Abstract: Methods and compositions for treatment of prostate cancers, such as androgen receptor (AR) deficient and androgen receptor (AR) low cancers, are disclosed. The methods include administration of an agent that inhibits activity of eIF4F or an agent that disrupts the eIF4F translation-initiation complex (composed of eIF4E, eIF4A, and eIF4G).

Abstract: Methods and compositions using a nucleic acid molecule encoding an atonal-associated factor in combination with a co-transcription factor and/or inhibitor of a gene silencing complex to change the sensory perception of an animal are described.

Abstract: The present disclosure is related to 2-(2-ethoxyethoxy)ethyl-functionalized polymers; their use in foldable intraocular lenses; and methods of making the same.

Abstract: Methods and apparatus for estimating properties of a mixture of two or more surfactant species are provided. Multiple molecular dynamics simulations of the mixture are performed, each simulation using a particular total concentration of the surfactant species and a particular ratio of the surfactant species, such that the multiple simulations cover a plurality of such total concentrations and a plurality of such ratios, each simulation being carried out above the critical micelle concentration of the simulated mixture. For each simulation, and from the results of each simulation, a distribution of each surfactant species between at least a micellar pseudo-phase and a non-micellar pseudo-phase of the mixture at the particular total concentration and particular ratio for that simulation is determined.

Abstract: Provided herein are methods for using 5-azacytidine in combination with additional agents to treat diseases and disorders including AML.

Abstract: A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH3 or CH2, Y is null, O or N, Z is O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, —(C?O)-alkyl, —(C?O)-aryl, —(C?O)-alkyl-aryl, —(C?O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO2, —NH2, —NR3R4, carbonyl, alkoxyl, alkyl or —OCF3, wherein R3 and R4 independently are H, alkyl, O2CH3, —(C?O)—CH3 or (C?O)—NH2.

Abstract: Disclosed herein are protease-based biological circuits for use in the diagnosis and treatment of disease and disorders characterized by aberrant protease signaling. An exemplary method of treating disease in a subject includes administering to the subject a plurality of therapeutic agent loaded-liposomes, wherein each of the liposomes comprises a different density of peptides surrounding the core and a different dose of the therapeutic agent, wherein the peptides comprise a cleavage site for a protease of interest, and wherein cleavage of the peptides open the liposome and release the therapeutic agent from within the liposome.

Abstract: Provided herein are aqueous compositions, kits and methods for the stabilization of cell-free nucleic acids. Provided herein are aqueous compositions for the stabilization of a cell-free nucleic acid (cfNA) population in a blood sample. In certain embodiments, the aqueous composition comprises a polyvinylpyrrolidone (PVP), an apoptosis inhibitor and one or more eryptosis inhibitors.

Abstract: Provided is a laser diode and a method for manufacturing the same. The diode includes a substrate including a DBR region having a channel hole, an active region, and a phase shift region, an optical waveguide provided on the substrate and extending from the active region to the DBR region, a lower insulation layer disposed on the optical waveguide, upper electrodes disposed on the lower insulation layer, and a heat blocking layer disposed in the channel hole of the DBR region and thermally separating the optical waveguide from the substrate.

Abstract: A method of strengthening a component made of a metallic material. The method includes subjecting the component to a mechanical grinding process incorporating a relative motion between a tool and the component forming a gradient structure on the surface of the component, resulting in increased tensile strength of the component. A method of strengthening a component made of a TWIP steel. The method includes subjecting the component made of TWIP steel to a mechanical grinding process incorporating a relative motion between a tool and the component forming a gradient structure containing a surface nanolaminate layer, a shear band layer, and an inner deformation twinned layer, resulting in increased tensile strength of the component. A component made of a TWIP steel containing a gradient structure with a surface nanolaminate layer, a shear band layer, and a deformation twinned layer.

Abstract: A method of forming a material film includes providing a non-photosensitive mask on a substrate to expose a partial region of the substrate, forming a material film on the partial region of the substrate using a sputtering process, removing the non-photosensitive mask, and heat-treating the substrate and the material film from which the non-photosensitive mask is removed under a first gas atmosphere. The material film includes a transition metal and a chalcogen element. The sputtering process may include an RF magnetron sputtering process. The heat treatment may be performed at a higher temperature than a temperature of the forming the material film.

Abstract: Provided are an optical system capable of improving the spatial resolution of hyperspectral imaging and an optical alignment method using the same. The optical system includes a digital micromirror device (DMD) having a rectangular shape, a first cylindrical lens curved to focus and form an image on an axis corresponding to a shorter side of the DMD, and a second cylindrical lens curved in the same axial direction as the axis to collimate light reflected from the DMD.

Abstract: The present invention relates to a pharmaceutical composition or functional food containing azelaic acid as an active ingredient, particularly, to a pharmaceutical composition or health functional food containing azelaic acid having an effect of promoting triglyceride hydrolysis in adipose tissue and reducing accumulation of the triglycerides through a cAMP-PKA-HSL signaling pathway by binding to an olfactory receptor 544 (Olfr544), which is a G-protein coupled receptor (GPCR) expressed in a membrane of the adipose tissue, to activate Olfr544 as an active ingredient.

Abstract: An image encoding/decoding method and apparatus are disclosed. The image decoding method includes acquiring prediction mode information of a current block from a bitstream, decoding an intra block copy prediction mode of the current block using the prediction mode information of the current block, and reconstructing the current block based on the intra block copy prediction mode. The intra block copy prediction mode is at least one of a block copy based SKIP mode, a block copy based MERGE mode or a block copy based AMVP mode.

Abstract: A fusion protein including a fragment of an anti-mesothelin antibody, an anti-CD3 antibody or an anti-EGFR antibody; a bispecific antibody that is specific to mesothelin and CD3; a trispecific antibody that is specific to mesothelin, CD3 and EGFR are provided. The fusion protein is effective in treating cancer. The bispecific or trispecific antibody can be prepared in a high yield and with high purity, and has excellent tumor killing and growth inhibitory effects, and thus can be effectively used in cancer treatment.

Abstract: The present disclosure provides insecticides that can specifically target mosquitoes based on their sex. These sex-specific insecticides prevent maturation or development of larvae into adult insects using interfering RNA (iRNA). The present disclosure further provides compositions comprising sex-linked iRNA and methods of controlling, reducing, or treating an insect infestation with the iRNA or compositions described herein. The compositions and methods described herein can be used to sort mosquitoes based on sex.

Abstract: The present disclosure relates to a method for restoring brainwave impairment in Alzheimer's brain using optogenetic technology. The method for restoring brainwave impairment in Alzheimer's brain according to the present disclosure can restore brainwave impairment in Alzheimer's brain to a normal level by specifying inhibitory neurons associated with brainwave impairment in Alzheimer's disease and selectively activating impaired neurons through optical stimulation rather than electrical stimulation.

Abstract: Disclosed is a method of operating a flow sensor according to an embodiment of the present disclosure, which includes receiving an ultrasonic signal reflected from a particle, generating first and second digital, generating a first Doppler frequency based on the first and second digital signals, a predetermined number of samples, and a first time period, comparing the first Doppler frequency with a second reference frequency, when the first Doppler frequency is less than a first reference frequency, down-sampling the predetermined number of samples to a first sampling frequency or a second sampling frequency, generating a second Doppler frequency based on the first and second digital signals, the number of down-sampled samples, and a second time period determining an output frequency based on the second Doppler frequency when the first Doppler frequency is less than a first reference frequency, and obtaining flow information of the particle based on the output frequency.

Abstract: A nonlimiting example method for converting implicit dynamic models into explicit dynamic models comprises: performing a block lower triangular (BLT) transformation on equations of an implicit dynamic differential algebraic equation (DAE) model to yield a BLT representation of the implicit dynamic DAE model; performing a nonlinear block extraction for a diagonal of the BLT representation of the implicit dynamic DAE model to yield one or more nonlinear blocks and one or more linear blocks; constructing a surrogate causal model for each of the one or more nonlinear blocks; training the surrogate causal model for each of the one or more nonlinear blocks; and constructing an explicit dynamic ordinary differential equation (ODE) model that corresponds to the implicit dynamic DAE model based on the linear blocks and the surrogate causal model. The explicit ODE model may be useful for controlling operations, diagnosing issues, and prognosticating conditions within a physical system.

Abstract: Provided is a desalination device using a solvent extraction method, comprising: a first mixing tank composed of a feed water inlet into which feed water comprising salt ions and water molecules flows, a first solvent inlet into which a first solvent selectively reacting more with the water molecules than with the salt ions flows, a first mixing tank body in which the feed water and the first solvent are mixed so as to form a mixed water, and a mixed water outlet through which the mixed water is discharged; a first separation tank composed of a mixed water inlet which communicates with the mixed water outlet so that the mixed water flows therein, a first separation tank body in which brine containing salt ions of the feed water and first treatment water formed from mixing the water molecules of the feed water and the first solvent of the mixed water are separated by layer, and a first treatment water outlet through which the first treatment water is discharged; a second mixing tank composed of a first treatme