Abstract: Embodiments provide, among other compounds, a family of compounds that can be used as therapeutic anti-cancer agents, methods for using such compounds to treat cancer, and methods of making such compounds.

Abstract: Control or repellency of biting arthropods, particularly biting insects, is accomplished by bringing the biting arthropods into contact with combinations of compounds identical or related to those found on human/animal skin or in plants acting synergistically with one another, or in combination with conventional repellents like N,N-diethyl-3-methylbenzamide (DEET®), para-menthane-3,8-diol (PMD), sec-butyl-2-(2-hydroxyethyl) piperidine carboxylate (“Picaridin”), or other nitrogen containing repellents selected from amines, amides and nitrogen containing heterocyclic compounds, or any synergistic combination of DEET®, PMD, Picaridin, or other nitrogen containing repellents selected from amines, amides and nitrogen containing heterocyclic compounds.

Abstract: The present invention relates to an ironmaking feedstock comprising a solid CaFe3O5 phase. The ironmaking feedstock may be produced by a process comprising reacting a combination of a calcium source and magnetite at elevated temperature under reducing conditions sufficient to produce the solid CaFe3O5 phase. The product may be in the form of agglomerates such as pellets, with a compressive strength such that the product is suitable for transportation.

Abstract: A tactile display device including a nodule having variable stiffness under a surface to provide a near-real feeling of palpation for a physician. The device utilizes granular jamming technology using pneumatic actuation to control a nodule that maintains its shape while allowing the modulation in stiffness. The nodule includes two hemispheres, a contact portion and an actuation portion, forming a sphere. The contact portion and the actuation portion include different thicknesses and/or materials, while the dimensions of the dimensions of the nodule are maintained. As such, a physician can utilize the device to identify the difference between a normal lump and an affected lump even if the shape of each lump appears to be the same. With the tactile display device, due to the different levels of stiffness, a physician can detect the severity of the lump.

Abstract: Systems and methods for controlling an autonomous vehicle are disclosed herein. One embodiment determines a reference path for the autonomous vehicle along a roadway segment and steers the autonomous vehicle along a path that includes controlled back and forth lateral deviations from the reference path along the roadway segment to provide feedback to an occupant of the autonomous vehicle, the feedback indicating to the occupant that the autonomous vehicle is in an autonomous driving mode and that the autonomous driving mode is operating correctly.

Abstract: A method and apparatus for generating a new chemical structure using a chemical structure generation model are provided. The method includes receiving a first descriptor of a first chemical structure, encoding the first descriptor into a latent variable using an encoder of the chemical structure generation model, generating a second descriptor by decoding the latent variable using a decoder of the chemical structure generation model, generating the second chemical structure corresponding to the second descriptor.

Abstract: Disclosed are compounds of formula (I) as follows: in which each of R1, R2, R3, R4, R5, L1, W, and Het is defined herein. Also provides are a method of inhibiting prostaglandin reductase 2 (“PTGR2”) using such a compound and a pharmaceutical composition containing same.

Abstract: Disclosed herein as ibuprofen hybrid conjugates and methods of their use to reduce inflammation, pain, and fever. The ibuprofen conjugates have potent anti-inflammatory and analgesic properties with low potential for ulcerogenic activity. An exemplary compound is an ibuprofen-amino acid-4-aminophenol hybrid. Also disclosed are methods of treating or reducing inflammation, pain, and fever in a subject.

Abstract: Subtractive plug and tab patterning with photobuckets for back end of line (BEOL) spacer-based interconnects is described. In an example, a back end of line (BEOL) metallization layer for a semiconductor structure includes an inter-layer dielectric (ILD) layer disposed above a substrate. A plurality of conductive lines is disposed in the ILD layer along a first direction. A conductive tab is disposed in the ILD layer, the conductive tab coupling two of the plurality of conductive lines along a second direction orthogonal to the first direction. A conductive via is coupled to one of the plurality of conductive lines, the conductive via having a via hardmask thereon. An uppermost surface of each of the ILD layer, the plurality of conductive lines, the conductive tab, and the via hardmask is planar with one another.

Abstract: Disclosed herein are a method for transmitting a broadcast signal for signaling information about a combination of Layered-Division Multiplexing (LDM) technology and Multiple-Input Multiple-Output (MIMO) technology and an apparatus using the method. The method includes generating first signaling information indicating whether MIMO technology is applied to an enhanced layer by LDM technology, generating second signaling information indicating an MIMO application method when the MIMO technology is applied to the enhanced layer, and generating a broadcast signal using the first signaling information and the second signaling information.

Abstract: A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a threaded outer sleeve that rotates relative to the outer shaft until locked down. Independent rotation of the threaded outer sleeve relative to the threaded distal tip allows compression or distraction to modify the gap between the vertebral bodies. The screws are passed from the inferior to superior vertebra or superior to inferior, for example, through a trans-pedicular route to avoid neurological compromise. At the same time, the path of screw insertion is oriented to reach superior or inferior vertebra. An intervertebral cage of the system is configured for lateral expansion from a nearly straight configuration to form a large footprint in the disc space. The screws and cage may be combined for improved fixation with minimal invasiveness.

Abstract: Provided is a portable simulated flood discharge culvert for surveying and mapping, including a supporting device, where the supporting device includes a plurality of telescopic support rods, and the telescopic support rods; a tarpaulin, where the tarpaulin is cover on outer walls of the telescopic support rods; connecting devices, where each of the connecting devices is installed between any two adjacent telescopic support rods; floors, where the floors are respectively arranged between the plurality of telescopic support rods, and top surfaces of the floors are provided with a plurality of protrusions; adjusting devices, where each of the adjusting devices includes angle adjusting mechanisms and a height adjusting mechanism, and the angle adjusting mechanisms and the height adjusting mechanism are respectively fixed on a bottom surface of each of the floors; a fog generating device, a lighting part, and additional blocks.

Abstract: A concrete mixture is provided. The mixture includes cement powder, a plant biomaterial in a solid form, wherein the plant biomaterial does not comprise ash, and concrete aggregate, wherein a ratio of cement powder to the biomaterial ranges from 10:1 to 100:1. Methods of controlling concrete setting by adding a plant biomaterial in a solid form to a concrete mixture are also provided.

Abstract: Optical fiber photonic integrated chip connector interfaces and photonic integrated chip assemblies utilizing low-profile optical fibers and methods thereof are disclosed. In one embodiment, an optical fiber photonic integrated chip (PIC) connector interface includes at least one low-profile optical fiber having an end face, at least one core, and a cladding layer, wherein the end face is non-rotationally symmetric with respect to the at least one core, and the cladding layer includes at least one minimum perimeter point that is a minimum distance from the at least one core as compared to remaining perimeter points of the cladding. The PIC connector interface further includes an interconnect substrate including a fiber mounting surface, and a mechanical coupling surface. The at least one low-profile optical fiber is disposed on the fiber mounting surface such that one or more surfaces of the cladding defining the at least one minimum perimeter point faces away from the fiber mounting surface.

Abstract: An ink formulation for additive manufacturing of low density syntactic foams is described. The ink formulation can include a thermoset resin, a curing agent suitable for use with the thermoset resin, a plurality of hollow spheres, such as glass microballoons, one or more solvents, and one or more non-hollow, viscosity modifying filler. Also described are a method of preparing the ink formulation, a method of preparing three-dimensional objects comprising low density syntactic foams, and the three-dimensional objects prepared thereby.

Abstract: A tissue oxygenation composition comprising (a) an oxygenated solution or a solution containing an oxygen carrier and (b) hydrogen sulfide (H2S). The disclosure also relates to methods of preserving, reperfusing and/or transfusing tissue with a tissue oxygenation composition according to the present disclosure.

Abstract: Disclosed are a method, an apparatus and an electronic device for controlling audio playback of multiple loudspeakers, wherein the method comprises: determining the location information of each speaker and voice signals issued by each speaker; determining the area where each speaker is located according to the location information of each speaker; determining voice instruction corresponding to each voice signal; and controlling the multiple loudspeakers to play the audio indicated by the corresponding voice instruction respectively for the area where the speaker of each voice instruction is located. According to the method and apparatus and/or the electronic device in an embodiment of the present disclosure, different audios can be played for different areas in a preset space.

Abstract: Disclosed is a frequency multiplication apparatus including a first frequency multiplier receiving a first signal having a first frequency and outputting a second signal having a second frequency by multiplying the first frequency by ‘n’ (‘n’ being a positive integer), a second frequency multiplier receiving the second signal and outputting a third signal having a third frequency by multiplying the second frequency by ‘m’ (‘m’ being a positive integer), and a coupler connected between an output of the first frequency multiplier and an input of the second frequency multiplier and outputting a part of the second signal.

Abstract: Disclosed are a neural network accelerator and an operating method thereof, which include an instruction analyzer that analyzes a first instruction instructing an operation with respect to a first layer of a neural network algorithm from an external device, a polymorphic operator array including a plurality of operators that performs the operation with respect to the first layer under a control of the instruction analyzer, an interface that communicates with the external device and an external memory under the control of the instruction analyzer, an internal memory, a type converter, a type conversion data mover that stores data received from the external memory through the interface in the internal memory under the control of the instruction analyzer, and an internal type converter that performs a conversion of data stored in the internal memory or data generated by the polymorphic operator array under the control of the instruction analyzer.