Abstract: The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.

Abstract: Fiber optic terminals and fiber optic networks having variable ratio couplers are disclosed. The fiber optic terminals comprise a shell having a portion of a variable ratio coupler disposed therein. The variable ratio coupler comprises an optical input, a first optical output, a second optical output and a control. The control may be adjusted for changing an output power level between the first optical output and the second optical output.

Abstract: A method for treating Parkinson's disease where insulin and GSH may be administered intranasally. The GSH and insulin that is administered may be in varying doses at least once daily. The GSH and insulin may be administered sequentially and/or simultaneously and the medications may be administered for differing periods of time depending upon a patient's tolerance and response to the GSH and insulin. The GSH and the insulin may be administered for a certain period of time and/or indefinitely.

Abstract: Disclosed are a method and an apparatus for transmitting or receiving feedback information in a communication system. An operation method of a terminal comprises the steps of: receiving, from a base station, DCI #1 including scheduling information of PDSCH #1 and transmission resource information of HARQ response #1 with respect to PDSCH #1; receiving, from the base station, DCI #2 including scheduling information of PDSCH #2 and transmission resource information of HARQ response #2 with respect to PDSCH #2; and when the transmission resource information of HARQ response #1 is configured as undefined, transmitting, to the base station, HARQ response #1 and HARQ response #2 by using a resource indicated by the transmission resource information of HARQ response #2. Therefore, the performance of the communication system can be improved.

Abstract: In some examples, a wafer bow measurement system comprises a measurement unit including: a wafer support assembly to impart rotational movement to a measured wafer supported in the measurement unit; an optical sensor; a calibration standard to calibrate the optical sensor; a linear stage actuator to impart linear direction of movement to the optical sensor; a wafer centering sensor to determine a centering of the measured wafer supported in the measurement unit; and a wafer alignment sensor to determine an alignment of the measured wafer supported in the measurement unit.

Abstract: The present invention relates to a semi-automatic scanner for ultrasonic inspection of a branch pipe weld that has a small size and is able to perform an inspection while moving in a state of being attached to a test object by a magnetic force, thereby being applied to fittings having various shapes, such as a branch pipe and an elbow.

Abstract: A filament platform insert for insertion into a bowl includes a plurality protruding stages and a plurality of recesses that are each formed in arcuate shapes to form a plurality of arcuate filament channels. An access channel extending along the platform insert, between a top and bottom, and between a rear and front, provides access for insertion of a finger or tool for manipulating an endovascular filament stored in the filament channel. The platform insert is dimensioned such that alignment of multiple such platforms will form filament raceways within a bowl for the coiled reception and storage of multiple endovascular filaments, with each filament reliably isolated from one another. In an alternative configuration, an endovascular filament bowl may be made to have the filament platform as a monolithic component thereof.

Abstract: The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human MSLN on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Abstract: Provided herein are DNA-glycan conjugates that include a glycan and a covalently attached polynucleotide. The polynucleotide includes a plurality of modules. Each module includes a nucleotide string, and the plurality of modules includes a monomer module that corresponds to each carbohydrate monomer present in the DNA-glycan conjugate, and a linkage module that corresponds to each glycosidic linkage present between each carbohydrate monomer in the DNA-glycan conjugate. The nucleotide sequence of the plurality of modules corresponds to the glycan structure. Also provided herein are methods for making and using the DNA-glycan conjugates. Further provided is a computer-implemented method for translating data from a nucleotide sequence to a glycan structure, a system for converting data from a glycan structure to a nucleotide sequence, and a system for translating data from a nucleotide sequence to a glycan structure.

Abstract: A satellite for implementing a protocol associated with a distributed satellite position verification system is provided. The satellite, on implementing the protocol, verifies records of positions of one or more other satellites in the distributed satellite position verification system. According to the protocol, the satellite performs, at different time instances, a first operation, a second operation, or a third operation to act as a first satellite, a second satellite, or a third satellite, respectively in the distributed satellite position verification system. When the first satellites performs the first operation, the first satellite verifies at least some positions in the records of positions of the second satellite such that the first satellite: determines a verified position of the second satellite; calculates a deviation between the verified position and a prior estimated position of the second satellite; and records the verified position into the records, based on the calculated deviation.

Abstract: Compositions comprising a tetraaryl ammonium salt, a tetraaryl ammonium salt covalently bound to a polymer and methods for manufacturing the same are disclosed. The disclosed compositions are useful e.g., for an anion exchange membrane, or an anion conducting polymer, and may further be used in electrochemical devices such as alkaline fuel cells, and alkaline redox-flow batteries.

Abstract: A band filter (100, 200) for filtering a discrete time series signal (110) is provided. The band filter (100, 200) includes an input frequency shifter (120, 220) configured to frequency down shift the discrete time series signal (110, 210) to provide a frequency down shifted discrete time series signal (120a, 220a), a regression based zero frequency centered band filter (130, 230) communicatively coupled to the input frequency shifter (120, 220), the regression based zero frequency centered band filter (130. 230) being configured to filter the frequency down shifted discrete time series signal (120a, 220a) to provide a filtered and frequency down shifted discrete time series signal (130a, 230a), and an output frequency shifter (140, 240) communicatively coupled to the regression based zero frequency centered band filter (130, 230), the output frequency shifter (140, 240) being configured to frequency up shift the filtered and frequency down shifted discrete time series signal (130a, 230a).

Abstract: A method and an apparatus for virtual training based on tangible interaction are provided. The apparatus acquires data for virtual training, and acquires a three-dimensional position of a real object based on a depth image and color image of the real object and infrared (IR) data included in the obtained data. Then, virtualization of an overall appearance of a user is performed by extracting a depth from depth information on a user image included in the obtained data and matching the extracted depth with the color information, and depth data and color data for the user obtained according to virtualization of the user is visualized in virtual training content. In addition, the apparatus performs correction on joint information using the joint information and the depth information included in the obtained data, estimates a posture of the user using the corrected joint information, and estimates a posture of a training tool using the depth information and IR data included in the obtained data.

Abstract: A method for decoding an image, according to the present invention, can comprise the steps of: drawing out a vector predictor of a block vector for indicating a reference block with respect to a current block to be predicted within a current picture; drawing out the block vector on the basis of the vector predictor and a vector differential value corresponding to a different value of the block vector and the vector predictor; and generating a prediction block with respect to the current block on the basis of the block vector.

Abstract: A method and an arrangement for light adaptation of the eyes of a driver of a vehicle when exiting a tunnel. The method and arrangement determines a tunnel exit position and changes a light source luminous flux of at least one light source in the vehicle as the vehicle approaches the tunnel exit position in response to the determination of the tunnel exit position.

Abstract: The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for treating LHRH-R expressing cancer in a patient. The present teachings relate generally to method of making conjugates comprising an LHRH-R antagonist.

Abstract: The present invention relates to a helmet that includes an outer shell, a heads-up information system that comprises a display, and an attachment assembly. The heads-up information system is movable from a storage position within the outer shell to a use position in which the display of the heads-up information system is visible by a user, without obstructing the field of vision of the user, when the helmet is worn by the user. The attachment assembly is coupled to outer shell and the heads-up information system, and is operable to move the heads-up information system between the storage position and the use position.

Abstract: A system and method for providing discharge monitoring of a firearm can include an inertial measurement unit (IMU) and an event detection module. The IMU is disposed on the firearm and senses accelerations. The event detection module receives a plurality of input signals from the IMU indicative of the accelerations. The event detection module assigns the plurality of input signals to sample event candidates at respective windows of time, creates and runs an identification algorithm at a machine learning module using the plurality of input signals. An occurrence of a shot discharge is identified based on an output of the identification algorithm.

Abstract: The present disclosure relates to a lens that can be used for a hologram, an augmented/virtual reality display, and the like, and more particularly, to a meta-lens using a meta surface.