Abstract: A lock mandrel is described herein. The lock mandrel includes an upper connector and a lower connector. The upper connector includes locking keys configured to attach the lock mandrel to a landing nipple on a tubing within a hydrocarbon well. The upper connector also includes a spring-loaded locking collar configured to prevent the locking keys from disengaging from the landing nipple by pressing radially against the locking keys from the inside when in a seated position, and allow the locking keys to disengage from the landing nipple by retracting away from the locking keys when in an unseated position. The lower connector includes a tool adaptor configured to attach a downhole tool to the lock mandrel.

Abstract: The present invention provides a crucible for melting and casting a metal fuel, which includes a reaction preventing layer including: LaYO3; or ZrO2 containing a Y2O3 stabilizer at 5 to 10 wt %, and a method of melting and casting a metal fuel using the same.

Abstract: The present disclosure provides extended release trihexyphenidyl compositions suitable for once- or twice-daily administration. The compositions comprise a core comprising at least one organic acid; at least one drug layer comprising trihexyphenidyl or a pharmaceutically acceptable salt thereof over the core; and a functional coat over the drug-layered core. The compositions of the disclosure provide extended release with reduced Cmax, a Cmin:Cmax ratio of ?0.4, Fluctuation Index of ?1, while providing and maintaining at least a minimum therapeutically effective plasma concentration, of the trihexyphenidyl or the pharmaceutically acceptable salt thereof for at least about 10 hours. The compositions of the disclosure improve solubility of the trihexyphenidyl or the pharmaceutically acceptable salt thereof at a pH of greater than or equal to 5, to provide and maintain at least a minimum effective concentration of the drug at such pH.

Abstract: The claimed subject matter provides for a method for conjugating an active material to a Pt complex.

Abstract: The invention provides the use of SWELL1-LRRC8 modulators and/or binding molecules for therapeutic use, e.g., to treat nonalcoholic fatty liver disease (NAFLD), immune deficiency, and/or male infertility and to regulate vascular tone, systemic arterial and/or pulmonary arterial blood pressure and/or blood flow.

Abstract: A p16INK4a inhibitor, a composition that includes the p16INK4a inhibitor, or a pharmaceutical composition that includes the p16INK4a inhibitor, for use in the prevention and/or the treatment of Huntington's disease, wherein the p16INK4a inhibitor is a nucleic acid or a peptide, a small compound molecule or a marketed drug.

Abstract: The present disclosure is directed to genetically modified carrier/donor cells that are engineered to be resistant to its oligonucleotide payload, and methods of delivering an oligonucleotide into a target cell. The disclosure is also directed to methods of treating cancer using the engineered carrier cells of the disclosure. An aspect of this disclosure is directed to engineering carrier cells to be resistant to the detrimental effects of an oligonucleotide.

Abstract: A method for imaging a lung of a patient is provided. The method includes acquiring a full inspiration computed tomography (CT) scan of the lung to provide a total lung capacity (TLC) image and acquiring a functional residual capacity contrast enhanced multi-energy CT scan of the lung. The method further includes processing the functional residual capacity contrast enhanced multi-energy CT scan of the lung to generate a perfused blood volume (PBV) image and a virtual non-contrast (VNC) image. The method further includes registering the TLC image to at least one of the PBV and VNC images so as to provide a map of regional ventilation and to co-register local ventilation with blood perfusion, generating a lung performance metric using the co-registered images, and outputting the lung performance metric at a user interface of a computing device.

Abstract: Systems and methods for under-floor storage include a robotic retrieval system. The robotic retrieval system includes a robot disposed under an upper floor. The robot may retrieve and deposit objects in a space under the upper floor. A portal provides access to the space from above the upper floor. Objects are stored in locations within the space. The robot selectively locates and retrieves the objects.

Abstract: A nutritional health supplement is provided for the brain. In one exemplary embodiment, a nutritional health supplement comprises an antioxidant that delays neuronal death under excitotoxic conditions, a neuroprotective agent having antioxidant, anti-inflammatory, and anti-apoptic properties, and a neuroprotective agent that is a precursor for glutathione synthesis. In another exemplary embodiment, a nutritional health supplement comprises an antioxidant that delays neuronal death under excitotoxic conditions, a neuroprotective agent that is a precursor for glutathione synthesis, a NAD+ precursor, a ketone body or ketone precursor, and an antioxidant with free-radical species-deactivating properties.

Abstract: A nozzle includes a nozzle member includes a first passage, a second passage surrounding the first passage and configured to eject powder and fluid from an end portion, a diffusion room apart from the end portion and configured to supply the powder and the fluid to the second passage, and a supply path to supply the powder and the fluid to the diffusion room. A first inner surface of the nozzle member includes a first curved surface in a conical shape having a diameter decreasing toward the end portion. A second inner surface of the nozzle member includes a second curved surface in a conical shape having a diameter decreasing toward the end portion. The second passage is formed between the first curved surface and the second curved surface. The diffusion room is formed between the first inner surface and the second inner surface.

Abstract: The invention relates synthetic silicate granules comprising a mixture of SiO2, Al2O3, Na2O and CaO, which can be obtained by sintering; to their use in manufacturing an agglomerate stone material and to the agglomerate stone material resulting thereof.

Abstract: Antigen binding molecules capable of binding to CD122 and/or common ? chain (CD132) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.

Abstract: A beam expanding film includes a first material layer and a photonic crystal layer that expands a width of incident light and emits light having an expanded width. The photonic crystal layer includes a first material layer and a plurality of second material layers buried in the first material layer. A holographic display apparatus includes a backlight unit configured to provide coherent collimated light; a beam expanding film described above and facing the backlight unit; a flat panel arranged between the backlight unit and the beam expanding film to provide a hologram; and a lens configured to focus a holographic image on a space.

Abstract: An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.

Abstract: An operation method of a terminal in a communication system may comprise: receiving, from a base station, an SPS PDSCH; receiving a first PDSCH from the base station; generating SPS HARQ ACK/NACK information for the SPS PDSCH; generating first HARQ ACK/NACK information for the first PDSCH; and when the SPS HARQ-ACK/NACK information is not transmitted in a first slot and transmission of the SPS HARQ-ACK/NACK information is deferred, transmitting both the SPS HARQ ACK/NACK information and the first HARQ ACK/NACK information in a second slot after the first slot.

Abstract: The present invention provides an X-ray CT apparatus capable of obtaining a high-quality X-ray CT image by suppressing occurrence of an artifact. The X-ray CT apparatus including an X-ray imaging system including an X-ray irradiation unit and an X-ray detector, a rotating stage disposed between the X-ray irradiation unit and the X-ray detector, a rotation mechanism configured to relatively rotate the X-ray imaging system and the rotating stage about a rotation axis orthogonal to an optical axis of an X-ray that runs from the X-ray irradiation unit to the X-ray detector, and a load mechanism which is set on the stage and applies test force to a test piece includes an angle changing mechanism that tilts a bending tester to change the direction of the test force applied to the test piece by the bending tester from a direction orthogonal to the optical axis of the X-ray.

Abstract: The present invention relates to a method for encoding and decoding an image. The method for decoding an image includes: deriving an initial motion vector from a merge candidate list of a current block; deriving a refined motion vector using the initial motion vector; and generating a prediction block of the current block using the refined motion vector.

Abstract: Disclosed herein are an apparatus and method for searching for a global minimum of a point cloud registration error. The apparatus includes memory in which at least one program is recorded and a processor for executing the program. The program performs collecting multiple registration results in which the registration error between a source point cloud and a target point cloud is a local minimum as candidates and selecting the registration result in which the registration error between the source point cloud and the target point cloud is a global minimum, among the candidates. Collecting the multiple registration results may comprise repeatedly randomly initializing the source point cloud and the target point cloud and registering the initialized source point cloud to the initialized target point cloud to thereby search for a registration result in which the registration error therebetween is a local minimum.

Abstract: Agents which inhibit Gads dimerization are provided. Accordingly there is provided an agent which inhibits Gads (SEQ ID NO: 1) dimerization, the agent interacting with a pharmacophore binding site comprising an amino acid selected from the group consisting of F55, P56, W58, F59, E61, G62, A84-F92, V107-N111, Y115, F116, L125 and N126 of SEQ ID NO: 1. Also provided an agent which inhibits Gads (SEQ ID NO: 1) dimerization, the agent interacting with a pharmacophore binding site comprising an amino acid sequence of an SH3 domain of SEQ ID NO: 1. Also provided are methods of inhibiting activation of a T cell and/or a mast cell and methods of treating or preventing a disease associated with activation of T cells or an allergic response.