Patents Assigned to Regents of the University of Minnesota
  • Patent number: 11302472
    Abstract: Techniques are disclosed concerning applied magnetic field synthesis and processing of iron nitride magnetic materials. Some methods concern casting a material including iron in the presence of an applied magnetic field to form a workpiece including at least one ironbased phase domain including uniaxial magnetic anisotropy, wherein the applied magnetic field has a strength of at least about 0.01 Tesla (T). Also disclosed are workpieces made by such methods, apparatus for making such workpieces and bulk materials made by such methods.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: April 12, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Jian-Ping Wang, Yanfeng Jiang
  • Patent number: 11300116
    Abstract: Hydraulic cylinders and methods of fabricating hydraulic cylinders, including long-stroke rolling diaphragm cylinders with any stroke length. In some embodiments, the cylinders are manufactured to have a stroke length to bore diameter (“stroke-to-bore”) ratio optionally greater than 1:1. Various embodiments are suitable for use in a passive hydraulic body-powered wearable robot, for example.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: April 12, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Saeed Hashemi, William Keith Durfee
  • Patent number: 11303377
    Abstract: Techniques are described for carrier frequency offset (CFO) and channel estimation of orthogonal frequency division multiplexing (OFDM) transmissions over multiple-input multiple-output (MIMO) frequency-selective fading channels. A wireless transmitter forms blocks of symbols by inserting training symbols within two or more blocks of information-bearing symbols. The transmitter applies a hopping code to each of the blocks of symbols to insert a null subcarrier at a different position within each of the blocks of symbols, and a modulator outputs a wireless signal in accordance with the blocks of symbols. A receiver receives the wireless signal and estimates the CFO, and outputs a stream of estimated symbols based on the estimated CFO.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: April 12, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Georgios B. Giannakis, Xiaoli Ma
  • Patent number: 11301030
    Abstract: A method includes generating gate-level activity information of a processor design for all possible executions of a target application for any possible inputs to the target application. The method includes performing a constrained timing analysis on the processor design based on the gate-level activity information to determine a minimum operating voltage for executing the target application on the processor.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: April 12, 2022
    Assignees: Regents of the University of Minnesota, The Board of Trustees of the University of Illinois
    Inventors: Hari Cherupalli, Rakesh Kumar, John Sartori
  • Patent number: 11293914
    Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a it-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: April 5, 2022
    Assignees: Boston Scientific Scimed, Inc., REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Xue Zhen, Philippe Pierre Joseph Buhlmann, Steven J. Koester, Justin Theodore Nelson
  • Patent number: 11286518
    Abstract: Analytical standards can allow one to detect and/or measure sampling, processing, and/or amplification errors in a sample that includes a plurality of polynucleotide molecules. The analytical standards can provide an internal control to detect errors in the representation of the original sample reflected in data obtained after manipulating and/or processing of sample molecules.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: March 29, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Kenneth Beckman, Daryl Gohl
  • Publication number: 20220088089
    Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.
    Type: Application
    Filed: December 1, 2021
    Publication date: March 24, 2022
    Applicants: Arizona Board Regents on behalf of Arizona State University, Regents of the University of Minnesota, Finch Therapeutics Holdings LLC
    Inventors: James ADAMS, Rosa KRAJMALNIK-BROWN, Dae-Wook KANG, Michael J. SADOWSKY, Alexander KHORUTS, Thomas J. BORODY
  • Publication number: 20220088134
    Abstract: The present invention in certain embodiments provides a method of inhibiting PD-1 in a cell by administering a CD200 activation receptor ligand (CD200AR-L) to the cell. The present invention in certain embodiments provides a method of enhancing efficacy of a tumor lysate vaccine in a mammal comprising administering a CD200 activation receptor ligand (CD200AR-L) to the mammal prior to the administration of the tumor lysate vaccine.
    Type: Application
    Filed: January 13, 2020
    Publication date: March 24, 2022
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventor: Michael OLIN
  • Patent number: 11279701
    Abstract: The invention provides a method for stimulating an immune response in an animal with a compound of formula: or a pharmaceutically acceptable salt thereof, wherein R1-R3, Ra, and Rb have any of the values defined herein.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: March 22, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventor: David Ferguson
  • Patent number: 11280789
    Abstract: A cell-capturing substrate, methods of using the cell-capturing substrate that allow for label-free cell separation, and kits that incorporate the cell-capturing substrate.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: March 22, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Wei Shen, Mengen Zhang, Bin Xu
  • Patent number: 11279780
    Abstract: A semicrystalline multiblock copolymer includes alternating blocks of semicrystalline isotactic polypropylene (iPP) and semicrystalline polyethylene (PE), having a block arrangement according to formula (I): (iPPw)p(PEx)(iPPy)m(PEz)n?? (I), wherein p is 0 or 1; m is 0 or 1; n is 0 or 1; the sum of p, m, and n is 1, 2, or 3; and the sum of w, x, y, and z is greater than or equal to 40 kg/mol, with the provisos that: when m and n are 0, the sum of w and x is greater than or equal to 140 kg/mol; and when p and n are 0, the sum of y and x is greater than or equal to 140 kg/mol. Related compositions and methods are also provided.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: March 22, 2022
    Assignees: CORNELL UNIVERSITY, REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Geoffrey Coates, James Eagan, Anne Lapointe, Frank S. Bates
  • Patent number: 11280031
    Abstract: Garments having active and passive knitted rows can provide desired levels of compression. Garments made of active and passive knitted rows can provide dynamic levels of compression with respect to both location and over time to address a variety of conditions.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: March 22, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Rachael Margaret Granberry, Kevin Eschen, Julianna Abel, Bradley Holschuh
  • Publication number: 20220082386
    Abstract: Localization and navigation systems and techniques are described. An electronic device comprises a processor configured to maintain a state vector storing estimates for a position of the electronic device at poses along a trajectory within an environment along with estimates for positions for one or more features within the environment. The processor computes, from the image data, one or more constraints based on features observed from multiple poses of the electronic device along the trajectory, and computes updated state estimates for the position of the electronic device in accordance with the motion data and the one or more computed constraints without computing updated state estimates for the features for which the one or more constraints were computed.
    Type: Application
    Filed: November 30, 2021
    Publication date: March 17, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: Stergios I. Roumeliotis, Anastasios I. Mourikis
  • Patent number: 11274294
    Abstract: Materials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: March 15, 2022
    Assignees: Regents of the University of Minnesota, Iowa State University Research Foundation Inc.
    Inventors: Daniel F. Voytas, Adam J. Bogdanove, Feng Zhang
  • Patent number: 11275563
    Abstract: Example devices are described that include a computational unit configured to process first set of data bits encoding a first numerical value and a second set of data bits encoding a second numerical value. The computational unit includes a bit-stream generator configured to generate bit combinations representing first and second bit sequences that encode the first and second numerical values, respectively, based on a proportion of the data bits in the sequence that are high relative to the total data bits. The first bit sequence is generated using a first Sobol sequence source, and the second bit sequence is generated using a second Sobol sequence source different from the first Sobol sequence source. The device also includes computation logic configured to perform a computational operation on the bit combinations and produce an output bit-stream having a set of data bits indicating a result of the computational operation.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: March 15, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Mohammadhassan Najafi, David J. Lilja, Marcus Riedel, Kiarash Bazargan, Sayed Abdolrasoul Faraji, Bingzhe Li
  • Patent number: 11275132
    Abstract: An apparatus for transmitting and receiving radiofrequency (RF) signals in a magnetic resonance imaging system for proton and X-nuclear imaging includes at least one radiofrequency (RF) coil and an ultrahigh dielectric constant material incorporated within the at least one RF coil. The permittivity of the ultrahigh dielectric constant material depends on a temperature of the material and is tunable. The apparatus also includes a temperature controller that is thermally coupled to the ultrahigh dielectric constant material. The temperature controller is configured to control a temperature of the ultrahigh dielectric constant material to tune and optimize the permittivity of the ultrahigh dielectric constant material. A chemical structure and composition of the ultrahigh dielectric constant material is selected to control and optimize the permittivity and a dielectric loss of the ultrahigh dielectric constant material and a temperature dependence of the ultrahigh dielectric constant material.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: March 15, 2022
    Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, The Penn State Research Foundation
    Inventors: Wei Chen, Byeong-Yeul Lee, Xiao-Hong Zhu, Hannes M. Wiesner, Michael T. Lanagan, Qing X. Yang, Sebastian Rupprecht, Navid P. Gandji, Maryam Sarkarat
  • Patent number: 11275941
    Abstract: Systems, techniques, and devices for detecting plant biometrics, for example, plants in a crop field. An imaging device of an unmanned vehicle may be used to generate a plurality of images of the plants, and the plurality of images may be used to generate a 3D model of the plants. The 3D model may define locations and orientations of leaves and stems of plants. The 3D model may be used to determine at least one biometric parameter of at least one plant in the crop. Such detection of plant biometrics may facilitate the automation of crop monitoring and treatment.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: March 15, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Nikolaos Papanikolopoulos, Vassilios Morellas, Dimitris Zermas, David Mulla, Mike Bazakos
  • Patent number: 11266692
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: March 8, 2022
    Assignees: Regents of the University of Minnesota, Intima Bioscience, Inc., The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • Publication number: 20220054485
    Abstract: The present invention provides in certain embodiments methods of treating right ventricular dysfunction in pulmonary hypertension or an elevated blood level of IL-6 by administering a composition comprising a GP130 antagonist in a patient in need thereof. The present invention also provides in certain embodiments a method of treating an elevated blood level of IL-6 by administering a first composition comprising a GP130 antagonist in a patient in need thereof.
    Type: Application
    Filed: August 19, 2021
    Publication date: February 24, 2022
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Kurt Prins, Sasha Prisco
  • Publication number: 20220060769
    Abstract: Aspects of the subject disclosure may include, for example, embodiments for obtaining video content from a video content server, determining a quality parameter for each of the plurality of adjusted video content, and adjusting the video content to generate the plurality of adjusted video content. Each of the plurality of adjusted video content comprises a different point cloud density according to the quality parameter. Further embodiments can include receiving a request for the video content from a video content application on a communication device, and determining a distance from a viewpoint to a point-cloud object on the video content application of the communication device. Additional embodiments can include selecting an adjusted video content based on the distance from the viewpoint to the point-cloud object and the quality parameter of the adjusted video content, and providing the adjusted video content to the communication device for presentation. Other embodiments are disclosed.
    Type: Application
    Filed: October 28, 2021
    Publication date: February 24, 2022
    Applicants: AT&T Intellectual Property I, L.P., Regents of the University of Minnesota
    Inventors: Bo Han, Cheuk Yiu Ip, Jackson Jarrell Pair, Feng Qian