Abstract: The invention provides antibiotic BPI Fold Containing Family A Member 2 (BPIFA2) peptides, compositions comprising a BPIFA2 peptide, hydrogels comprising a BPIFA2 peptide, nanofibrillar networks comprising a BPIFA2 peptide, and tissue scaffolds comprising BPIFA2 peptides. The peptide, compositions, hydrogels nanofibrillar networks and tissue scaffolds are useful for medical therapy in an animal.

Abstract: Described here are systems and methods for volumetric excitation in magnetic resonance imaging (“MRI”) using frequency modulated radio frequency (“RF”) pulses. In general, quadratic phase modulation along the slice encoding direction is implemented for additional spatiotemporal encoding, which better distributes signal content in the slice direction and enables higher acceleration rates that are robust to slice-undersampling.

Abstract: A system and computerized method for generating magnetic resonance imaging (MRI) images is provided that includes accessing data acquired from a subject using an MRI system that includes Nyquist ghosts and processing the data using a cost function that exploits a cosine and sine modulation in a ghosted image component of the data. An image of the subject is produced from the data after processing the data using the cost function.

Abstract: Described herein are compositions that inhibit/degrade STAT3, and methods of using such compositions for chemoprevention of non-small cell lung cancer (NSCLC).

Abstract: A method includes constructing a three-dimensional model of a front side of a row of trees based on a plurality of images of the front side of the row of trees and constructing a three-dimensional model of a back side of the row of trees based on a plurality of images of the back side of the row of trees. The three-dimensional model of the front side of the row of trees is merged with the three-dimensional model of the back side of the row of trees by linking a trunk in the three-dimensional model of the front side to a trunk in the three-dimensional model of the back side to form a merged three-dimensional model of the row of trees. The merged three-dimensional model of the row of trees is used to determine a physical attribute of the row of trees.

Abstract: A method of determining whether to treat soybeans for soybean aphids, the method includes collecting at least one image of a soybean canopy using one or more remote sensing instruments and processing the image into spectral reflectance data and selecting from the spectral reflectance data optimal spectral wavelength bands. The selected reflectance data is classified into one of a plurality of classification groupings using a machine learned classification model. To treat or not treat the soybean canopy for aphids is determined based on the classification of the reflectance data into one of the class groupings.

Abstract: Genetically modified cells, tissues, and organs for treating or preventing diseases are disclosed. Also disclosed are methods of making the genetically modified cells and non-human animals.

Abstract: Embodiments relate to multi-focal intravascular pressure catheters and related systems and methods. In an embodiment, a catheter comprises a plurality of pressure sensors spaced apart along at least a portion of the catheter. Each of the plurality of pressure sensors can comprise a pressure membrane arranged over an aperture in the catheter. In an embodiment, the pressure membrane can comprise carbon nanotubes, silver or gold nanoparticles, or another suitable material that can provide a signal in response to a mechanical change (e.g., deformation or flexing of the pressure membrane) to indicate a pressure or change in pressure. Signals from the plurality of pressure sensors can be communicated to an electrical interface which can calibrate or convert the signals into a visual indication of the pressure at any one of the plurality of pressure sensors as well as pressure gradients between various ones of the plurality of pressure sensors.

Abstract: This disclosure describes an adaptive NK cell, an isolated population of adaptive Natural Killer (NK) cells, a composition including an adaptive NK cell, and methods for producing, preparing, and using an adaptive NK cell or an isolated population or composition including an adaptive NK cell. The adaptive NK cells may be used to treat a viral infection or a tumor.

Abstract: Methods and compositions for increasing the suppressive function of regulatory T-cells (Tregs) are provided.

Abstract: This disclosure describes techniques for processing data bits using pseudo-random deterministic bit-streams. In some examples, a device includes a pseudo-random bit-stream generator configured to generate bit combinations encoding first and second numerical values based on a proportion of the data bits in the sequence that are high relative to the total data bits in the sequence. The device also includes a stochastic computational unit configured to perform a computational operation on the bit combinations and produce an output bit-stream having a set of data bits indicating a result of the computational operation, wherein the data bits of the output bit-stream represent the result based on a probability that any data bit in the set of data bits of the output bit-stream is high.

Abstract: Pennycress (Thlaspi arvense) seed, seed lots, seed meal, and compositions with reduced glucosinolate content as well as plants that yield such seed, seed lots, seed meal, and compositions are provided. Methods of making and using the pennycress plants and/or seed that provide such seed, seed lots, seed meal, and compositions are also provided.

Abstract: Bioactive coatings that include a base and a protein associated with the base for actively promoting the removal of organic stains are provided. In aspects, bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.

Abstract: The invention provide a compound of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, processes for preparing a compound of formula I or a pharmaceutically acceptable salt thereof, intermediates useful for preparing a compound of formula I or a pharmaceutically acceptable salt thereof, and therapeutic methods comprising the administration of a compound of formula I or a pharmaceutically acceptable salt thereof. The compounds and salts are useful for inhibiting glycolysis and mitochondrial function and are useful for treating cancer, autoimmune diseases, NASH, CGvHD, and obesity. The compounds and salts are are useful for treating transplant rejection.

Abstract: Disclosed herein are methods of controlling the amount of carboxyl groups attached to a hydrochar, the methods including subjecting a composition that includes a stover composition to hydrothermal carbonization to form a hydrochar, wherein the amount of carboxyl groups attached to the hydrochar can be controlled by the amount of lipids in the composition. Methods of removing ammonia from a gas using disclosed hydrochars and the hydrochars themselves are also disclosed.

Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

Abstract: Embodiments are directed to compounds of the formulae (I), (Ia), (Ib), (II), (IIa) (III), (IV), (V), and (VI); methods for treating cancer with one or more compounds of the formulae (I), (Ia), (Ib), (II), (IIa); (III), (IV), (V), and (VI); and methods for inhibiting a human topoisomerase with one or more compounds of the formulae (I), (Ia), (Ib), (II), (IIa); (III), (IV), (V), and (VI).

Abstract: The present invention provides in certain embodiments compositions comprising at least one CD200 inhibitor, and methods of reversing or modulating immune suppression in a patient having a disease or disorder arising from abnormal cell growth, function or behavior, which method comprises administering to a patient in need thereof a CD200 inhibitor composition.

Abstract: A method for treating a subject having, or at risk of having, ataxia, generally includes administering to the subject an amount of a composition comprising a cholecystokinin receptor (Cck1R) agonist effective to ameliorate at least one symptom or clinical sign of ataxia.

Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.