Patents Assigned to Research Triangle Institute
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Patent number: 11452970Abstract: The present disclosure provides methods to use calcium cobalt zirconium perovskites as oxygen-selective sorbents for the separation of oxygen from a gas mixture such as air. Systems and high temperature oxygen detectors are also provided. In a preferred embodiment, the perovskite is configured as a membrane.Type: GrantFiled: February 27, 2020Date of Patent: September 27, 2022Assignee: Research Triangle InstituteInventors: Qinghe Zheng, Marty Lail, Shaojun Zhou
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Patent number: 11413572Abstract: A method with corresponding systems for reducing emission of amines to the atmosphere. The method includes a a) introducing a gas containing CO2 into an absorber; b) flowing the flue gas through an absorber having an absorbent with a water-lean solution having less than 50% water and one or more amines, with the absorbent capturing the CO2 and forming a reduced CO2 content gas having a baseline CO2 content; and c) washing the reduced CO2 content gas in a wash column with a wash solution comprising carbonic acid formed by addition of gaseous CO2 into the wash solution. In this method, the washing removes the amines from the reduced CO2 content gas and produces a reduced amine content gas exiting from the wash column.Type: GrantFiled: June 18, 2020Date of Patent: August 16, 2022Assignee: Research Triangle InstituteInventors: Aravind V. Rayer Rabindran, Vijay Gupta, Paul D. Mobley, Jak Tanthana, Shaojun Zhou, Finn Andrew Tobiesen, Thor Mejdell, Andreas Grimstvedt, Geir Haugen
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Patent number: 11406971Abstract: The present disclosure provides methods of making confined nanocatalysts within mesoporous materials (MPMs). The methods utilize solid state growth of nanocrystalline metal organic frameworks (MOFs) followed by controlled transformation to generate nanocatalysts in situ within the mesoporous material. The disclosure also provides applications of the nanocatalysts to a wide variety of fields including, but not limited to, liquid organic hydrogen carriers, synthetic liquid fuel preparation, and nitrogen fixation.Type: GrantFiled: March 26, 2019Date of Patent: August 9, 2022Assignee: Research Triangle InstituteInventors: Ignacio Luz Minguez, Mustapha Soukri, Marty Lail, John R Carpenter, Sameer Parvathikar, Michael Carpenter
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Patent number: 11292783Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.Type: GrantFiled: September 15, 2017Date of Patent: April 5, 2022Assignee: Research Triangle InstituteInventors: Frank Ivy Carroll, Chad M. Kormos, Pauline W. Ondachi, Scott P. Runyon, Hernan A. Navarro, James B. Thomas, S. Wayne Mascarella
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Patent number: 11285430Abstract: The disclosure provides methods and systems for decreasing nitrosamine content, e.g., in the context of non-aqueous solvent systems. It includes a method including receiving a non-aqueous solvent system and contacting the non-aqueous solvent system with a composition including one or more alkoxides to give a treated solvent system having a nitrosamine content that is lower than the starting nitrosamine content. Similarly, it includes a system including a first unit configured to remove undesirable components from a gas stream; a second unit holding a composition including one or more alkoxides, and a conduit to connect these units.Type: GrantFiled: January 21, 2020Date of Patent: March 29, 2022Assignee: Research Triangle InstituteInventors: Marty Lail, Aravind Villava Rayer Rabindran, Samuel John Thompson
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Patent number: 11220526Abstract: Neuropeptide S receptor agonists are provided. The NPS agonists include trimeric, tetrameric, pentameric or hexameric peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The peptidomimetic molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.Type: GrantFiled: March 23, 2017Date of Patent: January 11, 2022Assignee: Research Triangle InstituteInventors: Scott Runyon, Danni Harris, Rainer Reinscheid, Yanyan Zhang, Carla Hassler
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Patent number: 11213869Abstract: A solid waste treatment system includes: a solid-liquid separator module configured to receive mixed solid and liquid waste and separating solid material from the mixed solid and liquid waste; an accumulator and macerator module configured to receive and macerate the solid material from the solid-liquid separator module; a drying module configured to receive and dry the macerated solid material from the accumulator and macerator module; and a combustion module configured to receive and combust the dried macerated solid material from the drying module.Type: GrantFiled: February 5, 2019Date of Patent: January 4, 2022Assignee: Research Triangle InstituteInventors: Jeffrey Robert Piascik, Charles David Stokes, Ethan Klem, Brian Rhys Stoner, Christopher Gregory, Nicholas G. Baldasaro, Katelyn Lea Sellgren, David E. Rogers, Brian Grant, Brian Thomas Hawkins, Enzo Cellini
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Patent number: 11179704Abstract: The present disclosure provides perovskite catalytic materials and catalysts comprising platinum-group metals and perovskites. These catalysts may be used as oxygen storage materials with automotive applications, such as three-way catalysts. They are also useful for water or CO2 reduction, or thermochemical energy storage.Type: GrantFiled: November 14, 2017Date of Patent: November 23, 2021Assignee: Research Triangle InstituteInventors: Qinghe Zheng, Marty Lail, Kelly E. Amato
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Patent number: 11142546Abstract: Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.Type: GrantFiled: March 23, 2017Date of Patent: October 12, 2021Assignee: Research Triangle InstituteInventors: Scott Runyon, Carla Hassler, Craig Shiner, Sanju Narayanan
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Patent number: 11084781Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.Type: GrantFiled: May 10, 2018Date of Patent: August 10, 2021Assignee: Research Triangle InstituteInventors: Yanan Zhang, Thuy Nguyen, Nadezhda German
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Patent number: 11078411Abstract: The present disclosure relates to delivery and release systems wherein a plurality of particles is provided, and the particles are formed of a vehicle component and a cargo component. The systems and methods particularly can be useful in delivery of various chemicals to a petroleum reservoir. The vehicle component can undergo a change in situ such that at least a portion of the cargo component is released.Type: GrantFiled: January 17, 2017Date of Patent: August 3, 2021Assignee: Research Triangle InstituteInventors: Leah Marie Johnson, Ginger Denison Rothrock, Chasity Antoninette Norton, Sarah Dorothy Shepherd, Nicolas Daniel Huffman, Jeffrey Brent Mecham
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Patent number: 11078404Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.Type: GrantFiled: August 21, 2019Date of Patent: August 3, 2021Assignee: Research Triangle InstituteInventors: Leah Marie Johnson, Ginger Denison Rothrock, Chasity Antoninette Norton, Nicolas Daniel Huffman, Jeffrey Brent Mecham
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Patent number: 11047787Abstract: An optical system for particle detection.Type: GrantFiled: April 29, 2020Date of Patent: June 29, 2021Assignee: Research Triangle InstituteInventors: Anthony Clint Clayton, Howard Jerome Walls, Roger H. Pope
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Patent number: 10960345Abstract: A solvent system for the removal of acid gases from mixed gas streams is provided. Also provided is a process for removing acid gases from mixed gas streams using the disclosed solvent systems. The solvent systems may be utilized within a gas processing system.Type: GrantFiled: August 8, 2018Date of Patent: March 30, 2021Assignee: Research Triangle InstituteInventors: Marty Lail, Luke Coleman
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Patent number: 10954181Abstract: A process for selectively recovering a phenolic compound from feedstock comprising bio-crude and/or bio-oil is described. The recovery efficiency of the selected phenolic compound is greater than 70 wt % and the purity of the recovered selected phenolic compound is higher than 80 wt %. The process comprises distilling the feedstock to isolate the selected phenolic compound in a first distillate fraction comprising the selected phenolic compound, concentrating the selected phenolic compound from the first distillate fraction in a concentrated mixture, and purifying the concentrated mixture to recover the selected phenolic compound.Type: GrantFiled: July 9, 2019Date of Patent: March 23, 2021Assignee: Research Triangle InstituteInventors: Ofei D. Mante, Mustapha Soukri, Samuel J. Thompson, David C. Dayton
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Patent number: 10954247Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.Type: GrantFiled: May 18, 2018Date of Patent: March 23, 2021Assignee: Research Triangle InstituteInventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
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Patent number: 10947139Abstract: A liquid waste treatment system includes: a baffle tank subsystem for particle settling; a preprocess tank subsystem downstream of the baffle tank subsystem; a process tank subsystem downstream of the preprocess tank subsystem; and a storage tank subsystem downstream of the process tank subsystem for the storage of treated liquid. A Microbial Fuel Cell (MFC) processing module may be included and may be inserted into the preprocess tank subsystem or implemented in a second process tank downstream of the process tank subsystem. A faster disinfection may occur in the process tank subsystem, and a slower disinfection may occur in the second process tank according to distinct respective kill curves. An electrochemical cell may be operated in a pulse mode in liquid waste in a pulsed mode.Type: GrantFiled: February 5, 2019Date of Patent: March 16, 2021Assignee: Research Triangle InstituteInventors: Jeffrey Robert Piascik, Charles David Stokes, Ethan Klem, Brian Rhys Stoner, Christopher Gregory, Nicholas G. Baldasaro, Katelyn Lea Sellgren, David E. Rogers, Brian Grant, Brian Thomas Hawkins, Enzo Cellini
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Patent number: 10919841Abstract: The invention provides bupropion analogue compounds capable of inhibiting the reuptake of one or more monoamines. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin. Such compounds may be used to treat conditions that are responsive to inhibition of the reuptake of monoamines, including addiction, depression, and obesity.Type: GrantFiled: December 22, 2016Date of Patent: February 16, 2021Assignee: Research Triangle InstituteInventors: Frank Ivy Carroll, Bruce Edward Blough, Philip Abraham
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Patent number: 10696677Abstract: This disclosure is directed to various compounds and methods of preparation of improved compounds that are capable of functioning as cannabinoid receptor 1 (CB1) antagonists with reduced central nervous system (CNS) side effects. The application is also directed to pharmaceutical compositions containing one or more of these compounds, which may also contain one or more additional therapeutic agents. It is also directed to methods of treatment of various conditions that may be responsive to antagonism of the CB1 receptors, including, but not limited to, metabolic syndromes (including liver disease, obesity, and diabetes).Type: GrantFiled: December 20, 2017Date of Patent: June 30, 2020Assignee: Research Triangle InstituteInventors: Rangan Maitra, Robert W. Wiethe, Yanan Zhang, George S. Amato
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Patent number: 10549233Abstract: A solvent system comprising a diluent and a nitrogenous base for the removal of CO2 from mixed gas streams is provided. Also provided is a process for removing CO2 from mixed gas streams using the disclosed solvent system. The solvent system may be utilized within a gas processing system.Type: GrantFiled: May 18, 2017Date of Patent: February 4, 2020Assignee: Research Triangle InstituteInventors: Marty Lail, Luke Coleman