Patents Assigned to Research Triangle Institute
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Patent number: 8981102Abstract: Provided herein are compounds and methods of preparation of compounds that are capable of functioning as agonists or antagonists of a nicotinic receptor. Also provided are pharmaceutical compositions comprising one or more of these compounds, which may further comprise one or more additional therapeutic agents. Further provided are methods of treatment of various conditions that may be responsive to such activity at the nicotinic receptors, such as nicotine dependence.Type: GrantFiled: August 19, 2011Date of Patent: March 17, 2015Assignee: Research Triangle InstituteInventors: Frank Ivy Carroll, Pauline Wanjiku Ondachi
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Patent number: 8975464Abstract: The present invention provides a method of increasing the efficiency of exothermic CO2 capture processes. The method relates to withdrawing heat generated during the exothermic capture of CO2 with various sorbents via heat exchange with a working fluid. The working fluid is provided at a temperature and pressure such that it is in the liquid state, and has a vaporization temperature in a range such that the heat arising from the reaction of the CO2 and the sorbent causes a phase change from liquid to vapor state in whole or in part and transfers heat from to the working fluid. The resulting heated working fluid may subsequently be used to generate power.Type: GrantFiled: December 16, 2011Date of Patent: March 10, 2015Assignee: Research Triangle InstituteInventors: Aqil Jamal, Raghubir P. Gupta
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Patent number: 8975753Abstract: A three-dimensional interconnect includes a first substrate bonded to a second substrate, the first substrate including a device layer and a bulk semiconductor layer, a metal pad disposed on the second substrate, an electrically insulating layer disposed between the first and second substrates. The structure has a via-hole extending through the device layer, the bulk semiconductor layer and the electrically insulating layer to the metal pad on the second substrate. The structure has a dielectric coating on a sidewall of the via-hole, and a plasma-treated region of the metal pad disposed on the second substrate. The structure includes a via metal monolithically extending from the plasma-treated region of the metal pad through the via-hole and electrically interconnecting the device layer of the first substrate to the metal pad of the second substrate.Type: GrantFiled: March 3, 2010Date of Patent: March 10, 2015Assignee: Research Triangle InstituteInventors: Charles Kenneth Williams, Christopher A. Bower, Dean Michael Malta, Dorota Temple
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Publication number: 20150008390Abstract: Integrated upconversion devices capable of upconverting incident visible to short wavelength infrared photons to visible photons are disclosed. The device may include a quantum dot-based photodiode and a light-emitting diode. The device may further include a gain element such as a thin-film transistor.Type: ApplicationFiled: March 17, 2014Publication date: January 8, 2015Applicant: Research Triangle InstituteInventors: John Lewis, Ethan Klem
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Patent number: 8906908Abstract: The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.Type: GrantFiled: November 19, 2012Date of Patent: December 9, 2014Assignees: Research Triangle Institute, Dignity Health, Virginia Commonwealth UniversityInventors: F. Ivy Carroll, Bruce E. Blough, Hernan A. Navarro, S. Wayne Mascarella, Ana Zamfira Muresan, M. Imad Damaj, Ronald J. Lukas
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Publication number: 20140347663Abstract: A gas processing device such as an aerosol exposure monitor is configured for acquiring chronic data, acute data, or both simultaneously, and may include a pump and a noise dampening device. The noise dampening device may include an elastomeric membrane between an inlet chamber and an outlet chamber. In another aspect, an aerosol exposure monitor may include an impactor, a collection filter, and a nephelometer that includes a sample chamber integrated with an aerosol flow path associated with the impactor and collection filter.Type: ApplicationFiled: October 26, 2012Publication date: November 27, 2014Applicant: Research Triangle InstituteInventors: Charles E. Rodes, J. Randall Newsome
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Publication number: 20140335496Abstract: A multicellular fluidic enhanced airway model system of the conducting airways as a tool for the evaluation of biological threats and medical countermeasures is provided. The airway model system can include a first chamber having an inlet and an outlet and containing epithelial cells; a second chamber having an inlet and an outlet and containing an extracellular matrix, wherein the second chamber is separated from the first chamber by a porous membrane; and a third chamber having an inlet and an outlet, wherein the third chamber is separated from the second chamber by a porous membrane, and wherein the airway tissue model system is configured to provide a separate fluidic pathway through each of said first, second, and third chambers. A method of analyzing tissue response to an agent via an airway tissue model system is also provided.Type: ApplicationFiled: December 4, 2012Publication date: November 13, 2014Applicants: Research Triangle Institute, The University of North Carolina at Chapel HillInventors: Sonia Grego, Kristin Hedgepath Gilchrist, Scott H. Randell
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Patent number: 8884507Abstract: A fiber-based reflective lighting device and a lighting device. The fiber-based reflective lighting device includes a source configured to generate a primary light, a mat of reflective fibers which diffusely reflects light upon illumination with at least the primary light, and a light exit configured to emanate the reflected light. The lighting device includes a housing, a source configured to generate primary light and direct the primary light into the housing, a reflective mat of fibers disposed inside the housing at a position to reflect the primary light, and a light exit in the housing configured to emanate the reflected light from the housing.Type: GrantFiled: November 17, 2010Date of Patent: November 11, 2014Assignee: Research Triangle InstituteInventors: James Lynn Davis, Howard J. Walls, Karmann Mills, Vijay Gupta, Michael Kasper Lamvik
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Publication number: 20140318593Abstract: A thermoelectric composite and a thermoelectric device and a method of making the thermoelectric composite. The thermoelectric composite is a semiconductor material formed from mechanically-alloyed powders of elemental constituents of the semiconductor material to produce nano-particles of the semiconductor material, and compacted to have at least a bifurcated grain structure. The bifurcated grain structure has at least two different grain sizes including small size grains in a range of 2-200 nm and large size grains in a range of 0.5 to 5 microns. The semiconductor material has a figure of merit ZT, defined as a ratio of the product of square of Seebeck coefficient, S2, and electrical conductivity ? divided by the thermal conductivity k, which varies from greater than 1 at 300 K to 2.5 at temperatures of 300 to 500K.Type: ApplicationFiled: November 21, 2012Publication date: October 30, 2014Applicants: Research Triangle Institute, North Carolina State UniversityInventors: Rama Venkatasubramanian, Judy Stuart, Ryan Wiitala, Peter Thomas, Carl C. Koch, Tsungta Ethan Chan
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Patent number: 8866080Abstract: A detector array and method for making the detector array. The array includes a substrate including a plurality of trenches formed therein, and includes a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charge particles incident on respective ones of the collectors and to output from said collectors signals indicative of charged particle collection. The array includes a plurality of readout circuits disposed on a side of the substrate opposite openings to the collectors. The readout circuits are configured to read charge collection signals from respective ones of the plurality of collectors.Type: GrantFiled: February 27, 2009Date of Patent: October 21, 2014Assignee: Research Triangle InstituteInventors: Christopher A. Bower, Kristin Hedgepath Gilchrist, Brian R. Stoner, Dorota Temple
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Patent number: 8866081Abstract: A detector array and method for making the detector array. The detector array includes a substrate including a plurality of trenches formed therein, and a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charged particles incident on respective ones of the collectors and to output from the collectors signals indicative of charged particle collection. In the detector array, adjacent ones of the plurality of trenches are disposed in a staggered configuration relative to one another. The method forms in a substrate a plurality of trenches across a surface of the substrate such that adjacent ones of the trenches are in a staggered sequence relative to one another, forms in the plurality of trenches a plurality of collectors, and connects a plurality of electrodes respectively to the collectors.Type: GrantFiled: February 24, 2009Date of Patent: October 21, 2014Assignee: Research Triangle InstituteInventors: Christopher A. Bower, Kristin Hedgepath Gilchrist, Brian R. Stoner
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Patent number: 8864341Abstract: A fiber-based reflective lighting device. The lighting device includes a source configured to generate a primary light, a substrate including a mat of reflective nanofibers, and a light exit configured to emanate the reflected light. The fibers have an average fiber diameter AFD less than 500 nm which diffusively reflects visible light upon illumination with at least the primary light. The mat has a basis weight less than 40 gram per square meter (gsm) and a reflectance greater than 80%.Type: GrantFiled: December 11, 2013Date of Patent: October 21, 2014Assignee: Research Triangle InstituteInventors: James Lynn Davis, Larry Charles Michael, Karmann C. Mills
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Patent number: 8851693Abstract: A stimulated lighting device for stimulatable light emission including a luminescent sheet including light stimulatable particles which emit secondary light upon receiving primary light. The lighting device includes a source configured to generate and direct the primary light obliquely onto the luminescent sheet, at least one reflector configured to reflect at least a part of the primary light and a part of the secondary light onto the luminescent sheet and configured to reflect at least a part of scattered primary light and a part of the secondary light from the luminescent sheet toward the light exit, and a light exit configured to emanate light as a combination of the primary light and the secondary light.Type: GrantFiled: April 14, 2010Date of Patent: October 7, 2014Assignee: Research Triangle InstituteInventors: Michael Kasper Lamvik, James Lynn Davis
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Publication number: 20140272799Abstract: A dental component comprising a modified porcelain veneering coating thereon is provided, wherein the porcelain veneering coating can comprise a plurality of crystalline inclusions. The crystalline inclusions can serve to strengthen the porcelain veneering coating and the dental component as a whole. A method for the preparation of such treated implants is also provided, the method involving providing a dental component; applying a porcelain slurry comprising about 5% or more by weight of an additive capable of forming a crystalline silicate phase to at least a portion of the surface of the dental component to give a coated dental component; and firing the porcelain-coated dental component.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Research Triangle InstituteInventors: Jeffrey Robert Piascik, Brian R. Stoner
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Publication number: 20140239164Abstract: The present disclosure provides sensing systems and methods that are useful for monitoring materials (e.g., cement) via light diffusion to identify characteristics thereof and changes therein. The systems can utilize a light source, a light sensor, and light transmitting members combined with the material to be monitored. In use, light from the light source can be allowed to scatter through the material via the light transmitting members for detection by the light sensor. The data regarding the light transfer can be transmitted utilizing a communication interface and can be analyzed using data processing equipment. The systems and methods may particularly be utilized in monitoring the reinforcing cement positioned between the casing and the formation in an oil well.Type: ApplicationFiled: February 26, 2014Publication date: August 28, 2014Applicant: Research Triangle InstituteInventors: Ginger D. Rothrock, Mark W. Roberson, Vijay Gupta, Michele L. Ostraat, David F. Myers
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Publication number: 20140225063Abstract: A photodetector includes one or more photodiodes and a signal processing circuit. Each photodiode includes a transparent first electrode, a second electrode, and a heterojunction interposed between the first electrode and the second electrode. Each heterojunction includes a quantum dot layer and a fullerene layer disposed directly on the quantum dot layer. The signal processing circuit is in signal communication each the second electrode. The photodetector may be responsive to wavelengths in the infrared, visible, and/or ultraviolet ranges. The quantum dot layer may be treated with a chemistry that increases the charge carrier mobility of the quantum dot layer.Type: ApplicationFiled: April 16, 2014Publication date: August 14, 2014Applicant: Research Triangle InstituteInventors: ETHAN KLEM, JOHN LEWIS
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Publication number: 20140160723Abstract: A fiber-based reflective lighting device. The lighting device includes a source configured to generate a primary light, a substrate including a mat of reflective nanofibers, and a light exit configured to emanate the reflected light. The fibers have an average fiber diameter AFD less than 500 nm which diffusively reflects visible light upon illumination with at least the primary light. The mat has a basis weight less than 40 gram per square meter (gsm) and a reflectance greater than 80%.Type: ApplicationFiled: December 11, 2013Publication date: June 12, 2014Applicant: Research Triangle InstituteInventors: James Lynn Davis, Larry Charles Michael, Karmann C. Mills
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Patent number: 8742398Abstract: A photodetector includes one or more photodiodes and a signal processing circuit. Each photodiode includes a transparent first electrode, a second electrode, and a heterojunction interposed between the first electrode and the second electrode. Each heterojunction includes a quantum dot layer and a fullerene layer disposed directly on the quantum dot layer. The signal processing circuit is in signal communication each the second electrode. The photodetector may be responsive to wavelengths in the infrared, visible, and/or ultraviolet ranges. The quantum dot layer may be treated with a chemistry that increases the charge carrier mobility of the quantum dot layer.Type: GrantFiled: September 29, 2010Date of Patent: June 3, 2014Assignee: Research Triangle Institute, Int'l.Inventors: Ethan Klem, John Lewis
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Publication number: 20140144971Abstract: Low temperature bond balls connect two structures having disparate coefficients of linear thermal expansion. An integrated circuit is made to heat the device such that the low temperature bond balls melt. After melting, the bond balls solidify, and the device is operated with the bond balls solidified. In one example, one of the two structures is a semiconductor substrate, and the other structure is a printed circuit board. The integrated circuit is a die mounted to the semiconductor substrate. The bond balls include at least five percent indium, and the integrated circuit is an FPGA loaded with a bit stream. The bit stream configures the FPGA such that the FPGA has increased power dissipation, which melts the balls. After the melting, a second bit stream is loaded into the FPGA and the FPGA is operated in a normal user-mode using the second bit stream.Type: ApplicationFiled: January 29, 2014Publication date: May 29, 2014Applicant: Research Triangle InstituteInventors: Robert O. Conn, Daniel S. Stevenson
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Patent number: 8729528Abstract: An optoelectronic device includes a first electrode, a quantum dot layer disposed on the first electrode including a plurality of quantum dots, a fullerene layer disposed directly on the quantum dot layer wherein the quantum dot layer and the fullerene layer form an electronic heterojunction, and a second electrode disposed on the fullerene layer. The device may include an electron blocking layer. The quantum dot layer may be modified by a chemical treatment to exhibit increased charge carrier mobility.Type: GrantFiled: September 29, 2010Date of Patent: May 20, 2014Assignee: Research Triangle InstituteInventors: Ethan Klem, John Lewis
