Abstract: A steering system for a steerable flexible elongate member such as for delivering a medical device and/or system. The steering system may be configured for two-way or four-way steering. A control knob is rotatable to control steering of the steerable flexible elongate member in a first direction or a second direction within a steering plane. In a four-way steering system, a first control knob steers the steerable flexible elongate member in a first steering plane, and a second control knob steers the steerable flexible elongate member in a second steering plane transverse to the first steering plane. The steering system may be supported on a stand configured to allow rotational support of the steering system. The stand may support two steering systems in a manner allowing relative axial translation therebetween.

Abstract: Disclosed are a PAM restriction-free adenine base editor fused protein and use. A mutant polypeptide is provided, which comprises an N-terminal fragment of SpRY(D10A), a TadA8e fragment, and a C-terminal fragment of SpRY(D10A) polypeptide in sequence from the N terminus to the C terminus. A fused protein including the mutant polypeptide can target the whole genome, thereby broadening the editable range of the genome. It can induce a base transition of A:T to G:C more efficiently, and has great use potential, including but not limited to, simulation or correction of pathogenic sites in genetic disorders. It lowers off-target at the transcriptome level, and is a mutant form with high efficiency and low off-target.

Abstract: The present application generally relates to natural killer cells (NK) and genetically modified NK cells, methods of transformation, and methods of use in combination with other molecules for targeting cells of interest.

Abstract: An environmental sensor system for monitoring nucleation in a lyophilization chamber is disclosed which includes a sensor unit, including a temperature sensor, a pressure sensor, and a reader circuit in electronic communication with the sensor unit; wherein the sensor unit is adapted to sealingly fit around a vial placed in a lyophilization chamber and further adapted to be energized by the reader circuit and provide signals associated with temperature and pressure within the vial in a non-invasive manner in which the sensors are configured to be positioned in a headspace within the vial but not in contact with product within the vial.

Abstract: An encoding, a decoding method, a system for encoding and decoding, an encoder, and a decoder are provided. The encoding method includes the following. In a palette mode, if colors of pixels of a coding unit block are all represented by one or more major colors of the coding unit block, a flag is set as a first state value, and if the color of at least one pixel of the coding unit block is not represented by the one or more major colors of the coding unit block, the flag is set as a second state value. The encoding method further includes establishing a palette table corresponding to the coding unit block according to a state value of the flag and the one or more major colors.

Abstract: Disclosed are a composition for diagnosis of SARS-CoV-2 infectious disease, a diagnostic kit, a method for providing information for diagnosis, a method for screening a therapeutic agent, and a composition for prevention or treatment, wherein it is expected that the diagnosis or prognostic prediction of the severity of SARS-CoV-2 infectious disease can be attained and the control of expression and activity of TOX, which is a marker, can be advantageously used in the development of a therapeutic agent for SARS-CoV-2 infectious disease.

Abstract: The present disclosure provides a method and apparatus for deconvolving feature data using convolution hardware. The method includes: reading a feature map and deconvolution kernel into on-chip memory, and padding zeroes to the feature map; determining convolution kernels based on the deconvolution kernel; removing a row and/or column of each convolution kernel whose elements all are invalid weights, to obtain an optimized convolution kernel, and removing a corresponding row and/or column in the zero-padded feature map to obtain an corresponding optimized feature map; convolving each optimized convolution kernel with corresponding optimized feature map using the multiply-add array, to obtain convolutional outputs; and interleaving and synthesizing the convolutional outputs to obtain an interleaving synthetic output including at least a deconvolutional output corresponding to the feature map and deconvolution kernel.

Abstract: The invention provides metal-peptoid complexes for use as electrocatalyst in water oxidation processes.

Abstract: The present disclosure generally relates to a composition matter and a method for cancer treatment. In particular, a composition of soft, non-cationic nanocapsules, termed Nanosac, for systemic delivery of siRNA. Nanosac is produced by sequential attachment of siRNA and polydopamine on a sacrificial MSN core, followed by removal of the MSN. Encapsulating siRNA in the capsules, Nanosac avoids the issues common to cationic gene carriers, such as toxicity and non-specific protein binding while protecting siRNA from RNase. Nanosac entered tumor cells by caveolae-mediated endocytosis, likely via albumin recruited from serum, trafficked to the cytosol, and silenced target genes.

Abstract: An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.

Abstract: A laser processing method includes: a forming step of forming a plurality of modified spots along an imaginary plane inside a work piece by irradiating an inside of the work piece with laser light from a surface. The work piece includes a first region and second region when viewed in a direction perpendicular to the surface. In the forming step, a plurality of modified spot rows formed of the plurality of modified spots arranged along a boundary between the first region and the second region are formed in the second region, the plurality of modified spot rows being arranged along a direction intersecting an arrangement direction of the plurality of modified spots, and a crack extending from the second region to the first region is formed by forming the plurality of modified spot rows.

Abstract: A capsule for protecting an electronic device for an earth moving machine, the capsule comprising walls enclosing an inner chamber configured for housing an electronic device or components thereof, the capsule comprising a slot antenna arranged in at least one of the walls, the at least one of the walls in which the slot antenna is arranged is a cover that can be removably coupled to one or more of the walls of the capsule. Also, a device for an earth moving machine comprising a capsule, a process of manufacturing a capsule, and a process of manufacturing a device for an earth moving machine.

Abstract: A quantum computing system includes a first silicon nitride resonator couplable to a first alkali atom, a second silicon resonator couplable to a second alkali atom, and a plurality of lasers for trapping, cooling, and manipulating the first alkali atom and the second alkali atom. Detectors detect a presence of the trapped first alkali atom and the trapped second alkali atom, and a processor is configured to receive at least one input signal from at least one of the detectors, the input signal indicating a presence of the trapped first alkali atom and the trapped second alkali atom, and, based on the received input, control at least some of the plurality of lasers to manipulate at least one of the trapped first alkali atom and the trapped second alkali atom to thereby generate photonic qubits using the trapped first alkali atom or generate entanglement between photonic qubits transmitted to the trapped second alkali atom.

Abstract: The present disclosure provides a mode switching method for reducing training overheads in a reconfigurable intelligent surface (RIS)-assisted communication system. The system includes one single-antenna base station, one single-antenna user terminal, and an RIS including N reflection elements, the single-antenna user terminal sends data to the single-antenna base station, however, when a direct link of a user-base station is blocked by a blockage, the data can be sent to the single-antenna base station only via the RIS; the RIS determines a proper reflection solution by using a controller, and dynamically adjusts a phase shift thereof to improve an achievable data rate of the system; and necessary information for phase shift adjustment can be obtained at the base station by uplink training, and transmitted to the RIS controller by using a control link.

Abstract: A voltage control method and a voltage control circuit for an anti-fuse memory array, including: obtaining a storage data address, dividing the storage data address into multiple subdata addresses, decoding each subdata address to obtain a corresponding group of decoder output signals, converting the corresponding group of decoder output signals into a group of control signals by a corresponding group of high voltage converters; connecting multiple groups of data selectors in series, outputting selection voltages input to each group of data selectors to an anti-fuse unit under the control of the corresponding group of control signals; programming or reading an anti-fuse unit; the selection voltages include one of a programming selection voltage, a reading selection voltage, and a non-designated selection voltage. The present disclosure reduces the number of transistors and saves layout areas when the programming or reading operation is performed.

Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

Abstract: The present disclosure is directed to multi-stage falling particle receivers and methods of falling particle heating. As the particles fall through the receiver, the particles are periodically collected and released by flow retarding devices. The periodic catch-and-release of the particles falling through the receiver reduces particle flow dispersion, increases particle opacity and solar absorption, and reduces erosion and damage to surfaces caused by direct particle impingement.

Abstract: A silicon carbide single crystal contains a heavy metal element having a specific gravity higher than a specific gravity of iron. An addition density of the heavy metal element at least in an outer peripheral portion of the silicon carbide single crystal is set to 1×1015 cm?3 or more.

Abstract: Disclosed are a method and system for vertically utilizing unconventional water source. The system includes a water collection unit, a water treatment unit, and a monitoring, regulation and reuse unit. The water collection unit is configured to collect rainwater and/or domestic wastewater; the water treatment unit is in communication with the water collection unit and configured to purify the rainwater and/or the domestic wastewater collected by the water collection unit; and the monitoring, regulation and reuse unit is in communication with the water treatment unit and configured to use reclaimed water obtained through treatment by the water treatment unit. The method and the system for vertically utilizing unconventional water source in the present disclosure have advantages of a simple structure, low costs, and high treatment efficiency, effectively save energy and water resources, and are suitable for decentralized treatment and recycling of urban domestic wastewater.