Abstract: Genonie-edited primary B cells, methods of making genome-edited primary B cells, a therapeutic cassette that can be introduced into primary B cells, and methods of using the genome-edited primary B cells and the therapeutic cassette.

Abstract: This document relates to materials and methods for generating early flowering oilseed (e.g., pennycress) plants. For example, oilseed plants (e.g., modified oilseed plants) having one or more modifications in a polypeptide involved in early flowering (e.g., early flowering six (ELF6)), as well as materials and methods for making and using early flowering oilseed plants are provided.

Abstract: A non-pneumatic tire defining axial, radial, and circumferential directions. The tire includes an annular lattice structure extending radially between an inner circumferential edge and an outer circumferential edge. The lattice structure exhibits topological polarization, with the inner circumferential edge being stiffer than the outer circumferential edge. The topological polarization includes asymmetry in mechanical response to opposing forces applied to the inner and outer circumferential edges. The lattice structure which provides topological polarization endows the tire with localized softness along the outer radius, which enables extreme absorption of asperities, without transferring significant forces to the axle. In some embodiments, the lattice structure further exhibits topological protection, including the topological polarization characteristics being maintained upon experiencing wear at the outer circumferential edge.

Abstract: A system and method for cardiac activation imaging includes non-invasively or minimally invasively acquiring data about an electrical activation of a heart of a subject using at least one sensor. An activation image of the heart of the subject is reconstructed using a weighted sparse constrained reconstruction.

Abstract: Real-time systems for monitoring base editing in living cells, including base editing by APOBEC-Cas9 fusions, is provided herein.

Abstract: Certain embodiments of the invention provide a cyclic compound of formula I: wherein: Pro is a residue of L-proline; X1 is a residue of Arg or DArg; X2 is a residue of Phe or DPhe; X3 is a residue of Phe, DPhe or hPhe; X4 is a residue of a natural or unnatural amino acid; X5 is a residue of Ala, Asp, Glu, Lys, His, Phe, Ser, Leu or Gly; X6 is a residue of Phe, Ala, Gly, Ser, Lys, Asp, Leu, Nle, Trp, Tyr, Cha or hPhe; and DPro is a residue of D-proline; or a salt thereof. Certain embodiments also provide compositions comprising such compounds, as well as methods of using such compounds and compositions.

Abstract: In some examples, a device includes a dielectric material, a ferromagnetic material, and a topological material positioned between the dielectric material and the ferromagnetic material. The device is configured to trap electric charge inside the dielectric material or at an interface of the dielectric material and the topological material. The device is configured to switch a magnetization state of the ferromagnetic material based on a current through the topological material or based on a voltage in the topological material.

Abstract: Systems, methods, and computer-readable media are provided for simulating the coupled axial/torsional dynamics of drilling systems.

Abstract: Described here is a deep brain stimulation (“DBS”) approach that targets several relevant nodes within brain circuitry, while monitoring multiple symptoms for efficacy. This approach to multi-symptom monitoring and stimulation therapy may be used as an extra stimulation setting in extant DBS devices, particularly those equipped for both stimulation and sensing. The therapeutic efficacy of DBS devices is extended by optimizing them for multiple symptoms (such as sleep disturbance in addition to movement disorders), thus increasing quality of life for patients.

Abstract: A method includes accessing information stored for positions along a road and using the accessed information to identify an expected trajectory for a vehicle. Position information for the vehicle is received from a global positioning system for two different time points and is used to determine a trajectory of the vehicle. The trajectory of the vehicle and the expected trajectory are used to determine a lateral offset of the vehicle from the expected trajectory and the lateral offset is used to determine when to issue a lane departure warning for the vehicle.

Abstract: Techniques are described for additive manufacturing, e.g., 3D printing, stretchable tactile sensors. As described, the techniques may allow the stretchable tactile sensors to be 3D printed under ambient conditions via nanocomposite inks. In various embodiments, sinter-free inks are described with adjustable viscosities and electrical conductivities. Moreover, conductive compositions are described in which micron or submicron-sized silver particles are dispersed in a highly stretchable silicone elastomer. Techniques are described herein in which the inks are used 3D printing process to form tactile sensing platforms and integrated arrays.

Abstract: The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD (cGVHD) using compounds having the formulae 1-XXV, as set forth herein.

Abstract: An example method of removing hydrogen sulfide from an input gas includes exposing an adsorbent material to an input gas to obtain an output gas. A concentration of hydrogen sulfide of the output gas is less than a concentration of hydrogen sulfide of the input gas. The adsorbent material includes copper oxide, magnesium oxide, and aluminum oxide. An atomic ratio of copper to magnesium to aluminum of the adsorbent material is X:Y:Z, where X is greater than or equal to 0.6 and less than or equal to 0.9, where Y is greater than or equal to 0 and less than or equal to 0.2, where Z is greater than or equal to 0 and less than or equal to 0.2, and where X+Y+Z is equal to 1.

Abstract: A cryopreservation composition generally includes a cryoprotective agent and a laser absorber that includes a metal. Rewarming a cryopreserved specimen that includes the cryopreservation composition includes subjecting the cryopreserved specimen to a laser pulse effective to heat the laser absorber sufficiently to thaw the cryopreserved biospecimen.

Abstract: Solid-contact electrodes include a molecular redox buffer that is covalently attached to one of the components of the electrodes. These electrodes can be incorporated into electrochemical sensor systems. The electrode components are an electron conductor, a membrane and optionally, an interlayer. The electrode includes covalent attachment of the molecular redox buffer to the interlayer, to the electron conductor or the membrane. The interlayer includes nanoporous carbon such as CIM-carbon. The molecular redox buffer includes a well-defined redox pair, e.g., a complex of Co(II)/Co(III). The electrodes are ion-selective electrodes (ISEs) or reference electrodes. Methods include constructing solid contact electrodes and using the electrodes in electrochemical sensor systems to determine the quantity of an analyte in a sample. The electrochemical sensor systems include disposable paper-based devices and/or wearable devices for measuring analytes in a sample.

Abstract: A method includes setting an output of each memory cell in an array of memory cells to a same first value, decreasing power to the array of memory cells and then increasing power to the array of memory cells. Memory cells in the array of memory cells with outputs that switched to a second value different from the first value are then identified in response to decreasing and then increasing the power. A set of memory cells is then selected from the identified memory cells to use in hardware security.

Abstract: A foam that includes a polylactide polymer in the form of a star polymer having at least three arms. The foam is an open cell foam having a density no greater than 0.1 g/cm3.

Abstract: Compositions and methods of the invention are directed to the formation and use of teratoma-derived skeletal muscle stem cells. In one embodiment, the teratoma-derived skeletal muscle stem cells improve muscle contractile force (definition “functional”) when administered to a patient in need thereof.

Abstract: According to embodiments, a substantially coaxial arrangement of a camera, a light source, and an ultrasonic sensor can be positioned in an housing of a system that can be deployed from the tool port of a standard bronchoscope. Illumination from the light source facilitates positioning of the system by an operator using information from the camera. The ultrasonic system can determine when an object to be biopsied is adjacent to a biopsy needle.

Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.