Patents Assigned to Regents of the University of Minnesota
  • Patent number: 10314302
    Abstract: This disclosure describes a cryopreservative composition and methods for storing cells. Generally, the cryopreservative composition includes a sugar component and a sugar alcohol component, and is effective for storing and recovering cells without requiring dimethyl sulfoxide (DMSO).
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: June 11, 2019
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Allison Hubel, Kathryn Lindsay Pollock
  • Patent number: 10307398
    Abstract: A resuscitation composition is described herein, as are methods of making and using such a composition.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: June 4, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Gregory Beilman, Andrea Wolf, Raj Suryanarayanan, Seema Thakral
  • Publication number: 20190159953
    Abstract: The disclosure relates to wearable devices and methods that utilize laryngeal or neck vibro-tactile stimulation (VTS) as a non-invasive form of neuromodulation that induces measurable improvements in the patients with focal dystonia of the head, neck and voice including cervical dystonia and/or spasmodic symptoms.
    Type: Application
    Filed: November 27, 2018
    Publication date: May 30, 2019
    Applicant: Regents of the University of Minnesota
    Inventors: Jürgen Konczak, Arash Mahnan
  • Patent number: 10302711
    Abstract: An article may include a substantially perpendicularly magnetized free layer having a first magnetic orientation in the absence of an applied magnetic field. The article may also include a spin Hall channel layer configured to conduct a spin current configured to subject the perpendicularly magnetized free layer to a magnetic switching torque and a substantially in-plane magnetized bias layer configured to bias the substantially perpendicularly magnetized free layer to a second magnetic orientation. The second magnetic orientation is different than the first magnetic orientation and is out of a plane of the substantially perpendicularly magnetized free layer.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: May 28, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Jian-Ping Wang, Angeline Klemm Smith, Mahdi Jamali, Zhengyang Zhao
  • Publication number: 20190153664
    Abstract: Described herein is a continuous process fear modifying the properties of polyester and polyester based fibers, such as a poly(butylene terephthalate) (PBT) fiber, comprising subjecting the PBT fiber to alkaline hydrolysis, and optionally further comprising functionalizing the PBT fiber by solution grafting such as fluorination. The alkaline hydrolysis and optionally subsequent functionalization such as fluorination process can be continuous, following the melt blowing/spinning or spun-bonding process. Also described is a nonwoven PBT fiber mat obtained by the surface modification process. Further described is a filtration device comprising the nonwoven PBT fiber mat.
    Type: Application
    Filed: November 30, 2018
    Publication date: May 23, 2019
    Applicants: CUMMINS FILTRATION IP, INC., Regents of the University of Minnesota
    Inventors: Zaifei Wang, Frank S. Bates, Christopher W. Macosko, Kan Wang, William C. Haberkamp, Christopher E. Holm
  • Publication number: 20190150733
    Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.
    Type: Application
    Filed: October 15, 2018
    Publication date: May 23, 2019
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Robert Vince, Swati Sudhakar More
  • Patent number: 10294459
    Abstract: This disclosure provides isolated infectious polynucleotides, such as infectious clones, having a nucleotide sequence with identity to PRRS viruses such as VR-2332, Lelystad, or others, and optionally further including a deletion in a region of ORF1 that encodes the nsp2 polypeptide.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: May 21, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Kay Faaberg, Jun Han, Gongping Liu, Yue Wang
  • Publication number: 20190144503
    Abstract: The present disclosure provides bifunctional compounds including a polypeptide targeting moiety conjugated to a small molecule in a site-specific manner both of which bind to the same target protein resulting in potent and specific binding characteristics and methods of identifying such compounds.
    Type: Application
    Filed: April 27, 2017
    Publication date: May 16, 2019
    Applicant: Regents of the University of Minnesota
    Inventor: Roy R. Lobb
  • Patent number: 10287173
    Abstract: An ammonia-producing system comprises a reactor that catalytically converts nitrogen and hydrogen feed gases to ammonia to form a reaction mixture of the ammonia, unreacted nitrogen gas, and unreacted hydrogen gas. A feed system feeds the nitrogen and hydrogen gases to the reactor at a reaction pressure of from about 9 to about 100 atmospheres. A reactor control system controls the temperature during conversion of the nitrogen and hydrogen to ammonia by maintaining a reaction temperature of from about 330° C. to about 550° C. An absorbent selectively absorbs at least a portion of the ammonia from the reaction mixture, and an absorbent control system controls one or both of a temperature and pressure at the absorbent during selective absorption of the ammonia from the reaction mixture. A recycle line downstream of the absorbent recycles the unreacted nitrogen and unreacted hydrogen to the reactor.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: May 14, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Mohammadmahdi Malmali, Alon V. McCormick, Edward L. Cussler
  • Patent number: 10286011
    Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: May 14, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Michael J. Sadowsky, Alexander Khoruts, Alexa R. Weingarden, Matthew J. Hamilton
  • Patent number: 10287572
    Abstract: This disclosure describes non-naturally occurring protein scaffolds and methods of making and using the protein scaffolds. In one aspect, therefore, this disclosure describes a non-naturally occurring protein scaffold that includes a plurality of structural domains and a plurality of loop regions that include an amino acid sequence that varies from a naturally-occurring loop region by at least one amino acid deletion, substitution, or addition. Generally, the structural domain or domains can include at least one ? structure and/or at least one a helix.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: May 14, 2019
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Benjamin Joseph Hackel, Max Anthony Kruziki, Sumit Bhatnagar, Hong Zhou
  • Patent number: 10286012
    Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: May 14, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Michael J. Sadowsky, Alexander Khoruts, Alexa R. Weingarden, Matthew J. Hamilton
  • Patent number: 10281476
    Abstract: Provided herein are methods for identifying a compound that modulates a Ryanodine receptor (Ryr). Fluorescence resonance energy transfer between an FKBP bound to an RyR and fluorescent derivatives of RyR binding partners (e.g., calmodulin) or domain-peptide biosensors is used to provide a readout dependent on the RyR functional state. The methods permit measurement of RyR present in a permeabilized cell or in a purified membrane.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: May 7, 2019
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Razvan L. Cornea, Donald M. Bers, David D. Thomas, Gregory D. Gillispie
  • Patent number: 10284395
    Abstract: A time-based decision feedback equalizer (TB-DFE) circuit may include a voltage-to-time converter configured to convert a communication signal into a time-based signal. A timing of when an edge of the time-based signal occurs is indicative of a voltage level of the communication signal. The circuit may include a plurality of delay circuits arranged to process the time-based signal in series to generate a delay data signal. The delay circuits may adjust the timing of when the edge of the time-based signal occurs, and a corresponding time delay introduced by each of the delay circuits may be based on a respective weighting factor applied to one or more samples of an output digital signal previously generated by the TB-DFE circuit. A phase detector may compare a timing of an edge of the delay data signal with a reference clock signal and generate the output digital signal based on the comparison.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: May 7, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Po-Wei Chiu, Somnath Kundu, Hyung-il Kim
  • Patent number: 10278435
    Abstract: One or more embodiments of a protective garment and a method of manufacturing such garments are disclosed. In one or more embodiments, the protective garment can include an elastic lumbar panel attached to a rear portion of a body of the protective garment in a waist region, left and right shoulder elastic straps each including a first end attached to a front portion of the body and a second end attached to the rear portion, a left side elastic waist strap attached to the front portion and extending around a left side of the garment where it is attached to the rear portion, and a right side elastic waist strap attached to the front portion and extending around a right side of the garment where it is attached to the rear portion.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: May 7, 2019
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Elizabeth Kersch Bye, Karen Louise LaBat, Linsey Ann Gordon, Theresa Elizabeth Lastovich
  • Patent number: 10283561
    Abstract: This disclosure describes an example device that includes a first contact line, a second contact line, a spin-orbital coupling channel, and a magnet. The spin-orbital coupling channel is coupled to, and is positioned between, the first contact line and second contact line. The magnet is coupled to the spin-orbital coupling channel and positioned between the first contact line and the second contact line. A resistance of the magnet and spin-orbital coupling channel is a unidirectional magnetoresistance.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: May 7, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Jian-Ping Wang, Yang Lv, Mahdi Jamali
  • Patent number: 10278372
    Abstract: Genetically modified cells, tissues, and organs for treating or preventing diseases are disclosed. Also disclosed are methods of making the genetically modified cells and non-human animals.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: May 7, 2019
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Bernhard J. Hering, Christopher Burlak
  • Patent number: 10274384
    Abstract: A stitched sensor including a plurality of threads stitched to a textile in a stitch geometry is described. The plurality of threads includes a conductive thread, and the stitch geometry is configured such that an electrical property of the stitched sensor changes based on at least one of stretching, relaxation, or bending of the textile. Methods for forming a stitched sensor are also described.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: April 30, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Lucy E. Dunne, Guido Gioberto
  • Patent number: 10272055
    Abstract: Biguanide compounds and salts thereof are disclosed. Also disclosed are pharmaceutical compositions and therapeutic methods for treating certain diseases including cancer such as breast cancer.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: April 30, 2019
    Assignees: Regents of the University of Minnesota, The Regents of the University of California
    Inventors: David A. Potter, Zhijun Guo, Elizabeth Amin, Gunda Georg, Tom Poulos, Irina Sevrioukova
  • Publication number: 20190117745
    Abstract: The present invention relates to a new drug delivery strategy based on prodrug conversion, in which a water-soluble prodrug and its converting enzyme are co-delivered and at a point of administration such as the nasal or buccal mucosa. Enzymatic conversion of the prodrug produces drug in concentrations exceeding the drug's thermodynamic solubility, or saturation level. The supersaturated drug crosses the mucosal membrane quickly, as a result of its high thermodynamic activity, prior to crystallization. This strategy is particularly useful when fast action is required, for example in preventing or responding rapidly to Status Epilepticus (SE) or other central nervous system conditions such as migraine.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 25, 2019
    Applicant: Regents of the University of Minnesota
    Inventors: Ronald A. Siegel, James Cloyd, Tate Winter, Mamta Kapoor