Patents Assigned to Purdue Research
  • REINFORCEMENT LEARNING BASED CLOSED-LOOP NEUROMODULATION SYSTEM
    Publication number: 20230191130
    Abstract: The neuromodulation system includes a sensor, a recording amplifier, a processor, and a stimulator. The neuromodulation system is configured to provide stimulation and control of an intended target. The processor utilizes a closed-loop feedback system which is configured to actively sense target brain states and apply corrective stimulation or feedback as dictated by its effectors. The processor implements reinforcement learning which creates real-time statistical models of current and recent past neural states which actively and automatically learns stimulation paradigms which create paths from pathological to nominal brain states.
    Type: Application
    Filed: December 17, 2022
    Publication date: June 22, 2023
    Applicant: Purdue Research Foundation
    Inventors: Edward Lee Bartlett, Brandon Steven Coventry
  • Optical quantum logic for use in large operational spaces
    Patent number: 11681200
    Abstract: A method of generating a photon with multiple dimensions includes a step of generating a first photon encoded with quantum information in each of two or more frequency bins and at least one time bin. The method further includes performing a frequency dependent time operation to entangle (i.e. make non-separable) the frequency bins and the time bins in the photon.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: June 20, 2023
    Assignee: Purdue Research Foundation
    Inventors: Andrew Weiner, Poolad Imany
  • Systems and methods for analyzing an analyte extracted from a sample using an adsorbent material
    Patent number: 11680876
    Abstract: Systems and methods for analyzing an analyte extracted from a sample using an adsorbent material.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: June 20, 2023
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Wenpeng Zhang
  • Semiconductor device and method of making the same
    Patent number: 11682749
    Abstract: A light emitting diode (LED) including a first contact. The LED further includes a first semiconductor layer over the first contact. The first semiconductor layer comprises hexagonal Boron Nitride. Additionally, the LED includes a second semiconductor layer over the first semiconductor layer. The second semiconductor layer comprises at least one hexagonal Boron Nitride quantum well and at least one hexagonal Boron Nitride quantum barrier. Moreover, the LED includes a third semiconductor layer over the second semiconductor layer. The third semiconductor layer comprises hexagonal Boron Nitride. Further, the LED includes a second contact over the third semiconductor layer.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: June 20, 2023
    Assignee: Purdue Research Foundation
    Inventor: Tillmann Christoph Kubis
  • Separation assembly for handheld metal detectors
    Patent number: 11681067
    Abstract: A separation assembly for use with handheld metal detectors. According to one aspect, the separation assembly is mounted to a handheld metal detector having a blade containing transmission and receiver components of the handheld metal detector. The separation assembly includes at least a first separation member formed of a nonferromagnetic material, and the first separation member is spaced a lateral separation distance from the blade of the handheld metal detector. The separation assembly may be incorporated as a permanent and integrated part of a handheld metal detector, or separately manufactured and installed on a handheld metal detector.
    Type: Grant
    Filed: December 28, 2021
    Date of Patent: June 20, 2023
    Assignee: Purdue Research Foundation
    Inventors: James Eric Dietz, Anthony David Hustedt, Michael Patrick Scott, Maria Nicole Carter, Blake Peter Wesling
  • CONTINUOUS FLOW SONOGASHIRA COUPLING SYNTHESIS METHOD
    Publication number: 20230183246
    Abstract: The present disclosure relates to a telescoped continuous flow Sonogashira coupling synthesis for some lead compounds to support in vivo studies and pre-clinical evaluation. The application of high throughput tools combined with the telescoped continuous synthesis method can enable an efficient and safe synthesis of compounds of interest involving hazardous coupling reagents such as HATU, while minimizing by-product formation.
    Type: Application
    Filed: May 13, 2021
    Publication date: June 15, 2023
    Applicant: Purdue Research Foundation
    Inventors: David Harley Thompson, Herman O. Sintim, Qingqing Qi, Shruti Biyani
  • Systems and methods for performing multiple precursor, neutral loss and product ion scans in a single ion trap
    Patent number: 11676805
    Abstract: The invention generally relates to systems and methods for performing multiple precursor, neutral loss and product ion scans in a single ion trap. In certain aspects, the invention provides systems including a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply at least one of the following ion scans to a single ion population in the single ion trap: multiple precursor ion scans, a plurality of segmented neutral loss scans, or multiple simultaneous neutral loss scans.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: June 13, 2023
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder
  • Depth-resolved mid-infrared photothermal imaging of living cells and organisms with sub-micron spatial resolution
    Patent number: 11674897
    Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: June 13, 2023
    Assignee: Purdue Research Foundation
    Inventors: Delong Zhang, Ji-Xin Cheng
  • MACHINE LEARNING ASSISTED SUPER RESOLUTION MICROSCOPY
    Publication number: 20230177642
    Abstract: A method of providing super-resolved images of a photon emitting particle is disclosed, which includes providing a machine-learning (ML) platform, wherein the ML platform is configured to receive pixel-based sparse autocorrelation data and generate a predicted super-resolved image of a photon emitting particle, receiving photons from the photon emitting particle by two or more photon detectors, each generating an electrical pulse associated with receiving an incident photon thereon, generating sparse autocorrelation data from the two or more photon detectors for each pixel within an image area, and inputting the pixel-based sparse autocorrelation data to the ML platform, thereby generating a predicted super-resolved image of the imaging area, wherein the resolution of the super-resolved image is improved by ?n as compared to a classical optical microscope limited by Abbe diffraction limit.
    Type: Application
    Filed: July 6, 2022
    Publication date: June 8, 2023
    Applicant: Purdue Research Foundation
    Inventors: Zhaxylyk A. Kudyshev, Demid Sychev, Zachariah Olson Martin, Simeon I. Bogdanov, Xiaohui Xu, Alexander Kildishev, Alexandra Boltasseva, Vladimir Shalaev
  • SEPARATIONS MEMBRANE AND METHOD OF MAKING THE SAME
    Publication number: 20230173437
    Abstract: The separations membrane system includes a substrate, a microporous layer, and a selective layer. The microporous layer may be disposed over the substrate. The selective layer may be disposed over the microporous layer, thereby sandwiching the microporous layer between the selective layer and the substrate. The microporous layer includes a thermoplastic material. The selective layer includes a polyamide structure of 2,2-Dimethyl-1,3-propanediamine and/or 1,3,5-Benzenetricarbonyl chloride.
    Type: Application
    Filed: December 5, 2022
    Publication date: June 8, 2023
    Applicant: Purdue Research Foundation
    Inventors: John Alan Howarter, Michael D. Toomey, Logan Kearney
  • Method of making components with metal matrix composites and components made therefrom
    Patent number: 11666974
    Abstract: Components made of a metal matrix composite and methods for the manufacture thereof. The metal matrix composite contains TiB2 particles, Al3Ti particles, and particles of an intermetallic compound of aluminum and at least one rare earth element dispersed in an aluminum matrix. Methods include casting a first melt to produce an ingot, remelting the ingot to form a second melt, forming a powder from the second melt using an atomization process, and fabricating a component utilizing the powder in an additive manufacturing process. The ingot and the powder include an aluminum matrix that contains dispersions of TiB2 particles and Al3Ti particles.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: June 6, 2023
    Assignee: Purdue Research Foundation
    Inventors: Xiaoming Wang, Qingyou Han
  • Methods of nanoscale directional wetting and uses thereof
    Patent number: 11666941
    Abstract: This invention discloses a method for controlling nanoscopic wetting near or at a molecular scale for synthetic material applications. In particular this invention relates to a method for preparing a monolayer or thin film with a patterned nanoscopic wetting surface using a ‘sitting’ phase of polymerizable amphiphile, wherein hydrophobic alkyl chains of the amphiphile extend along the supporting surface and the amphiphile molecules align side-to-side, effectively forming a repeating cross-section of bilayer with alternating hydrophilic and hydrophobic stripes of a ˜6 nm pitch tunable based on the chain length of the amphiphile. Products prepared according to the methods disclosed herein are within the scope of this invention. In some embodiments, monolayers or thin films so prepared are transferable.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: June 6, 2023
    Assignee: Purdue Research Foundation
    Inventors: Shelley A Claridge, Shi Wah Choong, Jae Jin Bang, Shane Richard Russell
  • In-memory bit-serial addition system
    Patent number: 11669302
    Abstract: An in-memory vector addition method for a dynamic random access memory (DRAM) is disclosed which includes consecutively transposing two numbers across a plurality of rows of the DRAM, each number transposed across a fixed number of rows associated with a corresponding number of bits, assigning a scratch-pad including two consecutive bits for each bit of each number being added, two consecutive bits for carry-in (Cin), and two consecutive bits for carry-out-bar (Cout), assigning a plurality of bits in a transposed orientation to hold results as a sum of the two numbers, for each bit position of the two numbers: computing the associated sum of the bit position; and placing the computed sum in the associated bit of the sum.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: June 6, 2023
    Assignee: Purdue Research Foundation
    Inventors: Mustafa Ali, Akhilesh Jaiswal, Kaushik Roy
  • Scaffold of adenylyl cyclase inhibitors for chronic pain and opioid dependence
    Patent number: 11667623
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: June 6, 2023
    Assignee: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel Patrick Flaherty, Jatinder Kaur
  • Soy protein straw and manufacturing process thereof
    Patent number: 11666164
    Abstract: The present application relates to environmentally friendly, biodegradable drinking straw manufactured from renewable resources and more specifically to drinking straws manufactured from soy protein isolate and the manufacturing process thereof. The manufacturing process and its products are within the scope of this disclosure.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: June 6, 2023
    Assignee: Purdue Research Foundation
    Inventors: Morgan J Malm, Natalie Stephenson, Ruth Zhong
  • Methods of enhancing the deformability of ceramic materials and ceramic materials made thereby
    Patent number: 11667576
    Abstract: Methods of determining and controlling the deformability of ceramic materials, as a nonlimiting example, YSZ, particularly through the application of a flash sintering process, and to ceramic materials produced by such methods. Such a method includes providing a nanocrystalline powder of a ceramic material, making a compact of the powder, and subjecting the compact to flash sintering by applying an electric field and thermal energy to the compact.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: June 6, 2023
    Assignee: Purdue Research Foundation
    Inventors: Xinghang Zhang, Haiyan Wang, Jin Li, Jaehun Cho, Xin Li Phuah, Han Wang
  • 3D printed fluoropolymer-based energetic compositions
    Patent number: 11660806
    Abstract: Three-dimensional (3D) printed fluoropolymer-based energetic compositions are made using 3D printing methods. The 3D printed fluoropolymer-based energetic compositions comprise a fluoropolymer and a reactive metal or metal oxide. The total weight percentage of the fluoropolymer and the reactive metal or metal oxide is 70-100% of the 3D printed fluoropolymer-based energetic composition, and the weight percentage of the reactive metal or metal oxide is 5-85 wt % of the total weight of the 3D printed fluoropolymer-based energetic material. The 3D printed fluoropolymer-based energetic material has a thickness of at least 200 ?m.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: May 30, 2023
    Assignee: Purdue Research Foundation
    Inventors: Jeffrey Frederick Rhoads, George Tsu-Chih Chiu, Ibrahim Emre Gunduz, Trevor John Fleck, Allison Kelly Murray, Steven Forrest Son
  • COMPOUNDS WITH IMMUNOMODULATORY ACTIVITY AND THERAPEUTIC USES THEREOF
    Publication number: 20230159475
    Abstract: The present invention generally relates to new compounds for therapeutic uses. In particular, the disclosed series compounds with immunomodulatory activities are useful for treatment of dysfunctions of the immune system and various cancers. Pharmaceutical composition matters and methods for treating a patient with an immune disease and/or a cancer by administering therapeutically effective amounts of such compound alone or together with other therapeutics are within the scope of this disclosure.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 25, 2023
    Applicant: Purdue Research Foundation
    Inventors: Gaurav Chopra, Prageeth Wijewardhane, Krupal P. Jethava, Jonathan Fine
  • Axially-offset differential interference contrast correlation spectroscopy
    Patent number: 11656164
    Abstract: A method of obtaining a measurement signal representative of the particle size distributions in nanocrystal suspensions that includes a step of providing a first light beam along a first axis to a first micro-retarder array to generate polarization wavefront shaped light. The shaped light is applied to an objective configured to focus two orthogonally polarized components of the polarization wavefront shaped light to produce first and second axially offset foci along the first axis. A sample having particles in suspension is disposed in one foci to produce a measurement optical signal having phase and intensity values corresponding to at least some of the particles in suspension. The method also includes determining intensity and quantitative phase information as a function of time based on the optical signals.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: May 23, 2023
    Assignee: Purdue Research Foundation
    Inventors: Garth Jason Simpson, Chen Li, Changqin Ding
  • Expandable apparatus for detecting RF signals and related method
    Patent number: 11656302
    Abstract: An apparatus for detecting RF signals in magnetic resonance testing procedure includes a multidirectional stretchable fabric and a flexible radio frequency (RF) coil. The flexible RF coil has a coil shape, and comprises conductive fiber stitched into the stretchable fabric in a plurality of repeating, non-linear stitch patterns. The plurality of stitch patterns collectively define the coil shape.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: May 23, 2023
    Assignee: Purdue Research Foundation
    Inventors: Joseph Vincent Rispoli, Jana M. Vincent