Abstract: Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds.

Abstract: A display panel including a substrate, a meshed shielding pattern, and a plurality of light-emitting devices is provided. The meshed shielding pattern is disposed on the substrate so as to define a plurality of pixel regions on the substrate. The light-emitting devices are disposed on the substrate. At least one light-emitting device of the light-emitting devices is disposed in each pixel region of the pixel regions, wherein an area of the pixel region is A1, an area of the light-emitting device is A2, and a ratio of A2 to A1 is below 50%.

Abstract: The present invention relates to a synthetic method for the preparation of phytosteryl ferulate using ferulic acid and phytosterols (isolated from soybean oil deodorizer distillate) comprising of (a) acetylation of ferulic acid to ferulic acid acetate; (b) esterification of ferulic acid acetate with phytosterols to obtain phytosteryl ferulate acetate; (c) deprotection of phytosteryl ferulate acetate to phytosteryl ferulate. The phytosteryl ferulate was evaluated for hypocholesteremic activity in hamsters in comparison with that of natural oryzanol isolated from rice bran oil soap stock. This study confirmed that the phytosteryl ferulate significantly lowers the elevated cholesterol levels and also interferes with the absorption of cholesterol and the effect is comparable with that of natural oryzanol and is useful as nutraceutical/food supplement. Hence phytosteryl ferulate is a potential substitute for natural oryzanol for several applications.

Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

Abstract: In a digital broadcasting signal transmission system, a transmission frame includes a frame body and a frame header, and the frame body is divided into a plurality of sub-bands in the frequency domain and is divided into a plurality of symbols in the time domain. The frame header is provided in the former part of the transmission frame and is transmitted with a signal in the time domain. The frame body includes a plurality of services, and the services respectively receive at least one sub-band and at least one symbol. The frame header includes information on the plurality of services, and information on the plurality of services includes information on the sub-band and the symbol to which the services are allocated, information on channel encoding levels of the services, and information on digital modulation levels of the services.

Abstract: Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds.

Abstract: A fault analysis method includes: using a matrix of two sets of microgrid power distribution networks to analyze and solve a fault current, and for various types of faults of the distributed power distribution system, obtaining appropriate boundary conditions to calculate a variety of different types of single or simultaneous fault currents of load points. The present invention may be further applied to a situation where a bus or impedance or parallel loop is added. The present invention has good robustness and execution speed, and requires small memory space for calculation of analysis and identification of a power flow fault of the distributed power distribution system, and may be actually applied to an instrument control system for identification and analysis of a fault of a large-scalemicrogrid distribution system.

Abstract: Disclosed herein are an apparatus and method for generating a Quality of Service (QoS) profile. The apparatus includes a user interface unit, a resource QoS policy generation unit, a traffic QoS policy generation unit, and a QoS profile generation unit. The user interface unit receives a QoS policy for Data Distribution Service (DDS) from a user. The resource QoS policy generation unit collects resource data for a device that performs the DDS, and generates a QoS policy for handling resources using the collected resource data. The traffic QoS policy generation unit collects traffic data for a network via which the DDS is performed, and generates a QoS policy for handling traffic using the collected traffic data. The QoS profile generation unit generates a QoS profile based on the QoS policy received from the user, the QoS policy for handling resources, and the QoS policy for handling traffic.

Abstract: Compositions and methods for the identification, prognosis, classification, treatment, and diagnosis of leukemia or a genetic predisposition to leukemia are provided. The present invention is based on the discovery of various genomic abnormalities of the IKZF1 gene which are shown herein to be associated with acute lymphoblastic leukemia (ALL), more particularly, associated with BCR-ABL1 positive ALL and/or shown to be associated with chronic myeloid leukemia (CML), more particularly, associated with blast crisis chronic myeloid leukemia (BC-CML) and/or the likelihood of progression into blastic transformation of CML. These various genomic abnormalities of the IKZF1 gene can further be used as prognostic markers to identify a subgroup of ALL having very poor outcomes.

Abstract: Multifunctional polymers are disclosed having a smart segment and a biodegradable segment. Advantageously, the biodegradable segment includes a hydrophilic segment and a hydrophobic segment. Embodiments include combining the multifunctional polymeric material with a biologically active substance in an aqueous loading environment and administering the composition as a drug delivery vehicle to a human subject.

Abstract: A system and a method for optical transmission are provided. The system includes a power combiner, a laser light source, a negative chirp modulator, and multiple transmission units. Each transmission unit corresponds to a frequency band and generates a first output signal in the frequency band based on orthogonal frequency-division multiplexing (OFDM). The frequency bands are not overlapped with each other. The power combiner is coupled to each transmission unit. The power combiner combines each of the first output signals to generate a second output signal. The negative chirp modulator is coupled to the power combiner and the laser light source. The negative chirp modulator performs negative chirp modulation on the laser light source with the second output signal to generate a light signal and outputs the light signal to an optical fiber.

Abstract: The present invention is directed to a method of designing a plurality of capture oligonucleotide probes for use on a support to which complementary oligonucleotide probes will hybridize with little mismatch, where the plural capture oligonucleotide probes have melting temperatures within a narrow range. The first step of the method involves providing a first set of a plurality of tetramers of four nucleotides linked together, where (1) each tetramer within the set differs from all other tetramers in the set by at least two nucleotide bases, (2) no two tetramers within a set are complementary to one another, (3) no tetramers within a set are palindromic or dinucleotide repeats, and (4) no tetramer within a set has one or less or three or more G or C nucleotides. Groups of 2 to 4 of the tetramers from the first set are linked together to form a collection of multimer units.

Abstract: The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as “PPA derivatives”), particularly 1H-pyrrolo[3,2-c]pyridine-6-amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular, the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives, and pharmaceutical compositions comprising them.

Abstract: According to embodiments of the present invention, a writing circuit for a magnetoresistive memory cell is provided. The writing circuit includes a first connecting terminal configured to provide a first electrical signal to switch a variable magnetization orientation of the free magnetic layer from a first magnetization orientation to a second magnetization orientation; a second connecting terminal configured to provide a second electrical signal to switch the magnetization orientation from the second magnetization orientation to the first magnetization orientation; and a sourcing switch configured to provide for a write operation a connection of the first or second connecting terminal to a node coupleable to the magnetoresistive memory cell. The first and second electrical signals have different amplitudes, and the first and second electrical signals are of the same polarity. Further embodiments relate to a memory cell arrangement and a method of writing into a target magnetoresistive memory cell.

Abstract: An apparatus for preventing stiction of a three-dimensional MEMS (microelectromechanical system) microstructure, the apparatus including: a substrate; and a plurality of micro projections formed on a top surface of the substrate with a predetermined height in such a way that a cleaning solution flowing out from the microstructure disposed thereabove is discharged.

Abstract: An imager has first and second photosensitive sites and an interpolator located in a semiconductor substrate. The first photosensitive site is configured to receive light having a spectral component, and the second photosensitive site is configured to measure the level of the spectral component in light received by the second photosensitive site. The interpolator is configured to estimate the level of the spectral component in the light received by the first photosensitive site based on the measurement by the second photosensitive site.

Abstract: Provided is a nanocomplex comprising a core consisting of a metal; and a periphery being formed on a surface of the core to surround the core and consisting of an inorganic substance and a conductive polymer.

Abstract: Provided are a photonics chip and an optical apparatus including the same. The chip may include a substrate, an optical waveguide, an optical coupler, and a plurality of alignment units. The optical waveguide is formed on the substrate. The optical coupler is formed at the optical waveguide. The alignment units align an optical connector which fixes at least one optical fiber coupled to the optical coupler, on the substrate.

Abstract: A composition of matter includes at least one carbon nanotube (CNT) or a graphene type structure having an outer surface, and a plurality of crystalline polymer supramolecular structures that include a conjugated polymer that are non-covalently secured to the outer surface of the CNTs or the graphene type structure. The conjugated polymer can be a conjugated homopolymer or a block copolymer including at least one conjugated block. The supramolecular structures extend outward from the outer surface of the CNTs or graphene type structures.

Abstract: A Voltage Source Converter having at least one phase leg connected to opposite poles of a direct voltage side of the converter and including a series connection of switching cells has an arrangement configured to apply a pressure to opposite ends of stacks of semiconductor assemblies for pressing the assemblies towards each other so as to obtain electric contact between semiconductor assemblies in the stack while ensuring that the semiconductor assemblies of a first path of each switching cell of the converter go into a permanently closed circuit state in case of a failure of the respective switching cell. A second path of each switching cell has a member configured to keep the second path including an energy storing capacitor non-conducting upon occurrence of the failure.