparing quinoline derivative compounds, and administering such compounds in the treatment of solid and non-solid tumors, notably on liver cancer.
Type:
Grant
Filed:
August 21, 2007
Date of Patent:
April 26, 2016
Assignee:
The Hong Kong Polytechnic University
Inventors:
Albert Sun-chi Chan, Johnny Cheuk-on Tang, Kim-hung Lam, Chung-hin Chui, Stanton Hon-lung Kok, Sau Hing Chan, Filly Cheung, Roberto Gambari, Chor Hing Cheng
Abstract: The present invention relates to a system for product storage and methods of categorizing, storing, and delivering products to end users via the system, the system's components including a processor, a “smart shelving” device, boxes for insertion into and utilization by the “smart shelving” device, and ID readers. Through the present invention, products are able to be securely and more certainly delivered to the proper recipient of the products.
Abstract: A vertical type light emitting diode includes a nitride semiconductor having a p-n conjunction structure with a transparent material layer formed on a p type clad layer, the transparent material layer having a refractive index different from that of the p type clad layer and having a pattern structure of mesh, punched plate, or one-dimensional grid form, etc. A reflective metal electrode layer is formed on the transparent material layer as a p-electrode. A stereoscopic pattern is formed in the transparent material layer and the p-electrode deposited, and thereby forming the pattern in the p-electrode. Depositing the p-electrode on only 10 to 70% of the upper portion of the p type clad layer in an ultraviolet ray light emitting diode such that an area where the p type clad layer is exposed is wide increases the transmittance of ultraviolet rays through an area where the p-electrode is not deposited.
Type:
Application
Filed:
March 28, 2014
Publication date:
April 7, 2016
Applicant:
Korea Polytechnic University Industry Academic Cooperation Foundation