Patents Assigned to Regents of the University of Minnesota
  • Patent number: 11027121
    Abstract: In accordance with some embodiments of the disclosed subject matter, mechanisms (which can, for example, include systems, methods, and media) for directional coordinated reset deep brain stimulation are provided. In some embodiments, a method is provided, comprising: implanting a lead with segmented electrodes into an anatomical structure; selecting a first subset of the electrodes corresponding to the anatomical structure as active electrodes; causing electrical pulses at a first stimulation level to be applied at the active electrodes in a first sequence; causing electrical pulses at a second stimulation level that is lower than the first stimulation level to be applied at the active electrodes in a second sequence during a second time period; and inhibiting electrical pulses from being applied at inactive electrodes during the second time period.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: June 8, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Jing Wang, Gregory F. Molnar, Jerrold L. Vitek
  • Patent number: 11022602
    Abstract: The invention provides a conjugate of formula I: R-L-Y?? I or a salt thereof, wherein R, L, and Y have any of the values described in the specification, as well as compositions comprising a conjugate of formula I. The conjugates are useful for labeling.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: June 1, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Erin Elizabeth Carlson, Shabnam Sharifzadeh
  • Patent number: 11015149
    Abstract: Bioactive coatings that include a base and a protein associated with the base for actively promoting the removal of organic stains are provided. In aspects, bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: May 25, 2021
    Assignees: Toyota Motor Corporation, Regents of the University of Minnesota
    Inventors: Andreas Buthe, Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Minjuan Zhang
  • Patent number: 11014921
    Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1, R2, and R3 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as immunomodulating agents.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: May 25, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Sunil A. David, Janardhan Banothu, Mallesh Beesu, Michael Brush
  • Patent number: 11017880
    Abstract: Disclosed in some examples are methods including selecting a first plurality of single gene mutants from a pool of possible single gene mutants of an organism. The first plurality of single gene mutants is less than a number of possible single mutants. A computer processor is used to iteratively select a second plurality of single gene mutants by selecting single gene mutants from the pool of possible single gene mutants that increases a sum of products of similarities between the first plurality of single gene mutants and corresponding functional relationships. The second plurality of single gene mutants is larger in number than the first plurality of single gene mutants, and wherein the second plurality of single gene mutants is less than the number of possible single gene mutants of the organism. A set of genes is outputted comprising the first and second pluralities of single gene mutants.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 25, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Raamesh Deshpande, Justin Nelson, Chad L. Myers, Scott William Simpkins
  • Patent number: 11018689
    Abstract: In some examples, a device includes shuffling circuitry configured to receive an input unary bit stream and generate a shuffled bit stream by selecting n-tuple combinations of bits of the input unary bit stream. The device also includes stochastic logic circuitry having a plurality of stochastic computational units configured to perform operations on the shuffled bit stream in parallel to produce an output unary bit stream, each of the stochastic computational units operating on a different one of the n-tuple combinations of the bits.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: May 25, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Soheil Mohajer, Zhiheng Wang, Kiarash Bazargan, Marcus Riedel, David J. Lilja, Sayed Abdolrasoul Faraji
  • Publication number: 20210147496
    Abstract: The invention provides antibiotic BPI Fold Containing Family A Member 2 (BPIFA2) peptides, compositions comprising a BPIFA2 peptide, hydrogels comprising a BPIFA2 peptide, nanofibrillar networks comprising a BPIFA2 peptide, and tissue scaffolds comprising BPIFA2 peptides. The peptide, compositions, hydrogels nanofibrillar networks and tissue scaffolds are useful for medical therapy in an animal.
    Type: Application
    Filed: November 16, 2020
    Publication date: May 20, 2021
    Applicant: Regents of the University of Minnesota
    Inventors: Sven-Ulrik Gorr, Conrado Aparicio, Zhou Ye
  • Patent number: 11009576
    Abstract: Described here are systems and methods for volumetric excitation in magnetic resonance imaging (“MRI”) using frequency modulated radio frequency (“RF”) pulses. In general, quadratic phase modulation along the slice encoding direction is implemented for additional spatiotemporal encoding, which better distributes signal content in the slice direction and enables higher acceleration rates that are robust to slice-undersampling.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: May 18, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Steen Moeller, Mehmet Akcakaya
  • Patent number: 11009577
    Abstract: A system and computerized method for generating magnetic resonance imaging (MRI) images is provided that includes accessing data acquired from a subject using an MRI system that includes Nyquist ghosts and processing the data using a cost function that exploits a cosine and sine modulation in a ghosted image component of the data. An image of the subject is produced from the data after processing the data using the cost function.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: May 18, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Jessica McKay, Patrick Bolan
  • Publication number: 20210139899
    Abstract: Described herein are compositions that inhibit/degrade STAT3, and methods of using such compositions for chemoprevention of non-small cell lung cancer (NSCLC).
    Type: Application
    Filed: March 28, 2019
    Publication date: May 13, 2021
    Applicant: Regents of the University of Minnesota
    Inventors: Jill M. SIEGFRIED, Christian Nzinkeu NJATCHA, Mariya FAROOQUI
  • Patent number: 11003908
    Abstract: A method of determining whether to treat soybeans for soybean aphids, the method includes collecting at least one image of a soybean canopy using one or more remote sensing instruments and processing the image into spectral reflectance data and selecting from the spectral reflectance data optimal spectral wavelength bands. The selected reflectance data is classified into one of a plurality of classification groupings using a machine learned classification model. To treat or not treat the soybean canopy for aphids is determined based on the classification of the reflectance data into one of the class groupings.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: May 11, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Robert L. Koch, Ian V. MacRae, Zachary Peter Dragan Marston, David Mulla
  • Patent number: 11004262
    Abstract: A method includes constructing a three-dimensional model of a front side of a row of trees based on a plurality of images of the front side of the row of trees and constructing a three-dimensional model of a back side of the row of trees based on a plurality of images of the back side of the row of trees. The three-dimensional model of the front side of the row of trees is merged with the three-dimensional model of the back side of the row of trees by linking a trunk in the three-dimensional model of the front side to a trunk in the three-dimensional model of the back side to form a merged three-dimensional model of the row of trees. The merged three-dimensional model of the row of trees is used to determine a physical attribute of the row of trees.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: May 11, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Ibrahim Volkan Isler, Wenbo Dong, Pravakar Roy
  • Patent number: 10993629
    Abstract: Embodiments relate to multi-focal intravascular pressure catheters and related systems and methods. In an embodiment, a catheter comprises a plurality of pressure sensors spaced apart along at least a portion of the catheter. Each of the plurality of pressure sensors can comprise a pressure membrane arranged over an aperture in the catheter. In an embodiment, the pressure membrane can comprise carbon nanotubes, silver or gold nanoparticles, or another suitable material that can provide a signal in response to a mechanical change (e.g., deformation or flexing of the pressure membrane) to indicate a pressure or change in pressure. Signals from the plurality of pressure sensors can be communicated to an electrical interface which can calibrate or convert the signals into a visual indication of the pressure at any one of the plurality of pressure sensors as well as pressure gradients between various ones of the plurality of pressure sensors.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: May 4, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Sean Lester Moen, Andrew Misselt, Jack Stubbs
  • Patent number: 10993959
    Abstract: Methods and compositions for increasing the suppressive function of regulatory T-cells (Tregs) are provided.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: May 4, 2021
    Assignees: Regents of the University of Minnesota, New York University
    Inventors: Bruce R. Blazar, Cameron McDonald-Hyman, Michael Dustin, Sudha Kumari, Tom Neubert, James Muller, Keli Hippen
  • Patent number: 10993419
    Abstract: Genetically modified cells, tissues, and organs for treating or preventing diseases are disclosed. Also disclosed are methods of making the genetically modified cells and non-human animals.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: May 4, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Bernhard J. Hering, Christopher Burlak
  • Patent number: 10996929
    Abstract: This disclosure describes techniques for processing data bits using pseudo-random deterministic bit-streams. In some examples, a device includes a pseudo-random bit-stream generator configured to generate bit combinations encoding first and second numerical values based on a proportion of the data bits in the sequence that are high relative to the total data bits in the sequence. The device also includes a stochastic computational unit configured to perform a computational operation on the bit combinations and produce an output bit-stream having a set of data bits indicating a result of the computational operation, wherein the data bits of the output bit-stream represent the result based on a probability that any data bit in the set of data bits of the output bit-stream is high.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: May 4, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Mohammadhassan Najafi, David J. Lilja
  • Patent number: 10995317
    Abstract: This disclosure describes an adaptive NK cell, an isolated population of adaptive Natural Killer (NK) cells, a composition including an adaptive NK cell, and methods for producing, preparing, and using an adaptive NK cell or an isolated population or composition including an adaptive NK cell. The adaptive NK cells may be used to treat a viral infection or a tumor.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: May 4, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Jeffrey Miller, Frank Cichocki, Yenan Bryceson, Heinrich Schlums
  • Patent number: 10988714
    Abstract: Bioactive coatings that include a base and a protein associated with the base for actively promoting the removal of organic stains are provided. In aspects, bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: April 27, 2021
    Assignees: Regents of the University of Minnesota, Toyota Motor Corporation
    Inventors: Andreas Buthe, Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Minjuan Zhang
  • Publication number: 20210114975
    Abstract: The invention provide a compound of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, processes for preparing a compound of formula I or a pharmaceutically acceptable salt thereof, intermediates useful for preparing a compound of formula I or a pharmaceutically acceptable salt thereof, and therapeutic methods comprising the administration of a compound of formula I or a pharmaceutically acceptable salt thereof. The compounds and salts are useful for inhibiting glycolysis and mitochondrial function and are useful for treating cancer, autoimmune diseases, NASH, CGvHD, and obesity. The compounds and salts are are useful for treating transplant rejection.
    Type: Application
    Filed: October 21, 2020
    Publication date: April 22, 2021
    Applicant: Regents of the University of Minnesota
    Inventor: Venkatram R. Mereddy
  • Patent number: 10981951
    Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: April 20, 2021
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg