Patents Assigned to Research Triangle Institute
  • Patent number: 10018551
    Abstract: A particle detector includes a housing, a light source, and a photo-responsive material. The housing includes a sample inlet and a sample outlet, and encloses a detection cavity. The light source directs irradiating light along a longitudinal axis to particles of a sample fluid flowing in the detection cavity. The photo-responsive material surrounds at least a portion of the detection cavity, and receives measurement light propagating from the particles in a plurality of measurement light paths angled relative to the longitudinal axis. The particle detector may be utilized to measure scattered light and/or light emitted due to autofluorescence. Fluids sampled may include aerosols, bio-aerosols, and liquids.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: July 10, 2018
    Assignee: Research Triangle Institute
    Inventors: Howard Jerome Walls, Anthony Clint Clayton, Randall J. Newsome, Paul G. Hoertz
  • Patent number: 9994759
    Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a carrier element forming an outer shell that defines an inner core. The core can include a reactive agent that is adapted to react with the shell, particularly at an inner interface of the shell with the core materials. The reaction can provide an inside-out degradation of the shell and release of one or more materials therein. The reactive agent may be separated from the shell, such as using a phase change material (PCM). Upon reaching specific environmental conditions, the PCM can change so as the release the reactive agent for reaction with the shell. The systems can be used in various methods to deliver a material to various environments, including underground reservoirs.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: June 12, 2018
    Assignee: Research Triangle Institute
    Inventors: Ginger D. Rothrock, Leah Marie Johnson
  • Patent number: 9988664
    Abstract: A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers formed into a fiber mat and configured to collect bioparticles thereon, and includes a viability enhancing material provider disposed in a vicinity of the plurality of fibers and configured to provide a viability enhancing material to the collected bioparticles to maintain viability of the bioparticles collected by the fiber mat. The aerosol collection system includes an aerosol pumping device configured to entrain particles in an gas stream, an aerosol saturation device configured to saturate the particles in the gas stream with a biocompatible liquid, and an aerosol collection medium downstream from the aerosol saturation device and including a plurality of fibers formed into a fiber mat for collection of the saturated aerosol particles.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: June 5, 2018
    Assignee: Research Triangle Institute
    Inventors: David Samuel Ensor, Howard Jerome Walls, Karin K Foarde
  • Patent number: 9943466
    Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: April 17, 2018
    Assignees: Research Triangle Institute, The University of North Carolina at Chapel Hill
    Inventors: Leah Marie Johnson, Ginger Denison Rothrock, Sarah Dorothy Shepherd, Sandra Cordel O'Buckley, Andrea Gail Neely
  • Patent number: 9944857
    Abstract: Described herein are processes for converting a biomass starting material (such as lignocellulosic materials) into a low oxygen containing, stable liquid intermediate that can be refined to make liquid hydrocarbon fuels. More specifically, the process can be a catalytic biomass pyrolysis process wherein an oxygen removing catalyst is employed in the reactor while the biomass is subjected to pyrolysis conditions. The stream exiting the pyrolysis reactor comprises bio-oil having a low oxygen content, and such stream may be subjected to further steps, such as separation and/or condensation to isolate the bio-oil.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: April 17, 2018
    Assignee: Research Triangle Institute
    Inventors: David C. Dayton, Raghubir P. Gupta, Brian S. Turk, Atish Kataria, Jian-Ping Shen
  • Patent number: 9915600
    Abstract: A particle detector includes a housing, a light source, and a photo-responsive material. The housing includes a sample inlet and a sample outlet, and encloses a detection cavity. The light source directs irradiating light to particles of a sample fluid flowing in the detection cavity. The photo-responsive material faces the detection cavity, and receives measurement light propagating from the particles in a plurality of measurement light paths angled relative to a longitudinal axis. The particle detector may be utilized to measure scattered light and/or light emitted due to autofluorescence. Fluids sampled may include aerosols, bio-aerosols, and liquids.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: March 13, 2018
    Assignee: Research Triangle Institute
    Inventors: Howard Jerome Walls, Anthony Clint Clayton, Randall J. Newsome, Paul G. Hoertz
  • Patent number: 9884313
    Abstract: This invention is directed to novel mixed transition metal iron (II/III) catalysts for the extraction of oxygen from CO2 and the selective reaction with organic compounds.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: February 6, 2018
    Assignee: Research Triangle Institute
    Inventors: Jian-ping Shen, Marty Lail, Brian Turk, Paul D. Mobley, Jason S. Norman, Laura Douglas, Jonathan Peters
  • Patent number: 9881905
    Abstract: An electronic package includes an adhesion layer between a first substrate and a second substrate. The adhesion layer is patterned to define openings aligned with through-substrate interconnects and corresponding bond pads. A conductive plane is formed between the first substrate and the second substrate, adjacent to the adhesion layer.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: January 30, 2018
    Assignee: Research Triangle Institute
    Inventors: Eric Paul Vick, Dorota Temple
  • Patent number: 9839875
    Abstract: A solvent system comprising an ionic Liquid formed from a relatively acidic component and a nitrogenous base for the removal of acid gases from mixed gas streams is provided. Also provided is a process for removing acid gases from mixed gas streams using the disclosed solvent system. The solvent system may be utilized within a gas processing system.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: December 12, 2017
    Assignee: Research Triangle Institute
    Inventors: Marty Lail, Luke Coleman
  • Patent number: 9808783
    Abstract: A mixed salt composition adapted for use as a sorbent for carbon dioxide removal from a gaseous stream is provided, the composition being in solid form and including magnesium oxide, an alkali metal carbonate, and an alkali metal nitrate, wherein the composition has a molar excess of magnesium characterized by a Mg:X atomic ratio of at least about 3:1, wherein X is the alkali metal. A process for preparing the mixed salt is also provided, the process including mixing a magnesium salt with a solution comprising alkali metal ions, carbonate ions, and nitrate ions to form a slurry or colloid including a solid mixed salt including magnesium carbonate; separating the solid mixed salt from the slurry or colloid to form a wet cake; drying the wet cake to form a dry cake including the solid mixed salt; and calcining the dry cake to form a mixed salt sorbent.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: November 7, 2017
    Assignee: Research Triangle Institute
    Inventors: Jian-Ping Shen, Luke James Ivor Coleman, Marty Alan Lail, Raghubir Prasad Gupta, Brian Scott Turk
  • Patent number: 9707510
    Abstract: A solvent system comprising a diluent and a nitrogenous base for the removal of CO2 from mixed gas streams is provided. Also provided is a process for removing CO2 from mixed gas streams using the disclosed solvent system. The solvent system may be utilized within a gas processing system.
    Type: Grant
    Filed: September 3, 2011
    Date of Patent: July 18, 2017
    Assignee: Research Triangle Institute
    Inventors: Marty Lail, Luke Coleman
  • Patent number: 9709541
    Abstract: A gas processing device includes a sample inlet defining a gas flow path into a housing, and a pump and a noise dampening device disposed in the housing. The noise dampening device includes an inlet chamber, an outlet chamber, and an elastomeric membrane interposed between and fluidly isolating the inlet chamber and the outlet chamber. The inlet chamber is interposed between the sample inlet and the pump inlet, and the outlet chamber communicates with the pump outlet.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: July 18, 2017
    Assignee: Research Triangle Institute
    Inventors: Charles E. Rodes, J. Randall Newsome
  • Publication number: 20170197198
    Abstract: Solid sorbent materials have been prepared by combining polyethyleneimine (PEI) with silica precursors. The solid sorbent materials can be used, for example, for acid gas separation, gas purification, and water purification applications. Advantageously, such materials can be water stable and the capacity of such solid sorbent materials does not diminish substantially after repeated use and regeneration.
    Type: Application
    Filed: July 14, 2015
    Publication date: July 13, 2017
    Applicant: Research Triangle Institute
    Inventors: Mustapha Soukri, Luke Coleman, Marty Lail
  • Patent number: 9651313
    Abstract: A heat transfer system and related method of heat transfer is provided. The heat transfer system includes a tubular receiver positioned to receive heat from a heat source, the receiver comprising one or more enclosed tubes configured for gravity-driven flow of a particulate heat transfer fluid therethrough in a dense, unfluidized state having a particle volume fraction of at least about 25%; and at least one storage vessel in fluid communication with the tubular receiver and positioned to receive the heat transfer fluid therefrom, wherein the particulate heat transfer fluid includes a plurality of particles of a metal-containing material having a melting point of greater than 800 C, the heat transfer fluid being substantially free of a liquid component.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: May 16, 2017
    Assignee: Research Triangle Institute
    Inventors: James Arthur Trainham, Paul G. Hoertz, Christopher A. Bonino, John S. Newman
  • Patent number: 9617229
    Abstract: Provided herein are compounds and prodrugs and methods of preparation of compounds and prodrugs that are capable of functioning as releasers and/or uptake inhibitors of one or more monoamine neurotransmitters, including dopamine, serotonin, and norepinephrine. Also provided are pharmaceutical compositions comprising one or more of these compounds or prodrugs, which may further comprise one or more additional therapeutic agents. Also provided are methods of treatment of various conditions that may be responsive to modification of monoamine neurotransmitter levels, such as pre-obesity, obesity, addiction, and depression.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: April 11, 2017
    Assignees: Research Triangle Institute, The United States of America, As Represented by the Secretary Department of Health and Human Services
    Inventors: Bruce E. Blough, Richard Rothman, Antonio Landavazo, Kevin M. Page, Ann Marie Decker
  • Patent number: 9576889
    Abstract: An electronic package may be fabricated by forming a first layer of insulating material on a first substrate such that the first layer covers a contact pad; forming an opening through the first layer to expose the contact pad; forming an un-patterned second layer on the first layer, the second layer including an adhesive having a viscosity less than that of the first layer, wherein a region of the second layer obstructs the contact pad; removing the region to re-expose the contact pad; aligning a second substrate with the first substrate such that a via of the second substrate is aligned with the opening; bonding the first substrate and the second substrate together at the second layer; and forming an interconnect in contact with the contact pad by depositing a conductive material through the via and the opening.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: February 21, 2017
    Assignee: Research Triangle Institute
    Inventor: Erik Paul Vick
  • Patent number: 9567841
    Abstract: The present disclosure relates to cementitious fluids comprising additives configured to form a permeable cement matrix after curing of the cement. The cementitious fluids can comprise a cementitious medium (e.g., a cement slurry) with a plurality of fibers dispersed therein. The fibers can be hollow, can be porous, and can be degradable. The cementitious fluid particularly can be used in methods of stimulating hydrocarbon bearing formations. Specifically, the cementitious fluid can be injected into the formation to form or enlarge a fracture, and the fluid can be cured to form the permeable cement matrix, said permeability arising from a loosely assembled tubular network and/or passages remaining after degradation of the fibers.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: February 14, 2017
    Assignee: Research Triangle Institute
    Inventors: Ginger D. Rothrock, Vikram Rao, Vijay Gupta, Leah Johnson
  • Patent number: 9562671
    Abstract: A lighting device (100) includes a housing (104) enclosing a housing interior (108), a light source (132), a light converter (136), and a color tuning device. The light source is configured for emitting a primary light beam of a primary wavelength (140) through the housing interior. The light converter includes a luminescent material (144) facing the housing interior and configured for emitting secondary light (156, 158) of one or more wavelengths different from the primary wavelength, in response to excitation by the primary light beam. The housing includes a light exit (124) for outputting a combination of primary light and secondary light. The color tuning device is configured for adjusting a position of the primary light beam relative to the luminescent material.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: February 7, 2017
    Assignee: Research Triangle Institute
    Inventor: James Lynn Davis
  • Patent number: 9562001
    Abstract: The invention provides bupropion analog compounds capable of inhibiting the reuptake of one or more monoamines. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin. Such compounds may be used to treat conditions that are responsive to inhibition of the reuptake of monoamines, including addiction, depression, and obesity.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: February 7, 2017
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Bruce Edward Blough, Philip Abraham
  • Patent number: 9527823
    Abstract: The invention provides hydroxybupropion analogs capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: December 27, 2016
    Assignees: Research Triangle Institute, Dignity Health, Virginia Commonwealth University
    Inventors: Frank Ivy Carroll, Bruce E. Blough, Hernan A. Navarro, S. Wayne Mascarella, Ana Zamfira Muresan, M. Imad Damaj, Ronald J. Lukas