Abstract: The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.

Abstract: Provided is a novel Nanofiltration-DiaNanofiltration (NF-DiaNF) system and method for extracting divalent ions from saline water (e.g., seawater) to produce solutions rich in divalent ions (in particular Mg2+, Ca2+ and SO42?), while minimizing the concentrations of undesirable species (e.g., Cl?, Br?, B and Na+). The solutions may be added to water (e.g., desalinated, soft, drinking or irrigation water) to enrich the water with divalent ions, thereby improving its quality.

Abstract: Power train architectures with low-loss lubricant bearings and low-density materials are disclosed. The gas turbine used in these architectures can include a compressor section, a turbine section, and a combustor section. A generator, coupled to the rotor shaft, is driven by the turbine section. The compressor section, the turbine section, and the generator each include rotating components, at least one of the rotating components in at least one of the compressor section, the turbine section, and the generator including a low-density material. Bearings support the rotor shaft within the compressor section, the turbine section and the generator, wherein at least one of the bearings is a low-loss bearing having a low-loss lubricant.

Abstract: In an embodiment, a pose estimation device obtains an image of an object, and generates a pose estimate of the object. The pose estimate includes a respective heatmap for each of a plurality of pose components of a pose of the object, and the respective heatmap for each of the pose components includes a respective uncertainty indication of an uncertainty of the pose component at each of one or more pixels of the image.

Abstract: Devices and methods of a transistor device that include a flexible memory cell. The flexible memory cell having a gate stack with sidewalls provided over a substrate. The gate stack including a metal gate layer provided over the substrate. A buffer layer provided over the metal gate layer. A ferroelectric layer provided over the buffer layer. A dielectric layer provided over the ferroelectric layer. Further, a two-dimensional (2D) material layer provided over a portion of a top surface of the dielectric layer. Source and drain regions provided on separate portions of the top surface of the dielectric layer so as to create a cavity that the 2D material layer are located.

Abstract: The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R1a, R3a, R5a, Xa and Ya are as defined herein.

Abstract: Provided is a sound event recognition method that may improve a sound event recognition performance using a correlation between difference sound signal feature parameters based on a neural network, in detail, that may extract a sound signal feature parameter from a sound signal including a sound event, and recognize the sound event included in the sound signal by applying a convolutional neural network (CNN) trained using the sound signal feature parameter.

Abstract: Herein provided is a new soybean variety designated ‘G13LL-44’ as well as the seeds, plants and derivatives of the new soybean variety ‘G13LL-44’. Also provided are tissue cultures of the new soybean variety ‘G13LL-44’ and the plants regenerated therefrom. Methods for producing soybean plants by crossing the new soybean variety ‘G13LL-44’ with itself or another soybean variety and plants produced by such methods are also provided. ‘G13LL-44’ is a MG VII line with glufosinate tolerance technology, and with resistance to race 3 of the soybean cyst nematode and frogeye leaf spot, and moderate resistance to southern root-knot nematode. ‘G13LL-44’ yielded 1.4 bu/ac (2.3%) greater than its recurrent parent ‘G00-3213’, across 11 environments and 0.5 bu/ac more than the high-yielding check cultivar ‘AG738 RR’. ‘G13LL-44’ provides a high yielding glufosinate tolerant soybean cultivar with superior nematode resistance.

Abstract: Provided according to an embodiment of the present invention is an antibody that binds specifically to B-cell maturation antigen (BCMA) and comprises a heavy chain variable domain (VH domain) composed of a sequence having a homology of 80% or higher with any one of the amino acid sequences of SEQ ID NOS: 1 to 20, or a fragment thereof.

Abstract: Disclosed are a heterogeneous zeolite membrane and a method of preparing the same, and more particularly a heterogeneous zeolite membrane that has CHA and DDR zeolite structures by growing seed particles into a crystal structure different from that of the zeolite membrane and can thus separate CO2/N2 and CO2/CH4 even under wet conditions, a method of preparing the same, and a method of capturing and removing carbon dioxide using the membrane.

Abstract: The present invention provides a remediation method for degradation of cadmium in soil. The specific steps are as follows: step 1, determining the content of cadmium in the soil; step 2, crushing and sieving soil from a soil surface, and weighing; step 3, wetting the soil, and removing part of cadmium in the soil to obtain semi-remediated soil; step 4, mixing the semi-remediated soil with a remediation agent, and allowing to stand to obtain improved soil; and step 5, planting Bidens pilosa in the improved soil, and when a growing season is finished, uprooting, and ashing to obtain finished soil. The present invention utilizes anode and cathodes and a remediation agent to treat the cadmium contaminated soil, and plants Bidens pilosa in the soil to achieve a joint effect of electrodynamic remediation, chemical remediation, microbial remediation and phytoremediation to remediate the cadmium contaminated soil.

Abstract: Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation.

Abstract: The presently-disclosed subject matter relates to RNA-based composition and method to treat gastric cancer in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure and composition containing a multiple branched RNA nanoparticle, a gastric cancer targeting module, and an effective amount of a therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanoparticle composition to treat gastric cancer in a subject having or at risk of having gastric cancer.

Abstract: A rotor for a salient pole, wound field, synchronous machine includes a rotor core, a plurality of pole bodies, and a field winding. Each pole body of the plurality of pole bodies includes a pole core, a pole shoe, and a single flux barrier. The single flux barrier forms an enclosed space filled with a material having a magnetic permeability between zero and 1000 relative to a magnetic permeability of a vacuum. The single flux barrier includes a top wall, a shaft mounting wall configured to mount adjacent a shaft when the rotor is mounted to the shaft, and a plurality of interior walls connected between the top wall and the shaft mounting wall. The plurality of interior walls extend parallel to and centered between a first pole core face and a second pole core face of the pole core that extend from the rotor core.

Abstract: Devices and methods can be used for artificial cardiac pacing and/or resynchronization. For example, this document provides improved electrodes for stimulating and sensing electrical activity of the heart, and provides pacing and resynchronization systems incorporating such electrodes. While the devices and methods provided herein are described primarily in the context of pacing, it should be understood that resynchronization can additionally or alternatively be performed in an analogous manner, and that the scope of this disclosure includes such subject matter.

Abstract: Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.

Abstract: Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (PRR) antagonist. In some instances the PRR antagonist is a polypeptide. The PRR antagonist can be a polypeptide having at least 70% identity to the amino acid sequence set forth in SEQ ID NO:2. Also disclosed are methods of decreasing proteinuria and methods of promoting wound healing by administering a PRR antagonist.

Abstract: Overhead lifts with control systems are disclosed. The overhead lifts may include a lift actuator communicatively coupled to a control system. The control system may include a control unit comprising a processor and a memory having computer readable and executable instructions and at least one port for communicatively coupling the control unit to at least one of a computer, a network, and a data storage device. The processor executes the computer readable and executable instructions to: determine at least one operating characteristic of the overhead lift and an operating time of the overhead lift as the overhead lift is actuated; determine an accumulated load-time parameter for the overhead lift based on the at least one operating characteristic and the operating time; and provide an indication that a component of the overhead lift requires service based on the comparison of the accumulated load-time parameter to a service constant.

Abstract: A mounting device for a consumer grade controller that allows for installation in an industrial application with reliability improvement features. The consumer grade controller is mounted to the mounting device using screws and standoffs, which securely fasten the consumer grade controller to the mounting device. The mounting device is compatible with an industry standard DIN rail allowing for easy installation and removal. The mounting device positions the consumer grade controller vertically with respect to the DIN rail to provide improved cooling and reduce DIN rail space. A power cable is secured with a built-in strain relief feature and held in place with a tie wrap to maintain pressure on the cable and preventing it from accidentally releasing. The mounting device, standoffs, and strain relief feature can be injected molded in one assembly for low cost manufacturing while still providing all the benefits that an industrial application requires.

Abstract: Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.