Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.
Type:
Grant
Filed:
April 8, 2021
Date of Patent:
January 9, 2024
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Timor Baasov, Dana Atia-Glikin, Jeyakumar Kandasamy, Valery Belakhov
Abstract: The present invention provides an apparatus and method for automatic generation and update of a knowledge graph from multi-modal sources. The apparatus comprises a conversation parsing module configured for updating a dynamic information word set VD with labelled words generated from extracted from the multi-modal sources; updating a static information word set VS based on extracted schema of relations extracted from the multi-modal sources; and generating pairs of question and answer based on the dynamic information word set VD, the static information word set VS and the one or more sentence patterns; and a knowledge graph container configured for updating a knowledge graph based on the extracted entities of interest and schema of relations. Therefore, an efficient and cost-effective way for question decomposition, query chain construction and entity association from unstructured data is achieved.
Type:
Grant
Filed:
August 27, 2021
Date of Patent:
January 9, 2024
Assignee:
Hong Kong Applied Science and Technology Research Institute Company Limited
Inventors:
Yunzhao Lu, Wai On Sam Lam, Man Choi Asa Chan
Abstract: A substrate support for a plasma chamber includes a base plate arranged along a plane, a first layer of an electrically insulating material arranged on the base plate along the plane, a plurality of heating elements arranged in the first layer along the plane, and a plurality of diodes arranged in respective cavities in the first layer. The plurality of diodes are connected in series to the plurality of heating elements, respectively. Each of the plurality of diodes includes a die of a semiconductor material arranged in a respective one of the cavities. The semiconductor material has a first coefficient of thermal expansion. A first side of the die is arranged on the first layer along the plane. A first terminal of the die is connected to a first electrical contact on the first layer.
Abstract: The present disclosure relates to a bifunctional catalyst for manufacturing a hydrocarbon from carbon dioxide and hydrogen. The bifunctional catalyst includes a carbon composite including cobalt (Co) and nitrogen (N) atoms forming a coordinate bond with the cobalt, and metal particles which exhibit a catalytic activity for a Fischer-Tropsch synthesis reaction and which are dispersed on the inner pore surface and/or the outer surface of the carbon composite support, thus simultaneously promoting a reverse water gas shift reaction and the Fischer-Tropsch synthesis reaction.
Type:
Grant
Filed:
January 23, 2020
Date of Patent:
January 9, 2024
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Sun Mi Hwang, Ki Won Jun, Seok Ki Kim, Hae Gu Park, Seung Ju Han
Abstract: The electronic apparatus includes a memory stored with a multiple light field unit (LFU) structure in which a plurality of light fields is arranged in a lattice structure, and a processor configured to, based on a view position within the lattice structure being determined, generate a 360-degree image based on the view position by using the multiple LFU structure, and the processor is configured to select an LFU to which the view position belongs from among the multiple LFU structure, allocate a rendering field-of-view (FOV) in predetermined degrees based on the view position, generate a plurality of view images based on a plurality of light fields comprising the selected LFU and the allocated FOV, and generate the 360-degree image by incorporating the generated plurality of view images.
Type:
Grant
Filed:
August 12, 2020
Date of Patent:
January 9, 2024
Assignee:
INHA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Inventors:
Chae Eun Rhee, Hyunmin Jung, Hyuk-Jae Lee
Abstract: The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-?) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.
Type:
Grant
Filed:
March 1, 2018
Date of Patent:
January 9, 2024
Assignee:
National Research Council of Canada
Inventors:
Anne E. G. Lenferink, John C. Zwaagstra, Traian Sulea, Maureen D. O'Connor-McCourt
Abstract: Provided are a memory access method and a server for performing the same. A memory access method performed by an optical interleaver included in a server includes receiving a request message from a requester processing engine included in the server, setting receiving buffers corresponding to different wavelengths corresponding to the number of external memory/storage devices connected to the server, multiplexing the same request message at the different wavelengths according to a wavelength division multiplexing (WDM) scheme, and transmitting the multiplexed request messages to the respective external memory/storage devices, wherein an address of a virtual memory managed by the server is separated and stored according to an interleaving scheme by a responder included in each of the external memory/storage devices.
Type:
Grant
Filed:
July 6, 2022
Date of Patent:
January 9, 2024
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Jongtae Song, Daeub Kim, Ji Wook Youn, Kyeong-Eun Han, Joon Ki Lee
Abstract: Disclosed are a method for inducing a prediction motion vector and an apparatus using the same. An image decoding method can include: a step of determining the information related to a plurality of spatial candidate prediction motion vectors from peripheral predicted blocks of a predicted target block; and a step of determining the information related to temporal candidate prediction motion vectors on the basis of the information related to the plurality of spatial candidate prediction motion vectors. Accordingly, the present invention can reduce complexity and can enhance coding efficiency when inducing the optimum prediction motion vector.
Type:
Grant
Filed:
July 13, 2020
Date of Patent:
January 9, 2024
Assignees:
Electronics and Telecommunications Research Institute, Industry-University Cooperation Foundation Korea Aerospace University
Inventors:
Sung Chang Lim, Hui Yong Kim, Jin Ho Lee, Jin Soo Choi, Jin Woong Kim, Jae Gon Kim, Sang Yong Lee, Un Ki Park
Abstract: Computerized apparatus and methods useful for authentication and/or handling and tracking of users and objects such as e.g., items being shipped or baggage associated with a user during travel. In one embodiment, a computerized apparatus located at a departure location (e.g., a kiosk) includes digital imaging and scanning apparatus to enable biometric user authentication, imaging of chattel associated with the user, as well as networked access to a computerized travel reservation system, so as to enable authentication of the user (and/or the item being shipped) as well as other aspects of the shipment transaction. The kiosk may further enable computerized control and operation of an item shipment receptable so as to allow or deny access based on the authentication processing.
Type:
Grant
Filed:
January 31, 2022
Date of Patent:
January 9, 2024
Assignee:
WEST VIEW RESEARCH, LLC
Inventors:
Mark J Gazdzinski, Robert F. Gazdzinski
Abstract: A method for reporting channel state information (CSI) by user equipment (UE) for beamforming based on an antenna array in a wireless communication system according to an embodiment of the present disclosure includes: receiving a channel state information reference signal (CSI-RS); generating channel state information using the CSI-RS and a codebook generated in advance; and reporting the channel state information. The channel state information includes information related to a codevector determined in the codebook, the antenna array has a three-dimensional shape having omnidirectional symmetry, the codebook is generated based on a position of the UE having a center of the three-dimensional shape as an origin, and the position of the UE is represented based on a polar coordinate system.
Type:
Grant
Filed:
September 5, 2019
Date of Patent:
January 9, 2024
Assignees:
LG ELECTRONICS INC., SOGANG UNIVERSITY RESEARCH FOUNDATION
Inventors:
Jonghyun Park, Wonjae Ryoo, Wonjin Sung, Hyukjun Lee, Haewook Park
Abstract: A workgroup-computing-entity-based fail-safe/evolvable hardware core structure is disclosed which includes a 3-hierarchical-level 6-workgroup-Basic-Building-Block (6-wBBB) created to supplant the node-computing-entity-based non-fail-safe/limited evolvable von-Neumann core structure of 3-hierarchical-level 3-node-BBB, (i.e., base-level IO-devices/mid-level main memory/top-level CPU) and all the first-time fail-safe workgroup systems can be subsequently generated in the second period along the workgroup-computing evolutionary timeline. Furthermore, based on the first 6-wBBB evolvable architecture, the workgroup evolutionary processes can go up to 7 generations in creating all the necessary workgroup-computing entity-based hardware core structures, so that all the real-time intelligent workgroup-computing systems can be generated in the third period along the workgroup-computing evolutionary timeline.
Abstract: Methods, systems, and computer programs are presented for selective deposition of etch-stop layers for enhanced patterning during semiconductor manufacturing. One method includes an operation for adding a photo-resist material (M2) on top of a base material (M1) of a substrate, M2 defining a pattern for etching M1 in areas where M2 is not present above M1. The method further includes operations for conformally capping the substrate with an oxide material (M3) after adding M2, and for gap filling the substrate with filling material M4 after the conformally capping. Further, a stop-etch material (M5) is selectively grown on exposed surfaces of M3 and not on surfaces of M4 after the gap filling. Additionally, the method includes operations for removing M4 from the substrate after selectively growing M5, and for etching the substrate after removing M4 to transfer the pattern into M1. M5 adds etching protection to enable deeper etching into M1.
Abstract: Provided herein is a method of forming a beta-lactone from a carboxylic acid having a beta-carbon with a hydrogen atom disposed thereon. The method comprises contacting a carboxylic acid of formula (1) as described herein with an effective amount of a palladium(II) catalyst, an effective amount of an N-protected aminoacid ligand, and t-butylhydroperoxide in a solvent comprising hexafluoroisopropanol (HFIP), at about 60° C. to provide a beta-lactone of formula (2) as described herein.
Abstract: A method for analyzing disaster prevention and mitigation effectiveness of an ecological seawall is provided, including: performing seawall ecologicalization on a target seawall; establishing three-dimensional space hydrodynamic force for the target ecological seawall; simulating wave climbing on a dike body and a wave overtopping on a dike top of the target ecological seawall to obtain a wave overtopping index; calculating wave-flow bottom shear stress of the target ecological seawall, establishing a sediment movement model, and calculating suspended load and bed load sediment transportation volumes; calculating the change index of coastal bed surface according to the suspended load and bed load sediment transportation volumes, and determining a development index of tidal flats in front of dike of the target ecological seawall according to the change index; and calculating the disaster prevention and mitigation effectiveness grade of the target ecological seawall according to the wave overtopping index and t
Type:
Grant
Filed:
August 30, 2023
Date of Patent:
January 9, 2024
Assignee:
Pearl River Water Resources Research Institute
Abstract: The present invention generally relates to a process of nanoparticle formulations and its composition matter for systemic treatment of sepsis. In particular, this invention discloses a method for preparing tannic acid-ferric nanoparticles, optionally incorporating a component of vitamin D3, coated with zwitterionic chitosan (ZWC) and polymyxin B (PMB). The invention described herein also pertains to pharmaceutical compositions and methods for the treatment of sepsis.
Abstract: Disclosed is an apparatus and method for processing a multichannel audio signal. A multichannel audio signal processing method may include: generating an N-channel audio signal of N channels by down-mixing an M-channel audio signal of M channels; and generating a stereo audio signal by performing binaural rendering of the N-channel audio signal.
Type:
Grant
Filed:
July 29, 2022
Date of Patent:
January 9, 2024
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Yong Ju Lee, Jeong Il Seo, Seung Kwon Beack, Kyeong Ok Kang, Jin Woong Kim, Jae Hyoun Yoo
Abstract: A switchable display system for providing virtual reality or augmented reality using a color calibration display apparatus may comprise: an augmented reality data server configured to provide virtual reality and augmented reality information; and a color calibration display apparatus using a color calibration display module configured to perform color calibration according to ambient illuminance in a use environment.
Type:
Grant
Filed:
November 2, 2021
Date of Patent:
January 9, 2024
Assignee:
POSTECH Research and Business Development Foundation
Inventors:
Ji Hyung Kim, Young Seok Kim, Sungeun Park, Wook Sung Kim
Abstract: Disclosed herein are prosthesis simulator devices comprising a first restraint configured to restrain one or more fingers of a wearer of the simulator, a second restraint configured to restrain a thumb of the wearer, and a plurality of artificial digits configured to move in a manner to simulate one or more prosthetic fingers and a prosthetic thumb of a prosthesis. The first restraint can be attached to a roof plate connected to a base plate and defining a dorsal side of the prosthesis simulator. The second restraint can be attached to a holster connected to the base plate on a palmar side of the prosthesis simulator. Also disclosed herein are methods of using the same.
Type:
Grant
Filed:
September 8, 2021
Date of Patent:
January 9, 2024
Assignee:
Georgia Tech Research Corporation
Inventors:
Bennett Leonard Alterman, William D. Hendrix, John T. Johnson, Perry J. Lee, Lewis A. Wheaton