Patents Assigned to Research Triangle Institute
  • Publication number: 20170197198
    Abstract: Solid sorbent materials have been prepared by combining polyethyleneimine (PEI) with silica precursors. The solid sorbent materials can be used, for example, for acid gas separation, gas purification, and water purification applications. Advantageously, such materials can be water stable and the capacity of such solid sorbent materials does not diminish substantially after repeated use and regeneration.
    Type: Application
    Filed: July 14, 2015
    Publication date: July 13, 2017
    Applicant: Research Triangle Institute
    Inventors: Mustapha Soukri, Luke Coleman, Marty Lail
  • Patent number: 9651313
    Abstract: A heat transfer system and related method of heat transfer is provided. The heat transfer system includes a tubular receiver positioned to receive heat from a heat source, the receiver comprising one or more enclosed tubes configured for gravity-driven flow of a particulate heat transfer fluid therethrough in a dense, unfluidized state having a particle volume fraction of at least about 25%; and at least one storage vessel in fluid communication with the tubular receiver and positioned to receive the heat transfer fluid therefrom, wherein the particulate heat transfer fluid includes a plurality of particles of a metal-containing material having a melting point of greater than 800 C, the heat transfer fluid being substantially free of a liquid component.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: May 16, 2017
    Assignee: Research Triangle Institute
    Inventors: James Arthur Trainham, Paul G. Hoertz, Christopher A. Bonino, John S. Newman
  • Patent number: 9622995
    Abstract: Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: April 18, 2017
    Assignees: TEMPLE UNIVERSITY—Of The Commonwealth System of Higher Education, DUKE UNIVERSITY, RESEARCH TRIANGLE INSTITUTE
    Inventors: Mary E. Abood, Pingwei Zhao, Lawrence S. Barak, Herbert H. Seltzman
  • Patent number: 9617229
    Abstract: Provided herein are compounds and prodrugs and methods of preparation of compounds and prodrugs that are capable of functioning as releasers and/or uptake inhibitors of one or more monoamine neurotransmitters, including dopamine, serotonin, and norepinephrine. Also provided are pharmaceutical compositions comprising one or more of these compounds or prodrugs, which may further comprise one or more additional therapeutic agents. Also provided are methods of treatment of various conditions that may be responsive to modification of monoamine neurotransmitter levels, such as pre-obesity, obesity, addiction, and depression.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: April 11, 2017
    Assignees: Research Triangle Institute, The United States of America, As Represented by the Secretary Department of Health and Human Services
    Inventors: Bruce E. Blough, Richard Rothman, Antonio Landavazo, Kevin M. Page, Ann Marie Decker
  • Patent number: 9598282
    Abstract: A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, and a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance. The method measures at least one change in an electrical impedance between spatially separated electrodes, and identifies the chemical species based on the measured change in the electrical impedance.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: March 21, 2017
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Li Han, Anthony L. Andrady, David S. Ensor
  • Publication number: 20170051008
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Application
    Filed: November 2, 2016
    Publication date: February 23, 2017
    Applicants: RESEARCH TRIANGLE INSTITUTE, The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Scott P. RUNYON, Michael ROGAWSKI, Edgar COOK, John KEPLER, Herman NAVARRO, Rafal KAMINSKI, Matthew ORR
  • Patent number: 9576889
    Abstract: An electronic package may be fabricated by forming a first layer of insulating material on a first substrate such that the first layer covers a contact pad; forming an opening through the first layer to expose the contact pad; forming an un-patterned second layer on the first layer, the second layer including an adhesive having a viscosity less than that of the first layer, wherein a region of the second layer obstructs the contact pad; removing the region to re-expose the contact pad; aligning a second substrate with the first substrate such that a via of the second substrate is aligned with the opening; bonding the first substrate and the second substrate together at the second layer; and forming an interconnect in contact with the contact pad by depositing a conductive material through the via and the opening.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: February 21, 2017
    Assignee: Research Triangle Institute
    Inventor: Erik Paul Vick
  • Patent number: 9567841
    Abstract: The present disclosure relates to cementitious fluids comprising additives configured to form a permeable cement matrix after curing of the cement. The cementitious fluids can comprise a cementitious medium (e.g., a cement slurry) with a plurality of fibers dispersed therein. The fibers can be hollow, can be porous, and can be degradable. The cementitious fluid particularly can be used in methods of stimulating hydrocarbon bearing formations. Specifically, the cementitious fluid can be injected into the formation to form or enlarge a fracture, and the fluid can be cured to form the permeable cement matrix, said permeability arising from a loosely assembled tubular network and/or passages remaining after degradation of the fibers.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: February 14, 2017
    Assignee: Research Triangle Institute
    Inventors: Ginger D. Rothrock, Vikram Rao, Vijay Gupta, Leah Johnson
  • Patent number: 9562001
    Abstract: The invention provides bupropion analog compounds capable of inhibiting the reuptake of one or more monoamines. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin. Such compounds may be used to treat conditions that are responsive to inhibition of the reuptake of monoamines, including addiction, depression, and obesity.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: February 7, 2017
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Bruce Edward Blough, Philip Abraham
  • Patent number: 9562671
    Abstract: A lighting device (100) includes a housing (104) enclosing a housing interior (108), a light source (132), a light converter (136), and a color tuning device. The light source is configured for emitting a primary light beam of a primary wavelength (140) through the housing interior. The light converter includes a luminescent material (144) facing the housing interior and configured for emitting secondary light (156, 158) of one or more wavelengths different from the primary wavelength, in response to excitation by the primary light beam. The housing includes a light exit (124) for outputting a combination of primary light and secondary light. The color tuning device is configured for adjusting a position of the primary light beam relative to the luminescent material.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: February 7, 2017
    Assignee: Research Triangle Institute
    Inventor: James Lynn Davis
  • Patent number: 9539541
    Abstract: The invention relates to a mixed salt composition which is useful as a CO2 sorbent. The mixed salt composition comprises a Mg salt, and at least one Group IA element salt, where the Mg and Group IA element are present at a molar ratio of from 3:1 to 8:1. The resulting composition can adsorb about 20% or more of CO2 in a gas. Via varying the molar ratios of the components, and the Group IA element, one can develop compositions which show optional functionality at different conditions. The composition is especially useful in the adsorptive capture of CO2 on mobile sources, such as transportation vehicles, where it can be recovered during regeneration of the adsorbent composition and the CO2 used as a coolant gas, as a reactant in manufacture of fuel, and so forth.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: January 10, 2017
    Assignees: SAUDI ARABIAN OIL COMPANY, RESEARCH TRIANGLE INSTITUTE
    Inventors: Esam Zaki Hamad, Wajdi Issam Al-Sadat, Luke Coleman, J. P. Shen, Raghubir Gupta
  • Patent number: 9527823
    Abstract: The invention provides hydroxybupropion analogs capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: December 27, 2016
    Assignees: Research Triangle Institute, Dignity Health, Virginia Commonwealth University
    Inventors: Frank Ivy Carroll, Bruce E. Blough, Hernan A. Navarro, S. Wayne Mascarella, Ana Zamfira Muresan, M. Imad Damaj, Ronald J. Lukas
  • Patent number: 9518080
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: December 13, 2016
    Assignees: RESEARCH TRIANGLE INSTITUTE, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Scott P Runyon, Michael Rogawski, Edgar Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • Patent number: 9512105
    Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: December 6, 2016
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Frank I. Carroll, James B. Thomas, Hernan A. Navarro, S. Wayne Mascarella, Scott P. Runyon, Chunyang Jin, Chad M. Kormos
  • Patent number: 9458160
    Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: October 4, 2016
    Assignee: Research Triangle Institute
    Inventors: Rangan Maitra, Alan Bradley Fulp, Yanan Zhang, Herbert H. Seltzman
  • Patent number: 9441811
    Abstract: A lighting device (100) includes a housing (104), a light converter (136), one or more light sources (132), and one or more optical waveguides (160). The housing includes a light exit (124) for outputting a combination of primary light (140) and secondary light (156,158). The light source emits a primary light beam of a primary wavelength. The optical waveguide includes an input end (162) optically coupled to the light source, and an output end (164) facing a housing interior (108) and positioned at an angle to an axial direction through the housing interior. The optical waveguide directs the primary light beam from the light source, through the housing interior and toward a luminescent material of the light converter. The luminescent material emits secondary light of one or more wavelengths different from the primary wavelength in response to excitation by the primary light beam. The light source may be mounted outside the housing interior so as not to obstruct light propagation.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: September 13, 2016
    Assignee: Research Triangle Institute
    Inventors: Michael Lamvik, James Lynn Davis, Brent Thomas Ward
  • Patent number: 9437796
    Abstract: A thermoelectric material and a thermoelectric converter using this material. The thermoelectric material has a first component including a semiconductor material and a second component including a rare earth material included in the first component to thereby increase a figure of merit of a composite of the semiconductor material and the rare earth material relative to a figure of merit of the semiconductor material. The thermoelectric converter has a p-type thermoelectric material and a n-type thermoelectric material. At least one of the p-type thermoelectric material and the n-type thermoelectric material includes a rare earth material in at least one of the p-type thermoelectric material or the n-type thermoelectric material.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: September 6, 2016
    Assignees: RESEARCH TRIANGLE INSTITUTE, U.S. DEPARTMENT OF ENERGY
    Inventors: Rama Venkatasubramanian, Bruce Allen Cook, Evgenii M. Levin, Joel Lee Harringa
  • Publication number: 20160243480
    Abstract: A filtration device including a contoured support having 1) an interior surface, 2) an outside peripheral surface spaced farther from a center of the contoured support than the interior surface, and 3) a rim enclosed and sealed to a perimeter of the contoured support. The filtration device includes macroscopic openings in the contoured support extending from the interior surface to the outside peripheral surface, and a plurality of nanofibers having diameters less than 1 micron. The nanofibers are disposed on the outside peripheral surface of the contoured support, and cover the macroscopic openings to form a filtration medium on the contoured support.
    Type: Application
    Filed: December 21, 2015
    Publication date: August 25, 2016
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Howard Jerome WALLS, Randall J. NEWSOME, Anthony Clint CLAYTON, Robert W. YAGA, David Samuel ENSOR
  • Patent number: 9402697
    Abstract: A fluoride treated ceramic material is provided, the ceramic material comprising fluorinated metal oxide on its surface. A method for the preparation of such treated ceramics is also provided, the method involving exposure of the ceramic to a fluorine-containing reagent. The ceramic materials can be further functionalized so as to bond to functional ligands and/or resins. The ceramic materials can be, for example, ceramic medical implants or particulate ceramic, which can be incorporated within dental and/or orthopedic composites.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: August 2, 2016
    Assignee: Research Triangle Institute
    Inventors: Jeffrey Robert Piascik, Brian R. Stoner
  • Publication number: 20160195488
    Abstract: A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured, and a membrane encasing the fibers and having a thickness ranging from 50 ?m to 5.0 mm. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance.
    Type: Application
    Filed: December 18, 2013
    Publication date: July 7, 2016
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: David S. ENSOR, Li HAN