Abstract: A solid waste treatment system includes: a solid-liquid separator module configured to receive mixed solid and liquid waste and separating solid material from the mixed solid and liquid waste; an accumulator and macerator module configured to receive and macerate the solid material from the solid-liquid separator module; a drying module configured to receive and dry the macerated solid material from the accumulator and macerator module; and a combustion module configured to receive and combust the dried macerated solid material from the drying module.
Type:
Grant
Filed:
February 5, 2019
Date of Patent:
January 4, 2022
Assignee:
Research Triangle Institute
Inventors:
Jeffrey Robert Piascik, Charles David Stokes, Ethan Klem, Brian Rhys Stoner, Christopher Gregory, Nicholas G. Baldasaro, Katelyn Lea Sellgren, David E. Rogers, Brian Grant, Brian Thomas Hawkins, Enzo Cellini
Abstract: The present disclosure provides perovskite catalytic materials and catalysts comprising platinum-group metals and perovskites. These catalysts may be used as oxygen storage materials with automotive applications, such as three-way catalysts. They are also useful for water or CO2 reduction, or thermochemical energy storage.
Type:
Grant
Filed:
November 14, 2017
Date of Patent:
November 23, 2021
Assignee:
Research Triangle Institute
Inventors:
Qinghe Zheng, Marty Lail, Kelly E. Amato
Abstract: The disclosure provides biomedical devices comprising indicator agents sensitive to the environment of use, methods of using same to enhance adherence to a treatment or usage regimen, and systems for monitoring compliance of use of the biomedical device. The biomedical device may be an intravaginal ring comprised of biocompatible polymeric material having indicator agent incorporated therein capable of producing a detectable change in response to a stimulus within the vaginal environment.
Type:
Grant
Filed:
October 25, 2016
Date of Patent:
October 19, 2021
Assignee:
RESEARCH TRIANGLE INSTITUTE
Inventors:
Leah Marie Johnson, Stephanie Lynn Swarner, Ginger Denison Rothrock, Ariane Van Der Straten Ponthoz, Brian Rhys Stoner
Abstract: Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.
Type:
Grant
Filed:
March 23, 2017
Date of Patent:
October 12, 2021
Assignee:
Research Triangle Institute
Inventors:
Scott Runyon, Carla Hassler, Craig Shiner, Sanju Narayanan
Abstract: The present disclosure provides mixed molybdenum oxide catalysts, methods for preparing epoxides from olefins and CO2 using them, and methods of making the mixed molybdenum oxide catalysts by impregnation or co-precipitation. In a preferred embodiment, the mixed molybdenum oxide catalysts are silver/molybdenum oxide catalysts, ruthenium/molybdenum oxide catalysts, or a combination thereof.
Type:
Grant
Filed:
July 26, 2017
Date of Patent:
September 21, 2021
Assignee:
RESEARCH TRIANGLE INSTITUTE
Inventors:
Marty Lail, Paul Mobley, Jonathan Peters, Sree Nandita Akunuri, Joshua J. Hlebak
Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.
Type:
Grant
Filed:
May 10, 2018
Date of Patent:
August 10, 2021
Assignee:
Research Triangle Institute
Inventors:
Yanan Zhang, Thuy Nguyen, Nadezhda German
Abstract: The present disclosure relates to delivery and release systems wherein a plurality of particles is provided, and the particles are formed of a vehicle component and a cargo component. The systems and methods particularly can be useful in delivery of various chemicals to a petroleum reservoir. The vehicle component can undergo a change in situ such that at least a portion of the cargo component is released.
Type:
Grant
Filed:
January 17, 2017
Date of Patent:
August 3, 2021
Assignee:
Research Triangle Institute
Inventors:
Leah Marie Johnson, Ginger Denison Rothrock, Chasity Antoninette Norton, Sarah Dorothy Shepherd, Nicolas Daniel Huffman, Jeffrey Brent Mecham
Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.
Type:
Grant
Filed:
August 21, 2019
Date of Patent:
August 3, 2021
Assignee:
Research Triangle Institute
Inventors:
Leah Marie Johnson, Ginger Denison Rothrock, Chasity Antoninette Norton, Nicolas Daniel Huffman, Jeffrey Brent Mecham
Abstract: The present disclosure provides novel solid sorbents synthesized by the reaction of polyamines with polyaldehyde phosphorous dendrimer (P-dendrimer) compounds. The sorbents are highly stable and exhibit rapid reaction kinetics with carbon dioxide, making the sorbents applicable for carbon capture, and can be easily regenerated for further use. The material is stable to aqueous and organic media, as well as strong acid and bases. The sorbent maintains full capacity over extended use. The material can be used for CO2 capture from pure CO2 streams, mixed gas streams, simulated flue gas, and ambient air. Additionally, the material can be adhered to surfaces for reversible CO2 capture applications outside of bulk particle-based processes.
Type:
Grant
Filed:
January 17, 2019
Date of Patent:
May 4, 2021
Assignee:
RESEARCH TRIANGLE INSTITUTE
Inventors:
Samuel John Thompson, III, Mustapha Soukri
Abstract: A solvent system for the removal of acid gases from mixed gas streams is provided. Also provided is a process for removing acid gases from mixed gas streams using the disclosed solvent systems. The solvent systems may be utilized within a gas processing system.
Abstract: A process for selectively recovering a phenolic compound from feedstock comprising bio-crude and/or bio-oil is described. The recovery efficiency of the selected phenolic compound is greater than 70 wt % and the purity of the recovered selected phenolic compound is higher than 80 wt %. The process comprises distilling the feedstock to isolate the selected phenolic compound in a first distillate fraction comprising the selected phenolic compound, concentrating the selected phenolic compound from the first distillate fraction in a concentrated mixture, and purifying the concentrated mixture to recover the selected phenolic compound.
Type:
Grant
Filed:
July 9, 2019
Date of Patent:
March 23, 2021
Assignee:
Research Triangle Institute
Inventors:
Ofei D. Mante, Mustapha Soukri, Samuel J. Thompson, David C. Dayton
Abstract: A mannikin-based optical analyzer for analyzing an exposure of a subject to an environmental lighting condition. The analyzer has a mannikin with an outer surface replicating a facial profile of the subject, an interior inside the outer surface, and at least one pupil for admission of light into the interior of the mannikin. The analyzer has at least one optical detector configured to acquire and wavelength analyze light directed through the at least one pupil.
Type:
Grant
Filed:
August 30, 2019
Date of Patent:
March 16, 2021
Assignee:
RESEARCH TRIANGLE INSTITUTE
Inventors:
Kelley Jo Rountree, James Lynn Davis, Karmann Cressman Mills, Georgiy Bobashev, Robert Furberg, Anthony Clint Clayton
Abstract: A liquid waste treatment system includes: a baffle tank subsystem for particle settling; a preprocess tank subsystem downstream of the baffle tank subsystem; a process tank subsystem downstream of the preprocess tank subsystem; and a storage tank subsystem downstream of the process tank subsystem for the storage of treated liquid. A Microbial Fuel Cell (MFC) processing module may be included and may be inserted into the preprocess tank subsystem or implemented in a second process tank downstream of the process tank subsystem. A faster disinfection may occur in the process tank subsystem, and a slower disinfection may occur in the second process tank according to distinct respective kill curves. An electrochemical cell may be operated in a pulse mode in liquid waste in a pulsed mode.
Type:
Grant
Filed:
February 5, 2019
Date of Patent:
March 16, 2021
Assignee:
Research Triangle Institute
Inventors:
Jeffrey Robert Piascik, Charles David Stokes, Ethan Klem, Brian Rhys Stoner, Christopher Gregory, Nicholas G. Baldasaro, Katelyn Lea Sellgren, David E. Rogers, Brian Grant, Brian Thomas Hawkins, Enzo Cellini
Abstract: The invention provides bupropion analogue compounds capable of inhibiting the reuptake of one or more monoamines. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin. Such compounds may be used to treat conditions that are responsive to inhibition of the reuptake of monoamines, including addiction, depression, and obesity.
Type:
Grant
Filed:
December 22, 2016
Date of Patent:
February 16, 2021
Assignee:
Research Triangle Institute
Inventors:
Frank Ivy Carroll, Bruce Edward Blough, Philip Abraham
Abstract: The disclosure provides monoamine neurotransmitter releaser and/or monoamine uptake inhibitor compounds having biogenic amine transporter activity but lacking substantial activity at 5-HT2 receptor subtypes. The phenethylamine or vinylogous phenethylamine compounds of the disclosure are useful in treating diseases, conditions and/or disorders mediated by activity of one or more of the monoamine neurotransmitters.
Type:
Grant
Filed:
May 11, 2017
Date of Patent:
January 26, 2021
Assignee:
RESEARCH TRIANGLE INSTITUTE
Inventors:
Bruce Blough, Ann Decker, Richard Rothman
Abstract: A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured, and a membrane encasing the fibers and having a thickness ranging from 50 ?m to 5.0 mm. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance.
Abstract: This disclosure is directed to various compounds and methods of preparation of improved compounds that are capable of functioning as cannabinoid receptor 1 (CB1) antagonists with reduced central nervous system (CNS) side effects. The application is also directed to pharmaceutical compositions containing one or more of these compounds, which may also contain one or more additional therapeutic agents. It is also directed to methods of treatment of various conditions that may be responsive to antagonism of the CB1 receptors, including, but not limited to, metabolic syndromes (including liver disease, obesity, and diabetes).
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
June 30, 2020
Assignee:
Research Triangle Institute
Inventors:
Rangan Maitra, Robert W. Wiethe, Yanan Zhang, George S. Amato