Patents Assigned to Regents of the University of Minnesota
  • Patent number: 10973844
    Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: April 13, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Mark Osborn, Jakub Tolar, Bruce Robert Blazar, Daniel Voytas
  • Publication number: 20210105177
    Abstract: The concepts and technologies disclosed herein are directed to a network-assisted Raft consensus protocol, referred to herein as “NetRaft.” According to one aspect of the concepts and technologies disclosed herein, a system can include a plurality of servers operating in a server cluster, and a plurality of P4 switches corresponding to the plurality of servers. Each server of the plurality of servers can include a back-end that executes a complete Raft algorithm to perform leader election, log replication, and log commitment of a Raft consensus algorithm. Each P4 switch of the plurality of P4 switches can include a front-end that executes a partial Raft algorithm to perform the log replication and the log commitment of the Raft consensus algorithm. The back-end can maintain a complete state for responding to requests that cannot be fulfilled by the front-end. The requests can include read requests and/or write requests.
    Type: Application
    Filed: November 23, 2020
    Publication date: April 8, 2021
    Applicants: AT&T Intellectual Property I, L.P., Regents of the University of Minnesota
    Inventors: Bo Han, Vijay Gopalakrishnan, Marco Platania, Zhi-Li Zhang, Yang Zhang
  • Patent number: 10969387
    Abstract: Compounds and complexes that can be useful as enterobactin probes not necessary are disclosed herein. Methods of detecting bacteria and/or methods of determining susceptibility of bacteria to an antibiotic using such compounds and complexes are also disclosed herein.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: April 6, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Valerie Christine Pierre, Sylvie Pailloux
  • Patent number: 10967062
    Abstract: Certain embodiments of the present invention provide functionalized nanoparticles and methods of use thereof. Certain embodiments provide nanoparticles functionalized with streptokinase. Certain embodiments of the present invention provide methods for treating a pathological fibrin associated disorder (e.g., cancer) in an animal.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: April 6, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Jayanth Panyam, Tanmoy Sadhukha, Ameya Kirtane
  • Patent number: 10962617
    Abstract: Methods for fast magnetic resonance imaging (“MRI”) using a combination of outer volume suppression (“OVS”) and accelerated imaging, which may include simultaneous multislice (“SMS”) imaging, data acquisitions amenable to compressed sensing reconstructions, or combinations thereof. The methods described here do not introduce fold-over artifacts that are otherwise common to reduced field-of-view (“FOV”) techniques.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: March 30, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Sebastian Weingartner, Steen Moeller, Mehmet Akcakaya
  • Patent number: 10962474
    Abstract: A system includes a detector and a computing device communicatively coupled to the detector. The detector detects spatial or temporal spectral features of a light beam after transmission of the light beam through a turbulent or aberrated medium and generate a measurement signal indicative of the spectral feature. The computing device receives the measurement signal and a comparative signal indicative of a spectral feature of the light beam prior to or after transmission of the light beam through the medium. The computing device compares the measurement signal and the comparative signal and determines, based on the comparison of the measurement signal and the comparative signal, one or more values related to variations in refractive indices of the medium.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: March 30, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Joseph Talghader, Merlin Lyn Mah
  • Patent number: 10961615
    Abstract: A method may include annealing a material including iron and nitrogen in the presence of an applied magnetic field to form at least one Fe16N2 phase domain. The applied magnetic field may have a strength of at least about 0.2 Tesla (T).
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: March 30, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Michael P. Brady, Orlando Rios, Yanfeng Jiang, Gerard M. Ludtka, Craig A. Bridges, Jian-Ping Wang, Xiaowei Zhang, Lawrence F. Allard, Edgar Lara-Curzio
  • Patent number: 10954368
    Abstract: A blend that includes (a) a continuous phase comprising isotactic polypropylene and (b) a dispersed phase comprising a poly-(ethylene-alt-propylene)-b-poly(ethylene-ran-ethyl ethylene) diblock copolymer. The amount of diblock copolymer is less than 20 wt % based on the total weight of the blend.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: March 23, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Jun Xu, Frank S. Bates
  • Publication number: 20210079484
    Abstract: Certain embodiments of the invention provide a method for identifying a horse having the ability to pace, comprising assaying a nucleic acid sample from the horse to detect the genotype of at least one single nucleotide polymorphism (SNP) described herein.
    Type: Application
    Filed: April 16, 2019
    Publication date: March 18, 2021
    Applicant: Regents of the University of Minnesota
    Inventors: Molly Elizabeth MCCUE, Annette Marie MCCOY
  • Publication number: 20210081506
    Abstract: Systems, methods, and computer-readable media are provided for simulating the coupled axial/torsional dynamics of drilling systems.
    Type: Application
    Filed: September 17, 2019
    Publication date: March 18, 2021
    Applicants: Regents of the University of Minnesota, HALLIBURTON ENERGY SERVICES, INC.
    Inventors: Emmanuel DETOURNAY, Ganesh RAMAKRISHNAN, Kaixiao TIAN
  • Patent number: 10950777
    Abstract: An example power generation system includes two capacitors and an electric load. A first capacitor includes a dielectric material that is configured to transition from a ferroelectric phase to a paraelectric or antiferroelectric phase when heated above a first transition temperature, and to transition from the paraelectric or antiferroelectric phase to the ferroelectric phase when cooled below a second transition temperature. A second capacitor is electrically coupled in parallel to the first capacitor. The electric load is electrically coupled to the first capacitor and the second capacitor. The system is configured to cyclically cool the dielectric material below the second transition temperature to draw a charge from the second capacitor to the first capacitors through the electric load, and heat the dielectric material beyond the first transition temperature to draw a charge from the first capacitor to the second capacitors through the electric load.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: March 16, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Richard D. James, Bharat Jalan
  • Patent number: 10948447
    Abstract: An electrical device includes at least one graphene quantum capacitance varactor. In some examples, the graphene quantum capacitance varactor includes an insulator layer, a graphene layer disposed on the insulator layer, a dielectric layer disposed on the graphene layer, a gate electrode formed on the dielectric layer, and at least one contact electrode disposed on the graphene layer and making electrical contact with the graphene layer. In other examples, the graphene quantum capacitance varactor includes an insulator layer, a gate electrode recessed in the insulator layer, a dielectric layer formed on the gate electrode, a graphene layer formed on the dielectric layer, wherein the graphene layer comprises an exposed surface opposite the dielectric layer, and at least one contact electrode formed on the graphene layer and making electrical contact with the graphene layer.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: March 16, 2021
    Assignee: Regents of the University of Minnesota
    Inventor: Steven J. Koester
  • Patent number: 10945622
    Abstract: Three-dimensional electrical source imaging of electrical activity in a biological system (e.g., brain or heart) may involve sensor array recording, at multiple locations, of signals (e.g. electrical or magnetic signals) of electrical activity. An initial estimate of an underlying source is obtained. Edge sparsity is imposed on the estimated electrical activity to eliminate background activity and create clear edges between an active source and background activity. The initial estimate is iteratively reweighted and a series of subsequent optimization problems launched to converge to a more accurate estimation of the underlying source. Images depicting a spatial distribution of a source are generated based on the iteratively reweighted edge sparsity, and the time-course of activity for estimated sources generated. Iterative reweighting penalizes locations with smaller source amplitude based on solutions obtained in previous iterations, and continues until a desirable solution is obtained with clear edges.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: March 16, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Abbas Sohrabpour, Bin He
  • Patent number: 10951221
    Abstract: In some examples, a device includes an analog-to-digital converter (ADC) configured to receive an analog signal and output digital codes based on values of the analog signal. The device also includes a plurality of counters, where each counter of the plurality of counters is configured to increment in response to a respective digital code outputted by the ADC.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: March 16, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Gyusung Park, Hyung-il Kim
  • Publication number: 20210072229
    Abstract: Systems and methods for evaluating one or more characteristics or parameters of a material, such as a soft material (e.g., hydrogel, human cell, UV-curable polymer, etc.). Methods include incorporating a plurality of magnetic nanowires into the material to form a test solution. The test solution is subjected to a magnetic field. A change in the magnetic nanowires in response to the magnetic field is recorded. A characteristic of the material is determined based upon the recorded change. In some embodiments, the applied magnetic field causes the magnetic nanowires to rotate from an initial orientation to a stimulated orientation, with the change in orientation being indicative of a stiffness (e.g., internal stiffness) of the material.
    Type: Application
    Filed: September 11, 2020
    Publication date: March 11, 2021
    Applicants: Regents of the University of Minnesota, Technische Universität Dresden
    Inventors: Bethanie Joyce Hills Stadler, Philipp Jan Mehner, Katinka Kohl, Andreas Richter
  • Patent number: 10941153
    Abstract: Embodiments of the present disclosure describe substituted phenethylamine derivatives, compositions comprising the substituted phenethylamine derivatives, methods of making the substituted phenethylamine derivatives, and methods of using the phenethylamine derivatives, and the like. Exemplary compounds of the present disclosure include compounds of the formula (I) and (II): wherein X, Ra, Rb, Rc, R1, R2, R3, and R4 are defined elsewhere.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: March 9, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Joseph John Topczewski, Matthew Ryan Porter
  • Patent number: 10942183
    Abstract: A method that includes testing for the presence of a phosphorylated Ser294 (phospho-Ser294) progesterone receptor (PR). A method that includes determining the expression level of a gene in a patient sample and comparing it to a control sample.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: March 9, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Carol Ann Lange, Todd P. Knutson
  • Patent number: 10940315
    Abstract: The invention provides methods for treating a neurological disorder or deficit, such as tinnitus and phantom limb pain.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: March 9, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Hubert H. Lim, Craig D. Markovitz, Sarah J. Offutt
  • Patent number: 10941433
    Abstract: The present invention is directed to methods of probiotic selection and use based on the capability of microbial biogenic amine uptake as a method for targeted clinical and veterinary applications, including promoting health and well-being and/or treating therapeutic conditions. The present invention utilizes a microbially-focused approach for the development of drug selection and/or probiotic administration in a variety of diseases and disorders.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: March 9, 2021
    Assignees: IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Mark Lyte, David Robert Brown
  • Publication number: 20210060088
    Abstract: The present disclosure provides compositions and methods for treating Clostridium difficile infection (CDI) including primary and recurrent CDI. In particular, the compositions and methods described herein are capable of achieving a CDI clearance rate of at least 80% through a single oral dose of pharmaceutical composition comprising a freeze-dried fecal microbiota preparation.
    Type: Application
    Filed: November 13, 2020
    Publication date: March 4, 2021
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Matthew J. HAMILTON, Alexander KHORUTS, Michael J. SADOWSKY, Christopher M. STALEY