Abstract: A method for tracing a digital information element in a computer system including electronic devices of users and a system for archiving digital information elements including a blockchain-type distributed database, the method including a step of making the digital information element from the electronic device of one of the users, a step of archiving the digital information element, the archiving step including a substep of generating an identification element of the version of the digital information element, the method including a step of adding the identification element signed with a secure element associated to this user and/or to their electronic device in the distributed database, the addition step including a substep of encrypting the identification element from a cryptographic algorithm and the secure element, the cryptographic algorithm including at least one metric variable associated to the user.

Abstract: A vacuum smelting device with mold-temperature control design includes: a chamber body and a cabin door, wherein the chamber body and the cabin door form a vacuum closed space; a smelting crucible disposed in the vacuum closed space for smelting raw materials to a molten metal; a casting mold also disposed in the vacuum closed space for accommodating the molten metal poured from the smelting crucible, and solidifying the molten metal to an as-cast alloy; and a mold-temperature control module surrounding the casting mold for controlling the temperature of the casting mold.

Abstract: An image recognition method, a training system for an object recognition model and a training method for an object recognition model are provided. The image recognition method includes the following steps. At least one original sample image of an object in a field and an object range information and an object type information in the original sample image are obtained. At least one physical parameter is adjusted to generate plural simulated sample images of the object. The object range information and the object type information of the object in each of the simulated sample images are automatically marked. A machine learning procedure is performed to train an object recognition model. An image recognition procedure is performed on an input image.

Abstract: Compounds of Formula (I) shown below and a pharmaceutical composition containing one of the compounds: Each of the variables is defined herein. Also disclosed is a method of treating a condition associated with uncontrolled cell growth with a compound of Formula (I).

Abstract: Various embodiments disclosed relate to a semiconductor package. The present semiconductor package includes a substrate. The substrate is formed from alternating conducting layers and dielectric layers. A first active electronic component is disposed on an external surface of the substrate, and a second active electronic component is at least partially embedded within the substrate. A first interconnect region is formed from a plurality of interconnects between the first active electronic component and the second active electronic component. Between the first active electronic component and the substrate a second interconnect region is formed from a plurality of interconnects. Additionally, a third interconnect region is formed from a plurality of interconnects between the second active electronic component and the substrate.

Abstract: A tracheal sampling device is used to collect or acquire cells from an animal, such as at or near the tracheo-bronchial or larynx of an animal. The device includes a flexible and elongated shaft or stem, and a collection member at a distal end of the device. The collection member could be a swab or other member to best collect mucus. The device is used by inserting the collection end into an animal to position the collection member at or near the cell collection site, which may be in or around the larynx. The collection member is removed after collecting cells, which can be reviewed, tested, or otherwise managed to determine the presence of a disease or other bacteria. The length of the shaft or stem allows for optimal positioning of the swab in a variety of animal species and ages. The device can be disposed after each use.

Abstract: Some embodiments provide a soft tissue device, such as a transverse carpal ligament cutting device having one or more balloons that are deflated when the device is in an inactive position and are inflated when the device is in an active position. Other embodiments provide a soft tissue cutting method, such as a method of cutting a transverse carpal ligament that uses a soft tissue cutting device.

Abstract: The present invention relates to a thermal insulator containing a polymer sorbent that regenerates by desorbing adsorbed moisture, and a thermal insulation material. The thermal insulator of the present invention has the thermal insulation performance and prevents deterioration of the object by repeatedly absorbing liquid water between the object to be thermally insulated and the thermal insulator to reduce and prevent retention of water droplets between an object to be thermally insulated and a thermal insulator.

Abstract: A method for detecting the monosaccharide and oligosaccharide content and fingerprint spectrum of a compound Sophora flavescens injection, comprising: carrying out detection by using a high-performance liquid chromatography-evaporation light scattering detection method, wherein the monosaccharides and oligosaccharides are D-anhydrous glucose, D-fructose, sucrose and pinitol. The present method is an improved method for detecting monosaccharides and oligosaccharides of a compound Sophora flavescens injection, and can measure four saccharide components in the compound Sophora flavescens injection at the same time, and constructs an HPLC-ELSD fingerprint spectrum to provide a technical method for the quality control of the saccharide components in the compound Sophora flavescens injection.

Abstract: A gastric bypass device includes an occlusion device that is adapted to be deployed relative to a patient's pyloric sphincter, an anastomosis anchor that is adapted to be deployed relative to an anastomosis between the patient's stomach and their small intestine, and a tether that extends through the patient's small intestine between the occlusion device and the anastomosis anchor. A dynamic leash may be secured relative to the occlusion device and may work in conjunction with the tether to help hold the occlusion device in place.

Abstract: There is described herein a method of prognosing and/or predicting disease progression and/or in subject with prostate cancer, the method comprising: a) providing a sample containing mitochondrial genetic material from prostate cancer cells; b) sequencing the mitochondrial genetic material with respect to at least 1 patient biomarker selected from CSB1, OHR, ATP8 and HV1 (hypervariable region 1); c) comparing the sequence of said patient biomarkers to control or reference biomarkers to determine mitochondrial single nucleotide variations (mtSNVs); and d) determining the a prostate cancer prognosis; wherein a relatively worse outcome is associated with the presence of mtSNVs in CSB1, OHR, ATP8 and a relatively better outcome is associated with the presence of mtSNVs in HV1.

Abstract: The present disclosure discloses an image/video feature descriptor extraction method and apparatus for image/video search. An image/video feature descriptor extraction method may comprise obtaining a search requested image/video from a user, performing spatio-temporal transformation on the search requested image/video, extracting a feature map from the image/video subjected to the spatio-temporal transformation, and extracting an image/video feature descriptor by applying TNIP (Temporal Nested Invariance Pooling) to the feature map.

Abstract: A method of a base station may comprise: transmitting discontinuous transmission (DTX) configuration information for a DTX operation to a terminal; transmitting discontinuous reception (DRX) configuration information for a DRX operation to the terminal; and transmitting information indicating activation of at least one of the DTX operation and the DRX operation to the terminal, wherein the DTX operation and the DRX operation are configured separately.

Abstract: Disclosed is an accelerator device, which includes a first NTT converter that performs an NTT operation on a first ciphertext of a first type to generate a first internal signal, a test polynomial generator that generates a test polynomial, a second NTT converter that performs the NTT operation on the test polynomial to generate a second internal signal, a first multiplier that performs a multiplication on the first internal signal and the second internal signal to generate a third internal signal, a first INTT converter that performs an INTT operation on the third internal signal to generate a fourth internal signal, a gadget decomposer that performs a gadget decomposition on the fourth internal signal to generate a fifth internal signal, and a third NTT converter that performs the NTT operation on the fifth internal signal to generate a sixth internal signal.

Abstract: The present invention provides monoclonal antibodies that recognize poliovirus receptor (PVR) and inhibit its binding to T cell immunoreceptor with Ig and ITIM domains (TIGIT). The present invention further provides pharmaceutical compositions comprising the antibodies and methods for their use in cancer immunotherapy, treating infections and in diagnosis.

Abstract: A method for manufacturing a timepiece component including successive steps of: providing a timepiece component (1); breaking the timepiece component (1) into a plurality of pieces (10); depositing the pieces (10) on a support (2) and creating a desired pattern to be reassembled, the pattern having interstices (1) between the various pieces (10) of the timepiece component (1); transferring the support (2) into a mould adapted by hot forming and placing a preform (3) on the pieces (10) of the timepiece component; heating the whole to a temperature higher than the vitreous transition temperature of the preform (3) and applying a force on the preform to fill the interstices (11) and obtain a reassembled timepiece component (1?); cooling the whole below the vitreous transition temperature of the preform (3) to form the reassembled timepiece component (1?); recovering the reassembled timepiece component (1?) and machining it to the required dimensions.

Abstract: The disclosure provides artificial nucleic acid introns configured for selective splicing in cells with aberrant RNA splicing activity, e.g., neoplastic cells. The artificial intron can comprise a 5? splice site, a canonical 3? splice site, at least one cryptic 3? splice site, a pyrimidine-rich domain, and at least one branchpoint. Also provided are constructs integrating the artificial introns with exons in a configuration that, when the artificial intron is spliced out by the aberrant RNA splicing factors, encode a functional protein. Also disclosed are methods that employ the disclosed platform of selective expression, including, targeted gene therapy methods (e.g., in cancers), diagnostics and imaging, and drug screening.

Abstract: The invention relates generally to antigen-binding molecules that specifically bind to Myosin Heavy Chain 9 (MYH9) and uses thereof for the treatment of specific cancers, such as mast cell tumors. In one embodiment, the MYH9 is canine MYH9 and the antigen-binding molecule is an antibody. In another embodiment, the antigen-binding molecule is conjugated to a toxin, for the treatment of canine mast cell tumors.

Abstract: An object of the present invention is to provide a novel chimeric antigen receptor. The object can be achieved by a chimeric antigen receptor, comprising an antigen-binding domain, a transmembrane domain, and an intracellular signal domain containing a CD79A intracellular domain and a CD40 intracellular domain, wherein (A) the number of constituent amino acid residues between the antigen-binding domain and the transmembrane domain is 100 or less and/or (B) a target antigen of the antigen-binding domain is an antigen other than CD19.

Abstract: A method for determining an operational status of a firearm based on a discharge event is provided. A signal indicative of a plurality of accelerations sensed by an inertial measurement unit is received by an event detection module. A sample shot profile is determined based on the signal. The shot profile can comprise a first peak at a first time representing initial discharge of the firearm wherein a bolt of the firearm moves from an initial forward position, a second peak at a second time, representing the bolt engaging a rear buffer of the firearm, and a third peak at a third time, representing the bolt returning to the forward position. A measured bolt speed of the weapon is determined based on a difference between the second and third times. The measured bold speed is compared to a baseline weapon bolt speed. An operational status of the weapon is determined.