Patents Assigned to Regents of the University of Minnesota
  • Publication number: 20220195689
    Abstract: One example is directed to an end effector position estimation system for an off-road vehicle, which includes at least one inertial measurement unit (IMU) configured to be positioned on at least one of actuators and links of the vehicle that together move the end effector of the vehicle, and configured to generate measurement signals. The position estimation system includes at least one other IMU configured to be positioned on a base of the vehicle, and configured to generate other measurement signals. The position estimation system includes an estimation unit to estimate a position of the end effector of the vehicle based at least in part on the measurement signals and the other measurement signals, wherein the estimation unit is configured to perform an estimation method that removes an influence of terrain-induced vibrations and terrain slope in the measurement signals based on the other measurement signals.
    Type: Application
    Filed: December 17, 2021
    Publication date: June 23, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: Rajesh Rajamani, Gregory W. Johnson
  • Patent number: 11357743
    Abstract: Pharmaceutical formulations comprising ketamine, propofol, and a lipid are provided. Methods of making the formulations and methods of using the formulations to provide sedation, amnesia, analgesia, anxiolysis, and/or stable hemodynamics are also provided.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: June 14, 2022
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Nathan J. Smischney, Wayne T. Nicholson, Jayanth Panyam
  • Publication number: 20220169995
    Abstract: A trans-disciplinary system for cell-free biosynthesis includes a cell-free transcription-translation (TX-TL) tool and modular, generalizable microfluidic architectures. Both components of the system are independently functional and are combinable into a cell-free biosynthesis platform. In the first component, modular plasmid libraries are used to program bacterial cell-free TX-TL systems. Each plasmid holds one gene or operon, and all the genes are controlled by the same promoter, so that the stoichiometry of enzyme synthesis is determined by the stoichiometry of plasmids in the reaction. In the second part, in order to facilitate high throughput mixing and matching of gene units from the modular plasmid libraries, a modular, reconfigurable, flexible, and scalable microfluidic architecture is employed.
    Type: Application
    Filed: October 6, 2021
    Publication date: June 2, 2022
    Applicants: Massachusetts Institute of Technology, Regents of the University of Minnesota
    Inventors: Andreas Mershin, Vincent Noireaux, James Francis Pelletier, Neil A. Gershenfeld
  • Publication number: 20220168342
    Abstract: Genonie-edited primary B cells, methods of making genome-edited primary B cells, a therapeutic cassette that can be introduced into primary B cells, and methods of using the genome-edited primary B cells and the therapeutic cassette.
    Type: Application
    Filed: September 12, 2017
    Publication date: June 2, 2022
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Branden S. MORIARITY, John HUNZEKER, Matthew JOHNSON, Kanut LAOHARAWEE
  • Patent number: 11337391
    Abstract: This document relates to materials and methods for generating early flowering oilseed (e.g., pennycress) plants. For example, oilseed plants (e.g., modified oilseed plants) having one or more modifications in a polypeptide involved in early flowering (e.g., early flowering six (ELF6)), as well as materials and methods for making and using early flowering oilseed plants are provided.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: May 24, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Michael David Marks, Kevin Dorn
  • Publication number: 20220153061
    Abstract: A non-pneumatic tire defining axial, radial, and circumferential directions. The tire includes an annular lattice structure extending radially between an inner circumferential edge and an outer circumferential edge. The lattice structure exhibits topological polarization, with the inner circumferential edge being stiffer than the outer circumferential edge. The topological polarization includes asymmetry in mechanical response to opposing forces applied to the inner and outer circumferential edges. The lattice structure which provides topological polarization endows the tire with localized softness along the outer radius, which enables extreme absorption of asperities, without transferring significant forces to the axle. In some embodiments, the lattice structure further exhibits topological protection, including the topological polarization characteristics being maintained upon experiencing wear at the outer circumferential edge.
    Type: Application
    Filed: November 16, 2021
    Publication date: May 19, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: Stefano Gonella, William Zunker
  • Patent number: 11331030
    Abstract: A system and method for cardiac activation imaging includes non-invasively or minimally invasively acquiring data about an electrical activation of a heart of a subject using at least one sensor. An activation image of the heart of the subject is reconstructed using a weighted sparse constrained reconstruction.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: May 17, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Bin He, Long Yu
  • Patent number: 11332749
    Abstract: Real-time systems for monitoring base editing in living cells, including base editing by APOBEC-Cas9 fusions, is provided herein.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: May 17, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Reuben S. Harris, Daniel James Salamango, Amber Renee St. Martin
  • Patent number: 11332499
    Abstract: Certain embodiments of the invention provide a cyclic compound of formula I: wherein: Pro is a residue of L-proline; X1 is a residue of Arg or DArg; X2 is a residue of Phe or DPhe; X3 is a residue of Phe, DPhe or hPhe; X4 is a residue of a natural or unnatural amino acid; X5 is a residue of Ala, Asp, Glu, Lys, His, Phe, Ser, Leu or Gly; X6 is a residue of Phe, Ala, Gly, Ser, Lys, Asp, Leu, Nle, Trp, Tyr, Cha or hPhe; and DPro is a residue of D-proline; or a salt thereof. Certain embodiments also provide compositions comprising such compounds, as well as methods of using such compounds and compositions.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: May 17, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Carrie Haskell-Luevano, Mark Ericson
  • Patent number: 11328757
    Abstract: In some examples, a device includes a dielectric material, a ferromagnetic material, and a topological material positioned between the dielectric material and the ferromagnetic material. The device is configured to trap electric charge inside the dielectric material or at an interface of the dielectric material and the topological material. The device is configured to switch a magnetization state of the ferromagnetic material based on a current through the topological material or based on a voltage in the topological material.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: May 10, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Jian-Ping Wang, Protyush Sahu
  • Patent number: 11318311
    Abstract: Described here is a deep brain stimulation (“DBS”) approach that targets several relevant nodes within brain circuitry, while monitoring multiple symptoms for efficacy. This approach to multi-symptom monitoring and stimulation therapy may be used as an extra stimulation setting in extant DBS devices, particularly those equipped for both stimulation and sensing. The therapeutic efficacy of DBS devices is extended by optimizing them for multiple symptoms (such as sleep disturbance in addition to movement disorders), thus increasing quality of life for patients.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: May 3, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Gregory Frederick Molnar, Luke Johnson, David Escobar Sanabria, Edward Mark Bello, II, Jerrold L. Vitek, Matthew D. Johnson
  • Patent number: 11320284
    Abstract: A method includes accessing information stored for positions along a road and using the accessed information to identify an expected trajectory for a vehicle. Position information for the vehicle is received from a global positioning system for two different time points and is used to determine a trajectory of the vehicle. The trajectory of the vehicle and the expected trajectory are used to determine a lateral offset of the vehicle from the expected trajectory and the lateral offset is used to determine when to issue a lane departure warning for the vehicle.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: May 3, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: M. Imran Hayee, Muhammad Faizan, Shah Hussain
  • Patent number: 11320323
    Abstract: Techniques are described for additive manufacturing, e.g., 3D printing, stretchable tactile sensors. As described, the techniques may allow the stretchable tactile sensors to be 3D printed under ambient conditions via nanocomposite inks. In various embodiments, sinter-free inks are described with adjustable viscosities and electrical conductivities. Moreover, conductive compositions are described in which micron or submicron-sized silver particles are dispersed in a highly stretchable silicone elastomer. Techniques are described herein in which the inks are used 3D printing process to form tactile sensing platforms and integrated arrays.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: May 3, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Michael C. McAlpine, Shuangzhuang Guo
  • Patent number: 11321506
    Abstract: Systems, methods, and computer-readable media are provided for simulating the coupled axial/torsional dynamics of drilling systems.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: May 3, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Emmanuel Detournay, Ganesh Ramakrishnan, Kaixiao Tian
  • Patent number: 11311008
    Abstract: A cryopreservation composition generally includes a cryoprotective agent and a laser absorber that includes a metal. Rewarming a cryopreserved specimen that includes the cryopreservation composition includes subjecting the cryopreserved specimen to a laser pulse effective to heat the laser absorber sufficiently to thaw the cryopreserved biospecimen.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: April 26, 2022
    Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA., SMITHSONIAN INSTITUTION
    Inventors: John Bischof, Kanav Khosla, Zhenpeng Qin, Mary Margaret Hagedorn, Cari Suzanne Dutcher
  • Patent number: 11311855
    Abstract: An example method of removing hydrogen sulfide from an input gas includes exposing an adsorbent material to an input gas to obtain an output gas. A concentration of hydrogen sulfide of the output gas is less than a concentration of hydrogen sulfide of the input gas. The adsorbent material includes copper oxide, magnesium oxide, and aluminum oxide. An atomic ratio of copper to magnesium to aluminum of the adsorbent material is X:Y:Z, where X is greater than or equal to 0.6 and less than or equal to 0.9, where Y is greater than or equal to 0 and less than or equal to 0.2, where Z is greater than or equal to 0 and less than or equal to 0.2, and where X+Y+Z is equal to 1.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: April 26, 2022
    Assignees: Regents of the University of Minnesota, Khalifa University of Science and Technology
    Inventors: Michael Tsapatsis, Veerappan Vaithilingam Balasubramanian, Yasser Al Wahedi, Saleh Al Hashimi
  • Patent number: 11311541
    Abstract: The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD (cGVHD) using compounds having the formulae 1-XXV, as set forth herein.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: April 26, 2022
    Assignees: KADMON CORPORATION, LLC, REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Alexandra Zanin-Zhorov, Bruce Robert Blazar, Ryan Flynn
  • Patent number: 11307165
    Abstract: Solid-contact electrodes include a molecular redox buffer that is covalently attached to one of the components of the electrodes. These electrodes can be incorporated into electrochemical sensor systems. The electrode components are an electron conductor, a membrane and optionally, an interlayer. The electrode includes covalent attachment of the molecular redox buffer to the interlayer, to the electron conductor or the membrane. The interlayer includes nanoporous carbon such as CIM-carbon. The molecular redox buffer includes a well-defined redox pair, e.g., a complex of Co(II)/Co(III). The electrodes are ion-selective electrodes (ISEs) or reference electrodes. Methods include constructing solid contact electrodes and using the electrodes in electrochemical sensor systems to determine the quantity of an analyte in a sample. The electrochemical sensor systems include disposable paper-based devices and/or wearable devices for measuring analytes in a sample.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: April 19, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Jinbo Hu, Philippe Buhlmann, Andreas Stein, Xue Zhen
  • Patent number: 11309018
    Abstract: A method includes setting an output of each memory cell in an array of memory cells to a same first value, decreasing power to the array of memory cells and then increasing power to the array of memory cells. Memory cells in the array of memory cells with outputs that switched to a second value different from the first value are then identified in response to decreasing and then increasing the power. A set of memory cells is then selected from the identified memory cells to use in hardware security.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: April 19, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Muqing Liu, Chen Zhou, Keshab K. Parhi, Hyung-Il Kim
  • Patent number: 11306192
    Abstract: A foam that includes a polylactide polymer in the form of a star polymer having at least three arms. The foam is an open cell foam having a density no greater than 0.1 g/cm3.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: April 19, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Philip T. Dirlam, David J. Goldfeld, Marc A. Hillmyer