Patents Assigned to Research
  • Recombinant metapneumovirus F proteins and their use
    Patent number: 11786591
    Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: October 17, 2023
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Institute for Research in Biomedicine
    Inventors: Peter Kwong, Michael Gordon Joyce, Baoshan Zhang, Yongping Yang, Peter Collins, Ursula Buchholz, Davide Corti, Antonio Lanzavecchia, Guillaume Stewart-Jones
  • Pivoting guide device for a pivoting mass and timepiece resonator mechanism
    Patent number: 11789407
    Abstract: A device (10) for guiding a pivoting mass in rotary pivoting, in particular for a horological movement comprising, arranged in series substantially in the same plane, a first support (2), a first pair of uncrossed strips (5, 6), a second support (3), a pair of crossed strips (7, 8), and a third support (4), the pair of uncrossed strips including, a first (5) and a second (6) flexible strip connecting the first support (2) to the second support (3) without crossing each other, the pair of crossed strips including a third (7) and a fourth (8) flexible strip connecting the second support (3) to the third support (4), the third (7) and fourth (8) flexible strips crossing each other between the second (3) and the third (4) support.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: October 17, 2023
    Assignee: The Swatch Group Research and Development Ltd
    Inventors: Mohammad Hussein Kahrobaiyan, Gianni Di Domenico
  • High resolution depth-encoding PET detector with prismatoid light guide array
    Patent number: 11789167
    Abstract: Provided is a particle detection device and method of fabrication thereof. The particle detection device includes a scintillator array that includes a plurality of scintillator crystals; a plurality of detectors provided on a bottom end of the scintillator array; and a plurality of prismatoids provided on a top end of the scintillator array. Prismatoids of the plurality of prismatoids are configured to redirect particles between top ends of crystals of the scintillator array. Bottom ends of a first group of crystals of the scintillator array are configured to direct particles to a first detector of the plurality of detectors and bottom ends of a second group of crystals of the scintillator array are configured to direct particles to a second detector substantially adjacent to the first detector.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: October 17, 2023
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Amirhossein Goldan, Andrew Labella, Wei Zhao, Anthony R. Lubinsky
  • Gas/liquid plasma reactor with pulsed power supply and secondary direct current electrodes
    Patent number: 11787709
    Abstract: A method for reacting a liquid phase chemical species includes the steps of providing liquid phase containing at least one liquid phase chemical species, providing a gas phase, and providing a reactor vessel for containing the liquid phase and the gas phase. The liquid phase and the gas phase are placed in the reactor vessel so as to form a liquid-gas interface between the liquid phase and the gas phase within the reactor vessel. A pulsed discharge cathode and anode are provided for creating a pulsed discharge electric field at the liquid-gas interface. A pulsed power input to the pulsed discharge cathode and anode is provided, thereby creating a plasma comprising ions at the liquid-gas interface. A secondary electric field is directed transverse to the liquid-gas interface, wherein the secondary electric field will drive ions from the gas phase into the liquid phase to react with the liquid phase species.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: October 17, 2023
    Assignee: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Bruce R. Locke, Robert J. Wandell, Youneng Tang
  • Tetrahydroquinoline-based bromodomain inhibitors
    Patent number: 11787768
    Abstract: In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: October 17, 2023
    Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
    Inventors: R. Kip Guy, P Jake Slavish, William Robert Shadrick, Brandon M. Young, Vincent A. Boyd, Nagakumar Bharatham, Jeanine E. Price, Anang Shelat
  • System and method for fusion recognition using active stick filter
    Patent number: 11790555
    Abstract: Provided is a system and method for fusion recognition using an active stick filter. The system for fusion recognition using the active stick filter includes a data input unit configured to receive input information for calibration between an image and a heterogeneous sensor, a matrix calculation unit configured to calculate a correlation for projection of information of the heterogeneous sensor, a projection unit configured to project the information of the heterogeneous sensor onto an image domain using the correlation, and a two-dimensional (2D) heterogeneous sensor fusion unit configured to perform stick calibration modeling and design and apply a stick calibration filter.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: October 17, 2023
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Jin Woo Kim, Ki Tae Kim
  • Osseointegration system
    Patent number: 11786385
    Abstract: Improved osseointegration devices and structures, including such structures that can be used in connection with prosthetic limbs. Examples include a self-centering implant/nut configuration, a centering device, a tapered mounting screw hole, a coupling device, and an aiming device. The devices are highly efficacious. For example, they can be secured with minimal residual bone, and may be removed without significant bone destruction.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: October 17, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Benjamin K. Wilke, Shawn P. Robinson, James M. Jeter
  • COMPOSITIONS AND METHODS FOR THE DETECTION AND MOLECULAR PROFILING OF MEMBRANE BOUND VESICLES WITH NANOPARTICLES
    Publication number: 20230324376
    Abstract: The present disclosure featured compositions and methods related to the detection and molecular profiling of extracellular vesicles using optical probes, dual imaging approaches, and computationally programing-based image analysis methods. These compositions and methods leverage the unique optoelectrical properties of quantum dots, fluorescently labeled nanoparticles, and gold nanoparticles, which allow reliable, real-time detection of extracellular vesicles and vesicle surface bound or lumenal molecules at single vesicle level.
    Type: Application
    Filed: April 10, 2023
    Publication date: October 12, 2023
    Applicant: The University of Memphis Research Foundation
    Inventors: Xiaohua HUANG, Thang Ba HOANG, Yongmei WANG, Caleb Edward GALLOPS
  • COMPUTER-IMPLEMENTED SYSTEM AND METHOD FOR PROVIDING WEBSITE NAVIGATION RECOMMENDATIONS
    Publication number: 20230325453
    Abstract: A system and method for providing Website navigation recommendations is provided. A Web page of interest is identified as a destination Web page. A domain of Web pages related to the destination Web page is determined. Information is extracted from each Web page in the domain and a recommendation comprising instructions for navigating to the destination Web page is generated based on the extracted information.
    Type: Application
    Filed: June 13, 2023
    Publication date: October 12, 2023
    Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
    Inventors: Kristian Lyngbaek, Lester D. Nelson, Eric A. Bier, Margaret H. Szymanski
  • SYSTEMS AND METHODS FOR CORONARY OCCLUSION TREATMENT
    Publication number: 20230320576
    Abstract: Exemplary embodiments of the present disclosure include systems and methods for treatment of occlusions, including coronary artery chronic total occlusions.
    Type: Application
    Filed: November 28, 2022
    Publication date: October 12, 2023
    Applicant: Research Development Foundation
    Inventors: Marc D. FELDMAN, Thomas E. MILNER, Nitesh KATTA, Arnold ESTRADA, Meagan OGLESBY, Andrew Giles CABE, Mehmet CILINGIROGLU
  • VETO CAR-T CELLS
    Publication number: 20230321235
    Abstract: A method of generating a population of genetically modified veto cells is disclosed. The method comprising: (a) providing a population of cells comprising T cells, the T cells comprising at least 40% memory CD8+ T cells; (b) culturing the population of cells comprising T cells with an antigen or antigens under conditions which allow enrichment of tolerance-inducing antigen-specific cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being depleted of graft versus host (GVH) reactivity; and (c) transducing the cells with a polynucleotide encoding a heterologous cell surface receptor comprising a T cell receptor signaling module, thereby generating the population of genetically modified veto cells.
    Type: Application
    Filed: August 11, 2021
    Publication date: October 12, 2023
    Applicants: Yeda Research and Development Co. Ltd., Ichilov Tech Ltd.
    Inventors: Yair REISNER, Anat GLOBERSON LEVIN, Esther BACHAR-LUSTIG, Assaf LASK, Bar NATHANSOHN-LEVI, Tova WAKS, Galit HORN, Zelig ESHHAR
  • COMPOSITION FOR ANTI-AGING OR SKIN REGENERATION COMPRISING OKANIN
    Publication number: 20230321003
    Abstract: Disclosed is a composition for anti-aging or skin regeneration comprising Okanin, and use of Okanin or a salt thereof and, more particularly, to a composition for anti-aging or skin regeneration comprising Okanin represented by the following formula (1) or a salt thereof, and use of Okanin or a salt thereof.
    Type: Application
    Filed: August 27, 2021
    Publication date: October 12, 2023
    Applicants: POSCO CO., LTD, POSTECH Research and Business Development Foundation, RESEARCH INSTITUTE OF INDUSTRIAL SCIENCE & TECHNOLOGY
    Inventors: Kyong-Tai KIM, Kwang-Ho KWON, Sung-Wook KIM, Sung-Woo JEONG
  • CHIMERIC ANTIGEN RECEPTOR T CELLS FOR TREATING AUTOIMMUNITY
    Publication number: 20230321239
    Abstract: Disclosed are compositions and methods for treating autoimmune diseases such as lupus, including immune cells expressing at least a chimeric antigen receptor (CAR) polypeptides that binds CD83 and uses thereof for suppressing and/or killing autoreactive cells in a subject having an autoimmune disease.
    Type: Application
    Filed: August 13, 2021
    Publication date: October 12, 2023
    Applicants: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC., REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Brian BETTS, Marco DAVILA
  • ELECTRICAL TOPOLOGY OF INTEGRATED DC CHARGING STATION AND OPERATION CONTROL METHOD THEREOF
    Publication number: 20230322098
    Abstract: Disclosed is an electrical topology of an integrated DC charging station and an operation control method. The electrical topology comprises a supply side DC bus, K discrete charging pile units and a mutual aid total DC bus; each charging pile unit comprises an input DC bus, a mutual aid sub-DC bus, an output DC bus, N isolation branches, a non-isolation DC/DC module and an output terminal, the input DC bus is connected to the supply side DC bus, and the mutual aid sub-DC bus of each charging pile unit is connected to the mutual aid total DC bus; the isolation branch comprises an output branch and a mutual aid branch; and when all the output branches of one charging pile, unit are started and the output power cannot meet the required power, the mutual aid branches of other charging pile units are started to meet the required power.
    Type: Application
    Filed: July 2, 2021
    Publication date: October 12, 2023
    Applicants: STATE GRID JIANGSU ELECTRIC POWER CO., LTD. RESEARCH INSTITUTE, JIANGSU ELECTRIC POWER RESEARCH INSTITUTE CO., LTD.
    Inventors: Tiankui SUN, Mingming SHI, Xiaolong XIAO, Jinggang YANG, Liguo LIU, Qifeng HUANG, Shuyi ZHUANG, Wei SU, Lei GAO, Yubo YUAN, Xiaodong YUAN, Jian LIU, Shu CHEN
  • HIGH-VOLTAGE BUSHING AND HIGH-VOLTAGE POWER TRANSMISSION SYSTEM
    Publication number: 20230328918
    Abstract: A high-voltage bushing, comprising a conductive rod and an air cooling device. The conductive rod is internally provided with an air duct, and the air duct comprises an air inlet and an air outlet. The air cooling device comprises at least one fan, and the fan is configured to output airflow so as to blow the airflow into the air duct through the air inlet.
    Type: Application
    Filed: April 28, 2022
    Publication date: October 12, 2023
    Applicants: State Grid Corporation of China, State Grid Smart Grid Research Institute Co., LTD.
    Inventors: Shan LIU, Zehong LIU, Shaowu WANG, Xianshan GUO, Yong HUANG, Jin ZHANG, Shengli SONG, Jinzhong LI, Licheng LU, Yunpeng LI, Jianhui ZHOU, Hang WANG, Zhe JIANG, Junyi HOU
  • ELECTROCHEMICAL DEHYDROGENATION, EPOXIDATION, SUBSTITUTION, AND HALOGENATION OF HYDROCARBONS AND HYDROCARBON DERIVATIVES
    Publication number: 20230323544
    Abstract: A method of making alkenes and/or epoxides from alkanes and hydroxy-alkanes, respectively. In a reactor having an anode and a cathode separated by an ion exchange membrane, and containing a solution comprising water, halogen ions, and an alkane and/or a hydroxy-alkane, apply a potential across the anode and the cathode such that a halogenated intermediate is produced at the anode as an anolyte and hydroxyl ions are produced at the cathode as a catholyte; and combining the anolyte and the catholyte to yield an alkene and/or an epoxide.
    Type: Application
    Filed: June 14, 2023
    Publication date: October 12, 2023
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Marcel Schreier, Christine E. Lucky
  • DEVICE CONTROL FOR WIRELESS CHARGING
    Publication number: 20230327489
    Abstract: Embodiments of a system and method for controlling a device charging on a wireless charger are generally described herein. A method may include disabling, in response to determining that the device is currently charging on the wireless charger, haptic feedback at the device, determining whether the device is in a night mode or a day mode, in response to determining that the device is in the night mode and currently charging on the wireless charger, disabling notifications of the device, and enabling, in response to determining that the device is in the day mode, the haptic feedback and the notifications when the device has been removed from the wireless charger.
    Type: Application
    Filed: October 26, 2022
    Publication date: October 12, 2023
    Applicant: Tahoe Research, Ltd.
    Inventors: Anna-Marie MANSOUR, Kahyun KIM, Andrea TORTORIELLO
  • NANO-LIGAND FOR PROMOTING CELL ADHESION AND DIFFERENTIATION OF STEM CELLS AND METHOD OF PROMOTING CELL ADHESION AND DIFFERENTIATION OF STEM CELLS BY USING THE SAME
    Publication number: 20230324326
    Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and differentiation of stem cells and a method of promoting cell adhesion and differentiation of stem cells by using the nano-ligand, and the method of promoting cell adhesion and differentiation of stem cells according to the present invention may temporally and spatially, and reversibly control nano-ligand sliding by applying a magnetic field to a substrate including the nano-ligands, and efficiently control stem cell adhesion and differentiation ex vivo or in vivo through the magnetic-field based on spatiotemporal control.
    Type: Application
    Filed: June 21, 2023
    Publication date: October 12, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Hee-Min KANG, Chandra Khatua, Gun-Hyu Bae, Hyo-Jun Choi, Sun-Hong Min
  • AMERICAN CHESTNUT LEAF COMPOSITIONS COMPRISING OXALATE OXIDASE AND METHODS FOR TREATMENT OF OXALATE-RELATED DISORDERS
    Publication number: 20230321202
    Abstract: The invention provides American chestnut leaf compositions comprising oxalate oxidase. The compositions reduce oxalate levels in dietary sources of oxalate and are useful in reducing oxalate levels and reducing stone disease in patients. The invention provides methods of extracting and purifying oxalate oxidase from American chestnut leaf. The invention provides methods of extracting oxalate from biological samples.
    Type: Application
    Filed: March 16, 2023
    Publication date: October 12, 2023
    Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED, The Research Foundation for The State University of New York (RFSUNY)
    Inventors: Paul R. Dominguez-Gutierrez, William L. Donelan, Tania Quesada, William A. Powell
  • METHOD, DEVICE AND SYSTEM FOR CALCULATING DANGER DEGREE OF EVENT SCENE
    Publication number: 20230325956
    Abstract: Disclosed herein a method, device and system for calculating danger degree of event scene. The method includes: calculating the danger degree of the event scene based on event scene information that includes report data of the event and at least one of brief situation data specifying an outline of an event and data about an event inducer; and providing response information for dealing with the event at the event scene based on the danger degree.
    Type: Application
    Filed: February 3, 2023
    Publication date: October 12, 2023
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Hyunho PARK, Eunjung KWON, Sungwon BYON, Dong Man JANG, Eui-Suk JUNG